Overview
Background
I am a physician at RBWH where I did my undergraduate training. I subspecialised in THoracic Medicine with a focus on bronchoscopy. I helped to create a large interventional service here. Part of that inlcuded instituting endobronchial ultrasound ( EBUS), an Australian first, in 2003. This has become standard of care for diagnosing lung cancer.
My research has been centred on how specimens from EBUS can be optimised. I have had strong collaboration with UQCCR, Pathology Queensland and QIMR Berghofer. Our work has expanded on 2 fronts- 1. use of simple cytology smears as the source for panel molecular testing and 2. The expanded role of WES and WGS on these samples.
We have instituted a large Australia wide collaborative network who are collecting samples along with us( The Debutant studies).We have Cancer Council Australia / CCQ/ and NHMRC grants fr these studies
Availability
- Associate Professor David Fielding is:
- Available for supervision
Fields of research
Qualifications
- Bachelor of Medicine and Surgery and Medical Science, The University of Queensland
Research interests
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Lung Cancer Genomics
The Debutant study is an Australia wide study ( based at RBWH and UQCCR and QIMR Berghofer) of maximising the utility of specimens for lung cancer genomics when they are collected at biopsy using Endobronchial ultrasound.
Research impacts
Our work has proposed workflow solutions including use of diff quik smears as alternative samples to formalin base samples for genomic study
Our work has built upon the idea of smears being " what yiou see is what you get" as far as samples for genomics, and the way smear microscopy can predict DNA content of the samples, thereby alllowing decision making for genomic testing
We will also continue to build workflow solutions starting from small increasing to large panel, then WES, then WGS, hopefully putting these concepts into the clinic
Works
Search Professor David Fielding’s works on UQ eSpace
2024
Journal Article
Performance of somatic structural variant calling in lung cancer using Oxford Nanopore sequencing technology
Liu, Lingchen, Zhang, Jia, Wood, Scott, Newell, Felicity, Leonard, Conrad, Koufariotis, Lambros T., Nones, Katia, Dalley, Andrew J., Chittoory, Haarika, Bashirzadeh, Farzad, Son, Jung Hwa, Steinfort, Daniel, Williamson, Jonathan P., Bint, Michael, Pahoff, Carl, Nguyen, Phan T., Twaddell, Scott, Arnold, David, Grainge, Christopher, Simpson, Peter T., Fielding, David, Waddell, Nicola and Pearson, John V. (2024). Performance of somatic structural variant calling in lung cancer using Oxford Nanopore sequencing technology. BMC genomics, 25 (1) 898. doi: 10.1186/s12864-024-10792-3
2024
Journal Article
World Association for Bronchology and Interventional Pulmonology (<scp>WABIP</scp>) guidelines on airway stenting for malignant central airway obstruction
Chaddha, Udit, Agrawal, Abhinav, Kurman, Jonathan, Ortiz‐Comino, Rosamaria, Dutau, Herve, Freitag, Lutz, Trisolini, Rocco, Dooms, Christophe, Zuccatosta, Lina, Gasparini, Stefano, Herth, Felix, Saka, Hideo, Lee, Pyng, Fielding, David, Oki, Masahide, Rosell, Antoni and Murgu, Septimiu (2024). World Association for Bronchology and Interventional Pulmonology (WABIP) guidelines on airway stenting for malignant central airway obstruction. Respirology, 29 (7), 563-573. doi: 10.1111/resp.14764
2024
Conference Publication
Systematic Endoscopic Staging of Mediastinum to Determine Impact on Radiotherapy for Locally Advanced Lung Cancer (seismic): An International Multicentre Single-arm Clinical Trial
Steinfort, D., Kothari, G., Wallace, N., Hardcastle, N., Rangamuwa, K., Lee, P., Yo, S., Bashirzadeh, F., Nguyen, P., Jennings, B.R., Fielding, D.I., Crombag, L., Irving, L., Yasufuku, K., Annema, J., Ost, D.E. and Siva, S. (2024). Systematic Endoscopic Staging of Mediastinum to Determine Impact on Radiotherapy for Locally Advanced Lung Cancer (seismic): An International Multicentre Single-arm Clinical Trial. American Thoracic Society 2024 International Conference, San Diego, CA United States, 17-22 May 2024. New York, NY United States: American Thoracic Society. doi: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a4964
2024
Conference Publication
Impact of Synoptic Reporting on Completeness of Systematic Endoscopic Lymph Node Sampling in Non-small Cell Lung Cancer Patients: A Post-hoc Analysis From the SEISMIC Study
Steinfort, D., Watson, J.M., Kothari, G., Wallace, N., Hardcastle, N., Rangamuwa, K., Curran, J., Yo, S., Bashirdazeh, F., Nguyen, P., Jennings, B.R., Fielding, D.I., Irving, L., Siva, S., Crombag, L., Annema, J., Yasufuku, K. and Ost, D.E. (2024). Impact of Synoptic Reporting on Completeness of Systematic Endoscopic Lymph Node Sampling in Non-small Cell Lung Cancer Patients: A Post-hoc Analysis From the SEISMIC Study. American Thoracic Society 2024 International Conference, San Diego, CA United States, 17-22 May 2024. New York, NY United States: American Thoracic Society. doi: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a1284
2024
Journal Article
Evaluation of Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration (EBUS-TBNA) samples from advanced non-small cell lung cancer for whole genome, whole exome and comprehensive panel sequencing
Fielding, David, Lakis, Vanessa, Dalley, Andrew J., Chittoory, Haarika, Newell, Felicity, Koufariotis, Lambros T., Patch, Ann-Marie, Kazakoff, Stephen, Bashirzadeh, Farzad, Son, Jung Hwa, Ryan, Kimberley, Steinfort, Daniel, Williamson, Jonathan P., Bint, Michael, Pahoff, Carl, Nguyen, Phan Tien, Twaddell, Scott, Arnold, David, Grainge, Christopher, Pattison, Andrew, Fairbairn, David, Gune, Shailendra, Christie, Jemma, Holmes, Oliver, Leonard, Conrad, Wood, Scott, Pearson, John V., Lakhani, Sunil R., Waddell, Nicola ... Nones, Katia (2024). Evaluation of Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration (EBUS-TBNA) samples from advanced non-small cell lung cancer for whole genome, whole exome and comprehensive panel sequencing. Cancers, 16 (4) 785. doi: 10.3390/cancers16040785
2024
Journal Article
Cone‐beam <scp>CT</scp> imaging for robotic navigation bronchoscopy
Fielding, David and van der Heijden, Erik H. F. M. (2024). Cone‐beam CT imaging for robotic navigation bronchoscopy. Respirology, 29 (4), 274-276. doi: 10.1111/resp.14654
2024
Journal Article
Comparison of nasopharyngeal swab vs. lower respiratory tract specimen PCR for the diagnosis of Pneumocystis jirovecii pneumonia
Chew, Rusheng, Tozer, Sarah, Ulett, Kimberly, Paterson, David L., Whiley, David, Sloots, Theo, Fielding, David, Zappala, Christopher, Bashirzadeh, Farzad, Hundloe, Justin, Bletchley, Cheryl and Woods, Marion L. (2024). Comparison of nasopharyngeal swab vs. lower respiratory tract specimen PCR for the diagnosis of Pneumocystis jirovecii pneumonia. Open Forum Infectious Diseases, 11 (3) ofae071, ofae071. doi: 10.1093/ofid/ofae071
2024
Journal Article
Systematic endoscopic staging of mediastinum to guide radiotherapy planning in patients with locally advanced non-small-cell lung cancer (SEISMIC): an international, multicentre, single-arm, clinical trial
Steinfort, Daniel P, Kothari, Gargi, Wallace, Neil, Hardcastle, Nicholas, Rangamuwa, Kanishka, Dieleman, Edith M T, Lee, Percy, Li, Peixuan, Simpson, Julie A, Yo, Shaun, Bashirdazeh, Farzad, Nguyen, Phan, Jennings, Barton R, Fielding, David, Crombag, Laurence, Irving, Louis B, Yasufuku, Kazuhiro, Annema, Jouke T, Ost, David E and Siva, Shankar (2024). Systematic endoscopic staging of mediastinum to guide radiotherapy planning in patients with locally advanced non-small-cell lung cancer (SEISMIC): an international, multicentre, single-arm, clinical trial. The Lancet Respiratory Medicine, 12 (6), 467-475. doi: 10.1016/S2213-2600(24)00010-9
2024
Journal Article
Glycan profiling in small extracellular vesicles with a SERS microfluidic biosensor identifies early malignant development in lung cancer
Zhou, Quan, Niu, Xueming, Zhang, Zhen, O'Byrne, Kenneth, Kulasinghe, Arutha, Fielding, David, Möller, Andreas, Wuethrich, Alain, Lobb, Richard J. and Trau, Matt (2024). Glycan profiling in small extracellular vesicles with a SERS microfluidic biosensor identifies early malignant development in lung cancer. Advanced Science, 11 (33) 2401818, e2401818. doi: 10.1002/advs.202401818
2024
Journal Article
The diagnostic yield of Cone Beam Computed Tomography combined with Radial-Endobronchial Ultrasound for the diagnosis of Peripheral Pulmonary Nodules: Systematic review and Meta-Analysis
Brown, Michael V., Badiei, Arash, Arnold, Matthew, Jersmann, Hubertus, Sullivan, Thomas, Fielding, David and Nguyen, Phan (2024). The diagnostic yield of Cone Beam Computed Tomography combined with Radial-Endobronchial Ultrasound for the diagnosis of Peripheral Pulmonary Nodules: Systematic review and Meta-Analysis. CHEST Pulmonary, 2 (2) 100037, 100037. doi: 10.1016/j.chpulm.2024.100037
2023
Journal Article
Discrepancies in tumor mutation burden reporting from sequential endobronchial ultrasound transbronchial needle aspiration samples within single lymph node stations - brief report
Fielding, David, Dalley, Andrew J., Singh, Mahendra, Nandakumar, Lakshmy, Lakis, Vanessa, Chittoory, Haarika, Fairbairn, David, Patch, Ann-Marie, Kazakoff, Stephen H., Ferguson, Kaltin, Bashirzadeh, Farzad, Bint, Michael, Pahoff, Carl, Son, Jung Hwa, Ryan, Kimberley, Hodgson, Alan, Sharma, Sowmya, Pearson, John V., Waddell, Nicola, Lakhani, Sunil R., Hartel, Gunter, Simpson, Peter T. and Nones, Katia (2023). Discrepancies in tumor mutation burden reporting from sequential endobronchial ultrasound transbronchial needle aspiration samples within single lymph node stations - brief report. Frontiers in Oncology, 13 1259882, 1-10. doi: 10.3389/fonc.2023.1259882
2023
Conference Publication
Dosimetric Impact of Systematic Mediastinal Staging via Endobronchial Ultrasound for Patients with Locally Advanced Lung Cancer: The SEISMIC Trial
Siva, S., Wallace, N., Hardcastle, N., Kothari, G., Crombag, L., Rangamuwa, K., Annema, J., Lee, P., Dieleman, E.M., Jennings, B., Yo, S., Nguyen, P., Bashirzadeh, F., Fielding, D., Yasufuku, K., Ost, D., Irving, L. and Steinfort, D. (2023). Dosimetric Impact of Systematic Mediastinal Staging via Endobronchial Ultrasound for Patients with Locally Advanced Lung Cancer: The SEISMIC Trial. 65th Annual Meeting Of The American Society For Radiation Oncology (ASTRO), San Diego, CA United States, 1-4 October 2023. Philadelphia, PA United States: Elsevier. doi: 10.1016/j.ijrobp.2023.06.290
2023
Journal Article
Whole genome sequencing in advanced lung cancer can be performed using diff-quik cytology smears derived from endobronchial ultrasound, transbronchial needle aspiration (EBUS TBNA)
Fielding, David, Dalley, Andrew J., Singh, Mahendra, Nandakumar, Lakshmy, Lakis, Vanessa, Chittoory, Haarika, Fairbairn, David, Ferguson, Kaltin, Bashirzadeh, Farzad, Bint, Michael, Pahoff, Carl, Son, Jung Hwa, Hodgson, Alan, Pearson, John V., Waddell, Nicola, Lakhani, Sunil R., Hartel, Gunter, Nones, Katia and Simpson, Peter T. (2023). Whole genome sequencing in advanced lung cancer can be performed using diff-quik cytology smears derived from endobronchial ultrasound, transbronchial needle aspiration (EBUS TBNA). Lung, 201 (4), 407-413. doi: 10.1007/s00408-023-00631-9
2023
Journal Article
Evaluating Diff‐Quik cytology smears for large‐panel mutation testing in lung cancer—Predicting DNA content and success with low‐malignant‐cellularity samples
Fielding, David I., Dalley, Andrew J., Singh, Mahendra, Nandakumar, Lakshmy, Lakis, Vanessa, Chittoory, Haarika, Fairbairn, David, Patch, Ann‐Marie, Kazakoff, Stephen H., Ferguson, Kaltin, Bashirzadeh, Farzad, Bint, Michael, Pahoff, Carl, Son, Jung Hwa, Hodgson, Alan, Sharma, Sowmya, Waddell, Nicola, Lakhani, Sunil R., Hartel, Gunter, Nones, Katia and Simpson, Peter T. (2023). Evaluating Diff‐Quik cytology smears for large‐panel mutation testing in lung cancer—Predicting DNA content and success with low‐malignant‐cellularity samples. Cancer Cytopathology, 131 (6), 373-382. doi: 10.1002/cncy.22690
2023
Conference Publication
Systematic Endoscopic Staging of Mediastinum to Determine Impact on Radiotherapy for Locally Advanced Lung Cancer (SEISMIC): Initial Findings of a Prospective Multicentre Interventional Study
Steinfort, D., Siva, S., Yasufuku, K., Annema, J., Irving, L., Crombag, L., Jennings, B.R., Fielding, D.I., Bashirzadeh, F., Nguyen, P., Yo, S., Rangamuwa, K., Lee, P., Kothari, G., Hardcastle, N. and Ost, D.E. (2023). Systematic Endoscopic Staging of Mediastinum to Determine Impact on Radiotherapy for Locally Advanced Lung Cancer (SEISMIC): Initial Findings of a Prospective Multicentre Interventional Study. American Thoracic Society International Conference 2023, Washington, DC United States, 19-24 May 2023. Washington, DC United States: American Thoracic Society. doi: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a4459
2023
Journal Article
High-definition videobronchoscopy for the diagnosis of airway involvement in sarcoidosis: the enhance sarcoidosis multicenter study
Livi, Vanina, Sivokozov, Ilya, Annema, Jouke T., Candoli, Piero, Vasilev, Igor, Kramer, Tess, Ferrari, Marco, Madan, Karan, Fielding, David, Murgu, Septimiu, Cancellieri, Alessandra, Semyonova, Lyudmila A., Puci, Mariangela, Sotgiu, Giovanni and Trisolini, Rocco (2023). High-definition videobronchoscopy for the diagnosis of airway involvement in sarcoidosis: the enhance sarcoidosis multicenter study. Chest, 164 (5), 1243-1252. doi: 10.1016/j.chest.2023.04.034
2023
Journal Article
Assessment of background plastics contamination from human respiratory tract sample collection vessels
Okoffo, Elvis D., Rauert, Cassandra, Boots, Robert, Fielding, David, Bashiradeh, Farzard, Singh, Mahendra and Thomas, Kevin V. (2023). Assessment of background plastics contamination from human respiratory tract sample collection vessels. Water Emerging Contaminants and Nanoplastics, 1 (1) 4, 1-9. doi: 10.20517/wecn.2022.22
2023
Journal Article
Australian genomics: outcomes of a 5-year national program to accelerate the integration of genomics in healthcare
Stark, Zornitza, Boughtwood, Tiffany, Haas, Matilda, Braithwaite, Jeffrey, Gaff, Clara L., Goranitis, Ilias, Spurdle, Amanda B., Hansen, David P., Hofmann, Oliver, Laing, Nigel, Metcalfe, Sylvia, Newson, Ainsley J., Scott, Hamish S., Thorne, Natalie, Ward, Robyn L., Dinger, Marcel E., Best, Stephanie, Long, Janet C., Grimmond, Sean M., Pearson, John, Waddell, Nicola, Barnett, Christopher P., Cook, Matthew, Field, Michael, Fielding, David, Fox, Stephen B., Gecz, Jozef, Jaffe, Adam, Leventer, Richard J. ... North, Kathryn N. (2023). Australian genomics: outcomes of a 5-year national program to accelerate the integration of genomics in healthcare. American Journal of Human Genetics, 110 (3), 419-426. doi: 10.1016/j.ajhg.2023.01.018
2023
Conference Publication
Diff-Quik smears from EBUS TBNA procedures: Evaluating measures of tumour cellularity and feasibility of whole genome sequencing (WGS)
Fielding, David, Dalley, Andrew, Singh, Mahendra, Nandakumar, Lakshmy, Lakis, Vanessa, Chittoory, Haarika, Bashirzadeh, Farzad, Bint, Michael, Pahoff, Carl, Son, Jung, Hodgson, Alan, Sharma, Sowmya, Godbolt, David, Coleman, Kylie, Whitfield, Lenore, Waddell, Nicola, Lakhani, Sunil, Nones, Katia, Hartel, Gunter and Simpson, Peter (2023). Diff-Quik smears from EBUS TBNA procedures: Evaluating measures of tumour cellularity and feasibility of whole genome sequencing (WGS). 26th Congress of the Asian Pacific Society of Respirology Above and Beyond, Seoul, Korea, 17-20 November 2022. Richmond, VIC, Australia: John Wiley & Sons. doi: 10.1111/resp.14433
2023
Journal Article
Digital decoding of single extracellular vesicle phenotype differentiates early malignant and benign lung lesions
Li, Junrong, Sina, Abu A. I., Antaw, Fiach, Fielding, David, Möller, Andreas, Lobb, Richard, Wuethrich, Alain and Trau, Matt (2023). Digital decoding of single extracellular vesicle phenotype differentiates early malignant and benign lung lesions. Advanced Science, 10 (1) 2204207, e2204207. doi: 10.1002/advs.202204207
Supervision
Availability
- Associate Professor David Fielding is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Supervision history
Current supervision
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Master Philosophy
Second Primary Lung Cancer in HNSCC patients: understanding the high risk patient
Associate Advisor
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Master Philosophy
Second Primary Lung Cancer in HNSCC patients: understanding the high risk patient
Associate Advisor
Completed supervision
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2015
Doctor Philosophy
Improving Pleural Procedures: Training, Image Analysis and Pleural Manometry
Principal Advisor
-
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2025
Master Philosophy
Second Primary Lung Cancer in HNSCC patients: understanding the high risk patient
Associate Advisor
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2017
Doctor Philosophy
The Role of Exhaled Breath Analysis in the Diagnosis and Monitoring of Lung Diseases
Associate Advisor
Other advisors: Professor Kwun Fong, Professor Ian Yang, Associate Professor Paul Zimmerman
Media
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