Overview
Background
I am a physician at RBWH where I did my undergraduate training. I subspecialised in THoracic Medicine with a focus on bronchoscopy. I helped to create a large interventional service here. Part of that inlcuded instituting endobronchial ultrasound ( EBUS), an Australian first, in 2003. This has become standard of care for diagnosing lung cancer.
My research has been centred on how specimens from EBUS can be optimised. I have had strong collaboration with UQCCR, Pathology Queensland and QIMR Berghofer. Our work has expanded on 2 fronts- 1. use of simple cytology smears as the source for panel molecular testing and 2. The expanded role of WES and WGS on these samples.
We have instituted a large Australia wide collaborative network who are collecting samples along with us( The Debutant studies).We have Cancer Council Australia / CCQ/ and NHMRC grants fr these studies
Availability
- Associate Professor David Fielding is:
- Available for supervision
Fields of research
Qualifications
- Bachelor of Medicine and Surgery and Medical Science, The University of Queensland
Research interests
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Lung Cancer Genomics
The Debutant study is an Australia wide study ( based at RBWH and UQCCR and QIMR Berghofer) of maximising the utility of specimens for lung cancer genomics when they are collected at biopsy using Endobronchial ultrasound.
Research impacts
Our work has proposed workflow solutions including use of diff quik smears as alternative samples to formalin base samples for genomic study
Our work has built upon the idea of smears being " what yiou see is what you get" as far as samples for genomics, and the way smear microscopy can predict DNA content of the samples, thereby alllowing decision making for genomic testing
We will also continue to build workflow solutions starting from small increasing to large panel, then WES, then WGS, hopefully putting these concepts into the clinic
Works
Search Professor David Fielding’s works on UQ eSpace
2023
Conference Publication
Diff-Quik smears from EBUS TBNA procedures: Evaluating measures of tumour cellularity and feasibility of whole genome sequencing (WGS)
Fielding, David, Dalley, Andrew, Singh, Mahendra, Nandakumar, Lakshmy, Lakis, Vanessa, Chittoory, Haarika, Bashirzadeh, Farzad, Bint, Michael, Pahoff, Carl, Son, Jung, Hodgson, Alan, Sharma, Sowmya, Godbolt, David, Coleman, Kylie, Whitfield, Lenore, Waddell, Nicola, Lakhani, Sunil, Nones, Katia, Hartel, Gunter and Simpson, Peter (2023). Diff-Quik smears from EBUS TBNA procedures: Evaluating measures of tumour cellularity and feasibility of whole genome sequencing (WGS). 26th Congress of the Asian Pacific Society of Respirology Above and Beyond, Seoul, Korea, 17-20 November 2022. Richmond, VIC, Australia: John Wiley & Sons. doi: 10.1111/resp.14433
2023
Journal Article
Digital decoding of single extracellular vesicle phenotype differentiates early malignant and benign lung lesions
Li, Junrong, Sina, Abu A. I., Antaw, Fiach, Fielding, David, Möller, Andreas, Lobb, Richard, Wuethrich, Alain and Trau, Matt (2023). Digital decoding of single extracellular vesicle phenotype differentiates early malignant and benign lung lesions. Advanced Science, 10 (1) 2204207, e2204207. doi: 10.1002/advs.202204207
2022
Journal Article
Prospective optimization of endobronchial ultrasound-guided transbronchial needle aspiration lymph node assessment for lung cancer: Three needle agitations are noninferior to 10 agitations for adequate tumor cell and DNA yield
Fielding, David, Dalley, Andrew J., Singh, Mahendra, Nandakumar, Lakshmy, Nones, Katia, Lakis, Vanessa, Chittoory, Haarika, Ferguson, Kaltin, Bashirzadeh, Farzad, Bint, Michael, Pahoff, Carl, Son, Jung Hwa, Hodgson, Alan, Sharma, Sowmya, Godbolt, David, Coleman, Kylie, Whitfield, Lenore, Waddell, Nicola, Lakhani, Sunil R., Hartel, Gunter and Simpson, Peter T. (2022). Prospective optimization of endobronchial ultrasound-guided transbronchial needle aspiration lymph node assessment for lung cancer: Three needle agitations are noninferior to 10 agitations for adequate tumor cell and DNA yield. JTO Clinical and Research Reports, 3 (10) 100403, 100403. doi: 10.1016/j.jtocrr.2022.100403
2022
Journal Article
Systematic endoscopic staging of mediastinum to determine impact on radiotherapy for locally advanced lung cancer (SEISMIC): protocol for a prospective single arm multicentre interventional study
Steinfort, Daniel P., Siva, Shankar, Rangamuwa, Kanishka, Lee, Percy, Fielding, David, Nguyen, Phan, Jennings, Barton R., Yo, Shaun, Hardcastle, Nick, Kothari, Gargi, Crombag, Laurence, Annema, Jouke, Yasufuku, Kazuhiro, Ost, David E. and Irving, Louis B. (2022). Systematic endoscopic staging of mediastinum to determine impact on radiotherapy for locally advanced lung cancer (SEISMIC): protocol for a prospective single arm multicentre interventional study. BMC Pulmonary Medicine, 22 (1) 364. doi: 10.1186/s12890-022-02159-9
2022
Journal Article
Comparison of actionable events detected in cancer genomes by whole-genome sequencing, in silico whole-exome and mutation panels
Ramarao-Milne, P, Kondrashova, O, Patch, A-M, Nones, K, Koufariotis, L T, Newell, F, Addala, V, Lakis, V, Holmes, O, Leonard, C, Wood, S, Xu, Q, Mukhopadhyay, P, Naeini, M M, Steinfort, D, Williamson, J P, Bint, M, Pahoff, C, Nguyen, P T, Twaddell, S, Arnold, D, Grainge, C, Basirzadeh, F, Fielding, D, Dalley, A J, Chittoory, H, Simpson, P T, Aoude, L G, Bonazzi, V F ... Waddell, N (2022). Comparison of actionable events detected in cancer genomes by whole-genome sequencing, in silico whole-exome and mutation panels. ESMO Open, 7 (4) 100540, 1-11. doi: 10.1016/j.esmoop.2022.100540
2022
Journal Article
Using the GenCut core biopsy tool with the radial endobronchial ultrasound guide sheath enables a high-quality histology sample capable of programmed cell death ligand 1 (PD-L1) testing
Herath, Samantha, Bashirzadeh, Farzad, Mahajan, Hema, Ing, Alvin and Fielding, David (2022). Using the GenCut core biopsy tool with the radial endobronchial ultrasound guide sheath enables a high-quality histology sample capable of programmed cell death ligand 1 (PD-L1) testing. Respirology Case Reports, 10 (5) e0935, 1-4. doi: 10.1002/rcr2.935
2022
Journal Article
Blood-derived extracellular vesicle-associated miR-3182 detects non-small cell lung cancer patients
Visan, Kekoolani S., Lobb, Richard J., Wen, Shu Wen, Bedo, Justin, Lima, Luize G., Krumeich, Sophie, Palma, Carlos, Ferguson, Kaltin, Green, Ben, Niland, Colleen, Cloonan, Nicole, Simpson, Peter T., McCart Reed, Amy E., Everitt, Sarah J., MacManus, Michael P., Hartel, Gunter, Salomon, Carlos, Lakhani, Sunil R., Fielding, David and Möller, Andreas (2022). Blood-derived extracellular vesicle-associated miR-3182 detects non-small cell lung cancer patients. Cancers, 14 (1) 257, 257. doi: 10.3390/cancers14010257
2021
Journal Article
Bronchial Thermoplasty Global Registry (BTGR): 2-year results
Torrego, Alfons, Herth, Felix J, Munoz-Fernandez, Ana M, Puente, Luis, Facciolongo, Nicola, Bicknell, Stephen, Novali, Mauro, Gasparini, Stefano, Bonifazi, Martina, Dheda, Keertan, Andreo, Felipe, Votruba, Praha, Langton, David, Flandes, Javier, Fielding, David, Bonta, Peter I, Skowasch, Dirk, Schulz, Christian, Darwiche, Kaid, McMullen, Edmund, Grubb, G. Mark and Niven, Robert (2021). Bronchial Thermoplasty Global Registry (BTGR): 2-year results. BMJ Open, 11 (12) e053854, e053854. doi: 10.1136/bmjopen-2021-053854
2021
Journal Article
A randomised study of comfort during bronchoscopy comparing conscious sedation and anaesthetist-controlled general anaesthesia, including the utility of bispectral index monitoring
Skinner, Thomas R., Churton, Joseph, Edwards, Timothy P., Bashirzadeh, Farzad, Zappala, Christopher, Hundloe, Justin T., Tan, Hau, Pattison, Andrew J., Todman, Maryann, Hartel, Gunter F. and Fielding, David I. (2021). A randomised study of comfort during bronchoscopy comparing conscious sedation and anaesthetist-controlled general anaesthesia, including the utility of bispectral index monitoring. ERJ Open Research, 7 (2) 00895-2020, 00895-+. doi: 10.1183/23120541.00895-2020
2021
Journal Article
Cognitive load in electromagnetic navigational and robotic bronchoscopy for pulmonary nodules
Kapp, Christopher M., Akulian, Jason A., Yu, Diana H., Chen, Alexander, Cárdenas-García, José, Molena, Daniela, Vachani, Anil, Wahidi, Momen M., Maldonado, Fabien, Fielding, David, Yarmus, Lonny B. and Lee, Hans (2021). Cognitive load in electromagnetic navigational and robotic bronchoscopy for pulmonary nodules. ATS Scholar, 2 (1), 97-107. doi: 10.34197/ats-scholar.2020-0033OC
2020
Journal Article
Volatile organic compound breath testing detects in-situ squamous cell carcinoma of bronchial and laryngeal regions and shows distinct profiles of each tumour
Fielding, David, Hartel, Gunter, Pass, David, Davis, Mark, Brown, Michael, Dent, Annette G., Agnew, Julienne, Dickie, Graeme, Ware, Robert S. and Hodge, Robert (2020). Volatile organic compound breath testing detects in-situ squamous cell carcinoma of bronchial and laryngeal regions and shows distinct profiles of each tumour. Journal of Breath Research, 14 (4) 046013, 046013. doi: 10.1088/1752-7163/abb18a
2020
Journal Article
Reply: Non‐intubated electromagnetic‐guided localization and resection of small indeterminate peripheral pulmonary nodules
Oki, Masahide and Fielding, David (2020). Reply: Non‐intubated electromagnetic‐guided localization and resection of small indeterminate peripheral pulmonary nodules. Respirology, 25 (10) resp.13818, 1096-1096. doi: 10.1111/resp.13818
2020
Journal Article
Predicting the response to bronchial thermoplasty
Langton, David, Wang, Wei, Sha, Joy, Ing, Alvin, Fielding, David, Hersch, Nicole, Plummer, Virginia and Thien, Francis (2020). Predicting the response to bronchial thermoplasty. Journal of Allergy and Clinical Immunology: In Practice, 8 (4), 1253-1260.e2. doi: 10.1016/j.jaip.2019.10.034
2020
Journal Article
Safety and effectiveness of bronchial thermoplasty when FEV1 is less than 50%
Langton, David, Ing, Alvin, Fielding, David, Hersch, Nicole, Sha, Joy, Plummer, Virginia and Thien, Francis (2020). Safety and effectiveness of bronchial thermoplasty when FEV1 is less than 50%. Chest, 157 (3), 509-515. doi: 10.1016/j.chest.2019.08.2193
2020
Journal Article
Technologies for targeting the peripheral pulmonary nodule including robotics
Fielding, David and Oki, Masahide (2020). Technologies for targeting the peripheral pulmonary nodule including robotics. Respirology, 25 (9) resp.13791, 914-923. doi: 10.1111/resp.13791
2020
Book Chapter
Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration: Tips and Tricks
Fielding, David I.K. (2020). Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration: Tips and Tricks. Endobronchial Ultrasonography. (pp. 63-80) Oxford, United Kingdom: John Wiley & Sons. doi: 10.1002/9781119233961.ch5
2020
Book Chapter
Future Directions for Endobronchial Ultrasonography
Fielding, David I.K. (2020). Future Directions for Endobronchial Ultrasonography. Endobronchial Ultrasonography. (pp. 187-192) Oxford, United Kingdom: John Wiley & Sons. doi: 10.1002/9781119233961.ch16
2020
Book Chapter
Endobronchial Ultrasonography for Ground-GlassOpacity Lesions
Fielding, David I.K. (2020). Endobronchial Ultrasonography for Ground-GlassOpacity Lesions. Endobronchial Ultrasonography. (pp. 133-135) Oxford, United Kingdom: John Wiley & Sons. doi: 10.1002/9781119233961.ch11
2020
Book
Endobronchial Ultrasonography
Noriaki Kurimoto, David I.K. Fielding, Ali I. Musani, Christopher Kniese and Katsuhiko Morita eds. (2020). Endobronchial Ultrasonography. Oxford, United Kingdom: John Wiley & Sons. doi: 10.1002/9781119233961
2020
Book Chapter
Endobronchial Ultrasonography of Airway Integrity and Tumor Involvement
Fielding, David I.K. (2020). Endobronchial Ultrasonography of Airway Integrity and Tumor Involvement. Endobronchial Ultrasonography. (pp. 157-165) Oxford, United Kingdom: John Wiley & Sons. doi: 10.1002/9781119233961.ch13
Supervision
Availability
- Associate Professor David Fielding is:
- Available for supervision
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Supervision history
Current supervision
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Master Philosophy
Second Primary Lung Cancer in HNSCC patients: understanding the high risk patient
Associate Advisor
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Master Philosophy
Second Primary Lung Cancer in HNSCC patients: understanding the high risk patient
Associate Advisor
Completed supervision
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2015
Doctor Philosophy
Improving Pleural Procedures: Training, Image Analysis and Pleural Manometry
Principal Advisor
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2025
Master Philosophy
Second Primary Lung Cancer in HNSCC patients: understanding the high risk patient
Associate Advisor
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2017
Doctor Philosophy
The Role of Exhaled Breath Analysis in the Diagnosis and Monitoring of Lung Diseases
Associate Advisor
Other advisors: Professor Kwun Fong, Professor Ian Yang, Associate Professor Paul Zimmerman
Media
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