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2018 Conference Publication Evolutionary history and adaptation from high-coverage whole-genome sequences of the pygmy population of Flores, IndonesiaTucci, Serena, McCoy, Rajiv, Vernot, Benjamin, Vohr, Sam, Robinson, Matthew R., Barbieri, Chiara, Fu, Wenqing, Sudoyo, Herawati, Visscher, Peter M., Barbujani, Guido, Akey, Joshua M. and Green, Richard E. (2018). Evolutionary history and adaptation from high-coverage whole-genome sequences of the pygmy population of Flores, Indonesia. 87th Annual Meeting of the American-Association-of-Physical-Anthropologists (AAPA), Austin, TX, United States, 11-14 April 2018. Hoboken, NJ, United States: John Wiley & Sons. |
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2018 Conference Publication Signatures of negative selection in the genetic architecture of human complex traitsZeng, Jian, de Vlaming, Ronald, Wu, Yang, Robinson, Matthew R., Lloyd-Jones, Luke R., Yengo, Loic, Yap, Chloe X., Xue, Angli, Sidorenko, Julia, Mcrae, Allan F., Powell, Joseph E., Montgomery, Grant W., Metspalu, Andres, Esko, Tonu, Gibson, Greg, Wray, Naomi R., Visscher, Peter M. and Yang, Jian (2018). Signatures of negative selection in the genetic architecture of human complex traits. 48th Annual Meeting of the Behavior-Genetics-Association (BGA), Boston MA, United States, 20-23 June 2018. New York, NY United States: Springer New York. |
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2017 Journal Article Challenges in understanding common diseaseVisscher, Peter M (2017). Challenges in understanding common disease. Genome medicine, 9 (1) 112, 1-4. doi: 10.1186/s13073-017-0506-1 |
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2017 Journal Article Gene networks associated with non-syndromic intellectual disabilityLee, Soohyun, Rudd, Stephen, Gratten, Jacob, Visscher, Peter M., Prins, Johannes B. and Dawson, Paul A. (2017). Gene networks associated with non-syndromic intellectual disability. Journal of Neurogenetics, 32 (1), 6-14. doi: 10.1080/01677063.2017.1404058 |
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2017 Journal Article Testing two evolutionary theories of human aging with DNA methylation dataRobins, Chloe, McRae, Allan F., Powell, Joseph E., Wiener, Howard W., Aslibekyan, Stella, Kennedy, Elizabeth M., Absher, Devin M., Arnett, Donna K., Montgomery, Grant W., Visscher, Peter M., Cutler, David J. and Conneely, Karen N. (2017). Testing two evolutionary theories of human aging with DNA methylation data. Genetics, 207 (4), 1547-1560. doi: 10.1534/genetics.117.300217 |
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2017 Journal Article A genome-wide association study suggests that <i>MAPK14</i> is associated with diabetic foot ulcersMeng, W., Veluchamy, A., Hebert, H. L., Campbell, A., Colhoun, H. M. and Palmer, C. N. A. (2017). A genome-wide association study suggests that MAPK14 is associated with diabetic foot ulcers. British Journal of Dermatology, 177 (6), 1664-1670. doi: 10.1111/bjd.15787 |
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2017 Journal Article Rare variant analysis of human and rodent obesity genes in individuals with severe childhood obesityHendricks, Audrey E., Bochukova, Elena G., Marenne, Gaelle, Keogh, Julia M., Atanassova, Neli, Bounds, Rebecca, Wheeler, Eleanor, Mistry, Vanisha, Henning, Elana, Koerner, Antje, Muddyman, Dawn, McCarthy, Shane, Hinney, Anke, Hebebrand, Johannes, Scott, Robert A., Langenberg, Claudia, Wareham, Nick J., Surendran, Praveen, Howson, Joanna M., Butterworth, Adam S., Danesh, John, Nordestgaard, Borge G., Nielsen, Sune F., Afzal, Shoaib, Papadia, Sofia, Ashford, Sofie, Garg, Sumedha, Millhauser, Glenn L., Palomino, Rafael I. ... Yang, Jian (2017). Rare variant analysis of human and rodent obesity genes in individuals with severe childhood obesity. Scientific Reports, 7 (1) 4394, 4394.1-4394.14. doi: 10.1038/s41598-017-03054-8 |
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2017 Journal Article Whole-exome sequencing in amyotrophic lateral sclerosis suggests NEK1 is a risk gene in ChineseGratten, Jacob, Zhao, Qiongyi, Benyamin, Beben, Garton, Fleur, He, Ji, Leo, Paul J., Mangelsdorf, Marie, Anderson, Lisa, Zhang, Zong-Hong, Chen, Lu, Chen, Xiang-Ding, Cremin, Katie, Deng, Hong-Weng, Edson, Janette, Han, Ying-Ying, Harris, Jessica, Henders, Anjali K., Jin, Zi-Bing, Li, Zhongshan, Lin, Yong, Liu, Xiaolu, Marshall, Mhairi, Mowry, Bryan J., Ran, Shu, Reutens, David C., Song, Sharon, Tan, Li-Jun, Tang, Lu, Wallace, Robyn H. ... Fan, Dongsheng (2017). Whole-exome sequencing in amyotrophic lateral sclerosis suggests NEK1 is a risk gene in Chinese. Genome Medicine, 9 (97) 97, 97. doi: 10.1186/s13073-017-0487-0 |
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2017 Journal Article Prokaryotic diversity and biogeochemical characteristics of benthic microbial ecosystems at La Brava, a hypersaline lake at Salar de Atacama, ChileEugenia Farias, Maria, Cecilia Rasuk, Maria, Gallagher, Kimberley L., Contreras, Manuel, Kurth, Daniel, Beatriz Fernandez, Ana, Poire, Daniel, Novoa, Fernando and Visscher, Pieter T. (2017). Prokaryotic diversity and biogeochemical characteristics of benthic microbial ecosystems at La Brava, a hypersaline lake at Salar de Atacama, Chile. Plos One, 12 (11) e0186867, e0186867. doi: 10.1371/journal.pone.0186867 |
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2017 Conference Publication GWAS of educational attainment: phase 3-main resultsOkbay, Aysu, Wedow, Robbee, Kong, Edward, Turley, Patrick, Lee, James, Zacher, Meghan, Thom, Kevin, Anh Tuan Nguyen, , Maghzian, Omeed, Linner, Richard Karlsson, Robinson, Matthew, Visscher, Peter, Benjamin, Daniel and Cesarini, David (2017). GWAS of educational attainment: phase 3-main results. 47th Annual Meeting of the Behavior-Genetics-Association (BGA), Oslo Norway, Jun 28-Jul 01, 2017. NEW YORK: SPRINGER. |
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2017 Journal Article Cross-ethnic meta-analysis identifies association of the GPX3-TNIP1 locus with amyotrophic lateral sclerosisBenyamin, Beben, He, Ji, Zhao, Qiongyi, Gratten, Jacob, Garton, Fleur, Leo, Paul J., Liu, Zhijun, Mangelsdorf, Marie, Al-Chalabi, Ammar, Anderson, Lisa, Butler, Timothy J., Chen, Lu, Chen, Xiang-Ding, Cremin, Katie, Deng, Hong-Weng, Devine, Matthew, Edson, Janette, Fifita, Jennifer A., Furlong, Sarah, Han, Ying-Ying, Harris, Jessica, Henders, Anjali K., Jeffree, Rosalind L., Jin, Zi-Bing, Li, Zhongshan, Li, Ting, Li, Mengmeng, Lin, Yong, Liu, Xiaolu ... Fan, Dongsheng (2017). Cross-ethnic meta-analysis identifies association of the GPX3-TNIP1 locus with amyotrophic lateral sclerosis. Nature Communications, 8 (1) 611, 611. doi: 10.1038/s41467-017-00471-1 |
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2017 Journal Article Genetic correlations reveal the shared genetic architecture of transcription in human peripheral bloodLukowski, Samuel W., Lloyd-Jones, Luke R., Holloway, Alexander, Kirsten, Holger, Hemani, Gibran, Yang, Jian, Small, Kerrin, Zhao, Jing, Metspalu, Andres, Dermitzakis, Emmanouil T., Gibson, Greg, Spector, Timothy D., Thiery, Joachim, Scholz, Markus, Montgomery, Grant W., Esko, Tonu, Visscher, Peter M. and Powell, Joseph E. (2017). Genetic correlations reveal the shared genetic architecture of transcription in human peripheral blood. Nature Communications, 8 (483) 483, 483. doi: 10.1038/s41467-017-00473-z |
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2017 Journal Article Concepts, estimation and interpretation of SNP-based heritabilityYang, Jian, Zeng, Jian, Goddard, Michael E., Wray, Naomi R. and Visscher, Peter M. (2017). Concepts, estimation and interpretation of SNP-based heritability. Nature Genetics, 49 (9), 1304-1310. doi: 10.1038/ng.3941 |
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2017 Journal Article Performance of risk prediction for inflammatory bowel disease based on genotyping platform and genomic risk score methodChen, Guo-Bo, Lee, Sang Hong, Montgomery, Grant W., Wray, Naomi R., Visscher, Peter M., Gearry, Richard B., Lawrance, Ian C., Andrews, Jane M., Bampton, Peter, Mahy, Gillian, Bell, Sally, Walsh, Alissa, Connor, Susan, Sparrow, Miles, Bowdler, Lisa M., Simms, Lisa A., Krishnaprasad, Krupa, Radford-Smith, Graham L. and Moser, Gerhard (2017). Performance of risk prediction for inflammatory bowel disease based on genotyping platform and genomic risk score method. BMC Medical Genetics, 18 (1) 94, 94. doi: 10.1186/s12881-017-0451-2 |
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2017 Journal Article Embracing polygenicity: a review of methods and tools for psychiatric genetics researchMaier, R. M., Visscher, P. M., Robinson, M. R. and Wray, N. R. (2017). Embracing polygenicity: a review of methods and tools for psychiatric genetics research. Psychological Medicine, 48 (7), 1055-1067. doi: 10.1017/s0033291717002318 |
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2017 Journal Article Constraints on eQTL fine mapping in the presence of multisite local regulation of gene expressionZeng, Biao, Lloyd-Jones, Luke R., Holloway, Alexander, Marigorta, Urko M., Metspalu, Andres, Montgomery, Grant W., Esko, Tonu, Brigham, Kenneth L., Quyyumi, Arshed A., Idaghdour, Youssef, Yang, Jian, Visscher, Peter M., Powell, Joseph E. and Gibson, Greg (2017). Constraints on eQTL fine mapping in the presence of multisite local regulation of gene expression. G3: Genes Genomes Genetics, 7 (8), 2533-2544. doi: 10.1534/g3.117.043752 |
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2017 Journal Article Detection and quantification of inbreeding depression for complex traits from SNP dataYengo, Loic, Zhu, Zhihong, Wray, Naomi R., Weir, Bruce S., Yang, Jian, Robinson, Matthew R. and Visscher, Peter M. (2017). Detection and quantification of inbreeding depression for complex traits from SNP data. PNAS: Proceedings of the National Academy of Sciences of the United States of America, 114 (32), 8602-8607. doi: 10.1073/pnas.1621096114 |
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2017 Journal Article <i>CKM</i> Glu83Gly Is Associated With Blunted Creatine Kinase Variation, but Not With MyalgiaSiddiqui, Moneeza Kalhan, Veluchamy, Abirami, Maroteau, Cyrielle, Tavendale, Roger, Carr, Fiona, Pearson, Ewan, Colhoun, Helen, Morris, Andrew D., George, Jacob, Doney, Alexander, Pirmohamed, Munir, Alfirevic, Ana, Wadelius, Mia, van der Zee, Anke H. Maitland, Ridker, Paul M., Chasman, Daniel I. and Palmer, Colin N. A. (2017). CKM Glu83Gly Is Associated With Blunted Creatine Kinase Variation, but Not With Myalgia. Circulation-Cardiovascular Genetics, 10 (4) e001737. doi: 10.1161/CIRCGENETICS.117.001737 |
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2017 Journal Article Genotype-covariate interaction effects and the heritability of adult body mass indexRobinson, Matthew R., English, Geoffrey, Moser, Gerhard, Lloyd-Jones, Luke R., Triplett, Marcus A., Zhu, Zhihong, Nolte, Ilja M., Van Vliet-Ostaptchouk, Jana V., Snieder, Harold, Esko, Tonu, Milani, Lili, Magi, Reedik, Metspalu, Andres, Magnusson, Patrik K. E., Pedersen, Nancy L., Ingelsson, Erik, Johannesson, Magnus, Yang, Jian, Cesarini, David and Visscher, Peter M. (2017). Genotype-covariate interaction effects and the heritability of adult body mass index. Nature Genetics, 49 (8), 1174-1181. doi: 10.1038/ng.3912 |
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2017 Journal Article 10 years of GWAS discovery: biology, function, and translationVisscher, Peter M., Wray, Naomi R., Zhang, Qian, Sklar, Pamela, McCarthy, Mark I., Brown, Matthew A. and Yang, Jian (2017). 10 years of GWAS discovery: biology, function, and translation. American Journal of Human Genetics, 101 (1), 5-22. doi: 10.1016/j.ajhg.2017.06.005 |
