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2018 Journal Article Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depressionWray, Naomi R., Ripke, Stephan, Mattheisen, Manuel, Trzaskowski, Maciej, Byrne, Enda M., Abdellaoui, Abdel, Adams, Mark J., Agerbo, Esben, Air, Tracy M., Andlauer, Till M. F., Bacanu, Silviu-Alin, Baekvad-Hansen, Marie, Beekman, Aartjan F. T., Bigdeli, Tim B., Binder, Elisabeth B., Blackwood, Douglas R. H., Bryois, Julien, Buttenschon, Henriette N., Bybjerg-Grauholm, Jonas, Cai, Na, Castelao, Enrique, Christensen, Jane Hvarregaard, Clarke, Toni-Kim, Coleman, Jonathan I. R., Colodro-Conde, Lucia, Couvy-Duchesne, Baptiste, Craddock, Nick, Crawford, Gregory E., Crowley, Cheynna A. ... Sullivan, Patrick F. (2018). Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Nature Genetics, 50 (5), 668-+. doi: 10.1038/s41588-018-0090-3 |
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2018 Journal Article Comparison of methods that use whole genome data to estimate the heritability and genetic architecture of complex traitsEvans, Luke M., Tahmasbi, Rasool, Vrieze, Scott I., Abecasis, Gonçalo R., Das, Sayantan, Gazal, Steven, Bjelland, Douglas W., de Candia, Teresa R., Haplotype Reference Consortium, Goddard, Michael E., Neale, Benjamin M., Yang, Jian, Visscher, Peter M. and Keller, Matthew C. (2018). Comparison of methods that use whole genome data to estimate the heritability and genetic architecture of complex traits. Nature genetics, 50 (5), 737-745. doi: 10.1038/s41588-018-0108-x |
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2018 Journal Article Signatures of negative selection in the genetic architecture of human complex traitsZeng, Jian, de Vlaming, Ronald, Wu, Yang, Robinson, Matthew R., Lloyd-Jones, Luke R., Yengo, Loic, Yap, Chloe X., Xue, Angli, Sidorenko, Julia, McRae, Allan F., Powell, Joseph E., Montgomery, Grant W., Metspalu, Andres, Esko, Tonu, Gibson, Greg, Wray, Naomi R., Visscher, Peter M. and Yang, Jian (2018). Signatures of negative selection in the genetic architecture of human complex traits. Nature Genetics, 50 (5), 746-753. doi: 10.1038/s41588-018-0101-4 |
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2018 Journal Article Cohort Profile: Genetics of Diabetes Audit and Research in Tayside Scotland (GoDARTS)Hebert, Harry L., Shepherd, Bridget, Milburn, Keith, Veluchamy, Abirami, Meng, Weihua, Carr, Fiona, Donnelly, Louise A., Tavendale, Roger, Leese, Graham, Colhoun, Helen M., Dow, Ellie, Morris, Andrew D., Doney, Alexander S., Lang, Chim C., Pearson, Ewan R., Smith, Blair H. and Palmer, Colin N. A. (2018). Cohort Profile: Genetics of Diabetes Audit and Research in Tayside Scotland (GoDARTS). International Journal of Epidemiology, 47 (2), 380-+. doi: 10.1093/ije/dyx140 |
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2018 Journal Article Narrow-sense heritability estimation of complex traits using identity-by-descent informationEvans, Luke M., Tahmasbi, Rasool, Jones, Matt, Vrieze, Scott I., Abecasis, Gonçalo R., Das, Sayantan, Bjelland, Douglas W., de Candia, Teresa R., Yang, Jian, Goddard, Michael E., Visscher, Peter M., Keller, Matthew C. and Haplotype Reference Consortium (2018). Narrow-sense heritability estimation of complex traits using identity-by-descent information. Heredity, 121 (6), 1-15. doi: 10.1038/s41437-018-0067-0 |
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2018 Journal Article A multi-trait Bayesian method for mapping QTL and genomic predictionKemper, Kathryn E., Bowman, Philip J., Hayes, Benjamin J., Visscher, Peter M. and Goddard, Michael E. (2018). A multi-trait Bayesian method for mapping QTL and genomic prediction. Genetics Selection Evolution, 50 (1) 10, 10. doi: 10.1186/s12711-018-0377-y |
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2018 Journal Article Improving genetic prediction by leveraging genetic correlations among human diseases and traitsMaier, Robert M, Zhu, Zhihong, Lee, Sang Hong, Trzaskowski, Maciej, Ruderfer, Douglas M, Stahl, Eli A, Ripke, Stephan, Wray, Naomi R, Yang, Jian, Visscher, Peter M and Robinson, Matthew R (2018). Improving genetic prediction by leveraging genetic correlations among human diseases and traits. Nature Communications, 9 (1) 989, 989. doi: 10.1038/s41467-017-02769-6 |
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2018 Journal Article Integrative analysis of omics summary data reveals putative mechanisms underlying complex traitsWu, Yang, Zeng, Jian, Zhang, Futao, Zhu, Zhihong, Qi, Ting, Zheng, Zhili, Lloyd-Jones, Luke R., Marioni, Riccardo E., Martin, Nicholas G., Montgomery, Grant W., Deary, Ian J., Wray, Naomi R., Visscher, Peter M., McRae, Allan F. and Yang, Jian (2018). Integrative analysis of omics summary data reveals putative mechanisms underlying complex traits. Nature Communications, 9 (918) 918, 918. doi: 10.1038/s41467-018-03371-0 |
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2018 Journal Article Reply to Kardos et al.: estimation of inbreeding depression from SNP dataYengo, Loic, Zhu, Zhihong, Wray, Naomi R., Weir, Bruce S., Yang, Jian, Robinson, Matthew R. and Visscher, Peter M. (2018). Reply to Kardos et al.: estimation of inbreeding depression from SNP data. Proceedings of the National Academy of Sciences, 115 (11), E2494-E2495. doi: 10.1073/pnas.1718598115 |
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2018 Journal Article Transformation of summary statistics from linear mixed model association on all-or-none traits to odds ratioLloyd-Jones, Luke R., Robinson, Matthew R., Yang, Jian and Visscher, Peter M. (2018). Transformation of summary statistics from linear mixed model association on all-or-none traits to odds ratio. Genetics, 208 (4), 1397-1408. doi: 10.1534/genetics.117.300360 |
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2018 Journal Article Seasonal Variability of Mineral Formation in Microbial Mats Subjected to Drying and Wetting Cycles in Alkaline and Hypersaline Sedimentary EnvironmentsCabestrero, O., Sanz-Montero, M. E., Arregui, L., Serrano, S. and Visscher, P. T. (2018). Seasonal Variability of Mineral Formation in Microbial Mats Subjected to Drying and Wetting Cycles in Alkaline and Hypersaline Sedimentary Environments. Aquatic Geochemistry, 24 (1), 79-105. doi: 10.1007/s10498-018-9333-2 |
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2018 Journal Article GWAS of epigenetic aging rates in blood reveals a critical role for TERTLu, Ake T., Xue, Luting, Salfati, Elias L., Chen, Brian H., Ferrucci, Luigi, Levy, Daniel, Joehanes, Roby, Murabito, Joanne M., Kiel, Douglas P., Tsai, Pei-Chien, Yet, Idil, Bell, Jordana T., Mangino, Massimo, Tanaka, Toshiko, McRae, Allan F., Marioni, Riccardo E., Visscher, Peter M., Wray, Naomi R., Deary, Ian J., Levine, Morgan E., Quach, Austin, Assimes, Themistocles, Tsao, Philip S., Absher, Devin, Stewart, James D., Li, Yun, Reiner, Alex P., Hou, Lifang, Baccarelli, Andrea A. ... Horvath, Steve (2018). GWAS of epigenetic aging rates in blood reveals a critical role for TERT. Nature Communications, 9 (1) 387, 387. doi: 10.1038/s41467-017-02697-5 |
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2018 Journal Article Causal associations between risk factors and common diseases inferred from GWAS summary dataZhu, Zhihong, Zheng, Zhili, Zhang, Futao, Wu, Yang, Trzaskowski, Maciej, Maier, Robert, Robinson, Matthew R., McGrath, John J, Visscher, Peter M, Wray, Naomi R and Yang, Jian (2018). Causal associations between risk factors and common diseases inferred from GWAS summary data. Nature Communications, 9 (1) 224, 224. doi: 10.1038/s41467-017-02317-2 |
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2018 Journal Article Evidence of directional and stabilizing selection in contemporary humansSanjak, Jaleal S., Sidorenko, Julia, Robinson, Matthew R., Thornton, Kevin R. and Visscher, Peter M. (2018). Evidence of directional and stabilizing selection in contemporary humans. Proceedings of the National Academy of Sciences of the United States of America, 115 (1), 151-156. doi: 10.1073/pnas.1707227114 |
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2018 Conference Publication Fine-mapping reveals complex genetic architecture underlying DNA methylationChundru, V. Kartik, Marioni, Riccardo E., Deary, Ian J., Wray, Naomi R., Visscher, Peter M. and McRae, Allan F. (2018). Fine-mapping reveals complex genetic architecture underlying DNA methylation. Human Genome Meeting, Yokohama, Japan, 12-15 March 2018. London, United Kingdom: Henry Stewart Publications. doi: 10.1186/s40246-018-0138-6 |
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2018 Journal Article Epigenetic influences on aging: a longitudinal genome-wide methylation study in old Swedish twinsWang, Yunzhang, Karlsson, Robert, Lampa, Erik, Zhang, Qian, Hedman, Åsa K., Almgren, Malin, Almqvist, Catarina, McRae, Allan F., Marioni, Riccardo E., Ingelsson, Erik, Visscher, Peter M., Deary, Ian J., Lind, Lars, Morris, Tiffany, Beck, Stephan, Pedersen, Nancy L. and Hägg, Sara (2018). Epigenetic influences on aging: a longitudinal genome-wide methylation study in old Swedish twins. Epigenetics, 13 (9), 1-13. doi: 10.1080/15592294.2018.1526028 |
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2018 Journal Article Association of whole-genome and NETRIN1 signaling pathway–derived polygenic risk scores for major depressive disorder and white matter microstructure in the UK BiobankBarbu, Miruna C., Zeng, Yanni, Shen, Xueyi, Cox, Simon R., Clarke, Toni-Kim, Gibson, Jude, Adams, Mark J., Johnstone, Mandy, Haley, Chris S., Lawrie, Stephen M., Deary, Ian J., Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Wray, Naomi R., Ripke, Stephan, Mattheisen, Manuel, Trzaskowski, Maciej, Byrne, Enda M., Abdellaoui, Abdel, Adams, Mark J., Agerbo, Esben, Air, Tracy M., Andlauer, Till F.M., Bacanu, Silviu-Alin, Bækvad-Hansen, Marie, Beekman, Aartjan T.F., Bigdeli, Tim B., Binder, Elisabeth B., Blackwood, Douglas H.R., Bryois, Julien ... Whalley, Heather C. (2018). Association of whole-genome and NETRIN1 signaling pathway–derived polygenic risk scores for major depressive disorder and white matter microstructure in the UK Biobank. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 4 (1), 91-100. doi: 10.1016/j.bpsc.2018.07.006 |
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2018 Conference Publication Invited abstract: Leveraging big GWAS data to address question about selection, pleiotropy, assortative mating and epidemiologyVisscher, Peter M., Wray, Naomi R. and Yang, Jian (2018). Invited abstract: Leveraging big GWAS data to address question about selection, pleiotropy, assortative mating and epidemiology. 27th Annual Meeting of the International Genetic Epidemiology Society (IGES), San Diego, CA, United States, 14-16 October 2018. Hoboken, NJ, United States: John Wiley & Sons. |
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2018 Journal Article Multi-trait analysis of genome-wide association summary statistics using MTAGTurley, Patrick, Walters, Raymond K., Maghzian, Omeed, Okbay, Aysu, Lee, James J., Fontana, Mark Alan, Nguyen-Viet, Tuan Anh, Wedow, Robbee, Zacher, Meghan, Furlotte, Nicholas A., Magnusson, Patrik, Oskarsson, Sven, Johannesson, Magnus, Visscher, Peter M., Laibson, David, Cesarini, David, Neale, Benjamin M., Benjamin, Daniel J., 23andMe Research Team and Social Science Genetic Association Consortium (2018). Multi-trait analysis of genome-wide association summary statistics using MTAG. Nature Genetics, 50 (229+), 229-237. doi: 10.1038/s41588-017-0009-4 |
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2018 Journal Article Accuracy of inferred APOE genotypes for a range of genotyping arrays and imputation reference panelsLupton, Michelle K., Medland, Sarah E., Gordon, Scott D., Goncalves, Tabatha, MacGregor, Stuart, Mackey, David A., Young, Terri L., Duffy, David L., Visscher, Peter M., Wray, Naomi R., Nyholt, Dale R., Bain, Lisa, Ferreira, Manuel A., Henders, Anjali K., Wallace, Leanne, Montgomery, Grant W., Wright, Margaret J. and Martin, Nicholas G. (2018). Accuracy of inferred APOE genotypes for a range of genotyping arrays and imputation reference panels. Journal of Alzheimer's Disease, 64 (1), 49-54. doi: 10.3233/JAD-171104 |
