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2017 Journal Article Enhancement of antibiotic-activity through complexation with metal ions - Combined ITC, NMR, enzymatic and biological studiesMöhler, Jasper S., Kolmar, Theresa, Synnatschke, Kevin, Hergert, Marcel, Wilson, Liam A., Ramu, Soumya, Elliott, Alysha G., Blaskovich, Mark A.T., Sidjabat, Hanna E., Paterson, David L., Schenk, Gerhard, Cooper, Matthew A. and Ziora, Zyta M. (2017). Enhancement of antibiotic-activity through complexation with metal ions - Combined ITC, NMR, enzymatic and biological studies. Journal of Inorganic Biochemistry, 167, 134-141. doi: 10.1016/j.jinorgbio.2016.11.028 |
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2016 Journal Article Surface ligand density of antibiotic-nanoparticle conjugates enhances target avidity and membrane permeabilization of vancomycin-resistant bacteriaHassan, Marwa Hussain Ali, Ranzoni, Andrea, Phetsang, Wanida, Blaskovich, Mark A. T. and Cooper, Matthew A. (2016). Surface ligand density of antibiotic-nanoparticle conjugates enhances target avidity and membrane permeabilization of vancomycin-resistant bacteria. Bioconjugate Chemistry, 28 (2), 353-361. doi: 10.1021/acs.bioconjchem.6b00494 |
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2016 Journal Article Old dogs and new tricks in antimicrobial discoveryButler, Mark, Blaskovich, Mark, Owen, Jeremy G. and Cooper, Matthew (2016). Old dogs and new tricks in antimicrobial discovery. Current Opinion in Microbiology, 33, 25-34. doi: 10.1016/j.mib.2016.05.011 |
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2016 Journal Article Nitroimidazole carboxamides as antiparasitic agents targeting Giardia lamblia, Entamoeba histolytica and Trichomonas vaginalisJarrad, A. M., Debnath, A., Miyamoto, Y., Hansford, K. A., Pelingon, R., Butler, M. S., Bains, T., Karoli, T., Blaskovich, M. A. T., Eckmann, L. and Cooper, M. A. (2016). Nitroimidazole carboxamides as antiparasitic agents targeting Giardia lamblia, Entamoeba histolytica and Trichomonas vaginalis. European Journal of Medicinal Chemistry, 120, 353-362. doi: 10.1016/j.ejmech.2016.04.064 |
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2016 Journal Article Discovery of functionally selective C5aR2 ligands: novel modulators of C5a signallingCroker, Daniel E., Monk, Peter N., Halai, Reena, Kaeslin, Geraldine, Schofield, Zoe, Wu, Mike C. L., Clark, Richard J., Blaskovich, Mark A. T., Morikis, Dimitrios, Floudas, Christodoulos A., Cooper, Matthew and Woodruff, Trent M. (2016). Discovery of functionally selective C5aR2 ligands: novel modulators of C5a signalling. Immunology and Cell Biology, 94 (8), 787-795. doi: 10.1038/icb.2016.43 |
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2016 Journal Article Chemical philanthropy: a path forward for antibiotic discovery?Hansford, Karl A., Blaskovich, Mark A. T. and Cooper, Matthew A. (2016). Chemical philanthropy: a path forward for antibiotic discovery?. Future Medicinal Chemistry, 8 (9), 925-929. doi: 10.4155/fmc-2016-0029 |
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2016 Other Outputs Methods of modulating the activity of the MC5 receptor and treatment of conditions related to this receptorMark Arnold Thomas Blaskovich and Peter Joseph Cassidy (2016). Methods of modulating the activity of the MC5 receptor and treatment of conditions related to this receptor. US9340517. |
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2016 Journal Article Short cationic lipopeptides as effective antibacterial agents: design, physicochemical properties and biological evaluationAzmi, Fazren, Elliott, Alysha G., Marasini, Nirmal, Ramu, Soumya, Ziora, Zyta, Kavanagh, Angela M., Blaskovich, Mark A. T., Cooper, Matthew A., Skwarczynski, Mariusz and Toth, Istvan (2016). Short cationic lipopeptides as effective antibacterial agents: design, physicochemical properties and biological evaluation. Bioorganic and Medicinal Chemistry, 24 (10), 2235-2241. doi: 10.1016/j.bmc.2016.03.053 |
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2016 Journal Article Contribution of amphipathicity and hydrophobicity to the antimicrobial activity and cytotoxicity of β‑hairpin peptidesEdwards, Ingrid A., Elliott, Alysha G., Kavanagh, Angela M., Zuegg, Johannes, Blaskovich, Mark A. T. and Cooper, Matthew A. (2016). Contribution of amphipathicity and hydrophobicity to the antimicrobial activity and cytotoxicity of β‑hairpin peptides. ACS Infectious Diseases, 2 (6), 442-450. doi: 10.1021/acsinfecdis.6b00045 |
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2016 Journal Article Activity and predicted nephrotoxicity of synthetic antibiotics based on polymyxin BGallardo-Godoy, Alejandra, Muldoon, Craig, Becker, Bernd, Elliott, Alysha G., Lash, Lawrence H, Huang, Johnny X., Butler, Mark S., Pelingon, Ruby, Kavanagh, Angela M., Ramu, Soumya, Phetsang, Wanida, Blaskovich, Mark A. T. and Cooper, Matthew A (2016). Activity and predicted nephrotoxicity of synthetic antibiotics based on polymyxin B. Journal of Medicinal Chemistry, 59 (3), 1068-1077. doi: 10.1021/acs.jmedchem.5b01593 |
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2016 Conference Publication Contribution of physicochemical parameters to the antimicrobial activity / toxicity index of B-Hairpin peptidesEdwards, I., Elliott, A., Blaskovich, M. and Cooper, M. (2016). Contribution of physicochemical parameters to the antimicrobial activity / toxicity index of B-Hairpin peptides. 34th European Peptide Symposium, Leipzig, Germany, 4‐9 September 2016. Oxford, United Kingdom: John Wiley & Sons. doi: 10.1002/psc.2950 |
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2015 Journal Article Clostridium difficile infection: current and emerging therapeuticsJarrad, Angie M., Blaskovich, Mark A. T., Lyras, Dena and Cooper, Matthew A. (2015). Clostridium difficile infection: current and emerging therapeutics. Current Treatment Options in Infectious Diseases, 7 (4), 317-334. doi: 10.1007/s40506-015-0062-4 |
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2015 Journal Article Mucin binding reduces colistin antimicrobial activityHuang, Johnny X., Blaskovich, Mark A.T., Pelingon, Ruby, Ramu, Soumya, Kavanagh, Angela, Elliott, Alysha G., Butler, Mark S., Montgomery, A. Bruce and Cooper, Matthew A. (2015). Mucin binding reduces colistin antimicrobial activity. Antimicrobial Agents and Chemotherapy, 59 (10), 5925-5931. doi: 10.1128/AAC.00808-15 |
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2015 Journal Article Metronidazole-triazole conjugates: activity against Clostridium difficile and parasitesJarrad, Angie M., Karoli, Tomislav, Anjan, Debnath, Tay, Chin Yen, Huang, Johnny X., Kaeslin, Geraldine, Elliott, Alysha G., Miyamoto, Yukiko, Ramu, Soumya, Kavanagh, Angela M., Zuegg, Johannes, Eckmann, Lars, Blaskovich, Mark A. and Cooper, Matthew A. (2015). Metronidazole-triazole conjugates: activity against Clostridium difficile and parasites. European Journal of Medicinal Chemistry, 101 7946, 96-102. doi: 10.1016/j.ejmech.2015.06.019 |
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2015 Other Outputs Antibacterial AgentsCooper, Matthew and Blaskovich, Mark (2015). Antibacterial Agents. WO/2015/117196. |
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2015 Journal Article Clostridium difficile drug pipeline: challenges in discover and development of new agentsJarrad, Angie M., Karoli, Tomislav, Blaskovich, Mark A.T., Lyras, Dena and Cooper, Matthew A. (2015). Clostridium difficile drug pipeline: challenges in discover and development of new agents. Journal of Medicinal Chemistry, 58 (13), 5164-5185. doi: 10.1021/jm5016846 |
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2015 Journal Article A new antibiotic with potent activity targets MscLIscla, Irene, Wray, Robin, Blount, Paul, Larkins-Ford, Johah, Conery, Annie L., Ausubel, Frederick M., Ramu, Soumya, Kavanagh, Angela, Huang, Johnny X., Blaskovich, Mark A., Cooper, Matthew A., Obregon-Henao, Andres, Orme, Ian, Tjandra, Edwin S., Stroeher, Uwe H., Brown, Melissa H., Macardle, Cindy, van Holst, Nick, Tong, Chee Ling, Slattery, Ashley D., Gibson, Christopher T., Raston, Colin L. and Boulos, Ramiz A. (2015). A new antibiotic with potent activity targets MscL. The Journal of Antibiotics, 68 (7), 453-462. doi: 10.1038/ja.2015.4 |
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2015 Journal Article Helping chemists discover new antibioticsBlaskovich, Mark A. T., Zuegg, Johannes, Elliott, Alysha G. and Cooper, Matthew (2015). Helping chemists discover new antibiotics. ACS Infectious Diseases, 1 (7), 285-287. doi: 10.1021/acsinfecdis.5b00044 |
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2015 Journal Article Evaluation of biomarkers for in vitro prediction of drug-induced nephrotoxicity: comparison of HK-2, immortalized human proximal tubule epithelial, and primary cultures of human proximal tubular cellsHuang, Johnny Xiao, Geraldine Kaeslin, Max Ranall, Blaskovich, Mark, Bernd Becker, Butler, Mark, Little, Melissa H., Lash, Lawrence H. and Cooper, Matthew (2015). Evaluation of biomarkers for in vitro prediction of drug-induced nephrotoxicity: comparison of HK-2, immortalized human proximal tubule epithelial, and primary cultures of human proximal tubular cells. Pharmacology Research and Perspectives, 3 (3) e00148, e00148. doi: 10.1002/prp2.148 |
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2015 Journal Article Self-assembling lipopeptides with a potent activity against Gram-positive bacteria, including multidrug resistant strainsAzmi, Fazren, Elliott, Alysha G., Khalil, Zeinab G., Hussein, Waleed M., Kavanagh, Angela, Huang, Johnny X., Quezada, Michelle, Blaskovich, Mark A. T., Capon, Robert J., Cooper, Matthew A., Skwarczynski, Mariusz and Toth, Istvan (2015). Self-assembling lipopeptides with a potent activity against Gram-positive bacteria, including multidrug resistant strains. Nanomedicine, 10 (22), 3359-3371. doi: 10.2217/nnm.15.137 |
