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2017 Journal Article Structure-Activity and -Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-1Edwards, Ingrid A, Elliott, Alysha G, Kavanagh, Angela M, Blaskovich, Mark A T and Cooper, Matthew A (2017). Structure-Activity and -Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-1. ACS infectious diseases, 3 (12), 917-926. doi: 10.1021/acsinfecdis.7b00123 |
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2017 Journal Article Nitroimidazoles: Molecular fireworks that combat a broad spectrum of infectious diseasesAng, Chee Wei, Jarrad, Angie M., Cooper, Matthew A. and Blaskovich, Mark A. T. (2017). Nitroimidazoles: Molecular fireworks that combat a broad spectrum of infectious diseases. Journal of Medicinal Chemistry, 60 (18), 7636-7657. doi: 10.1021/acs.jmedchem.7b00143 |
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2017 Journal Article Investigating the interaction of octapeptin A3 with model bacterial membranesHan, Mei-Ling, Shen, Hsin-Hui, Hansford, Karl A., Schneider, Elena K., Sivanesan, Sivashangarie, Roberts, Kade D., Thompson, Philip E., Le Brun, Anton P., Zhu, Yan, Sani, Marc-Antoine, Separovic, Frances, Blaskovich, Mark A. T., Baker, Mark A., Moskowitz, Samuel M., Cooper, Matthew A., Li, Jian and Velkov, Tony (2017). Investigating the interaction of octapeptin A3 with model bacterial membranes. ACS Infectious Diseases, 3 (8), 606-619. doi: 10.1021/acsinfecdis.7b00065 |
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2017 Journal Article From Breast Cancer to Antimicrobial: Combating Extremely Resistant Gram-Negative "superbugs" Using Novel Combinations of Polymyxin B with Selective Estrogen Receptor ModulatorsHussein, Maytham H., Schneider, Elena K., Elliott, Alysha G., Han, Meiling, Reyes-Ortega, Felisa, Morris, Faye, Blaskovich, Mark A. T., Jasim, Raad, Currie, Bart, Mayo, Mark, Baker, Mark, Cooper, Matthew A., Li, Jian and Velkov, Tony (2017). From Breast Cancer to Antimicrobial: Combating Extremely Resistant Gram-Negative "superbugs" Using Novel Combinations of Polymyxin B with Selective Estrogen Receptor Modulators. Microbial Drug Resistance, 23 (5), 640-650. doi: 10.1089/mdr.2016.0196 |
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2017 Journal Article Synthesis of octapeptin C4 and biological profiling against NDM-1 and polymyxin-resistant bacteriaBecker, Bernd, Butler, Mark S., Hansford, Karl A., Gallardo-Godoy, Alejandra, Elliott, Alysha G., Huang, Johnny X., Edwards, David J., Blaskovich, Mark A. T. and Cooper, Matthew A. (2017). Synthesis of octapeptin C4 and biological profiling against NDM-1 and polymyxin-resistant bacteria. Bioorganic and Medicinal Chemistry Letters, 27 (11), 2407-2409. doi: 10.1016/j.bmcl.2017.04.027 |
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2017 Other Outputs Multifactorial Chromosomal Variants Regulate Polymyxin Resistance in Extensively Drug-Resistant Klebsiella pneumoniaePitt, Miranda E, Elliott, Alysha G, Cao, Minh Duc, Ganesamoorthy, Devika, Karaiskos, Ilias, Giamarellou, Helen, Abboud, Cely S, Blaskovich, Mark AT, Cooper, Matthew A and Coin, Lachlan (2017). Multifactorial Chromosomal Variants Regulate Polymyxin Resistance in Extensively Drug-Resistant Klebsiella pneumoniae. doi: 10.1101/134684 |
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2017 Journal Article Institutional profile: Community for Open Antimicrobial Drug Discovery - crowdsourcing new antibiotics and antifungalsDesselle, Mathilde R., Neale, Ruth, Hansford, Karl A., Zuegg, Johannes, Elliott, Alysha G., Cooper, Matthew A. and Blaskovich, Mark A. T. (2017). Institutional profile: Community for Open Antimicrobial Drug Discovery - crowdsourcing new antibiotics and antifungals. Future Science OA, 3 (2) FSO171, FSO171. doi: 10.4155/fsoa-2016-0093 |
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2017 Journal Article Polishing the tarnished silver bullet: the quest for new antibioticsBlaskovich, Mark A. T., Butler, Mark S. and Cooper, Matthew A. (2017). Polishing the tarnished silver bullet: the quest for new antibiotics. Antimicrobial Resistance, 61 (1), 103-114. doi: 10.1042/EBC20160077 |
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2017 Journal Article Enhancement of antibiotic-activity through complexation with metal ions - Combined ITC, NMR, enzymatic and biological studiesMöhler, Jasper S., Kolmar, Theresa, Synnatschke, Kevin, Hergert, Marcel, Wilson, Liam A., Ramu, Soumya, Elliott, Alysha G., Blaskovich, Mark A.T., Sidjabat, Hanna E., Paterson, David L., Schenk, Gerhard, Cooper, Matthew A. and Ziora, Zyta M. (2017). Enhancement of antibiotic-activity through complexation with metal ions - Combined ITC, NMR, enzymatic and biological studies. Journal of Inorganic Biochemistry, 167, 134-141. doi: 10.1016/j.jinorgbio.2016.11.028 |
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2016 Journal Article Surface ligand density of antibiotic-nanoparticle conjugates enhances target avidity and membrane permeabilization of vancomycin-resistant bacteriaHassan, Marwa Hussain Ali, Ranzoni, Andrea, Phetsang, Wanida, Blaskovich, Mark A. T. and Cooper, Matthew A. (2016). Surface ligand density of antibiotic-nanoparticle conjugates enhances target avidity and membrane permeabilization of vancomycin-resistant bacteria. Bioconjugate Chemistry, 28 (2), 353-361. doi: 10.1021/acs.bioconjchem.6b00494 |
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2016 Journal Article Old dogs and new tricks in antimicrobial discoveryButler, Mark, Blaskovich, Mark, Owen, Jeremy G. and Cooper, Matthew (2016). Old dogs and new tricks in antimicrobial discovery. Current Opinion in Microbiology, 33, 25-34. doi: 10.1016/j.mib.2016.05.011 |
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2016 Journal Article Nitroimidazole carboxamides as antiparasitic agents targeting Giardia lamblia, Entamoeba histolytica and Trichomonas vaginalisJarrad, A. M., Debnath, A., Miyamoto, Y., Hansford, K. A., Pelingon, R., Butler, M. S., Bains, T., Karoli, T., Blaskovich, M. A. T., Eckmann, L. and Cooper, M. A. (2016). Nitroimidazole carboxamides as antiparasitic agents targeting Giardia lamblia, Entamoeba histolytica and Trichomonas vaginalis. European Journal of Medicinal Chemistry, 120, 353-362. doi: 10.1016/j.ejmech.2016.04.064 |
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2016 Journal Article Discovery of functionally selective C5aR2 ligands: novel modulators of C5a signallingCroker, Daniel E., Monk, Peter N., Halai, Reena, Kaeslin, Geraldine, Schofield, Zoe, Wu, Mike C. L., Clark, Richard J., Blaskovich, Mark A. T., Morikis, Dimitrios, Floudas, Christodoulos A., Cooper, Matthew and Woodruff, Trent M. (2016). Discovery of functionally selective C5aR2 ligands: novel modulators of C5a signalling. Immunology and Cell Biology, 94 (8), 787-795. doi: 10.1038/icb.2016.43 |
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2016 Journal Article Chemical philanthropy: a path forward for antibiotic discovery?Hansford, Karl A., Blaskovich, Mark A. T. and Cooper, Matthew A. (2016). Chemical philanthropy: a path forward for antibiotic discovery?. Future Medicinal Chemistry, 8 (9), 925-929. doi: 10.4155/fmc-2016-0029 |
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2016 Other Outputs Methods of modulating the activity of the MC5 receptor and treatment of conditions related to this receptorMark Arnold Thomas Blaskovich and Peter Joseph Cassidy (2016). Methods of modulating the activity of the MC5 receptor and treatment of conditions related to this receptor. US9340517. |
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2016 Journal Article Short cationic lipopeptides as effective antibacterial agents: design, physicochemical properties and biological evaluationAzmi, Fazren, Elliott, Alysha G., Marasini, Nirmal, Ramu, Soumya, Ziora, Zyta, Kavanagh, Angela M., Blaskovich, Mark A. T., Cooper, Matthew A., Skwarczynski, Mariusz and Toth, Istvan (2016). Short cationic lipopeptides as effective antibacterial agents: design, physicochemical properties and biological evaluation. Bioorganic and Medicinal Chemistry, 24 (10), 2235-2241. doi: 10.1016/j.bmc.2016.03.053 |
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2016 Journal Article Contribution of amphipathicity and hydrophobicity to the antimicrobial activity and cytotoxicity of β‑hairpin peptidesEdwards, Ingrid A., Elliott, Alysha G., Kavanagh, Angela M., Zuegg, Johannes, Blaskovich, Mark A. T. and Cooper, Matthew A. (2016). Contribution of amphipathicity and hydrophobicity to the antimicrobial activity and cytotoxicity of β‑hairpin peptides. ACS Infectious Diseases, 2 (6), 442-450. doi: 10.1021/acsinfecdis.6b00045 |
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2016 Journal Article Activity and predicted nephrotoxicity of synthetic antibiotics based on polymyxin BGallardo-Godoy, Alejandra, Muldoon, Craig, Becker, Bernd, Elliott, Alysha G., Lash, Lawrence H, Huang, Johnny X., Butler, Mark S., Pelingon, Ruby, Kavanagh, Angela M., Ramu, Soumya, Phetsang, Wanida, Blaskovich, Mark A. T. and Cooper, Matthew A (2016). Activity and predicted nephrotoxicity of synthetic antibiotics based on polymyxin B. Journal of Medicinal Chemistry, 59 (3), 1068-1077. doi: 10.1021/acs.jmedchem.5b01593 |
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2016 Conference Publication Contribution of physicochemical parameters to the antimicrobial activity / toxicity index of B-Hairpin peptidesEdwards, I., Elliott, A., Blaskovich, M. and Cooper, M. (2016). Contribution of physicochemical parameters to the antimicrobial activity / toxicity index of B-Hairpin peptides. 34th European Peptide Symposium, Leipzig, Germany, 4‐9 September 2016. Oxford, United Kingdom: John Wiley & Sons. doi: 10.1002/psc.2950 |
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2015 Journal Article Clostridium difficile infection: current and emerging therapeuticsJarrad, Angie M., Blaskovich, Mark A. T., Lyras, Dena and Cooper, Matthew A. (2015). Clostridium difficile infection: current and emerging therapeutics. Current Treatment Options in Infectious Diseases, 7 (4), 317-334. doi: 10.1007/s40506-015-0062-4 |
