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2019

Journal Article

Shared and specific genetic risk factors for lifetime major depression, depressive symptoms and neuroticism in three population-based twin samples

Kendler, Kenneth S., Gardner, Charles O., Neale, Michael C., Aggen, Steve, Heath, Andrew, Colodro-Conde, Lucía, Couvyduchesne, Baptiste, Byrne, Enda M., Martin, Nicholas G. and Gillespie, Nathan A. (2019). Shared and specific genetic risk factors for lifetime major depression, depressive symptoms and neuroticism in three population-based twin samples. Psychological Medicine, 49 (16), 2745-2753. doi: 10.1017/S003329171800377X

Shared and specific genetic risk factors for lifetime major depression, depressive symptoms and neuroticism in three population-based twin samples

2019

Journal Article

Genetic risk scores for major psychiatric disorders and the risk of postpartum psychiatric disorders

Bauer, Anna E., Liu, Xiaoqin, Byrne, Enda M., Sullivan, Patrick F., Wray, Naomi R., Agerbo, Esben, Nyegaard, Mette, Grove, Jakob, Musliner, Katherine L., Ingstrup, Katja G., Johannsen, Benedicte M. W., Mægbæk, Merete L., Wang, Yunpeng, Nordentoft, Merete, Mors, Ole, Børglum, Anders D., Werge, Thomas, Hougaard, David M., Mortensen, Preben Bo, Munk-Olsen, Trine and Meltzer-Brody, Samantha (2019). Genetic risk scores for major psychiatric disorders and the risk of postpartum psychiatric disorders. Translational Psychiatry, 9 (1) 288, 288. doi: 10.1038/s41398-019-0629-9

Genetic risk scores for major psychiatric disorders and the risk of postpartum psychiatric disorders

2019

Journal Article

The genetics of the mood disorder spectrum: Genome-wide association analyses of more than 185,000 cases and 439,000 controls

Coleman, Jonathan R.I., Gaspar, Héléna A., Bryois, Julien, Byrne, Enda M., Forstner, Andreas J., Holmans, Peter A., de Leeuw, Christiaan A., Mattheisen, Manuel, McQuillin, Andrew, Whitehead Pavlides, Jennifer M., Pers, Tune H., Ripke, Stephan, Stahl, Eli A., Steinberg, Stacy, Trubetskoy, Vassily, Trzaskowski, Maciej, Wang, Yunpeng, Abbott, Liam, Abdellaoui, Abdel, Adams, Mark J., Adolfsson, Annelie Nordin, Agerbo, Esben, Akil, Huda, Albani, Diego, Alliey-Rodriguez, Ney, Als, Thomas D., Andlauer, Till F.M., Anjorin, Adebayo, Antilla, Verneri ... Breen, Gerome (2019). The genetics of the mood disorder spectrum: Genome-wide association analyses of more than 185,000 cases and 439,000 controls. Biological Psychiatry, 88 (2), 169-184. doi: 10.1016/j.biopsych.2019.10.015

The genetics of the mood disorder spectrum: Genome-wide association analyses of more than 185,000 cases and 439,000 controls

2019

Journal Article

Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders

Andlauer, Till F. M., Guzman-Parra, Jose, Streit, Fabian, Strohmaier, Jana, González, Maria José, Gil Flores, Susana, Cabaleiro Fabeiro, Francisco J., del Río Noriega, Francisco, Perez, Fermin Perez, Haro González, Jesus, Orozco Diaz, Guillermo, de Diego-Otero, Yolanda, Moreno-Küstner, Berta, Auburger, Georg, Degenhardt, Franziska, Heilmann-Heimbach, Stefanie, Herms, Stefan, Hoffmann, Per, Frank, Josef, Foo, Jerome C., Treutlein, Jens, Witt, Stephanie H., Cichon, Sven, Kogevinas, Manolis, Stahl, Eli A, Breen, Gerome, Forstner, Andreas J, McQuillin, Andrew, Ripke, Stephan ... Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (2019). Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders. Molecular Psychiatry, 26 (4), 1286-1298. doi: 10.1038/s41380-019-0558-2

Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders

2019

Journal Article

The relationship between insomnia and complex diseases-insights from genetic data

Byrne, Enda M. (2019). The relationship between insomnia and complex diseases-insights from genetic data. Genome Medicine, 11 (1) 57, 57. doi: 10.1186/s13073-019-0668-0

The relationship between insomnia and complex diseases-insights from genetic data

2019

Journal Article

Classical human leukocyte antigen alleles and C4 haplotypes are not significantly associated With depression

Glanville, Kylie P., Coleman, Jonathan R. I., Hanscombe, Ken B., Euesden, Jack, Choi, Shing Wan, Purves, Kirstin L., Breen, Gerome, Air, Tracy M., Andlauer, Till F. M., Baune, Bernhard T., Binder, Elisabeth B., Blackwood, Douglas H. R., Boomsma, Dorret I., Buttenschøn, Henriette N., Colodro-Conde, Lucía, Dannlowski, Udo, Direk, Nese, Dunn, Erin C., Forstner, Andreas J., de Geus, Eco J. C., Grabe, Hans J., Hamilton, Steven P., Jones, Ian, Jones, Lisa A., Knowles, James A., Kutalik, Zoltán, Levinson, Douglas F., Lewis, Glyn, Lind, Penelope A. ... Børglum, Anders D. (2019). Classical human leukocyte antigen alleles and C4 haplotypes are not significantly associated With depression. Biological Psychiatry, 87 (5), 419-430. doi: 10.1016/j.biopsych.2019.06.031

Classical human leukocyte antigen alleles and C4 haplotypes are not significantly associated With depression

2019

Journal Article

GWAS of suicide attempt in psychiatric disorders and association with major depression polygenic risk scores

Mullins, Niamh, Bigdeli, Tim B., Børglum, Anders D., Coleman, Jonathan R.I., Demontis, Ditte, Mehta, Divya, Power, Robert A., Ripke, Stephan, Stahl, Eli A., Starnawska, Anna, Anjorin, Adebayo, Corvin, Aiden, Sanders, Alan R., Forstner, Andreas J., Reif, Andreas, Koller, Anna C., Tkowska, Beata Swia, Baune, Bernhard T., Müller-Myhsok, Bertram, Penninx, Brenda W.J.H., Pato, Carlos, Zai, Clement, Rujescu, Dan, Hougaard, David M., Quested, Digby, Levinson, Douglas F., Binder, Elisabeth B., Byrne, Enda M., Agerbo, Esben ... Lewis, Cathryn M. (2019). GWAS of suicide attempt in psychiatric disorders and association with major depression polygenic risk scores. American Journal of Psychiatry, 176 (8), 651-660. doi: 10.1176/appi.ajp.2019.18080957

GWAS of suicide attempt in psychiatric disorders and association with major depression polygenic risk scores

2019

Journal Article

Publisher Correction: Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection

Pardiñas, Antonio F., Holmans, Peter, Pocklington, Andrew J., Escott-Price, Valentina, Ripke, Stephan, Carrera, Noa, Legge, Sophie E., Bishop, Sophie, Cameron, Darren, Hamshere, Marian L., Han, Jun, Hubbard, Leon, Lynham, Amy, Mantripragada, Kiran, Rees, Elliott, MacCabe, James H., McCarroll, Steven A., Baune, Bernhard T., Breen, Gerome, Byrne, Enda M., Dannlowski, Udo, Eley, Thalia C., Hayward, Caroline, Martin, Nicholas G., McIntosh, Andrew M., Plomin, Robert, Porteous, David J., Wray, Naomi R., Caballero, Armando ... Walters, James T. R. (2019). Publisher Correction: Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection. Nature Genetics, 51 (7), 1193-1193. doi: 10.1038/s41588-019-0450-7

Publisher Correction: Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection

2019

Journal Article

Genome-wide association study identifies 30 loci associated with bipolar disorder

Stahl, Eli A., Breen, Gerome, Forstner, Andreas J., McQuillin, Andrew, Ripke, Stephan, Trubetskoy, Vassily, Mattheisen, Manuel, Wang, Yunpeng, Coleman, Jonathan R. I., Gaspar, Héléna A., de Leeuw, Christiaan A., Steinberg, Stacy, Pavlides, Jennifer M. Whitehead, Trzaskowski, Maciej, Byrne, Enda M., Pers, Tune H., Holmans, Peter A., Richards, Alexander L., Abbott, Liam, Agerbo, Esben, Akil, Huda, Albani, Diego, Alliey-Rodriguez, Ney, Als, Thomas D., Anjorin, Adebayo, Antilla, Verneri, Awasthi, Swapnil, Badner, Judith A., Bækvad-Hansen, Marie ... Sklar, Pamela (2019). Genome-wide association study identifies 30 loci associated with bipolar disorder. Nature Genetics, 51 (5), 793-803. doi: 10.1038/s41588-019-0397-8

Genome-wide association study identifies 30 loci associated with bipolar disorder

2019

Journal Article

Genome-wide association study of medication-use and associated disease in the UK Biobank

Wu, Yeda, Byrne, Enda M., Zheng, Zhili, Kemper, Kathryn E., Yengo, Loic, Mallett, Andrew J., Yang, Jian, Visscher, Peter M. and Wray, Naomi R. (2019). Genome-wide association study of medication-use and associated disease in the UK Biobank. Nature Communications, 10 (1) 1891, 1891. doi: 10.1038/s41467-019-09572-5

Genome-wide association study of medication-use and associated disease in the UK Biobank

2019

Journal Article

Assessment of bidirectional relationships between physical activity and depression among adults A 2-Sample mendelian randomization study

Choi, Karmel W., Chen, Chia-Yen, Stein, Murray B., Klimentidis, Yann C., Wang, Min-Jung, Koenen, Karestan C., Smoller, Jordan W., Wray, Naomi R., Ripke, Stephan, Mattheisen, Manuel, Trzaskowski, Maciej, Byrne, Enda M., Abdellaoui, Abdel, Adams, Mark J., Agerbo, Esben, Air, TracyM., Andlauer, Till F. M., Bacanu, Silviu-Alin, Baekvad-Hansen, Marie, Beekman, Aartjan T. F., Bigdeli, Tim B., Binder, Elisabeth B., Blackwood, Douglas H. R., Bryois, Julien, Buttenschon, Henriette N., Bybjerg-Grauholm, Jonas, Cai, Na, Castelao, Enrique, Hvarregaard, Jane ... Sullivan, Patrick F. (2019). Assessment of bidirectional relationships between physical activity and depression among adults A 2-Sample mendelian randomization study. JAMA Psychiatry, 76 (4), 399-408. doi: 10.1001/jamapsychiatry.2018.4175

Assessment of bidirectional relationships between physical activity and depression among adults A 2-Sample mendelian randomization study

2019

Journal Article

Identification of common genetic risk variants for autism spectrum disorder

Grove, Jakob, Ripke, Stephan, Als, Thomas D., Mattheisen, Manuel, Walters, Raymond K., Won, Hyejung, Pallesen, Jonatan, Agerbo, Esben, Andreassen, Ole A., Anney, Richard, Awashti, Swapnil, Belliveau, Rich, Bettella, Francesco, Buxbaum, Joseph D., Bybjerg-Grauholm, Jonas, Bækvad-Hansen, Marie, Cerrato, Felecia, Chambert, Kimberly, Christensen, Jane H., Churchhouse, Claire, Dellenvall, Karin, Demontis, Ditte, De Rubeis, Silvia, Devlin, Bernie, Djurovic, Srdjan, Dumont, Ashley L., Goldstein, Jacqueline I., Hansen, Christine S., Hauberg, Mads Engel ... Børglum, Anders D. (2019). Identification of common genetic risk variants for autism spectrum disorder. Nature Genetics, 51 (3), 431-444. doi: 10.1038/s41588-019-0344-8

Identification of common genetic risk variants for autism spectrum disorder

2019

Journal Article

Genome-wide by environment interaction studies of depressive symptoms and psychosocial stress in UK Biobank and Generation Scotland

Arnau-Soler, Aleix, Macdonald-Dunlop, Erin, Adams, Mark J., Clarke, Toni-Kim, MacIntyre, Donald J., Milburn, Keith, Navrady, Lauren, Hayward, Caroline, McIntosh, Andrew M., Thomson, Pippa A., Wray, Naomi R., Ripke, Stephan, Mattheisen, Manuel, Trzaskowski, Maciej, Byrne, Enda M., Abdellaoui, Abdel, Agerbo, Esben, Air, Tracy M., Andlauer, Till F. M., Bacanu, Silviu-Alin, Baekvad-Hansen, Marie, Beekman, Aartjan T. F., Bigdeli, Tim B., Binder, Elisabeth B., Blackwood, Douglas H. R., Bryois, Julien, Buttenscon, Henriette N., Bybjerg-Grauholm, Jonas, Cai, Na ... Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (2019). Genome-wide by environment interaction studies of depressive symptoms and psychosocial stress in UK Biobank and Generation Scotland. Translational Psychiatry, 9 (1) 14. doi: 10.1038/s41398-018-0360-y

Genome-wide by environment interaction studies of depressive symptoms and psychosocial stress in UK Biobank and Generation Scotland

2019

Journal Article

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions

Howard, David M., Adams, Mark J., Clarke, Toni-Kim, Hafferty, Jonathan D., Gibson, Jude, Shirali, Masoud, Coleman, Jonathan R. I., Hagenaars, Saskia P., Ward, Joey, Wigmore, Eleanor M., Alloza, Clara, Shen, Xueyi, Barbu, Miruna C., Xu, Eileen Y., Whalley, Heather C., Marioni, Riccardo E., Porteous, David J., Davies, Gail, Deary, Ian J., Hemani, Gibran, Berger, Klaus, Teismann, Henning, Rawal, Rajesh, Arolt, Volker, Baune, Bernhard T., Dannlowski, Udo, Domschke, Katharina, Tian, Chao, Hinds, David A. ... McIntosh, Andrew M. (2019). Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions. Nature Neuroscience, 22 (3), 343-352. doi: 10.1038/s41593-018-0326-7

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions

2019

Journal Article

Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms

Jones, Samuel E., Lane, Jacqueline M., Wood, Andrew R., van Hees, Vincent T., Tyrrell, Jessica, Beaumont, Robin N., Jeffries, Aaron R., Dashti, Hassan S., Hillsdon, Melvyn, Ruth, Katherine S., Tuke, Marcus A., Yaghootkar, Hanieh, Sharp, Seth A., Jie, Yingjie, Thompson, William D., Harrison, Jamie W., Dawes, Amy, Byrne, Enda M., Tiemeier, Henning, Allebrandt, Karla V., Bowden, Jack, Ray, David W., Freathy, Rachel M., Murray, Anna, Mazzotti, Diego R., Gehrman, Philip R., Lawlor, Debbie A., Frayling, Timothy M., Rutter, Martin K. ... Weedon, Michael N. (2019). Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms. Nature Communications, 10 (1) 343, 343. doi: 10.1038/s41467-018-08259-7

Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms

2019

Conference Publication

INVESTIGATING CAUSAL RELATIONSHIPS BETWEEN MAJOR DEPRESSIVE DISORDER AND GENETICALLY CORRELATED TRAITS USING MENDELIAN RANDOMISATION

Byrne, Enda, Trzaskowski, Maciej and Wray, Naomi (2019). INVESTIGATING CAUSAL RELATIONSHIPS BETWEEN MAJOR DEPRESSIVE DISORDER AND GENETICALLY CORRELATED TRAITS USING MENDELIAN RANDOMISATION. 25th World Congress of Psychiatric Genetics (WCPG), Orlando Fl, Oct 13-17, 2017. AMSTERDAM: ELSEVIER SCIENCE BV. doi: 10.1016/j.euroneuro.2017.08.020

INVESTIGATING CAUSAL RELATIONSHIPS BETWEEN MAJOR DEPRESSIVE DISORDER AND GENETICALLY CORRELATED TRAITS USING MENDELIAN RANDOMISATION

2019

Conference Publication

Comprehensive evaluation of enrichment for circadian clock gene sets in psychiatric traits: specific enrichment in clinical response to lithium

Papiol, Sergi, Heilbronner, Urs, Hou, Liping, McCarthy, Michael, Nievergelt, Caroline, Byrne, Enda, McMahon, Francis and Schulze, Thomas (2019). Comprehensive evaluation of enrichment for circadian clock gene sets in psychiatric traits: specific enrichment in clinical response to lithium. 25th World Congress of Psychiatric Genetics (WCPG), Orlando, FL, United States, 13-17 October 2017. Amsterdam, The Netherlands: Elsevier . doi: 10.1016/j.euroneuro.2017.08.270

Comprehensive evaluation of enrichment for circadian clock gene sets in psychiatric traits: specific enrichment in clinical response to lithium

2019

Conference Publication

A direct test of the diathesis-stress model for depression

Conde, Lucia Colodro, Couvy-Duchesne, Baptiste, Zhu, Gu, Coventry, William, Byrne, Enda, Gordon, Scott, Wright, Margaret, Montgomery, Grant, Madden, Pamela, Ripke, Stephan, Eaves, Lindon, Heath, Andrew, Wray, Naomi, Medland, Sarah E. and Martin, Nick (2019). A direct test of the diathesis-stress model for depression. 25th World Congress of Psychiatric Genetics (WCPG), Orlando, FL United States, 13-17 October 2017. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.euroneuro.2017.08.045

A direct test of the diathesis-stress model for depression

2019

Conference Publication

Genomic structural equation models of major depression symptoms

Adams, Mark, Grotzinger, Andrew, Jermy, Bradley, Thorp, Jackson, Nivard, Michel, Byrne, Enda, Hickie, Ian, Martin, Nick, Medland, Sarah, Wray, Naomi, Tucker-Drob, Elliot, Lewis, Cathryn, Derks, Eske and McIntosh, Andrew (2019). Genomic structural equation models of major depression symptoms. 27th World Congress of Psychiatric Genetics (WCPG), Los Angeles, CA, United States, 26-31 October 2019. Amsterdam, The Netherlands: Elsevier. doi: 10.1016/j.euroneuro.2019.08.042

Genomic structural equation models of major depression symptoms

2019

Conference Publication

Conditional genome-wide association analysis identifies genetic variants

Byrne, E. (2019). Conditional genome-wide association analysis identifies genetic variants. 21st Annual ISBD Conference: Global Advances in Bipolar Disorder and Depression, Sydney, Australia, 20-23 March 2019. Hoboken, NJ United States: Wiley-Blackwell Publishing.

Conditional genome-wide association analysis identifies genetic variants