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2025 Journal Article Harnessing cytokine immunocomplexes and cytokine fusion proteins for cancer Therapy: Mechanisms and clinical potentialKong, Wei Yang, Soderholm, Amelia, Brooks, Andrew J., Gonzalez Cruz, Jazmina L. and Wells, James W. (2025). Harnessing cytokine immunocomplexes and cytokine fusion proteins for cancer Therapy: Mechanisms and clinical potential. Cancer Treatment Reviews, 136 102937, 102937. doi: 10.1016/j.ctrv.2025.102937 |
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2025 Journal Article TLR4 endocytosis and endosomal TLR4 signaling are distinct and independent outcomes of TLR4 activationSchultz, Thomas E, Mathmann, Carmen D, Domínguez Cadena, Leslie C, Muusse, Timothy W, Kim, Hyoyoung, Wells, James W, Ulett, Glen C, Hamerman, Jessica A, Brooks, Andrew J, Kobe, Bostjan, Sweet, Matthew J, Stacey, Katryn J and Blumenthal, Antje (2025). TLR4 endocytosis and endosomal TLR4 signaling are distinct and independent outcomes of TLR4 activation. EMBO Reports 2250056, 1-27. doi: 10.1038/s44319-025-00444-2 |
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2025 Conference Publication Targeting replication stress promotes anti-tumour immune responses that are suppressed by tumour-associated myeloid cellsZeng, Zhen, Bhatt, Ritu, Gandini, Anastasia, Cruz, Jazmina Gonzalez, Proctor, Martina, Irvine, Katharine, Dolcetti, Riccardo, Wells, James and Gabrielli, Brian (2025). Targeting replication stress promotes anti-tumour immune responses that are suppressed by tumour-associated myeloid cells. AACR IO: Discovery and Innovation in Cancer Immunology: Revolutionizing Treatment through Immunotherapy, Los Angeles, CA USA, 23-26 February 2025. Washington, DC USA: American Association for Cancer Research. doi: 10.1158/2326-6074.io2025-a118 |
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2025 Journal Article A synthetic cyclic peptide for promoting antigen presentation and immune activationZhang, Jiahui, Madge, Harrison Y. R., Mahmoud, Asmaa, Lu, Lantian, Wang, Wanyi, Huang, Wenbin, Koirala, Prashamsa, Gonzalez Cruz, Jazmina L., Kong, Wei Yang, Bashiri, Sahra, Shalash, Ahmed O., Hussein, Waleed M., Khalil, Zeinab G., Wells, James W., Toth, Istvan and Stephenson, Rachel J. (2025). A synthetic cyclic peptide for promoting antigen presentation and immune activation. NPJ Vaccines, 10 (1) 9, 9-1. doi: 10.1038/s41541-024-01050-4 |
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2024 Conference Publication Unravelling the biology of double-positive CD4/CD8αβ T cells in peripheral tissuesKong, Wei Yang, Soderholm, Amelia, de Oca, Marcela Montes, Chew, Hui Yi, Brooks, Andrew, Cruz, Jazmina and Wells, James (2024). Unravelling the biology of double-positive CD4/CD8αβ T cells in peripheral tissues. Annual Meeting of the American-Association-of-Immunologists (IMMUNOLOGY), Chicago, IL USA, 3-7 May 2024. Cary, NC USA: Oxford University Press. doi: 10.4049/jimmunol.212.supp.1341.4154 |
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2024 Journal Article Utilizing murine dendritic cell line DC2.4 to evaluate the immunogenicity of subunit vaccines in vitroLu, Lantian, Kong, Wei Yang, Zhang, Jiahui, Firdaus, Farrhana, Wells, James W., Stephenson, Rachel J., Toth, Istvan, Skwarczynski, Mariusz and Cruz, Jazmina L. Gonzalez (2024). Utilizing murine dendritic cell line DC2.4 to evaluate the immunogenicity of subunit vaccines in vitro. Frontiers in Immunology, 15 1298721, 1-13. doi: 10.3389/fimmu.2024.1298721 |
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2024 Journal Article Arginase-induced cell death pathways and metabolic changes in cancer cells are not altered by insulinChew, Hui Yi, Cvetkovic, Goran, Tepic, Slobodan and Wells, James W. (2024). Arginase-induced cell death pathways and metabolic changes in cancer cells are not altered by insulin. Scientific Reports, 14 (1) 4112. doi: 10.1038/s41598-024-54520-z |
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2024 Journal Article Predicting tacrolimus concentrations in the skin of adult kidney transplant recipients: a feasibility studySartain, Felicity, Viecelli, Andrea K., Veitch, Margaret, Franklin, Michael E., Dymock, Brian W., Wells, James W. and Campbell, Scott B. (2024). Predicting tacrolimus concentrations in the skin of adult kidney transplant recipients: a feasibility study. Transplant International, 37 12019, 1-7. doi: 10.3389/ti.2024.12019 |
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2024 Journal Article Checkpoint kinase 1 inhibitor + low‐dose hydroxyurea efficiently kills BRAF inhibitor‐ and immune checkpoint inhibitor‐resistant melanomasZeng, Zhen, Ngo, Hung Long, Proctor, Martina, Rizos, Helen, Dolcetti, Riccardo, Cruz, Jazmina Gonzalez, Wells, James W. and Gabrielli, Brian (2024). Checkpoint kinase 1 inhibitor + low‐dose hydroxyurea efficiently kills BRAF inhibitor‐ and immune checkpoint inhibitor‐resistant melanomas. Pigment Cell and Melanoma Research, 37 (1), 45-50. doi: 10.1111/pcmr.13120 |
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2024 Journal Article Peritumoral administration of immunomodulatory antibodies as a triple combination suppresses skin tumor growth without systemic toxicityWright, Quentin G., Sinha, Debottam, Wells, James W., Frazer, Ian H., Gonzalez Cruz, Jazmina L. and Leggatt, Graham Robert (2024). Peritumoral administration of immunomodulatory antibodies as a triple combination suppresses skin tumor growth without systemic toxicity. Journal for ImmunoTherapy of Cancer, 12 (1) e007960. doi: 10.1136/jitc-2023-007960 |
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2023 Journal Article Local blockade of tacrolimus promotes T-cell-mediated tumor regression in systemically immunosuppressed hostsVeitch, Margaret, Beaumont, Kimberly, Pouwer, Rebecca, Chew, Hui Yi, Frazer, Ian H., Soyer, H. Peter, Campbell, Scott, Dymock, Brian W., Harvey, Andrew, Cock, Terrie-Anne and Wells, James W. (2023). Local blockade of tacrolimus promotes T-cell-mediated tumor regression in systemically immunosuppressed hosts. Journal for ImmunoTherapy of Cancer, 11 (9) e006783, 1-15. doi: 10.1136/jitc-2023-006783 |
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2023 Journal Article Mono-phosphorylation at Ser4 of barrier-to-autointegration factor (Banf1) significantly reduces its DNA binding capability by inducing critical changes in its local conformation and DNA binding surfaceTang, Ming, Suraweera, Amila, Nie, Xuqiang, Li, Zilin, Lai, Pinglin, Wells, James W., O’Byrne, Kenneth J., Woods, Robert J, Bolderson, Emma and Richard, Derek J (2023). Mono-phosphorylation at Ser4 of barrier-to-autointegration factor (Banf1) significantly reduces its DNA binding capability by inducing critical changes in its local conformation and DNA binding surface. Physical Chemistry Chemical Physics, 25 (36), 24657-24677. doi: 10.1039/d3cp02302h |
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2023 Journal Article Enhanced hydrophobicity of CeO2 thin films: role of the morphology, adsorbed species and crystallographyMamedov, D., Asland, A. C., Cooil, S. P., Rost, H. I., Bakkelund, J., Allaniyazov, A., Wells, J. W. and Karazhanov, S. (2023). Enhanced hydrophobicity of CeO2 thin films: role of the morphology, adsorbed species and crystallography. Materials Today Communications, 35 106323, 1-8. doi: 10.1016/j.mtcomm.2023.106323 |
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2023 Journal Article Liposomal formulations of a polyleucine–antigen conjugate as therapeutic vaccines against cervical cancerFirdaus, Farrhana Z., Bartlett, Stacey, Hussein, Waleed M., Lu, Lantian, Wright, Quentin, Huang, Wenbin, Nahar, Ummey J., Yang, Jieru, Khongkow, Mattaka, Veitch, Margaret, Koirala, Prashamsa, Ruktanonchai, Uracha R., Monteiro, Michael J., Gonzalez Cruz, Jazmina L., Stephenson, Rachel J., Wells, James W., Toth, Istvan and Skwarczynski, Mariusz (2023). Liposomal formulations of a polyleucine–antigen conjugate as therapeutic vaccines against cervical cancer. Pharmaceutics, 15 (2) 602, 1-15. doi: 10.3390/pharmaceutics15020602 |
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2022 Journal Article Cytokine/Chemokine assessment as a complementary diagnostic tool for inflammatory skin diseasesLiu, Timothy J., Lin, Lynlee L., McMeniman, Erin, Wu, Jason, Kao, Yung-Ching, Kumari, Snehlata, Boyle, Glen M., Wells, James W., Soyer, H. Peter and Gonzalez-Cruz, Jazmina L. (2022). Cytokine/Chemokine assessment as a complementary diagnostic tool for inflammatory skin diseases. Frontiers in Immunology, 13 1028435, 1-8. doi: 10.3389/fimmu.2022.1028435 |
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2022 Journal Article Assessment of patient-to-patient and intra-individual human abdominal skin immune cell variabilityVeitch, Margaret, Layt, Craig, Raymond, Emma, Croaker, Andrew and Wells, James (2022). Assessment of patient-to-patient and intra-individual human abdominal skin immune cell variability. Archives of Medical Science, 18 (6), 1683-1688. doi: 10.5114/aoms/155183 |
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2022 Journal Article Prevalence of AAV2.5 neutralizing antibodies in synovial fluid and serum of patients with osteoarthritisAbdul, Temilola Y., Hawse, Gresin P., Smith, Jay, Sellon, Jacob L., Abdel, Matthew P., Wells, James W., Coenen, Michael J., Evans, Christopher H. and De La Vega, Rodolfo E. (2022). Prevalence of AAV2.5 neutralizing antibodies in synovial fluid and serum of patients with osteoarthritis. Gene Therapy, 30 (7-8), 1-5. doi: 10.1038/s41434-022-00326-5 |
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2021 Other Outputs Compound for prevention or treatment of a skin cancer or skin precancerWells, James, Dymock, Brian William, Harvey, Andrew, Cock, Terrie-Anne, Pouwer, Rebecca and Beaumont, Kimberley (2021). Compound for prevention or treatment of a skin cancer or skin precancer. WO2021248189. |
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2021 Journal Article Cellular responses at the application site of a high-density microarray patch delivering an influenza vaccine in a randomized, controlled phase I clinical trialDepelsenaire, Alexandra C. I., Witham, Katey, Veitch, Margaret, Wells, James W., Anderson, Christopher D., Lickliter, Jason D., Rockman, Steve, Bodle, Jesse, Treasure, Peter, Hickling, Julian, Fernando, Germain J. P. and Forster, Angus H. (2021). Cellular responses at the application site of a high-density microarray patch delivering an influenza vaccine in a randomized, controlled phase I clinical trial. PLoS One, 16 (7) e0255282, e0255282. doi: 10.1371/journal.pone.0255282 |
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2021 Journal Article Targeting Replication Stress Using CHK1 Inhibitor Promotes Innate and NKT Cell Immune Responses and Tumour RegressionProctor, Martina, Gonzalez Cruz, Jazmina L., Daignault-Mill, Sheena M., Veitch, Margaret, Zeng, Bijun, Ehmann, Anna, Sabdia, Muhammed, Snell, Cameron, Keane, Colm, Dolcetti, Riccardo, Haass, Nikolas K., Wells, James W. and Gabrielli, Brian (2021). Targeting Replication Stress Using CHK1 Inhibitor Promotes Innate and NKT Cell Immune Responses and Tumour Regression. Cancers, 13 (15) 3733, 1-19. doi: 10.3390/cancers13153733 |
