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2021

Journal Article

Investigating T cell immunity in cancer: achievements and prospects

Zeng, Zhen, Chew, Hui Yi, Cruz, Jazmina G., Leggatt, Graham R. and Wells, James W. (2021). Investigating T cell immunity in cancer: achievements and prospects. International Journal of Molecular Sciences, 22 (6) 2907, 1-17. doi: 10.3390/ijms22062907

Investigating T cell immunity in cancer: achievements and prospects

2021

Journal Article

Manganese-doped silica-based nanoparticles promote the efficacy of antigen-specific immunotherapy

Chandra, Janin, Teoh, Siok Min, Kuo, Paula, Tolley, Lynn, Bashaw, Abate Assefa, Tuong, Zewen Kelvin, Liu, Yang, Chen, Zibin, Wells, James W., Yu, Chengzhong, Frazer, Ian H. and Yu, Meihua (2021). Manganese-doped silica-based nanoparticles promote the efficacy of antigen-specific immunotherapy. The Journal of Immunology, 206 (5), ji2000355-998. doi: 10.4049/jimmunol.2000355

Manganese-doped silica-based nanoparticles promote the efficacy of antigen-specific immunotherapy

2020

Journal Article

Peripheral tolerance checkpoints imposed by ubiquitous antigen expression limit antigen-specific B cell responses under strongly immunogenic conditions

Brooks, Jeremy F., Murphy, Peter R., Barber, James E. M., Wells, James W. and Steptoe, Raymond J. (2020). Peripheral tolerance checkpoints imposed by ubiquitous antigen expression limit antigen-specific B cell responses under strongly immunogenic conditions. The Journal of Immunology, 205 (5), ji2000377-1247. doi: 10.4049/jimmunol.2000377

Peripheral tolerance checkpoints imposed by ubiquitous antigen expression limit antigen-specific B cell responses under strongly immunogenic conditions

2020

Journal Article

Safety, tolerability and immunogenicity of influenza vaccination with a high-density microarray patch: results from a randomized, controlled phase I clinical trial

Forster, Angus H, Witham, Katey, Depelsenaire, Alexandra C.I., Veitch, Margaret, Wells, James W., Wheatley, Adam, Pryor, Melinda, Lickliter, Jason, Francis, Barbara, Rockman, Steve, Bodle, Jesse, Treasure, Peter, Hickling, Julian and Fernando, Germain J.P. (2020). Safety, tolerability and immunogenicity of influenza vaccination with a high-density microarray patch: results from a randomized, controlled phase I clinical trial. PLoS Medicine, 17 (3) e1003024, e1003024. doi: 10.1371/journal.pmed.1003024

Safety, tolerability and immunogenicity of influenza vaccination with a high-density microarray patch: results from a randomized, controlled phase I clinical trial

2020

Journal Article

Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies

Chew, Hui Yi, De Lima, Priscila O., Gonzalez Cruz, Jazmina L., Banushi, Blerida, Echejoh, Godwins, Hu, Lingbo, Joseph, Shannon R., Lum, Benedict, Rae, James, O'Donnell, Jake S., Merida de Long, Lilia, Okano, Satomi, King, Brigid, Barry, Rachael, Moi, Davide, Mazzieri, Roberta, Thomas, Ranjeny, Souza-Fonseca-Guimaraes, Fernando, Foote, Matthew, McCluskey, Adam, Robinson, Phillip J., Frazer, Ian H., Saunders, Nicholas A., Parton, Robert G., Dolcetti, Riccardo, Cuff, Katharine, Martin, Jennifer H., Panizza, Benedict, Walpole, Euan ... Simpson, Fiona (2020). Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies. Cell, 180 (5), 895-914.e27. doi: 10.1016/j.cell.2020.02.019

Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies

2020

Journal Article

Poly(amino acids) as a potent self-adjuvanting delivery system for peptide-based nanovaccines

Skwarczynski, Mariusz, Zhao, Guangzu, Boer, Jennifer C., Ozberk, Victoria, Azuar, Armira, Gonzalez Cruz, Jazmina, Kumar Giddam, Ashwini, Khalil, Zeinab G., Pandey, Manisha, Shibu, Mohini A., Hussein, Waleed M., Nevagi, Reshma J., Batzloff, Michael R., Wells, James W., Capon, Robert J., Plebanski, Magdalena, Good, Michael F. and Toth, Istvan (2020). Poly(amino acids) as a potent self-adjuvanting delivery system for peptide-based nanovaccines. Science Advances, 6 (5) eaax2285, eaax2285. doi: 10.1126/sciadv.aax2285

Poly(amino acids) as a potent self-adjuvanting delivery system for peptide-based nanovaccines

2020

Journal Article

Transfer of antigen-encoding bone marrow under immune-preserving conditions deletes mature antigen-specific B cells in recipients and inhibits antigen-specific antibody production

Brooks, Jeremy F., Barber, James E.M., Davies, Janet M., Wells, James W. and Steptoe, Raymond J. (2020). Transfer of antigen-encoding bone marrow under immune-preserving conditions deletes mature antigen-specific B cells in recipients and inhibits antigen-specific antibody production. Cytotherapy, 22 (8), 436-444. doi: 10.1016/j.jcyt.2020.04.041

Transfer of antigen-encoding bone marrow under immune-preserving conditions deletes mature antigen-specific B cells in recipients and inhibits antigen-specific antibody production

2019

Journal Article

Cytokine/chemokine profiles in squamous cell carcinoma correlate with precancerous and cancerous disease stage

Tuong, Zewen, Lewandowski, Andrew, Bridge, Jennifer, Gonzalez-Cruz, Jazmina, Yamada, Miko, Lambie, Duncan, Lewandowski, Richard, Steptoe, Raymond, Leggatt, Graham, Simpson, Fiona, Frazer, Ian, Soyer, Peter and Wells, James W. (2019). Cytokine/chemokine profiles in squamous cell carcinoma correlate with precancerous and cancerous disease stage. Scientific Reports, 9 (1) 17754, 17754. doi: 10.1038/s41598-019-54435-0

Cytokine/chemokine profiles in squamous cell carcinoma correlate with precancerous and cancerous disease stage

2019

Journal Article

Editorial: Insights into biomarkers, cytokines, and chemokines in skin cancer

Barrett, Lucy W., Gray, Elin S., Wells, James W. and Waithman, Jason (2019). Editorial: Insights into biomarkers, cytokines, and chemokines in skin cancer. Frontiers in Medicine, 6 199, 199. doi: 10.3389/fmed.2019.00199

Editorial: Insights into biomarkers, cytokines, and chemokines in skin cancer

2019

Journal Article

Bacillus anthracis Protective Antigen Shows High Specificity for a UV Induced Mouse Model of Cutaneous Squamous Cell Carcinoma

Crawford, Theo, Fletcher, Nicholas, Veitch, Margaret, Gonzalez Cruz, Jazmina L., Pett, Nicola, Brereton, Ian, Wells, James W., Mobli, Mehdi and Tesiram, Yasvir (2019). Bacillus anthracis Protective Antigen Shows High Specificity for a UV Induced Mouse Model of Cutaneous Squamous Cell Carcinoma. Frontiers in Medicine, 6 (FEB) 22, 22. doi: 10.3389/fmed.2019.00022

Bacillus anthracis Protective Antigen Shows High Specificity for a UV Induced Mouse Model of Cutaneous Squamous Cell Carcinoma

2019

Conference Publication

Antigen-encoding bone marrow deletes mature antigen-specific B cells in recipients and inhibits antigen-specific antibody production

Steptoe, R. J., Brooks, J. F. and Wells, J. W. (2019). Antigen-encoding bone marrow deletes mature antigen-specific B cells in recipients and inhibits antigen-specific antibody production. ESGCT 27th Annual Congress in collaboration with SETGyc Meeting, Barcelona Spain, 22-25 October 2019 . New Rochelle, NY, United States: Mary Anne Liebert.

Antigen-encoding bone marrow deletes mature antigen-specific B cells in recipients and inhibits antigen-specific antibody production

2019

Conference Publication

The involvement of IFN-gamma and CXCR3 in the CD8(+) T-cell-mediated regression of squamous cell carcinoma

Zeng, Z., Cruz, J. G., Pett, N., Veitch, M., Frazer, I. H. and Wells, J. W. (2019). The involvement of IFN-gamma and CXCR3 in the CD8(+) T-cell-mediated regression of squamous cell carcinoma. 17th International Congress of Immunology (IUIS), Beijing, Peoples R China, 19-23 October 2019. Weinheim, Germany: Wiley.

The involvement of IFN-gamma and CXCR3 in the CD8(+) T-cell-mediated regression of squamous cell carcinoma

2018

Journal Article

Liposomal formulation of polyacrylate-peptide conjugate as a new vaccine candidate against cervical cancer

Khongkow, Mattaka, Liu, Tzu-yu, Bartlett, Stacey, Hussein, Waleed M., Nevagi, Reshma, Jia, Zhongfan, Monteiro, Michael J., Wells, James, Ruktanonchai, Uracha Rungsardthong, Skwarczynski, Mariusz and Toth, Istvan (2018). Liposomal formulation of polyacrylate-peptide conjugate as a new vaccine candidate against cervical cancer. Precision Nanomedicine, 1 (3), 183-193. doi: 10.33218/prnano1(3).181003.1

Liposomal formulation of polyacrylate-peptide conjugate as a new vaccine candidate against cervical cancer

2018

Journal Article

Cytokines, chemokines, and other biomarkers of response for checkpoint inhibitor therapy in skin cancer

Bridge, Jennifer A., Lee, James C., Daud, Adil, Wells, James W. and Bluestone, Jeffrey A. (2018). Cytokines, chemokines, and other biomarkers of response for checkpoint inhibitor therapy in skin cancer. Frontiers in Medicine, 5 (DEC) 351, 351. doi: 10.3389/fmed.2018.00351

Cytokines, chemokines, and other biomarkers of response for checkpoint inhibitor therapy in skin cancer

2018

Journal Article

The role of CXCR3 and its chemokine ligands in skin disease and cancer

Kuo, Paula T., Zeng, Zhen, Salim, Nazhifah, Mattarollo, Stephen, Wells, James W. and Leggatt, Graham R. (2018). The role of CXCR3 and its chemokine ligands in skin disease and cancer. Frontiers in Medicine, 5 (SEP) 271, 271. doi: 10.3389/fmed.2018.00271

The role of CXCR3 and its chemokine ligands in skin disease and cancer

2018

Journal Article

An ex vivo human tumour assay reveals distinct patterns of EGFR trafficking in squamous cell carcinoma correlating to therapeutic outcomes

Joseph, Shannon R., Gaffney, Daniel, Barry, Rachael, Hu, Lingbo, Banushi, Blerida, Wells, James W., Lambie, Duncan, Strutton, Geoff, Porceddu, Sandro V., Burmeister, Bryan, Leggatt, Graham R., Schaider, Helmut, Dolcetti, Riccardo, Frazer, Ian H., Saunders, Nicholas A., Foote, Matthew, Soyer, H. Peter and Simpson, Fiona (2018). An ex vivo human tumour assay reveals distinct patterns of EGFR trafficking in squamous cell carcinoma correlating to therapeutic outcomes. Journal of Investigative Dermatology, 139 (1), 213-223. doi: 10.1016/j.jid.2018.06.190

An ex vivo human tumour assay reveals distinct patterns of EGFR trafficking in squamous cell carcinoma correlating to therapeutic outcomes

2018

Journal Article

Clinically-relevant rapamycin treatment regimens enhance CD8+ effector memory T cell function in the skin and allow their infiltration into cutaneous squamous cell carcinoma

Jung, Ji-Won, Veitch, Margaret, Bridge, Jennifer A., Overgaard, Nana H., Cruz, Jazmina L., Linedale, Richard, Franklin, Michael E., Saunders, Nicholas A., Simpson, Fiona, Frazer, Ian H., Steptoe, Raymond J. and Wells, James W. (2018). Clinically-relevant rapamycin treatment regimens enhance CD8+ effector memory T cell function in the skin and allow their infiltration into cutaneous squamous cell carcinoma. OncoImmunology, 7 (9) e1479627, 1-16. doi: 10.1080/2162402X.2018.1479627

Clinically-relevant rapamycin treatment regimens enhance CD8+ effector memory T cell function in the skin and allow their infiltration into cutaneous squamous cell carcinoma

2018

Journal Article

Tetramer-based identification of naïve antigen-specific B cells within a polyclonal repertoire

Brooks, Jeremy F., Liu, Xiao, Davies, Janet M., Wells, James W. and Steptoe, Raymond J. (2018). Tetramer-based identification of naïve antigen-specific B cells within a polyclonal repertoire. European Journal of Immunology, 48 (7), 1251-1254. doi: 10.1002/eji.201747447

Tetramer-based identification of naïve antigen-specific B cells within a polyclonal repertoire

2018

Journal Article

Characterization of 7A7, an anti-mouse EGFR monoclonal antibody proposed to be the mouse equivalent of cetuximab

He, Xuzhi, Cruz, Jazmina L., Joseph, Shannon, Pett, Nicola, Chew, Hui Yi, Tuong, Zewen K., Okano, Satomi, Kelly, Gabrielle, Veitch, Margaret, Simpson, Fiona and Wells, James W. (2018). Characterization of 7A7, an anti-mouse EGFR monoclonal antibody proposed to be the mouse equivalent of cetuximab. Oncotarget, 9 (15), 12250-12260. doi: 10.18632/oncotarget.24242

Characterization of 7A7, an anti-mouse EGFR monoclonal antibody proposed to be the mouse equivalent of cetuximab

2018

Conference Publication

Dendritic cell-targeted self-antigen restrains autoreactive B cells by deletion and anergy

Brooks, J., Davies, J., Wells, J. and Steptoe, R. (2018). Dendritic cell-targeted self-antigen restrains autoreactive B cells by deletion and anergy. 15th International Symposium on Dendritic Cells (DC), Aachen, Germany, 10-14 June 2018 . Weinheim, Germany: Wiley.

Dendritic cell-targeted self-antigen restrains autoreactive B cells by deletion and anergy