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2005

Journal Article

Ventilatory responses of healthy subjects to intravenous combinations of morphine and oxycodone under imposed hypercapnic and hypoxaemic conditions

Ladd, L. A., Kam, P. C., Williams, D. B., Wright, A. W. E., Smith, M. T. and Mather, L. E. (2005). Ventilatory responses of healthy subjects to intravenous combinations of morphine and oxycodone under imposed hypercapnic and hypoxaemic conditions. British Journal of Clinical Pharmacology, 59 (5), 524-535. doi: 10.1111/j.1365-2125.2005.02368.x

Ventilatory responses of healthy subjects to intravenous combinations of morphine and oxycodone under imposed hypercapnic and hypoxaemic conditions

2005

Conference Publication

Pain and its treatment

Smith, M. T. (2005). Pain and its treatment. 6th Australian Peptide Conference, Hamilton Island, Australia, 9-15 October, 2005.

Pain and its treatment

2005

Conference Publication

Insulin implants prevent the temporal development of tactile allodynia and opioid hyposensitivity for 24-wks in streptozotocin (STZ)-diabetic Wistar rats

Otto, K. J., Wyse, B. D., Cabot, P. J. and Smith, M. T. (2005). Insulin implants prevent the temporal development of tactile allodynia and opioid hyposensitivity for 24-wks in streptozotocin (STZ)-diabetic Wistar rats. 11th World Congress on Pain, Sydney, 21-26 Aug. 2005. USA: IASP Press.

Insulin implants prevent the temporal development of tactile allodynia and opioid hyposensitivity for 24-wks in streptozotocin (STZ)-diabetic Wistar rats

2004

Conference Publication

Anti-allodynic efficacy of the chi-conopeptide, Xen2174, in rats with neuropathic pain

Nielsen, C., Smith, M. T., Lewis, R., Alewood, D. and Drinkwater, R. D. (2004). Anti-allodynic efficacy of the chi-conopeptide, Xen2174, in rats with neuropathic pain. CPT2004: 8th World Congress on Clinical Pharmacology & Therapeutics, Brisbane, Qld, Australia, 1-6 August, 2004. Oxford, United Kingdom: Blackwell Scientific Publications. doi: 10.1111/j.1440-1681.2004.cep_4027.pdf.x

Anti-allodynic efficacy of the chi-conopeptide, Xen2174, in rats with neuropathic pain

2004

Conference Publication

The pro-allodynic effects of morphine-3-glucuronide (M3G) in the rat

Smith, M. T., Le, L., Hemstapat, K., De Cruz, S. E. and Nielsen, C. (2004). The pro-allodynic effects of morphine-3-glucuronide (M3G) in the rat. CTP 2004, Brisbane, 1-6 Aug 2004. Australia: Blackwell Publishing Asia.

The pro-allodynic effects of morphine-3-glucuronide (M3G) in the rat

2004

Conference Publication

Opioids and NMDA receptors: Neuro-excitation and abnormal pain behaviours

Smith, M. T. (2004). Opioids and NMDA receptors: Neuro-excitation and abnormal pain behaviours. ANZCA Annual Scientific Meeting, Perth, 1-5 May 2004. Australia: ANZCA.

Opioids and NMDA receptors: Neuro-excitation and abnormal pain behaviours

2004

Conference Publication

Effect of insulin treatment on diabetic characteristics in the STZ-diabetic rat

Otto, K. J., Wyse, B. D., Cabot, P. J. and Smith, M. T. (2004). Effect of insulin treatment on diabetic characteristics in the STZ-diabetic rat. 4th Annual Queensland Health and Medical Scientific Meeting, Brisbane, 30 Nov - 1 Dec 2004. Brisbane: Qld Government.

Effect of insulin treatment on diabetic characteristics in the STZ-diabetic rat

2004

Journal Article

Measurement of intracellular Ca2+ in cultured rat embryonic hippocampal neurons using a fluorescence microplate reader: Potential application to biomolecular screening

Hemstapat, K, Smith, M. T. and Monteith, G. R. (2004). Measurement of intracellular Ca2+ in cultured rat embryonic hippocampal neurons using a fluorescence microplate reader: Potential application to biomolecular screening. Journal of Pharmacological and Toxicological Methods, 49 (2), 81-87. doi: 10.1016/j.vascn.2003.10.002

Measurement of intracellular Ca2+ in cultured rat embryonic hippocampal neurons using a fluorescence microplate reader: Potential application to biomolecular screening

2004

Conference Publication

P2.3 longitudinal investigation of the comparative anti-allodynic potencies of oxycodone and morphine in the zucker rat relative to the streptozotocin-induced diabetic rat

Tsui, D.Y., Hawes, S., Patterson, M. and Smith, M. T. (2004). P2.3 longitudinal investigation of the comparative anti-allodynic potencies of oxycodone and morphine in the zucker rat relative to the streptozotocin-induced diabetic rat. 25th Annual Scientific Meeting of the Australian Pain Society, Canberra, 7-10 March 2004. Australia: Australian Pain Society.

P2.3 longitudinal investigation of the comparative anti-allodynic potencies of oxycodone and morphine in the zucker rat relative to the streptozotocin-induced diabetic rat

2004

Conference Publication

The pro-allodynic effects of morphine-3-glucuronide (M3G) appear to be opioid-receptor mediated

Nielsen, C., De Cruz, S. E. and Smith, M. T. (2004). The pro-allodynic effects of morphine-3-glucuronide (M3G) appear to be opioid-receptor mediated. 25th Annual Scientific Meeting of the Australian Pain Society, Canberra, 7-10 March 2004. Australia: Australian Pain Society.

The pro-allodynic effects of morphine-3-glucuronide (M3G) appear to be opioid-receptor mediated

2004

Conference Publication

Assessment of working spatial memory utilising T-maze and Morris water-maze for the study of a rodent model of alzheimer's disease

Patel, A., Smith, M. T. and Cabot, P. J. (2004). Assessment of working spatial memory utilising T-maze and Morris water-maze for the study of a rodent model of alzheimer's disease. 4th Annual Queensland Health and Medical Scientific Meeting, Brisbane, 30 November - 1 December 2004. Brisbane: Qld Government.

Assessment of working spatial memory utilising T-maze and Morris water-maze for the study of a rodent model of alzheimer's disease

2004

Conference Publication

Oxycodone: A dose ranging pharmacodynamic study in dogs

Bubb, L. M., Keates, H. L. and Smith, M. T. (2004). Oxycodone: A dose ranging pharmacodynamic study in dogs. Showcasing Faculty research through our postgraduates, Gatton, 5th November 2004. Gatton: NRAVS Faculty.

Oxycodone: A dose ranging pharmacodynamic study in dogs

2004

Conference Publication

Opioid rotation and methadone: Pharmacokinetic considerations

Smith, M. T., Fleming, J. A. and Connor, M. (2004). Opioid rotation and methadone: Pharmacokinetic considerations. 2004 ANZCA Annual Scientific Meeting, Perth, Western Australia, 1-5 May, 2004. Melbourne, Vic, Australia: Australian and New Zealand College of Anaesthetists (ANZCA).

Opioid rotation and methadone: Pharmacokinetic considerations

2004

Journal Article

Deletion of guanine nucleotide binding protein az subunit in mice induces a gene dose dependent tolerance to morphine

Leck, KJ, Bartlett, SE, Smith, MT, Megirian, D, Holgate, J, Powell, KL, Matthaei, KI and Hendry, IA (2004). Deletion of guanine nucleotide binding protein az subunit in mice induces a gene dose dependent tolerance to morphine. Neuropharmacology, 46 (6), 836-846. doi: 10.1016/j.neuropharm.2003.11.024

Deletion of guanine nucleotide binding protein az subunit in mice induces a gene dose dependent tolerance to morphine

2004

Conference Publication

Longitudinal investigation of the antinociceptive potency of oxycodone and morphine in the zucker rat

Tsui, D. Y., Hawes, S., Patterson, M. and Smith, M. T. (2004). Longitudinal investigation of the antinociceptive potency of oxycodone and morphine in the zucker rat. Clinical Pharmacology and Therapeutics 2004, Brisbane, 1-6 August, 2004. Australia: Blackwell Publishing.

Longitudinal investigation of the antinociceptive potency of oxycodone and morphine in the zucker rat

2004

Conference Publication

Determination of morphine, oxycodone, morphine-3-glucuronide, & noroxycodone concentrations in rat serum by liquid chromatography (LC) - electrospray mass spectrometry (EMS)

Edwards, S. R. and Smith, M. T. (2004). Determination of morphine, oxycodone, morphine-3-glucuronide, & noroxycodone concentrations in rat serum by liquid chromatography (LC) - electrospray mass spectrometry (EMS). CPT2004, Brisbane, 1-6 August 2004. Australia: Blackwell Publishing.

Determination of morphine, oxycodone, morphine-3-glucuronide, & noroxycodone concentrations in rat serum by liquid chromatography (LC) - electrospray mass spectrometry (EMS)

2004

Conference Publication

Comparative pharmacokinetics and metabolism of subcutaneous oxycodone in male dark agouti relative to sprague-dawley rats

Huang, L., Edwards, S. R. and Smith, M. T. (2004). Comparative pharmacokinetics and metabolism of subcutaneous oxycodone in male dark agouti relative to sprague-dawley rats. CTP 2004, Brisbane, 1-6 August 2004. Australia: Blackwell Publishing Asia.

Comparative pharmacokinetics and metabolism of subcutaneous oxycodone in male dark agouti relative to sprague-dawley rats

2004

Conference Publication

Oxycodone: A dose ranging pharmacodynamic study in dogs

Bubb, L. M., Keates, H. L. and Smith, M. T. (2004). Oxycodone: A dose ranging pharmacodynamic study in dogs. Proc. of Assoc. of Veterinary Anaesthetists, Vienna, Austria, 16-17 September 2004. Austria:

Oxycodone: A dose ranging pharmacodynamic study in dogs

2004

Conference Publication

Anti-allodynic effects of Xen2174 in rats with neuropathy. Abstract

Smith, M. T., Nielsen, C., Lewis, R., Alewood, D. and Drinkwater, R. D. (2004). Anti-allodynic effects of Xen2174 in rats with neuropathy. Abstract. ANZCA Annual Scientific Meeting, Perth, Western Australia, 1-5 May, 2004. Australia: ANZCA.

Anti-allodynic effects of Xen2174 in rats with neuropathy. Abstract

2003

Other Outputs

Methods of treatment and/or prophylaxis

Smith, M. T. and Brown, L. (2003). Methods of treatment and/or prophylaxis. PCT/AU03/00336.

Methods of treatment and/or prophylaxis