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2024 Journal Article Rational synthesis of a heparan sulfate saccharide that promotes the activity of BMP2Shaffer, Karl J., Smith, Raymond A. A., Daines, Alison M., Luo, Xiaoman, Lu, Xiaohua, Tan, Tuan Chun, Le, Bach Q., Schwörer, Ralf, Hinkley, Simon F. R., Tyler, Peter C., Nurcombe, Victor and Cool, Simon M. (2024). Rational synthesis of a heparan sulfate saccharide that promotes the activity of BMP2. Carbohydrate Polymers, 333 121979, 121979. doi: 10.1016/j.carbpol.2024.121979 |
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2024 Conference Publication Preserving clinical efficacy of mesenchymal stem cells with glycosaminoglycan additivesShokoohmand, A., Srinivasan, A., Ling, L., Silva, F. Rodrigues de Oliveira, Eio, M.Y., Lu, X., Loberas, M., Tao, K., Tan, C., Nurcombe, V., Hui, J., Smith, R. and Cool, S. (2024). Preserving clinical efficacy of mesenchymal stem cells with glycosaminoglycan additives. 30th Annual ISCT Meeting, Vancouver, BC, Canada, 29 May - 1 June 2024. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.jcyt.2024.03.116 |
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2024 Journal Article Fundamentals and translational applications of stem cells and biomaterials in dental, oral and craniofacial regenerative medicineDaneshian, Yasaman, Lewallen, Eric A., Badreldin, Amr A., Dietz, Allan B., Stein, Gary S., Cool, Simon M., Ryoo, Hyun-Mo, Cho, Young Dan and van Wijnen, Andre J. (2024). Fundamentals and translational applications of stem cells and biomaterials in dental, oral and craniofacial regenerative medicine. Critical Reviews in Eukaryotic Gene Expression, 34 (6), 37-60. doi: 10.1615/CritRevEukaryotGeneExpr.2024053036 |
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2023 Journal Article Enhancing BMP-2-mediated osteogenesis with a synthetic heparan sulfate mimeticSmith, Raymond A. A., Luo, Xiaoman, Lu, Xiaohua, Tan, Tuan Chun, Le, Bach Q., Zubkova, Olga V., Tyler, Peter C., Nurcombe, Victor and Cool, Simon M. (2023). Enhancing BMP-2-mediated osteogenesis with a synthetic heparan sulfate mimetic. Biomaterials Advances, 155 213671, 1-17. doi: 10.1016/j.bioadv.2023.213671 |
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2023 Journal Article Scalable mesenchymal stem cell enrichment from bone marrow aspirate using deterministic lateral displacement (DLD) microfluidic sortingTan Kwan Zen, Nicholas, Zeming, Kerwin Kwek, Teo, Kim Leng, Loberas, Mavis, Lee, Jialing, Goh, Chin Ren, Yang, Da Hou, Oh, Steve, Hui Hoi Po, James, Cool, Simon M., Hou, Han Wei and Han, Jongyoon (2023). Scalable mesenchymal stem cell enrichment from bone marrow aspirate using deterministic lateral displacement (DLD) microfluidic sorting. Lab on a Chip, 23 (19), 4313-4323. doi: 10.1039/d3lc00379e |
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2023 Journal Article Affinity-selected heparan sulfate collagen device promotes periodontal regeneration in an intrabony defect model in Macaca fascicularisLuo, Xiaoman, Lau, Chau Sang, Le, Bach Quang, Tan, Tuan Chun, Too, Jian Hui, Smith, Raymond Alexander Alfred, Yu, Na and Cool, Simon M. (2023). Affinity-selected heparan sulfate collagen device promotes periodontal regeneration in an intrabony defect model in Macaca fascicularis. Scientific Reports, 13 (1) 11774, 1-15. doi: 10.1038/s41598-023-38818-y |
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2023 Conference Publication Artificial small-diameter blood vessel with enhanced endothelialisation propertiesMarinval, Nicolas, Tang, Xuan Hao, Brackovic, Amira, Sugiarto, Sigit, Meroshini, M., Kai, Dan, Beh, Cyrus, Dunn, Ray and Cool, Simon (2023). Artificial small-diameter blood vessel with enhanced endothelialisation properties. European Chapter of the Tissue-Engineering-and-Regenerative-Medicine-International-Society (TERMIS), Manchester, United Kingdom, 28-31 March 2023. New Rochelle, NY United States: MARY ANN LIEBERT. |
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2023 Journal Article Bioactive polyethylene by ring opening metathesis polymerization for potential orthopaedic applicationsGuo, Jiayi, Park, Eun Ju, Teo, Yew Chin, Abbas, Asyraf, Goh, Denise, Smith, Raymond Alexander Alfred, Nie, Yuntong, Nguyen, Hang T. L., Yeong, Joe Poh Sheng, Cool, Simon, Haruyuki, Makio and Teo, Peili (2023). Bioactive polyethylene by ring opening metathesis polymerization for potential orthopaedic applications. Polymer Chemistry, 14 (15), 1743-1751. doi: 10.1039/d2py01545e |
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2022 Journal Article Bioactive PCL-peptide and PLA-peptide brush copolymers for bone tissue engineeringTeo, Yew Chin, Park, Eun Ju, Guo, Jiayi, Abbas, Asyraf, Smith, Raymond Alexander Alfred, Goh, Denise, Yeong, Joe Poh Sheng, Cool, Simon and Teo, Peili (2022). Bioactive PCL-peptide and PLA-peptide brush copolymers for bone tissue engineering. ACS Applied Bio Materials, 5 (10), 4770-4778. doi: 10.1021/acsabm.2c00455 |
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2022 Journal Article Strategies to enhance immunomodulatory properties and reduce heterogeneity in mesenchymal stromal cells during ex vivo expansionSrinivasan, Akshaya, Sathiyanathan, Padmapriya, Yin, Lu, Liu, Tong Ming, Lam, Alan, Ravikumar, Maanasa, Smith, Raymond Alexander Alfred, Loh, Han Ping, Zhang, Ying, Ling, Ling, Ng, Say Kong, Yang, Yuan Sheng, Lezhava, Alexander, Hui, James, Oh, Steve and Cool, Simon M. (2022). Strategies to enhance immunomodulatory properties and reduce heterogeneity in mesenchymal stromal cells during ex vivo expansion. Cytotherapy, 24 (5), 456-472. doi: 10.1016/j.jcyt.2021.11.009 |
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2022 Journal Article FGFR2 accommodates osteogenic cell fate determination in human mesenchymal stem cellsZhang, Ying, Ling, Ling, Ajayakumar, Arya Ajay D. O., Eio, Yating Michelle, van Wijnen, Andre J., Nurcombe, Victor and Cool, Simon M. (2022). FGFR2 accommodates osteogenic cell fate determination in human mesenchymal stem cells. Gene, 818 146199, 146199. doi: 10.1016/j.gene.2022.146199 |
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2022 Journal Article Variability in the composition of porcine mucosal heparan sulfatesSargison, Liam, Smith, Raymond A A, Carnachan, Susan M, Daines, Alison M, Brackovic, Amira, Kidgell, Joel T, Nurcombe, Victor, Cool, Simon M, Sims, Ian M and Hinkley, Simon F R (2022). Variability in the composition of porcine mucosal heparan sulfates. Carbohydrate Polymers, 282 119081. doi: 10.1016/j.carbpol.2021.119081 |
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2022 Journal Article A combined cell and growth factor delivery for the repair of a critical size tibia defect using biodegradable hydrogel implantsCohen, Talia, Kossover, Olga, Peled, Eli, Bick, Tova, Hasanov, Lena, Chun, Tan Tuan, Cool, Simon, Lewinson, Dina and Seliktar, Dror (2022). A combined cell and growth factor delivery for the repair of a critical size tibia defect using biodegradable hydrogel implants. Journal of Tissue Engineering and Regenerative Medicine, 16 (4), 380-395. doi: 10.1002/term.3285 |
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2021 Journal Article Bone marrow mesenchymal stem cells with low dose bone morphogenetic protein 2 enhances scaffold-based spinal fusion in a porcine modelHu, Tao, Liu, Ling, Lam, Raymond Wing Moon, Toh, Soo Yein, Abbah, Sunny Akogwu, Wang, Ming, Ramruttun, Amit Kumarsing, Bhakoo, Kishore, Cool, Simon, Li, Jun, Cho-Hong Goh, James and Wong, Hee-Kit (2021). Bone marrow mesenchymal stem cells with low dose bone morphogenetic protein 2 enhances scaffold-based spinal fusion in a porcine model. Journal of Tissue Engineering and Regenerative Medicine, 16 (1), 63-75. doi: 10.1002/term.3260 |
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2021 Journal Article Paraspinal myopathy-induced intervertebral disc degeneration and thoracolumbar kyphosis in TSC1mKO mice model—a preliminary studyHey, Hwee Weng Dennis, Lam, Wing Moon Raymond, Chan, Chloe Xiaoyun, Zhuo, Wen-Hai, Crombie, Elisa Marie, Tan, Tuan Chun, Chen, Way Cherng, Cool, Simon and Tsai, Shih Yin (2021). Paraspinal myopathy-induced intervertebral disc degeneration and thoracolumbar kyphosis in TSC1mKO mice model—a preliminary study. The Spine Journal, 22 (3), 483-494. doi: 10.1016/j.spinee.2021.09.003 |
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2021 Journal Article Combination of BMP2 and EZH2 inhibition to stimulate osteogenesis in a 3D bone reconstruction modelLui, Hayman, Samsonraj, Rebekah M., Vaquette, Cedryck, Denbeigh, Janet, Kakar, Sanjeev, Cool, Simon M., Dudakovic, Amel and Van Wijnen, Andre J. (2021). Combination of BMP2 and EZH2 inhibition to stimulate osteogenesis in a 3D bone reconstruction model. Tissue Engineering - Part A, 27 (15-16), 1084-1098. doi: 10.1089/ten.tea.2020.0218 |
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2021 Journal Article Application of a BMP2-binding heparan sulphate to promote periodontal regenerationLe, B. Q., Too, J. H., Tan, T. C., Smith, R. A. A., Nurcombe, , Cool, S. M. and Yu, N. (2021). Application of a BMP2-binding heparan sulphate to promote periodontal regeneration. European Cells and Materials, 42, 139-153. doi: 10.22203/eCM.v042a10 |
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2021 Journal Article Fibroblastic differentiation of mesenchymal stem/stromal cells (MSCs) is enhanced by hypoxia in 3D cultures treated with bone morphogenetic protein 6 (BMP6) and growth and differentiation factor 5 (GDF5)Lui, Hayman, Denbeigh, Janet, Vaquette, Cedryck, Tran, Hoai My, Dietz, Allan B., Cool, Simon M., Dudakovic, Amel, Kakar, Sanjeev and van Wijnen, Andre J. (2021). Fibroblastic differentiation of mesenchymal stem/stromal cells (MSCs) is enhanced by hypoxia in 3D cultures treated with bone morphogenetic protein 6 (BMP6) and growth and differentiation factor 5 (GDF5). Gene, 788 145662, 1-11. doi: 10.1016/j.gene.2021.145662 |
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2021 Journal Article Age-related changes in the inflammatory status of human mesenchymal stem cells: Implications for cell therapyZhang, Ying, Ravikumar, Maanasa, Ling, Ling, Nurcombe, Victor and Cool, Simon M. (2021). Age-related changes in the inflammatory status of human mesenchymal stem cells: Implications for cell therapy. Stem Cell Reports, 16 (4), 694-707. doi: 10.1016/j.stemcr.2021.01.021 |
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2021 Journal Article A biomimetic collagen-bone granule-heparan sulfate combination scaffold for BMP2 deliveryLe, Bach Quang, Tan, Tuan Chun, Lee, Seong-Baek, Jang, Ju Woong, Kim, Young Sik, Lee, Jung Soo, Choi, Jae Won, Sathiyanathan, Padmapriya, Nurcombe, Victor and Cool, Simon M. (2021). A biomimetic collagen-bone granule-heparan sulfate combination scaffold for BMP2 delivery. Gene, 769 145217, 145217. doi: 10.1016/j.gene.2020.145217 |
