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2015

Conference Publication

High-throughput microfluidic screening of human mesenchymal Stem Cell proliferative responses to FGF-2 and heparan sulfates

Titmarsh, D., Glass, N., Nurcombe, V., Cooper-White, J. and Cool, S. (2015). High-throughput microfluidic screening of human mesenchymal Stem Cell proliferative responses to FGF-2 and heparan sulfates. 4th TERMIS World Congress, Boston, MA USA, 8-11 September 2015. New Rochelle, NY USA: Mary Ann Liebert.

High-throughput microfluidic screening of human mesenchymal Stem Cell proliferative responses to FGF-2 and heparan sulfates

2015

Journal Article

Establishing criteria for human mesenchymal stem cell potency

Samsonraj, Rebekah M., Rai, Bina, Sathiyanathan, Padmapriya, Puan, Kia Joo, Rötzschke, Olaf, Hui, James H., Raghunath, Michael, Stanton, Lawrence W., Nurcombe, Victor and Cool, Simon M. (2015). Establishing criteria for human mesenchymal stem cell potency. Stem Cells, 33 (6), 1878-1891. doi: 10.1002/stem.1982

Establishing criteria for human mesenchymal stem cell potency

2014

Journal Article

Heparan sulfate proteoglycans and human breast cancer epithelial cell tumorigenicity

Okolicsanyi, Rachel K., Van Wijnen, Andre J., Cool, Simon M., Stein, Gary S., Griffiths, Lyn R. and Haupt, Larisa M. (2014). Heparan sulfate proteoglycans and human breast cancer epithelial cell tumorigenicity. Journal of Cellular Biochemistry, 115 (5), 967-976. doi: 10.1002/jcb.24746

Heparan sulfate proteoglycans and human breast cancer epithelial cell tumorigenicity

2014

Journal Article

Engineering a vascular endothelial growth factor 165-binding heparan sulfate for vascular therapy

Wang, Chunming, Poon, Selina, Murali, Sadasivam, Koo, Chuay-Yeng, Bell, Tracey J., Hinkley, Simon F., Yeong, Huiqing, Bhakoo, Kishore, Nurcombe, Victor and Cool, Simon M. (2014). Engineering a vascular endothelial growth factor 165-binding heparan sulfate for vascular therapy. Biomaterials, 35 (25), 6776-6786. doi: 10.1016/j.biomaterials.2014.04.084

Engineering a vascular endothelial growth factor 165-binding heparan sulfate for vascular therapy

2014

Journal Article

New strategies for cartilage regeneration exploiting selected glycosaminoglycans to enhance cell fate determination

Ayerst, Bethanie I., Day, Anthony J., Nurcombe, Victor, Cool, Simon M. and Merry, Catherine L.R. (2014). New strategies for cartilage regeneration exploiting selected glycosaminoglycans to enhance cell fate determination. Biochemical Society Transactions, 42 (3), 703-709. doi: 10.1042/BST20140031

New strategies for cartilage regeneration exploiting selected glycosaminoglycans to enhance cell fate determination

2013

Journal Article

FGFR1 signaling stimulates proliferation of human mesenchymal stem cells by inhibiting the cyclin-dependent kinase inhibitors p21Waf1 and p27Kip1

Dombrowski, Christian, Helledie, Torben, Ling, Ling, Grünert, Martin, Canning, Claire A., Jones, C. Michael, Hui, James H., Nurcombe, Victor, Van Wijnen, Andre J. and Cool, Simon M. (2013). FGFR1 signaling stimulates proliferation of human mesenchymal stem cells by inhibiting the cyclin-dependent kinase inhibitors p21Waf1 and p27Kip1. Stem Cells, 31 (12), 2724-2736. doi: 10.1002/stem.1514

FGFR1 signaling stimulates proliferation of human mesenchymal stem cells by inhibiting the cyclin-dependent kinase inhibitors p21Waf1 and p27Kip1

2013

Journal Article

MicroRNA-34c inversely couples the biological functions of the runt-related transcription factor RUNX2 and the tumor suppressor p53 in osteosarcoma

Van Der Deen, Margaretha, Taipaleenmäki, Hanna, Zhang, Ying, Teplyuk, Nadiya M., Gupta, Anurag, Cinghu, Senthilkumar, Shogren, Kristen, Maran, Avudaiappan, Yaszemski, Michael J., Ling, Ling, Cool, Simon M., Leong, David T., Dierkes, Christian, Zustin, Jozef, Salto-Tellez, Manuel, Ito, Yoshiaki, Bae, Suk-Chul, Zielenska, Maria, Squire, Jeremy A., Lian, Jane B., Stein, Janet L., Zambetti, Gerard P., Jones, Stephen N., Galindo, Mario, Hesse, Eric, Stein, Gary S. and Van Wijnen, Andre J. (2013). MicroRNA-34c inversely couples the biological functions of the runt-related transcription factor RUNX2 and the tumor suppressor p53 in osteosarcoma. Journal of Biological Chemistry, 288 (29), 21307-21319. doi: 10.1074/jbc.M112.445890

MicroRNA-34c inversely couples the biological functions of the runt-related transcription factor RUNX2 and the tumor suppressor p53 in osteosarcoma

2013

Journal Article

Affinity-selected heparan sulfate for bone repair

Murali, S., Rai, B., Dombrowski, C., Lee, J. L.J., Lim, Z. X.H., Bramono, D. S., Ling, L., Bell, T., Hinkley, S., Nathan, S. S., Hui, J. H., Wong, H. K., Nurcombe, V. and Cool, S. M. (2013). Affinity-selected heparan sulfate for bone repair. Biomaterials, 34 (22), 5594-5605. doi: 10.1016/j.biomaterials.2013.04.017

Affinity-selected heparan sulfate for bone repair

2013

Journal Article

Telomere length analysis of human mesenchymal stem cells by quantitative PCR

Samsonraj, Rebekah M., Raghunath, Michael, Hui, James H., Ling, Ling, Nurcombe, Victor and Cool, Simon M. (2013). Telomere length analysis of human mesenchymal stem cells by quantitative PCR. Gene, 519 (2), 348-355. doi: 10.1016/j.gene.2013.01.039

Telomere length analysis of human mesenchymal stem cells by quantitative PCR

2013

Book Chapter

Heparanated surfaces

Nurcombe, Victor, Birch, William R. and Cool, Simon M. (2013). Heparanated surfaces. Handbook of Biofunctional Surfaces. (pp. 617-638) Boca Raton, FL United States: Pan Stanford Publishing.

Heparanated surfaces

2013

Journal Article

The influence of collagen and hyaluronan matrices on the delivery and bioactivity of bone morphogenetic protein-2 and ectopic bone formation

Bhakta, Gajadhar, Lim, Zophia X.H., Rai, Bina, Lin, Tingxuan, Hui, James H., Prestwich, Glenn D., Van Wijnen, Andre J., Nurcombe, Victor and Cool, Simon M. (2013). The influence of collagen and hyaluronan matrices on the delivery and bioactivity of bone morphogenetic protein-2 and ectopic bone formation. Acta Biomaterialia, 9 (11), 9098-9106. doi: 10.1016/j.actbio.2013.07.008

The influence of collagen and hyaluronan matrices on the delivery and bioactivity of bone morphogenetic protein-2 and ectopic bone formation

2012

Journal Article

Hyaluronic acid-based hydrogels functionalized with heparin that support controlled release of bioactive BMP-2

Bhakta, Gajadhar, Rai, Bina, Lim, Zophia X.H., Hui, James H., Stein, Gary S., van Wijnen, Andre J., Nurcombe, Victor, Prestwich, Glenn D. and Cool, Simon M. (2012). Hyaluronic acid-based hydrogels functionalized with heparin that support controlled release of bioactive BMP-2. Biomaterials, 33 (26), 6113-6122. doi: 10.1016/j.biomaterials.2012.05.030

Hyaluronic acid-based hydrogels functionalized with heparin that support controlled release of bioactive BMP-2

2012

Journal Article

Heparan sulfate enhances the self-renewal and therapeutic potential of mesenchymal stem cells from human adult bone marrow

Helledie, Torben, Dombrowski, Christian, Rai, Bina, Lim, Zophia X.H., Hin, Ian Lee Hock, Rider, David A., Stein, Gary S., Hong, Wanjin, Van Wijnen, Andre J., Hui, James H., Nurcombe, Victor and Cool, Simon M. (2012). Heparan sulfate enhances the self-renewal and therapeutic potential of mesenchymal stem cells from human adult bone marrow. Stem Cells and Development, 21 (11), 1897-1910. doi: 10.1089/scd.2011.0367

Heparan sulfate enhances the self-renewal and therapeutic potential of mesenchymal stem cells from human adult bone marrow

2012

Journal Article

Translating human embryonic stem cells from 2-dimensional to 3-dimensional cultures in a defined medium on laminin- and vitronectin-coated surfaces

Heng, Boon Chin, Li, Jian, Chen, Allen Kuan-Liang, Reuveny, Shaul, Cool, Simon M., Birch, William R. and Oh, Steve Kah-Weng (2012). Translating human embryonic stem cells from 2-dimensional to 3-dimensional cultures in a defined medium on laminin- and vitronectin-coated surfaces. Stem Cells and Development, 21 (10), 1701-1715. doi: 10.1089/scd.2011.0509

Translating human embryonic stem cells from 2-dimensional to 3-dimensional cultures in a defined medium on laminin- and vitronectin-coated surfaces

2012

Journal Article

Bone marrow-derived heparan sulfate potentiates the osteogenic activity of bone morphogenetic protein-2 (BMP-2)

Bramono, Diah S., Murali, Sadasivam, Rai, Bina, Ling, Ling, Poh, Wei Theng, Lim, Zophia Xuehui, Stein, Gary S., Nurcombe, Victor, van Wijnen, Andre J. and Cool, Simon M. (2012). Bone marrow-derived heparan sulfate potentiates the osteogenic activity of bone morphogenetic protein-2 (BMP-2). Bone, 50 (4), 954-964. doi: 10.1016/j.bone.2011.12.013

Bone marrow-derived heparan sulfate potentiates the osteogenic activity of bone morphogenetic protein-2 (BMP-2)

2011

Journal Article

The three-dimensional vascularization of growth factor-releasing hybrid scaffold of poly (ɛ-caprolactone)/collagen fibers and hyaluronic acid hydrogel

Ekaputra, Andrew K., Prestwich, Glenn D., Cool, Simon M. and Hutmacher, Dietmar W. (2011). The three-dimensional vascularization of growth factor-releasing hybrid scaffold of poly (ɛ-caprolactone)/collagen fibers and hyaluronic acid hydrogel. Biomaterials, 32 (32), 8108-8117. doi: 10.1016/j.biomaterials.2011.07.022

The three-dimensional vascularization of growth factor-releasing hybrid scaffold of poly (ɛ-caprolactone)/collagen fibers and hyaluronic acid hydrogel

2011

Journal Article

Multifunctional silica nanoparticles with potentials of imaging and gene delivery

Bhakta, Gajadhar, Sharma, Rakesh Kumar, Gupta, Nikesh, Cool, Simon, Nurcombe, Victor and Maitra, Amarnath (2011). Multifunctional silica nanoparticles with potentials of imaging and gene delivery. Nanomedicine: Nanotechnology, Biology, and Medicine, 7 (4), 472-479. doi: 10.1016/j.nano.2010.12.008

Multifunctional silica nanoparticles with potentials of imaging and gene delivery

2011

Journal Article

The effect of human bone marrow stroma-derived heparan sulfate on the Ex vivo expansion of human cord blood hematopoietic stem cells

Bramono, Diah S., Rider, David A., Murali, Sadasivam, Nurcombe, Victor and Cool, Simon M. (2011). The effect of human bone marrow stroma-derived heparan sulfate on the Ex vivo expansion of human cord blood hematopoietic stem cells. Pharmaceutical Research, 28 (6), 1385-1394. doi: 10.1007/s11095-010-0352-y

The effect of human bone marrow stroma-derived heparan sulfate on the Ex vivo expansion of human cord blood hematopoietic stem cells

2011

Journal Article

Comparative assessment of the effects of gender-specific heparan sulfates on mesenchymal stem cells

Murali, Sadasivam, Leong, Denise F. M., Lee, Jaslyn J. L., Cool, Simon M. and Nurcombe, Victor (2011). Comparative assessment of the effects of gender-specific heparan sulfates on mesenchymal stem cells. Journal of Biological Chemistry, 286 (20), 17755-17765. doi: 10.1074/jbc.M110.148874

Comparative assessment of the effects of gender-specific heparan sulfates on mesenchymal stem cells

2011

Journal Article

Defining a threshold surface density of vitronectin for the stable expansion of human embryonic stem cells

Yap, Lynn Y.W., Li, Jian, Phang, In Yee, Ong, Lay Ting, Ow, Jo'An Zhu-En, Goh, James C.H., Nurcombe, Victor, Hobley, Jonathan, Choo, Andre B.H., Oh, Steve K.W., Cool, Simon M. and Birch, William R. (2011). Defining a threshold surface density of vitronectin for the stable expansion of human embryonic stem cells. Tissue Engineering - Part C: Methods, 17 (2), 193-207. doi: 10.1089/ten.tec.2010.0328

Defining a threshold surface density of vitronectin for the stable expansion of human embryonic stem cells