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2011 Journal Article Defining a threshold surface density of vitronectin for the stable expansion of human embryonic stem cellsYap, Lynn Y.W., Li, Jian, Phang, In Yee, Ong, Lay Ting, Ow, Jo'An Zhu-En, Goh, James C.H., Nurcombe, Victor, Hobley, Jonathan, Choo, Andre B.H., Oh, Steve K.W., Cool, Simon M. and Birch, William R. (2011). Defining a threshold surface density of vitronectin for the stable expansion of human embryonic stem cells. Tissue Engineering - Part C: Methods, 17 (2), 193-207. doi: 10.1089/ten.tec.2010.0328 |
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2011 Journal Article Heparan sulfate-based treatments for regenerative medicineRai, Bina, Nurcombe, Victor and Cool, Simon M. (2011). Heparan sulfate-based treatments for regenerative medicine. Critical Reviews in Eukaryotic Gene Expression, 21 (1), 1-12. doi: 10.1615/CritRevEukarGeneExpr.v21.i1.10 |
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2010 Journal Article Loss of CHSY1, a secreted FRINGE enzyme, causes syndromic brachydactyly in humans via increased NOTCH signalingTian, Jing, Ling, Ling, Shboul, Mohammad, Lee, Hane, O'Connor, Brian, Merriman, Barry, Nelson, Stanley F., Cool, Simon, Ababneh, Osama H., Al-Hadidy, Azmy, Masri, Amira, Hamamy, Hanan and Reversade, Bruno (2010). Loss of CHSY1, a secreted FRINGE enzyme, causes syndromic brachydactyly in humans via increased NOTCH signaling. American Journal of Human Genetics, 87 (6), 768-778. doi: 10.1016/j.ajhg.2010.11.005 |
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2010 Conference Publication Raman mapping glucose metabolism during adipogenesis from human mesenchymal stem cellsGomathy, S. S., Stylianou, C., Phang, I. Y., Cool, S., Nurcombe, V., Ample, F., Lear, M. J., Gorelik, S. and Hobley, J. (2010). Raman mapping glucose metabolism during adipogenesis from human mesenchymal stem cells. Photonics Global Conference, Orchard, Singapore, 14-16 December 2010. Piscataway, NJ, United States: Institute of Electrical and Electronics Engineers. doi: 10.1109/PGC.2010.5705978 |
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2010 Journal Article Differences between in vitro viability and differentiation and in vivo bone-forming efficacy of human mesenchymal stem cells cultured on PCL-TCP scaffoldsRai, Bina, Lin, Jane L., Lim, Zophia X.H., Guldberg, Robert E., Hutmacher, Dietmar W. and Cool, Simon M. (2010). Differences between in vitro viability and differentiation and in vivo bone-forming efficacy of human mesenchymal stem cells cultured on PCL-TCP scaffolds. Biomaterials, 31 (31), 7960-7970. doi: 10.1016/j.biomaterials.2010.07.001 |
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2010 Journal Article Cancer-related ectopic expression of the bone-related transcription factor RUNX2 in non-osseous metastatic tumor cells is linked to cell proliferation and motilityLeong, David T., Lim, Joleen, Goh, Xuewei, Pratap, Jitesh, Pereira, Barry P., Kwok, Hui Si, Nathan, Saminathan Suresh, Dobson, Jason R., Lian, Jane B., Ito, Yoshiaki, Voorhoeve, P Mathijs, Stein, Gary S., Salto-Tellez, Manuel, Cool, Simon M. and van Wijnen, Andre J. (2010). Cancer-related ectopic expression of the bone-related transcription factor RUNX2 in non-osseous metastatic tumor cells is linked to cell proliferation and motility. Breast Cancer Research, 12 (5) R89. doi: 10.1186/bcr2762 |
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2010 Journal Article Functional coupling between the extracellular matrix and nuclear lamina by wnt signaling in progeriaHernandez, Lidia, Roux, Kyle J., Wong, Esther Sook Miin, Mounkes, Leslie C., Mutalif, Rafidah, Navasankari, Raju, Rai, Bina, Cool, Simon, Jeong, Jae-Wook, Wang, Honghe, Lee, Hyun-Shik, Kozlov, Serguei, Grunert, Martin, Keeble, Thomas, Jones, C. Michael, Meta, Margarita D., Young, Stephen G., Daar, Ira O., Burke, Brian, Perantoni, Alan O. and Stewart, Colin L. (2010). Functional coupling between the extracellular matrix and nuclear lamina by wnt signaling in progeria. Developmental Cell, 19 (3), 413-425. doi: 10.1016/j.devcel.2010.08.013 |
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2010 Journal Article Synergism between Wnt3a and heparin enhances osteogenesis via a phosphoinositide 3-kinase/Akt/RUNX2 pathwayLing, Ling, Dombrowski, Christian, Foong, Kin Mun, Haupt, Larisa M., Stein, Gary S., Nurcombe, Victor, Van Wijnen, Andre J. and Cool, Simon M. (2010). Synergism between Wnt3a and heparin enhances osteogenesis via a phosphoinositide 3-kinase/Akt/RUNX2 pathway. Journal of Biological Chemistry, 285 (34), 26233-26244. doi: 10.1074/jbc.M110.122069 |
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2010 Journal Article Glycosaminoglycans modulate RANKL-induced osteoclastogenesisLing, Ling, Murali, Sadasivam, Stein, Gary S., Van Wijnen, Andre J. and Cool, Simon M. (2010). Glycosaminoglycans modulate RANKL-induced osteoclastogenesis. Journal of Cellular Biochemistry, 109 (6), 1222-1231. doi: 10.1002/jcb.22506 |
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2010 Journal Article Impact of vitronectin concentration and surface properties on the stable propagation of human embryonic stem cellsLib, Jian, Bardy, Jo'an, Yap, Lynn Y.W., Chen, Allen, Nurcombe, Victor, Cool, Simon M., Oh, Steve K. W. and Birch, William R. (2010). Impact of vitronectin concentration and surface properties on the stable propagation of human embryonic stem cells. Biointerphases, 5 (3), 132-142. doi: 10.1116/1.3525804 |
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2010 Journal Article The influence of fibrin based hydrogels on the chondrogenic differentiation of human bone marrow stromal cellsHo, Saey T.B., Cool, Simon M., Hui, James H. and Hutmacher, Dietmar W. (2010). The influence of fibrin based hydrogels on the chondrogenic differentiation of human bone marrow stromal cells. Biomaterials, 31 (1), 38-47. doi: 10.1016/j.biomaterials.2009.09.021 |
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2010 Journal Article FGF-2 modulates Wnt signaling in undifferentiated hESC and iPS cells through activated PI3-K/GSK3β signalingDing, Vanessa M. Y., Ling, Ling, Natarajan, Subaashini, Yap, Miranda G. S., Cool, Simon M. and Choo, Andre B. H. (2010). FGF-2 modulates Wnt signaling in undifferentiated hESC and iPS cells through activated PI3-K/GSK3β signaling. Journal of Cellular Physiology, 225 (2), 417-428. doi: 10.1002/jcp.22214 |
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2009 Journal Article Composite electrospun scaffolds for engineering tubular bone graftsEkaputra, Andrew Krishna, Zhou, Yefang, Cool, Simon McKenzie and Hutmacher, Dietmar Werner (2009). Composite electrospun scaffolds for engineering tubular bone grafts. Tissue Engineering - Part A, 15 (12), 3779-3788. doi: 10.1089/ten.tea.2009.0186 |
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2009 Journal Article Purification and characterization of heparan sulfate from human primary osteoblastsMurali, Sadasivam, Manton, Kerry J., Tjong, Vinalia, Su, Xiaodi, Haupt, Larisa M., Cool, Simon M. and Nurcombe, Victor (2009). Purification and characterization of heparan sulfate from human primary osteoblasts. Journal of Cellular Biochemistry, 108 (5), 1132-1142. doi: 10.1002/jcb.22340 |
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2009 Journal Article Runx2, p53, and pRB status as diagnostic parameters for deregulation of osteoblast growth and differentiation in a new pre-chemotherapeutic osteosarcoma cell line (OS1)Pereira, Barry P., Zhou, Yefang, Gupta, Anurag, Leong, David T., Aung, Khin Zarchi, Ling, Ling, Pho, Robert W. H., Galindo, Mario, Salto-Tellez, Manuel, Stein, Gary S., Cool, Simon M., Van Wijnen, Andre J. and Nathan, Saminathan S. (2009). Runx2, p53, and pRB status as diagnostic parameters for deregulation of osteoblast growth and differentiation in a new pre-chemotherapeutic osteosarcoma cell line (OS1). Journal of Cellular Physiology, 221 (3), 778-788. doi: 10.1002/jcp.21921 |
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2009 Journal Article The heparan sulfate proteoglycan (HSPG) glypican-3 mediates commitment of MC3T3-E1 cells toward osteogenesisHaupt, Larisa M., Murali, Sadasivam, Foong, Kin Mun, Teplyuk, Nadiya, Leong, Fong Mei, Stein, Gary S., Van Wijnen, Andre J., Nurcombe, Victor and Cool, Simon M. (2009). The heparan sulfate proteoglycan (HSPG) glypican-3 mediates commitment of MC3T3-E1 cells toward osteogenesis. Journal of Cellular Physiology, 220 (3), 780-791. doi: 10.1002/jcp.21825 |
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2009 Journal Article Dual loss of Rb1 and Trp53 in melanocytes perturbs melanocyte homeostasis and genetic stability in vitro but does not cause melanoma or pigmentation defects in vivoTonks, Ian D., Mould, Arne, Nurcombe, Victor, Cool, Simon M., Walker, Graeme J., Hacker, Elke, Keith, Patricia, Schroder, Wayne A., Cotterill, Andrew, Hayward, Nicholas K. and Kay, Graham F. (2009). Dual loss of Rb1 and Trp53 in melanocytes perturbs melanocyte homeostasis and genetic stability in vitro but does not cause melanoma or pigmentation defects in vivo. Pigment Cell and Melanoma Research, 22 (3), 328-330. doi: 10.1111/j.1755-148X.2009.00560.x |
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2009 Journal Article De-sulfation of MG-63 cell glycosaminoglycans delays in vitro osteogenesis, up-regulates cholesterol synthesis and disrupts cell cycle and the actin cytoskeletonKumarasuriyar, A., Lee, I., Nurcombe, V. and Cool, S. M. (2009). De-sulfation of MG-63 cell glycosaminoglycans delays in vitro osteogenesis, up-regulates cholesterol synthesis and disrupts cell cycle and the actin cytoskeleton. Journal of Cellular Physiology, 219 (3), 572-583. doi: 10.1002/jcp.21700 |
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2009 Journal Article The osteogenic transcription factor Runx2 regulates components of the fibroblast growth factor/proteoglycan signaling axis in osteoblastsTeplyuk, Nadiya M., Haupt, Larisa M., Ling, Ling, Dombrowski, Christian, Foong, Kin Mun, Nathan, Saminathan S., Lian, Jane B., Stein, Janet L., Stein, Gary S., Cool, Simon M. and Van Wijnen, Andre J. (2009). The osteogenic transcription factor Runx2 regulates components of the fibroblast growth factor/proteoglycan signaling axis in osteoblasts. Journal of Cellular Biochemistry, 107 (1), 144-154. doi: 10.1002/jcb.22108 |
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2009 Journal Article The stimulation of healing within a rat calvarial defect by mPCL-TCP/collagen scaffolds loaded with rhBMP-2Sawyer, A. A., Song, S. J., Susanto, E., Chuan, P., Lam, C. X.F., Woodruff, M. A., Hutmacher, D. W. and Cool, S. M. (2009). The stimulation of healing within a rat calvarial defect by mPCL-TCP/collagen scaffolds loaded with rhBMP-2. Biomaterials, 30 (13), 2479-2488. doi: 10.1016/j.biomaterials.2008.12.055 |
