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2002 Journal Article Effect of tamoxifen on the enzymatic activity of human cytochrome CYP2B6Sridar, C, Kent, UM, Notley, LM, Gillam, EMJ and Hollenberg, PF (2002). Effect of tamoxifen on the enzymatic activity of human cytochrome CYP2B6. Journal of Pharmacology And Experimental Therapeutics, 301 (3), 945-952. doi: 10.1124/jpet.301.3.945 |
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2002 Journal Article Opposites attract, or do they? Rethinking the P450 2D6 pharmacophore modelGillam, E. M. J. (2002). Opposites attract, or do they? Rethinking the P450 2D6 pharmacophore model. Trends in Pharmacological Sciences, 23 (11), 501-501. doi: 10.1016/s0165-6147(02)02121-1 |
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2002 Journal Article Use of heterologously-expressed cytochomre P450 and glutathione transferase enzymes in toxicity assaysGuengerich, F. P., Wheeler, J. B., Chun, Y. J., Kim, D., Shimada, T., Aryal, P., Oda, Y. and Gillam, E. M. J. (2002). Use of heterologously-expressed cytochomre P450 and glutathione transferase enzymes in toxicity assays. Toxicology, 181-182, 261-264. doi: 10.1016/S0300-483X(02)00293-7 |
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2001 Conference Publication Deletion of glutathione S-transferase theta-1 (GSTT1) and anticonvulsant (ACD)-induced hypersensitivity syndromeKinobe, RT, Dickinson, RG and Gillam, EMJ (2001). Deletion of glutathione S-transferase theta-1 (GSTT1) and anticonvulsant (ACD)-induced hypersensitivity syndrome. CLARE: ELSEVIER SCI IRELAND LTD. |
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2001 Journal Article Metabolic activation of polycyclic aromatic hydrocarbons and other procarcinogens by cytochromes P450 1A1 and P4501B1 allelic variants and other human cytochromes P450 in Salmonella typhimurium NM2009Shimada, T, Oda, Y, Gillam, EMJ, Guengerich, FP and Inoue, K (2001). Metabolic activation of polycyclic aromatic hydrocarbons and other procarcinogens by cytochromes P450 1A1 and P4501B1 allelic variants and other human cytochromes P450 in Salmonella typhimurium NM2009. Drug Metabolism And Disposition, 29 (9), 1176-1182. |
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2001 Journal Article The dark side of a 'detoxification' mechanismGillam, E. M. J. (2001). The dark side of a 'detoxification' mechanism. TRENDS in Pharmacological Sciences, 22 (1), 11-11. doi: 10.1016/s0165-6147(00)01601-1 |
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2001 Conference Publication Characterization of CYP3A4/3A5 chimeric enzymes: catalytic and electron paramagnetic resonance (EPR) studiesNotley, L., Avent, K., Noble, C. J., Hanson, G. R. and Gillam, E. M. J. (2001). Characterization of CYP3A4/3A5 chimeric enzymes: catalytic and electron paramagnetic resonance (EPR) studies. 6th International ISSX Meeting, Munich, 7-11 October 2001. New York: Marcel Dekker Inc.. |
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2001 Conference Publication Deletion of glutathione S-transferase theta-1 (GSTT1) and anti-convulsant (ACD)-induced hypersensitivity syndromeKinobe, R. T., Dickinson, R. G. and Gillam, E. M. J. (2001). Deletion of glutathione S-transferase theta-1 (GSTT1) and anti-convulsant (ACD)-induced hypersensitivity syndrome. IXth International Congress of Toxicology, Brisbane, 8-12 July 2001. Amsterdam: Elsevier. |
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2001 Journal Article Metabolic activation of heterocyclic amines and other procarcinogens in Salmonella typhimurium umu tester strains expressing human cytochrome P4501A1, 1A2, 1B1, 2C9, 2D6, 2E1, and 3A4 and human NADPH-P450 reductase and bacterial O-acetyltransferaseOda, Y, Aryal, P, Terashita, T, Gillam, EMJ, Guengerich, FP and Shimada, T (2001). Metabolic activation of heterocyclic amines and other procarcinogens in Salmonella typhimurium umu tester strains expressing human cytochrome P4501A1, 1A2, 1B1, 2C9, 2D6, 2E1, and 3A4 and human NADPH-P450 reductase and bacterial O-acetyltransferase. Mutation Research-genetic Toxicology And Environmental Mutagenesis, 492 (1-2), 81-90. doi: 10.1016/S1383-5718(01)00154-1 |
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2001 Journal Article Hang onto your haem....what's happened to CYP4A?Gillam, E. M. J. (2001). Hang onto your haem....what's happened to CYP4A?. TRENDS in Pharmacological Sciences, 22 (5), 220-220. doi: 10.1016/s0165-6147(00)01709-0 |
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2001 Conference Publication Characterization of chimeric mutant enzymes derived from P450S 3A4 and 3A5: catalytic and electron paramagnetic resonance (EPR) studiesNotley, L., Avent, K., Noble, C. J., Hanson, G. R. and Gillam, E. M. J. (2001). Characterization of chimeric mutant enzymes derived from P450S 3A4 and 3A5: catalytic and electron paramagnetic resonance (EPR) studies. 12th International Conference on Cytochrome P450, La Grande Motte, France, 11-15 September 2001. France: |
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2001 Journal Article Exploiting the versatility of human cytochrome P450 enzymes: The promise of blue roses from biotechnologyGillam, EMJ and Guengerich, FP (2001). Exploiting the versatility of human cytochrome P450 enzymes: The promise of blue roses from biotechnology. Iubmb Life, 52 (6), 271-277. doi: 10.1080/152165401317291110 |
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2001 Conference Publication Bioactivation of tamoxifen by recombinant human cytochrome P450 enzymesNotley, L., De Wolf, C., Wunsch, R. and Gillam, E. M. J. (2001). Bioactivation of tamoxifen by recombinant human cytochrome P450 enzymes. IXth International Congress of Toxicology, Brisbane, Australia, 8-12 July, 2001. Amsterdam, The Netherlands: Elsevier. doi: 10.1016/S0300-483X(01)00386-9 |
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2001 Journal Article Specificity of 17 beta-oestradiol and benzo[a] pyrene oxidation by polymorphic human cytochrome P4501B1 variants substituted at residues 48, 119 and 432Shimada, T, Watanabe, J, Inoue, K, Guengerich, FP and Gillam, EMJ (2001). Specificity of 17 beta-oestradiol and benzo[a] pyrene oxidation by polymorphic human cytochrome P4501B1 variants substituted at residues 48, 119 and 432. Xenobiotica, 31 (3), 163-176. doi: 10.1080/00498250110043490 |
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2001 Journal Article The PXR ligand-binding domain: How to be picky and promiscuous at the same timeGillam, E. M. J. (2001). The PXR ligand-binding domain: How to be picky and promiscuous at the same time. TRENDS in Pharmacological Sciences, 22 (9), 448-448. doi: 10.1016/S0165-6147(00)01847-2 |
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2001 Conference Publication Expressed P450s in toxicity assaysGuengerich, F. P., Wheeler, J.B., Chun, Y.J., Kim, D., Shimada, T., Aryal, P., Oda, Y. and Gillam, E. M. J. (2001). Expressed P450s in toxicity assays. 9th International Congress of Toxicology (ICT IX), Brisbane, Australia, 8-12 July, 2001. Amsterdam, The Netherlands: Elsevier. doi: 10.1016/S0300-483X(01)00386-9 |
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2000 Conference Publication What makes P450s work? Searches for answers with known and new P450sGuengerich, F. Peter, Parikh, Asit, Yun, Chul-Ho, Kim, Donghak, Nakamura, Katsunori, Notley, Lisa M. and Gillam, Elizabeth M. J. (2000). What makes P450s work? Searches for answers with known and new P450s. doi: 10.1081/DMR-100102334 |
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2000 Journal Article Formation of a dihydroxy metabolite of phenytoin in human liver microsomes/cytosol: roles of cytochromes P450 2C9, 2C19, and 3A4Komatsu, T., Yamazaki, H., Asahi, S., Gillam, E. M., Guengerich, F. P., Nakajima, M. and Yokoi, T. (2000). Formation of a dihydroxy metabolite of phenytoin in human liver microsomes/cytosol: roles of cytochromes P450 2C9, 2C19, and 3A4. Drug Metabolism and Disposition, 28 (11), 1361-1368. |
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2000 Journal Article Formation of a dihydroxy metabolite of phenytoin in human liver microsomes/cytosol: Roles of cytochromes P450 2C9, 2C19, and 3A4Komatsu, T., Yamazaki, H., Asahi, S., Gillam, E. M. J., Guengerich, F. P., Nakajima, M. and Yokoi, T. (2000). Formation of a dihydroxy metabolite of phenytoin in human liver microsomes/cytosol: Roles of cytochromes P450 2C9, 2C19, and 3A4. Drug Metabolism and Disposition, 28 (11), 1361-1368. |
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2000 Journal Article Roles of NADPH-P450 reductase in the O-Deethylation of 7-Ethoxycoumarin by recombinant human cytochrome P450 1B1 variants in Escherichia coliShimada, Tsutomu, Tsumura, Fujiko, Gillam, Elizabeth M. J., Guengerich, F. Peter and Inoue, Kiyoshi (2000). Roles of NADPH-P450 reductase in the O-Deethylation of 7-Ethoxycoumarin by recombinant human cytochrome P450 1B1 variants in Escherichia coli. Protein Expression and Purification, 20 (1), 73-80. doi: 10.1006/prep.2000.1302 |
