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2000 Journal Article Phenytoin metabolism by human cytochrome P450: Involvement of P450 3A and 2C Fprms in secondary metabolism and drug-protein adduct formationCuttle, L., Munns, A., Hogg, N., Scott, J. R., Hooper, W. D., Dickinson, R. G. and Gillam, E. M. J. (2000). Phenytoin metabolism by human cytochrome P450: Involvement of P450 3A and 2C Fprms in secondary metabolism and drug-protein adduct formation. Drug Metabolism and Disposition, 28 (8), 945-950. |
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2000 Journal Article Oxidation of Indole by Cytochrome P450 EnzymesGillam, E. M. J., Notley, L. M., Cai, H. L., De Voss, J. J. and Guengerich, F. P. (2000). Oxidation of Indole by Cytochrome P450 Enzymes. Biochemistry, 39 (45), 13817-13824. doi: 10.1021/bi001229u |
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2000 Conference Publication The biotransformation of tamoxifen by human vytochrome P450 enzymes leads to the production of potentially genotoxic metabolitesNotley, L., Crewe, K. H., Lennard, M. S. and Gillam, E. M. J. (2000). The biotransformation of tamoxifen by human vytochrome P450 enzymes leads to the production of potentially genotoxic metabolites. ASCEPT Annual Scientific Meeting 2000, Newcastle, Australia, 3 - 6 December, 2000. Sydney, Australia: ASCEPT. |
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2000 Journal Article Transgenic xenosensors: humanizing miceGillam, E. M. J. (2000). Transgenic xenosensors: humanizing mice. Trends in Pharmacological Sciences, 21 (9), 330-331. doi: 10.1016/S0165-6147(00)01532-7 |
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2000 Conference Publication Use of recombinant human P450 enzymes in the studies of drug metabolism and chemical carcinogenesisShimada, T., Aryal, P., Gillam, E. M. J., Guengerich, F. P. and Oda, Y. (2000). Use of recombinant human P450 enzymes in the studies of drug metabolism and chemical carcinogenesis. Millennial World Congress of Pharmaceutical Sciences, San Francisco, USA, 16 - 20 April, 2000. USA: |
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2000 Conference Publication Genetic deletion of glutathione S-Transferases Theta-1 (GSTT1) and MU-1 (GSTM1) and the aromatic anticonvulsant drug-induced hypersensitivity syndromeKinobe, R., Dickinson, R. G. and Gillam, E. M. J. (2000). Genetic deletion of glutathione S-Transferases Theta-1 (GSTT1) and MU-1 (GSTM1) and the aromatic anticonvulsant drug-induced hypersensitivity syndrome. ASCEPT Annual Scientific Meeting 2000, Newcastle, Australia, 3 - 6 December, 2000. Sydney, Australia: ASCEPT. |
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2000 Conference Publication Examining tissue-specific bioactivation in vitro: Cytochrome P450 1B1 and other extrahepatic forms in the metabolism of carcinogensGillam, E. M. J., Notley, L., Guengerich, F. P., Shimada, T. and Lennard, M. S. (2000). Examining tissue-specific bioactivation in vitro: Cytochrome P450 1B1 and other extrahepatic forms in the metabolism of carcinogens. Pacifichem 2000 Proceedings, Honolulu, USA, 13 - 20 December, 2000. American Chemical Society. |
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2000 Journal Article What makes P450s work? Searches for answers with known and new P450s*Guengerich, F. P., Parikh, A., Yun, C., Kim, D., Nakamura, K., Notley, L. and Gillam, E. M. J. (2000). What makes P450s work? Searches for answers with known and new P450s*. Drug Metabolism Reviews, 32 (3-4), 267-281. doi: 10.1081/DMR-100102334 |
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2000 Conference Publication Formation of indigo by recombinant mammalian cytochrome P450Kim, D., Gillam, E. M. J., Aguinaldo, A. M., Notley, L., Mundkowski, R. G., Volkov, A. A., Arnold, F. H., Soucek, P., De Voss, J. J. and Guengerich, F. P. (2000). Formation of indigo by recombinant mammalian cytochrome P450. Joint meeting ASBMB/ASPET 2000, Boston, MA, USA, 4 - 8 June, 2000. USA: The Federation of American Societies for Experimental Biology. |
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2000 Journal Article Association of CYP1B1 genetic polymorphism with incidence to breast and lung cancerWatanabe, J., Shimada, T., Gillam, E. M. J., Ikuta, T., Suemasu, K., Higashi, Y., Gotoh, O. and Kawajiri, K. (2000). Association of CYP1B1 genetic polymorphism with incidence to breast and lung cancer. Pharmacogenetics, 10 (1), 25-33. doi: 10.1097/00008571-200002000-00004 |
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2000 Conference Publication Oxidation of indole by human cytochrome P450 enzymesGuengerich, F. P., Cai, H., Notley, L., De Voss, J. J. and Gillam, E. M. J. (2000). Oxidation of indole by human cytochrome P450 enzymes. Joint meeting ASBMB/ASPET 2000, Boston, MA, USA, 4 - 8 June, 2000. BETHESDA: The Federation of American Societies for Experimental Biology. |
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2000 Conference Publication Involvement of human P450s in the metabolic activation of heterocyclic amines using UMU tester strainsOda, Y., Aryal, P., Gillam, E. M. J., Guengerich, F. P. and Shimada, T. (2000). Involvement of human P450s in the metabolic activation of heterocyclic amines using UMU tester strains. Meeting of the Environmental Mutagens Society, New Orleans, USA, April, 2000. USA: |
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1999 Journal Article Enhancement of cytochrome P-450 3A4 catalytic activities by cytochrome b(5) in bacterial membranesYamazaki, H, Nakajima, M, Nakamura, M, Asahi, S, Shimada, N, Gillam, EMJ, Guengerich, FP, Shimada, T and Yokoi, T (1999). Enhancement of cytochrome P-450 3A4 catalytic activities by cytochrome b(5) in bacterial membranes. Drug Metabolism and Disposition, 27 (9), 999-1004. |
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1999 Journal Article Catalytic properties of polymorphic human cytochrome P450 1B1 variantsShimada, Tsutomu, Watanabe, Junko, Kawajiri, Kaname, Sutter, Thomas R., Guengerich, F. Peter, Gillam, Elizabeth M. J. and Inoue, Kiyoshi (1999). Catalytic properties of polymorphic human cytochrome P450 1B1 variants. Carcinogenesis, 20 (8), 1607-1613. doi: 10.1093/carcin/20.8.1607 |
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1999 Journal Article Formation of indigo by recombinant mammalian cytochrome P450Gillam, E. M. J., Aguinaldo, A. M. A., Notley, L. M., Kim, D., Mundkowski, R. G., Volkov, A. A., Arnold, F. H., Soucek, P., DeVoss, J. J. and Guengerich, F. P. (1999). Formation of indigo by recombinant mammalian cytochrome P450. Biochemical and Biophysical Research Communications, 265 (2), 469-472. doi: 10.1006/bbrc.1999.1702 |
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1999 Journal Article Metabolism of Benzo(a)pyrene to trans-7,8Dihydroxy-7,8-dihydrobenzo(a)pyrene by Recombinant Human Cytochrome P450 1B1 and Purified Liver Epoxide HydrolaseShimada, Tsutomu, Gillam, Elizabeth M. J., Oda, Yoshimitsu, Tsumura, Fujiko, Sutter, Thomas R., Guengerich, F. Peter and Inoue, Kiyoshi (1999). Metabolism of Benzo(a)pyrene to trans-7,8Dihydroxy-7,8-dihydrobenzo(a)pyrene by Recombinant Human Cytochrome P450 1B1 and Purified Liver Epoxide Hydrolase. Chemical Research in Toxicology, 12 (7), 623-629. doi: 10.1021/tx990028s |
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1998 Journal Article Analysis of cytochrome P450 2D6: Substrate interactions by site-directed mutagenesisHanna, I. H. and Gillam, E. M J (1998). Analysis of cytochrome P450 2D6: Substrate interactions by site-directed mutagenesis. FASEB Journal, 12 (8) |
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1998 Journal Article Twenty years of biochemistry of human P450s - Purification, expression, mechanism, and relevance to drugsGuengerich, FP, Hosea, NA, Parikh, A, Bell-Parikh, LC, Johnson, WW, Gillam, EMJ and Shimada, T (1998). Twenty years of biochemistry of human P450s - Purification, expression, mechanism, and relevance to drugs. Drug Metabolism and Disposition, 26 (12), 1175-1178. |
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1998 Journal Article Human cytochrome P450 enzymes expressed in bacteria: Reagents to probe molecular interactions in toxicologyGillam, EMJ (1998). Human cytochrome P450 enzymes expressed in bacteria: Reagents to probe molecular interactions in toxicology. Clinical and Experimental Pharmacology and Physiology, 25 (11), 877-886. doi: 10.1111/j.1440-1681.1998.tb02338.x |
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1998 Journal Article Recombinant human cytochrome P450 1B1 expression in Escherichia coliShimada, T, Wunsch, RM, Hanna, IH, Sutter, TR, Guengerich, FP and Gillam, EMJ (1998). Recombinant human cytochrome P450 1B1 expression in Escherichia coli. Archives of Biochemistry and Biophysics, 357 (1), 111-120. doi: 10.1006/abbi.1998.0808 |
