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2012 Journal Article Cadmium(II) complexes: Mimics of organophosphate pesticide degrading enzymes and metallo-β-lactamasesDaumann, Lena J., Gahan, Lawrence R., Comba, Peter and Schenk, Gerhard (2012). Cadmium(II) complexes: Mimics of organophosphate pesticide degrading enzymes and metallo-β-lactamases. Inorganic Chemistry, 51 (14), 7669-7681. doi: 10.1021/ic300687y |
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2012 Journal Article Penicillin inhibitors of purple acid phosphataseFaridoon, Hussein, Waleed M., Islam, Nazar Ul, Guddat, Luke W., Schenk, Gerhard and McGeary, Ross P. (2012). Penicillin inhibitors of purple acid phosphatase. Bioorganic and Medicinal Chemistry Letters, 22 (7), 2555-2559. doi: 10.1016/j.bmcl.2012.01.123 |
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2012 Journal Article Monoesterase activity of a purple acid phosphatase mimic with a cyclam platformComba, Peter, Gahan, Lawrence R., Hanson, Graeme R., Mereacre, Valeriu, Noble, Christopher J., Powell, Annie K., Prisecaru, Ion, Schenk, Gerhard and Zajaczkowski-Fischer, Marta (2012). Monoesterase activity of a purple acid phosphatase mimic with a cyclam platform. Chemistry: A European Journal, 18 (6), 1700-1710. doi: 10.1002/chem.201100229 |
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2012 Journal Article Spectroscopic and catalytic characterization of a functional (FeFeII)-Fe-III biomimetic for the active site of uteroferrin and protein cleavageSmith, Sarah J., Peralta, Rosely A., Jovito, Rafael, Horn, Adolfo, Bortoluzzi, Adailton J., Noble, Christopher J., Hanson, Graeme R., Stranger, Robert, Jayaratne, Vidura, Cavigliasso, German, Gahan, Lawrence R., Schenk, Gerhard, Nascimento, Otaciro R., Cavalett, Angelica, Bortolotto, Tiago, Razzera, Guilherme, Terenzi, Hernan, Neves, Ademir and Riley, Mark J. (2012). Spectroscopic and catalytic characterization of a functional (FeFeII)-Fe-III biomimetic for the active site of uteroferrin and protein cleavage. Inorganic Chemistry, 51 (4), 2065-2078. doi: 10.1021/ic201711p |
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2012 Journal Article Phosphate-bound structure of an organophosphate-degrading enzyme from Agrobacterium radiobacterEly, Fernanda, Pedroso, Marcelo M., Gahan, Lawrence R., Ollis, David L., Guddat, Luke W. and Schenk, Gerhard (2012). Phosphate-bound structure of an organophosphate-degrading enzyme from Agrobacterium radiobacter. Journal of Inorganic Biochemistry, 106 (1), 19-22. doi: 10.1016/j.jinorgbio.2011.09.015 |
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2012 Journal Article 3-Mercapto-1,2,4-triazoles and N-acylated thiosemicarbazides as metallo-beta-lactamase inhibitorsFaridoon, Hussein, Waleed M., Vella, Peter, Ul Islam, Nazar, Ollis, David L., Schenk, Gerhard and McGeary, Ross P. (2012). 3-Mercapto-1,2,4-triazoles and N-acylated thiosemicarbazides as metallo-beta-lactamase inhibitors. Bioorganic and Medicinal Chemistry Letters, 22 (1), 380-386. doi: 10.1016/j.bmcl.2011.10.116 |
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2012 Journal Article The role of Zn-OR and Zn-OH nucleophiles and the influence of para-substituents in the reactions of binuclear phosphatase mimeticsDaumann, Lena J., Dalle, Kristian E., Schenk, Gerhard, McGeary, Ross P., Bernhardt, Paul V., Ollis, David L. and Gahan, Lawrence R. (2012). The role of Zn-OR and Zn-OH nucleophiles and the influence of para-substituents in the reactions of binuclear phosphatase mimetics. Dalton Transactions, 41 (6), 1695-1708. doi: 10.1039/c1dt11187f |
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2011 Journal Article Directed evolution combined with rational design increases activity of GpdQ toward a non-physiological substrate and alters the oligomeric structure of the enzymeYip, Sylvia H-C., Foo, Jee-Loon, Schenk, Gerhard, Gahan, Lawrence R., Carr, Paul D. and Ollis, David L. (2011). Directed evolution combined with rational design increases activity of GpdQ toward a non-physiological substrate and alters the oligomeric structure of the enzyme. Protein Engineering Design and Selection, 24 (12), 861-872. doi: 10.1093/protein/gzr048 |
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2011 Journal Article Synthesis and kinetic testing of new inhibitors for a metallo-beta-lactamase from Klebsiella pneumonia and Pseudomonas aeruginosaMohamed, Mosaad S., Hussein, Waleed M., McGeary, Ross P., Vella, Peter, Schenk, Gerhard and Abd El-hameed, Rania H. (2011). Synthesis and kinetic testing of new inhibitors for a metallo-beta-lactamase from Klebsiella pneumonia and Pseudomonas aeruginosa. European Journal of Medicinal Chemistry, 46 (12), 6075-6082. doi: 10.1016/j.ejmech.2011.10.030 |
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2011 Journal Article The identification of new metallo-beta-lactamase inhibitor leads from fragment-based screeningVella, Peter, Hussein, Waleed M., Leung, Eleanor W. W., Clayton, Daniel, Ollis, David L., Schenk, Gerhard and McGeary, Ross P. (2011). The identification of new metallo-beta-lactamase inhibitor leads from fragment-based screening. Bioorganic and Medicinal Chemistry Letters, 21 (11), 3282-3285. doi: 10.1016/j.bmcl.2011.04.027 |
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2011 Journal Article Electronic and geometric structures of the organophosphate-degrading enzyme from Agrobacterium radiobacter (OpdA)Ely, Fernanda, Hadler, Kieran S., Mitic, Natasa, Gahan, Lawrence R., Ollis, David L., Plugis, Nicholas M., Russo, Marie T., Larrabee, James A. and Schenk, Gerhard (2011). Electronic and geometric structures of the organophosphate-degrading enzyme from Agrobacterium radiobacter (OpdA). Journal of Biological Inorganic Chemistry, 16 (5), 777-787. doi: 10.1007/s00775-011-0779-6 |
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2011 Journal Article Synthesis, modelling and kinetic assays of potent inhibitors of purple acid phosphataseMohd-Pahmi, Siti Hajar, Hussein, Waleed M., Schenk, Gerhard and McGeary, Ross P. (2011). Synthesis, modelling and kinetic assays of potent inhibitors of purple acid phosphatase. Bioorganic and Medicinal Chemistry Letters, 21 (10), 3092-3094. doi: 10.1016/j.bmcl.2011.03.024 |
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2011 Journal Article A potentially polymerizable heterodinuclear FeIIIZnII purple acid phosphatase mimic. Synthesis, characterization, and phosphate ester hydrolysis studiesZee, Yoke Leng Michelle, Gahan, Lawrence R. and Schenk, Gerhard (2011). A potentially polymerizable heterodinuclear FeIIIZnII purple acid phosphatase mimic. Synthesis, characterization, and phosphate ester hydrolysis studies. Australian Journal of Chemistry, 64 (3), 258-264. doi: 10.1071/CH10424 |
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2011 Journal Article Using a genetically encoded fluorescent amino acid as a site-specific probe to detect binding of low-molecular weight compounds.Ugwumba, Isaac N., Ozawa, Kiyoshi, de la Cruz, Laura, Xu, Zhi-Qiang, Herlt, Anthony J., Hadler, Kieran S., Coppin, Chris, Brown, Susan E., Schenk, Gerhard, Oakeshott, John G. and Otting, Gottfried (2011). Using a genetically encoded fluorescent amino acid as a site-specific probe to detect binding of low-molecular weight compounds.. ASSAY and Drug Development Technologies, 9 (1), 50-57. doi: 10.1089/adt.2010.0306 |
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2011 Journal Article Improving a natural enzyme activity through incorporation of unnatural amino acidsUgwumba, Isaac N., Ozawa, Kiyoshi, Xu, Zhi-Qiang, Ely, Fernanda, Foo, Jee-Loon, Herlt, Anthony J., Coppin, Chris, Brown, Sue, Taylor, Matthew C., Ollis, David L., Mander, Lewis N., Schenk, Gerhard, Dixon, Nicholas E., Otting, Gottfried, Oakeshott, John G. and Jackson, Colin J. (2011). Improving a natural enzyme activity through incorporation of unnatural amino acids. Journal of The American Chemical Society, 133 (2), 326-333. doi: 10.1021/ja106416g |
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2011 Journal Article Phosphate ester cleavage promoted by a tetrameric iron(III) complexKantacha, A, Buchholz, R, Smith, SJ, Schenk, G and Gahan, LR (2011). Phosphate ester cleavage promoted by a tetrameric iron(III) complex. Journal of Biological Inorganic Chemistry, 16 (1), 25-32. doi: 10.1007/s00775-010-0696-0 |
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2010 Journal Article Electronic structure and spectro-structural correlations of FeIIIZnII biomimetics for purple acid phosphatases: Relevance to DNA cleavage and cytotoxic activityPeralta, RA, Bortoluzzi, AJ, de Souza, B, Jovito, R, Xavier, FR, Couto, RAA, Casellato, A, Nome, F, Dick, A, Gahan, LR, Schenk, G, Hanson, GR, de Paula, FCS, Pereira-Maia, EC, Machado, SD, Severino, PC, Pich, C, Bortolotto, T, Terenzi, H, Castellano, EE, Neves, A and Riley, MJ (2010). Electronic structure and spectro-structural correlations of FeIIIZnII biomimetics for purple acid phosphatases: Relevance to DNA cleavage and cytotoxic activity. Inorganic Chemistry, 49 (24), 11421-11438. doi: 10.1021/ic101433t |
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2010 Journal Article Tartrate-resistant acid phosphatase: A target for anti-osteoporotic chemotherapeuticsVella, Peter, McGeary, Ross P., Gahan, Lawrence R. and Schenk, Gerhard (2010). Tartrate-resistant acid phosphatase: A target for anti-osteoporotic chemotherapeutics. Current Enzyme Inhibition, 6 (3), 118-129. doi: 10.2174/157340810793384133 |
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2010 Journal Article The organophosphate-degrading enzyme from Agrobacterium radiobacter displays mechanistic flexibility for catalysisEly, Fernanda, Hadler, Kieran S., Gahan, Lawrence R., Guddat, Luke W., Ollis, David L. and Schenk, Gerhard (2010). The organophosphate-degrading enzyme from Agrobacterium radiobacter displays mechanistic flexibility for catalysis. Biochemical Journal, 432 (3), 565-573. doi: 10.1042/BJ20101054 |
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2010 Journal Article Paradigm shift for the purple acid phosphatase reaction mechanismSchenk, Gerhard (2010). Paradigm shift for the purple acid phosphatase reaction mechanism. Chemistry Australia, 77 (7), 9-9. |
