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2019 Conference Publication Structural and Biochemical Analysis of Plant TIR NAD plus Cleavage ActivityBurdett, H., Rank, M. X., Chen, J., Zhang, X., Shi, Y., Ve, T., Dodds, P. N. and Kobe, B. (2019). Structural and Biochemical Analysis of Plant TIR NAD plus Cleavage Activity. 18th Congress of International Society for Molecular Plant Microbe Interactions (IS-MPMI), Glasgow, Scotland, 14-18 July, 2019. St. Paul, MN, United States: American Phytopathological Society. doi: 10.1094/MPMI-32-10-S1.213 |
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2019 Conference Publication Animal TIR domains inform the molecular and structural basis of signaling by plant NLR TIR domainsKobe, B., Burdett, H., Zhang, X., Chen, J., Rank, M. X., Horsefield, S., Manik, M. K., Shi, Y., Qi, T., Dry, I. B., Williams, S. J., Staskawicz, B. J., Ve, T. and Dodds, P. N. (2019). Animal TIR domains inform the molecular and structural basis of signaling by plant NLR TIR domains. 18th Congress of International Society for Molecular Plant Microbe Interactions (IS-MPMI), Glasgow, Scotland, 14-18 July, 2019. St. Paul, MN, United States: American Phytopathological Society. doi: 10.1094/MPMI-32-10-S1.1 |
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2019 Conference Publication Interaction and structural study between plant TIR-containing NLRs and EDS1 immune regulatory complexRank, M. X., Kobe, B., Burdett, H., Horsefield, S., Manik, M. K., Zhang, X. and Shi, Y. (2019). Interaction and structural study between plant TIR-containing NLRs and EDS1 immune regulatory complex. 18th Congress of International Society for Molecular Plant Microbe Interactions (IS-MPMI), Glasgow, Scotland, 14-18 July, 2019. St. Paul, MN, United States: American Phytopathological Society. doi: 10.1094/MPMI-32-10-S1.1 |
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2019 Journal Article Handling of nutrient copper in the bacterial envelopeStewart, Louisa J., Thaqi, Denis, Kobe, Bostjan, McEwan, Alastair G., Waldron, Kevin J. and Djoko, Karrera Y. (2019). Handling of nutrient copper in the bacterial envelope. Metallomics, 11 (1), 50-63. doi: 10.1039/c8mt00218e |
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2019 Conference Publication Self-association and an intact NADase active site are required for plant TIR domain immune signalingChen, J., Zhang, X., Burdett, H., Rank, M. X., Ve, T., Rathjen, J., Kobe, B. and Dodds, P. N. (2019). Self-association and an intact NADase active site are required for plant TIR domain immune signaling. 18th Congress of International Society for Molecular Plant Microbe Interactions (IS-MPMI), Glasgow, Scotland, 14-18 July, 2019. St. Paul, MN, United States: American Phytopathological Society. doi: 10.1094/MPMI-32-10-S1.1 |
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2018 Journal Article Pathological mutations differentially affect the self-assembly and polymerisation of the innate immune system signalling adaptor molecule MyD88O'Carroll, Ailís, Chauvin, Brieuc, Brown, James W.P., Meagher, Ava, Coyle, Joanne, Schill, Jurgen, Bhumkhar, Akshay, Hunter, Dominic J.B., Ve, Thomas, Kobe, Bostjan, Sierecki, Emma and Gambin, Yann (2018). Pathological mutations differentially affect the self-assembly and polymerisation of the innate immune system signalling adaptor molecule MyD88. BMC Biology, 16 (149) 149, 149. doi: 10.1186/s12915-018-0611-7 |
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2018 Journal Article Megahertz serial crystallographyWiedorn, Max O., Oberthür, Dominik, Bean, Richard, Schubert, Robin, Werner, Nadine, Abbey, Brian, Aepfelbacher, Martin, Adriano, Luigi, Allahgholi, Aschkan, Al-Qudami, Nasser, Andreasson, Jakob, Aplin, Steve, Awel, Salah, Ayyer, Kartik, Bajt, Saša, Barák, Imrich, Bari, Sadia, Bielecki, Johan, Botha, Sabine, Boukhelef, Djelloul, Brehm, Wolfgang, Brockhauser, Sandor, Cheviakov, Igor, Coleman, Matthew A., Cruz-Mazo, Francisco, Danilevski, Cyril, Darmanin, Connie, Doak, R. Bruce, Domaracky, Martin ... Barty, Anton (2018). Megahertz serial crystallography. Nature Communications, 9 (1) 4025, 4025. doi: 10.1038/s41467-018-06156-7 |
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2018 Journal Article Antifungal benzo[b]thiophene 1,1-dioxide IMPDH inhibitors exhibit pan-assay interference (PAINS) profilesKummari, Lalith K., Butler, Mark S., Furlong, Emily, Blundell, Ross, Nouwens, Amanda, Silva, Alberto B., Kappler, Ulrike, Fraser, James A., Kobe, Bostjan, Cooper, Matthew A. and Robertson, Avril A.B. (2018). Antifungal benzo[b]thiophene 1,1-dioxide IMPDH inhibitors exhibit pan-assay interference (PAINS) profiles. Bioorganic and Medicinal Chemistry, 26 (20), 5408-5419. doi: 10.1016/j.bmc.2018.09.004 |
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2018 Journal Article Structural characterisation of the HT3 motif of the polyhistidine triad protein D from Streptococcus pneumoniaeLuo, Zhenyao, Pederick, Victoria G., Paton, James C., McDevitt, Christopher A. and Kobe, Bostjan (2018). Structural characterisation of the HT3 motif of the polyhistidine triad protein D from Streptococcus pneumoniae. FEBS letters, 592 (13), 2341-2350. doi: 10.1002/1873-3468.13122 |
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2018 Journal Article Regulation of signaling by cooperative assembly formation in mammalian innate immunity signalosomes by molecular mimicsNanson, Jeffrey D., Rahaman, Habibur, Ve, Thomas and Kobe, Bostjan (2018). Regulation of signaling by cooperative assembly formation in mammalian innate immunity signalosomes by molecular mimics. Seminars in Cell and Developmental Biology, 99, 96-114. doi: 10.1016/j.semcdb.2018.05.002 |
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2018 Journal Article Crystal structure and insights into the oligomeric state of UDP-glucose pyrophosphorylase from sugarcaneCotrim, Camila A., Soares, Jose Sergio M., Kobe, Bostjan and Menossi, Marcelo (2018). Crystal structure and insights into the oligomeric state of UDP-glucose pyrophosphorylase from sugarcane. PloS One, 13 (3) 0193667, 1-13. doi: 10.1371/journal.pone.0193667 |
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2018 Journal Article An optimized SEC-SAXS system enabling high X-ray dose for rapid SAXS assessment with correlated UV measurements for biomolecular structure analysisRyan, Timothy M., Trewhella, Jill, Murphy, James M., Keown, Jeremy R., Casey, Lachlan, Pearce, F. Grant, Goldstone, David C., Chen, Kelan, Luo, Zhenyao, Kobe, Bostjan, McDevitt, Christopher A., Watkin, Serena A., Hawley, Adrian M., Mudie, Stephen T., Boban, Vesna Samardzic and Kirby, Nigel (2018). An optimized SEC-SAXS system enabling high X-ray dose for rapid SAXS assessment with correlated UV measurements for biomolecular structure analysis. Journal of Applied Crystallography, 51 (1), 97-111. doi: 10.1107/S1600576717017101 |
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2018 Journal Article Structural and functional characterization of a cross-reactive dengue virus neutralizing antibody that recognizes a cryptic epitopeLi, Jie, Watterson, Daniel, Chang, Chiung-Wen, Che, Xiao-Yan, Li, Xiao-Quan, Ericsson, Daniel J., Qiu, Li-Wen, Cai, Jian-Piao, Chen, Jing, Fry, Scott R., Cheung, Stacey T. M., Cooper, Matthew A., Young, Paul R. and Kobe, Bostjan (2018). Structural and functional characterization of a cross-reactive dengue virus neutralizing antibody that recognizes a cryptic epitope. Structure, 26 (1), 51-59. doi: 10.1016/j.str.2017.11.017 |
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2018 Conference Publication Crystallographic and calorimetric studies with nuclear transport of DNA repair proteinsde Mattos Fontes, Marcos Roberto, de Barros, Andrea, Bernardes, Natalia, Takeda, Agnes, Dreyer, Thiago, Bertolini, Maria Celia and Kobe, Bostjan (2018). Crystallographic and calorimetric studies with nuclear transport of DNA repair proteins. Hoboken, NJ, United States: Wiley-Blackwell Publishing. doi: 10.1107/S2053273318092434 |
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2017 Journal Article DNA mismatch repair proteins MLH1 and PMS2 can be imported to the nucleus by a classical nuclear import pathwayde Barros, Andrea C, Takeda, Agnes A S, Dreyer, Thiago R, Velazquez-Campoy, Adrian, Kobe, Boštjan and Fontes, Marcos R M (2017). DNA mismatch repair proteins MLH1 and PMS2 can be imported to the nucleus by a classical nuclear import pathway. Biochimie, 146, 87-96. doi: 10.1016/j.biochi.2017.11.013 |
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2017 Journal Article Crystal structure of the Melampsora lini effector AvrP reveals insights into a possible nuclear function and recognition by the flax disease resistance protein PZhang, Xiaoxiao, Farah, Nadya, Rolston, Laura, Ericsson, Daniel J., Catanzariti, Ann-Maree, Bernoux, Maud, Ve, Thomas, Bendak, Katerina, Chen, Chunhong, Mackay, Joel P., Lawrence, Gregory J., Hardham, Adrienne, Ellis, Jeffrey G., Williams, Simon J., Dodds, Peter N., Jones, David A. and Kobe, Bostjan (2017). Crystal structure of the Melampsora lini effector AvrP reveals insights into a possible nuclear function and recognition by the flax disease resistance protein P. Molecular Plant Pathology, 19 (5), 1196-1209. doi: 10.1111/mpp.12597 |
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2017 Journal Article Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signalingHughes, Mark M., Lavrencic, Peter, Coll, Rebecca C., Ve, Thomas, Ryan, Dylan G., Williams, Niamh C., Menon, Deepthi, Mansell, Ashley, Board, Philip G., Mobli, Mehdi, Kobe, Bostjan and O'Neill, Luke A. J. (2017). Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling. Proceedings of the National Academy of Sciences, 114 (32), E6480-E6489. doi: 10.1073/pnas.1701868114 |
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2017 Journal Article Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signalingVe, Thomas, Vajjhala, Parimala, Hedger, Andrew, Croll, Tristan, DiMaio, Frank, Horsefield, Shane, Yu, Xiong, Lavrencic, Peter, Hassan, Zahid, Morgan, Garry P., Mansell, Ashley, Mobli, Mehdi, O'Carroll, Ailis, Chauvin, Brieuc, Gambin, Yann, Sierecki, Emma, Landsberg, Michael J., Stacey, Katryn, Egelman, Edward H. and Kobe, Bostjan (2017). Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling. Nature Structural and Molecular Biology, 24 (9), 743-751. doi: 10.1038/nsmb.3444 |
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2017 Journal Article Emerging insights into the functions of pathogenesis-related protein 1Breen, Susan, Williams, Simon J., Outram, Megan, Kobe, Bostjan and Solomon, Peter S. (2017). Emerging insights into the functions of pathogenesis-related protein 1. Trends in Plant Science, 22 (10), 871-879. doi: 10.1016/j.tplants.2017.06.013 |
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2017 Journal Article Cryptococcus neoformans ADS lyase is an enzyme essential for virulence whose crystal structure reveals features exploitable in antifungal drug designChitty, Jessica L., Blake, Kirsten L., Blundell, Ross D., Koh, Y. Q. Andre E., Thompson, Merinda, Robertson, Avril A. B., Butler, Mark S., Cooper, Matthew A., Kappler, Ulrike, Williams, Simon J., Kobe, Bostjan and Fraser, James A. (2017). Cryptococcus neoformans ADS lyase is an enzyme essential for virulence whose crystal structure reveals features exploitable in antifungal drug design. Journal of Biological Chemistry, 292 (28), 11829-11839. doi: 10.1074/jbc.M117.787994 |
