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2017 Conference Publication Prion - like protein polymerisation underlies signal transduction in innate immunity: the emergence of a universal mechanism ?O'Carroll, Allis, Ve, Thomas, Moustaqil, Mehdi, Giles, Nichole, Bhumkar, Akshay, Hunter, Dominic, Kobe, Bostjan, Sierecki, Emma and Gambin, Yann (2017). Prion - like protein polymerisation underlies signal transduction in innate immunity: the emergence of a universal mechanism ?. Annual Meeting of the American-Society-for-Pharmacology-and-Experimental-Therapeutics (ASPET) at Experimental Biology Meeting, Chicago, IL USA, Apr 22-26, 2017. Bethesda, MD, USA: Federation of American Societies for Experimental Biology. |
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2016 Journal Article Structure and function of the TIR domain from the grape NLR protein RPV1Williams, Simon J., Yin, Ling, Foley, Gabriel, Casey, Lachlan W., Outram, Megan A., Ericsson, Daniel J., Lu, Jiang, Boden, Mikael, Dry, Ian B. and Kobe, Bostjan (2016). Structure and function of the TIR domain from the grape NLR protein RPV1. Frontiers in Plant Science, 7 (DECEMBER2016) 1850, 1850. doi: 10.3389/fpls.2016.01850 |
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2016 Journal Article The CC domain structure from the wheat stem rust resistance protein Sr33 challenges paradigms for dimerization in plant NLR proteinsCasey, Lachlan W., Lavrencic, Peter, Bentham, Adam R., Cesari, Stella, Ericsson, Daniel J., Croll, Tristan, Turk, Dušan, Anderson, Peter A., Mark, Alan E., Dodds, Peter N., Mobli, Mehdi, Kobe, Bostjan and Williams, Simon J. (2016). The CC domain structure from the wheat stem rust resistance protein Sr33 challenges paradigms for dimerization in plant NLR proteins. Proceedings of the National Academy of Sciences, 113 (45), 12856-12861. doi: 10.1073/pnas.1609922113 |
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2016 Journal Article Prediction of kinase-specific phosphorylation sites through an integrative model of protein context and sequencePatrick, Ralph, Horin, Coralie, Kobe, Bostjan, Cao, Kim-Anh Le and Bodén, Mikael (2016). Prediction of kinase-specific phosphorylation sites through an integrative model of protein context and sequence. Biochimica et Biophysica Acta, 1864 (11), 1599-1608. doi: 10.1016/j.bbapap.2016.08.001 |
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2016 Journal Article Wheat PR-1 proteins are targeted by necrotrophic pathogen effector proteinsBreen, Susan, Williams, Simon J., Winterberg, Britta, Kobe, Bostjan and Solomon, Peter S. (2016). Wheat PR-1 proteins are targeted by necrotrophic pathogen effector proteins. Plant Journal, 88 (1), 13-25. doi: 10.1111/tpj.13228 |
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2016 Journal Article Disruption of de novo adenosine triphosphate (ATP) biosynthesis abolishes virulence in Cryptococcus neoformansBlundell, Ross D., Williams, Simon J., Arras, Samantha D. M., Chitty, Jessica L., Blake, Kirsten L., Ericsson, Daniel J., Tibrewal, Nidhi, Rohr, Jurgen, Koh, Y. Q. Andre, Kappler, Ulrike, Robertson, Avril A. B., Butler, Mark S., Cooper, Matthew A., Kobe, Bostjan and Fraser, James A. (2016). Disruption of de novo adenosine triphosphate (ATP) biosynthesis abolishes virulence in Cryptococcus neoformans. ACS Infectious Diseases, 2 (9), 651-663. doi: 10.1021/acsinfecdis.6b00121 |
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2016 Conference Publication Structural characterization of dihydroorotase domain in yeast CAD multienzymeJeon, Yujung, Ross, Ian, Landsberg, Michael, Schultz, Ben, Hankamer, Ben and Kobe, Bostjan (2016). Structural characterization of dihydroorotase domain in yeast CAD multienzyme. 30th European Crystallographic Meeting, Basel, Switzerland, 28 August - 1 September 2016. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1107/s2053273316096807 |
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2016 Journal Article Animal NLRs provide structural insights into plant NLR functionBentham, Adam, Burdett, Hayden, Anderson, Peter A., Williams, Simon J. and Kobe, Bostjan (2016). Animal NLRs provide structural insights into plant NLR function. Annals of Botany, 119 (5), 689-702. doi: 10.1093/aob/mcw171 |
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2016 Journal Article Multiple domain associations within the Arabidopsis immune receptor RPP1 regulate the activation of programmed cell deathSchreiber, Karl J., Bentham, Adam, Williams, Simon J., Kobe, Bostjan and Staskawicz, Brian J. (2016). Multiple domain associations within the Arabidopsis immune receptor RPP1 regulate the activation of programmed cell death. PLoS Pathogens, 12 (7) e1005769, e1005769. doi: 10.1371/journal.ppat.1005769 |
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2016 Journal Article Structural basis of thiol-based regulation of formaldehyde detoxification in H. influenzae by a MerR regulator with no sensor regionCouñago, Rafael M., Chen, Nathan H., Chang, Chiung-Wen, Djoko, Karrera Y., McEwan, Alastair G. and Kobe, Bostjan (2016). Structural basis of thiol-based regulation of formaldehyde detoxification in H. influenzae by a MerR regulator with no sensor region. Nucleic Acids Research, 44 (14), 6981-6993. doi: 10.1093/nar/gkw543 |
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2016 Journal Article Structural and calorimetric studies demonstrate that Xeroderma pigmentosum type G (XPG) can be imported to the nucleus by a classical nuclear import pathway via a monopartite NLS sequencede Barros, Andrea C., Takeda, Agnes A.S., Dreyer, Thiago R., Velazquez-Campoy, Adrian, Kobe, Bostjan and Fontes, Marcos R.M. (2016). Structural and calorimetric studies demonstrate that Xeroderma pigmentosum type G (XPG) can be imported to the nucleus by a classical nuclear import pathway via a monopartite NLS sequence. Journal of Molecular Biology, 428 (10), 2120-2131. doi: 10.1016/j.jmb.2016.01.019 |
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2016 Journal Article Structural biology and regulation of protein import into the nucleusChristie, Mary, Chang, Chiung-Wen, Róna, Gergely, Smith, Kate M., Stewart, Alastair G, Takeda, Agnes A. S., Fontes, Marcos R. M., Stewart, Murray, Vértessy, Beáta G., Forwood, Jade K. and Kobe, Bostjan (2016). Structural biology and regulation of protein import into the nucleus. Journal of Molecular Biology, 428 (10), 2060-2090. doi: 10.1016/j.jmb.2015.10.023 |
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2016 Journal Article Distinctive Conformation of Minor Site-Specific Nuclear Localization Signals Bound to Importin-alpha (vol 14, pg 1144, 2013)Chang, Chiung-Wen, Counago, Rafael Miguez, Williams, Simon J., Boden, Mikael and Kobe, Bostjan (2016). Distinctive Conformation of Minor Site-Specific Nuclear Localization Signals Bound to Importin-alpha (vol 14, pg 1144, 2013). Traffic, 17 (6), 704-704. doi: 10.1111/tra.12395 |
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2016 Journal Article TRIF-dependent TLR signaling, its functions in host defense and inflammation, and its potential as a therapeutic targetUllah, M. Obayed, Sweet, Matthew J., Mansell, Ashley, Kellie, Stuart and Kobe, Bostjan (2016). TRIF-dependent TLR signaling, its functions in host defense and inflammation, and its potential as a therapeutic target. Journal of Leukocyte Biology, 100 (1), 27-45. doi: 10.1189/jlb.2RI1115-531R |
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2016 Journal Article Protein crystal screening and characterization for serial femtosecond nanocrystallographyDarmanin, Connie, Strachan, Jamie, Adda, Christopher G., Ve, Thomas, Kobe, Bostjan and Abbey, Brian (2016). Protein crystal screening and characterization for serial femtosecond nanocrystallography. Scientific Reports, 6 (1) 25345, 25345.1-25345.8. doi: 10.1038/srep25345 |
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2016 Conference Publication Prion ‐ like protein polymerisation underlies signal transduction in innate immunity: the emergence of a universal mechanism ?O'Carroll, Ailis, Ve, Thomas, Lau, Derrick, Giles, Nichole, Moustaqil, Mehdi, Bhumkar, Akshay, Hunter, Dominic, Kobe, Bostjan, Boecking, Till, Sierecki, Emma and Gambin, Yann (2016). Prion ‐ like protein polymerisation underlies signal transduction in innate immunity: the emergence of a universal mechanism ?. Experimental Biology 2016 Meeting, San Diego, CA United States, 1-5 April 2016. Hoboken, NJ United States: John Wiley & Sons. doi: 10.1096/fasebj.30.1_supplement.814.3 |
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2016 Journal Article Production of small cysteine-rich effector proteins in Escherichia coli for structural and functional studiesZhang, Xiaoxiao, Nguyen, Neal, Breen, Susan, Outram, Megan A., Dodds, Peter N., Kobe, Bostjan, Solomon, Peter S. and Williams, Simon J. (2016). Production of small cysteine-rich effector proteins in Escherichia coli for structural and functional studies. Molecular Plant Pathology, 18 (1), 141-151. doi: 10.1111/mpp.12385 |
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2016 Journal Article Crystal structure of Mycobacterium tuberculosis ketol-acid reductoisomerase at 1.0 Å resolution: A potential target for anti-tuberculosis drug discoveryYou, Lv, Kandale, Ajit, Wun, Shun Jie, McGeary, Ross P., Williams, Simon J., Kobe, Bostjan, Sieber, Volker, Schembri, Mark A., Schenk, Gerhard and Guddat, Luke W. (2016). Crystal structure of Mycobacterium tuberculosis ketol-acid reductoisomerase at 1.0 Å resolution: A potential target for anti-tuberculosis drug discovery. Febs Journal, 283 (7), 1184-1196. doi: 10.1111/febs.13672 |
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2016 Journal Article Recombinant and epitope-based vaccines on the road to the market and implications for vaccine design and productionOyarzun, Patricio and Kobe, Bostjan (2016). Recombinant and epitope-based vaccines on the road to the market and implications for vaccine design and production. Human Vaccines and Immunotherapeutics, 12 (3), 763-767. doi: 10.1080/21645515.2015.1094595 |
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2016 Journal Article Comparative analysis of the flax immune receptors L6 and L7 suggests an equilibrium-based switch activation modelBernoux, Maud, Burdett, Hayden, Williams, Simon J., Zhang, Xiaoxiao, Chen, Chunhong, Newell, Kim, Lawrence, Gregory J., Kobe, Bostjan, Ellis, Jeffrey G., Anderson, Peter A. and Dodds, Peter N. (2016). Comparative analysis of the flax immune receptors L6 and L7 suggests an equilibrium-based switch activation model. Plant Cell, 28 (1), 146-159. doi: 10.1105/tpc.15.00303 |
