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Dr Meihua Yu
Dr

Meihua Yu

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Overview

Background

Dr Meihua Yu is a NHMRC Early Career Fellow in Prof Ian Frazer’s lab, University Queensland Diamantina Institute (UQDI). She received her PhD degree in Biomedical Engineering from the Australian Institute for Bioengineering and Nanotechnology (AIBN), UQ in 2014, under the guidance of Prof Chengzhong (Michael) Yu.

Dr Yu’s current research focuses on developing nanotechnology vaccines for the treatment of diseases and cancers. She has extensive experience in development of sophisticated nanotechnology with controllable architecture, composition and functionality, and delivery of anticancer drugs, genetic molecules and therapeutic proteins for enhanced cancer treatment.

Dr Yu was awarded two prestigious fellowships (Advance Queensland Research Fellow in 2016 and a NHMRC Early Career Fellow in 2017). She has secured over $1.2 million in funding from internal and external funding agencies (UQ Early Career grant, ARC Linkage, Queensland Biomedical Assistance Fund). In recognition of her research achievements, she was awarded the prestigious 2017 UQ Foundation Research Excellence Award, the 2017 Monash Engineering Women Leader Award and the 2018 Frazer Family Foundation Travel Award.

Dr Yu has published 59 papers in international top refereed journals such as Journal of the American Chemical Society, Small, Chemical Communications, Nanoscale, and so on. Her innovative research has led to three patents. She has actively explored the potential of these discoveries in commercial translation by engaging with industry partners (e.g. Ridley, Ellume, Jingang Medicines).

Dr Yu is an invited reviewer for national grants (e.g. ARC DP and ARC DECRA) and 19 journals including Vaccines, ACS Omega, Biomaterials Science and Journal of Hazardous Materials.

Availability

Dr Meihua Yu is:
Available for supervision

Qualifications

  • Doctor of Philosophy, The University of Queensland

Works

Search Professor Meihua Yu’s works on UQ eSpace

95 works between 2006 and 2026

1 - 20 of 95 works

2026

Journal Article

Enzyme-Triggered Self-Immobilization of an NIR Prodrug for Tumor-Selective Cancer Vaccination

Li, Yuyao, Ren, Hongze, Feng, Jiayi, Shan, Xiaochuan, Zhang, Chaoying, Nan, Jin, Tang, Zhengqi, Ding, Xueqin, Yu, Meihua, Xie, Hexin and Chen, Yu (2026). Enzyme-Triggered Self-Immobilization of an NIR Prodrug for Tumor-Selective Cancer Vaccination. Journal of the American Chemical Society, 148 (15), 15655-15671. doi: 10.1021/jacs.5c20321

Enzyme-Triggered Self-Immobilization of an NIR Prodrug for Tumor-Selective Cancer Vaccination

2026

Journal Article

Hierarchically collapsible nanoactuator modulates mitochondrial ferroptosis-bioenergetic homeostasis cascade to decouple ischemic stroke

Sun, Guangjie, Dong, Yize, Wang, Ying, Su, Yihong, Chen, Jiajun, Deng, Jiali, Luo, Lan, Cao, Xinyue, Lu, Weiping, Chen, Kai, Yu, Meihua, Xie, Yujie, Huang, Bingcang and Chen, Yu (2026). Hierarchically collapsible nanoactuator modulates mitochondrial ferroptosis-bioenergetic homeostasis cascade to decouple ischemic stroke. Cell reports. Medicine, 7 (3) 102640, 102640-3. doi: 10.1016/j.xcrm.2026.102640

Hierarchically collapsible nanoactuator modulates mitochondrial ferroptosis-bioenergetic homeostasis cascade to decouple ischemic stroke

2026

Journal Article

NIR-Actuated Morphodynamic 2D Nanopatches for Interface-Programmed Immunoactivation and Tumor Regression

Wu, Ye, Jia, Wencong, Xia, Tianlai, Liao, Jing, He, Wenjin, Wang, Huijing, Yang, Wei, Dai, Xinyue, Feng, Wei, O'reilly, Rachel K., Tong, Zaizai, Yu, Meihua, Xie, Yujie and Chen, Yu (2026). NIR-Actuated Morphodynamic 2D Nanopatches for Interface-Programmed Immunoactivation and Tumor Regression. Journal of the American Chemical Society, 148 (3) PMID 7503056, 2902-2919. doi: 10.1021/jacs.5c11219

NIR-Actuated Morphodynamic 2D Nanopatches for Interface-Programmed Immunoactivation and Tumor Regression

2026

Journal Article

Self‐Assembled Metal‐Polyphenol Colchicine Nanoparticles Targeting Oxidative Stress and Inflammation for Treatment of Atherosclerosis

Centurion, Franco, Zhang, Xiuwen, Dai, Chen, Kundi, Varun, Kumar, Priyank, Yu, Meihua, Appadoo, Dominique, Rawal, Aditya, Misra, Ashish, Patel, Sanjay, Chen, Yu and Gu, Zi (2026). Self‐Assembled Metal‐Polyphenol Colchicine Nanoparticles Targeting Oxidative Stress and Inflammation for Treatment of Atherosclerosis. Angewandte Chemie, 138 (7) e14547. doi: 10.1002/ange.202514547

Self‐Assembled Metal‐Polyphenol Colchicine Nanoparticles Targeting Oxidative Stress and Inflammation for Treatment of Atherosclerosis

2026

Journal Article

Self-Assembled Metal-Polyphenol Colchicine Nanoparticles Targeting Oxidative Stress and Inflammation for Treatment of Atherosclerosis

Centurion, Franco, Zhang, Xiuwen, Dai, Chen, Kundi, Varun, Kumar, Priyank, Yu, Meihua, Appadoo, Dominique, Rawal, Aditya, Misra, Ashish, Patel, Sanjay, Chen, Yu and Gu, Zi (2026). Self-Assembled Metal-Polyphenol Colchicine Nanoparticles Targeting Oxidative Stress and Inflammation for Treatment of Atherosclerosis. Angewandte Chemie-International Edition, 65 (7) PMID 370543. doi: 10.1002/anie.202514547

Self-Assembled Metal-Polyphenol Colchicine Nanoparticles Targeting Oxidative Stress and Inflammation for Treatment of Atherosclerosis

2025

Journal Article

Gadolinium-ceria hybrid system enables synergistic alleviation of oxidative stress and metabolic thrombo-inflammation for efficient ischemic stroke treatment

Nan, Jin, Xia, Chundongqiu, Zhang, Jingyi, Xie, Yujie, Shi, Shuyu, Yang, Wei, Yu, Meihua, Chen, Yu and Zhang, Jun (2025). Gadolinium-ceria hybrid system enables synergistic alleviation of oxidative stress and metabolic thrombo-inflammation for efficient ischemic stroke treatment. Biomaterials, 322 123379, 1-14. doi: 10.1016/j.biomaterials.2025.123379

Gadolinium-ceria hybrid system enables synergistic alleviation of oxidative stress and metabolic thrombo-inflammation for efficient ischemic stroke treatment

2025

Journal Article

Dual-locked polymeric STING nano-agonist/sonosensitizer augments spatiotemporally controlled cancer sono-immunotherapy

Jia, Yiwen, Jia, Wencong, Tang, Zhengqi, Wu, Ye, Yang, Wei, Ye, Weifan, Ren, Hongze, Xie, Yujie, Chen, Yu and Yu, Meihua (2025). Dual-locked polymeric STING nano-agonist/sonosensitizer augments spatiotemporally controlled cancer sono-immunotherapy. Angewandte Chemie (International Edition), 64 (44) e202514516, 1-15. doi: 10.1002/anie.202514516

Dual-locked polymeric STING nano-agonist/sonosensitizer augments spatiotemporally controlled cancer sono-immunotherapy

2025

Journal Article

Sono-destructive polymeric nanocapsules enable spatiotemporal orchestration of DC-T cell crosstalk in combined in situ vaccination and cytokine therapy

Jia, Wencong, Yang, Wei, Wu, Ye, Ren, Hongze, Jia, Yiwen, Ye, Weifan, Xie, Yujie, Chen, Yu and Yu, Meihua (2025). Sono-destructive polymeric nanocapsules enable spatiotemporal orchestration of DC-T cell crosstalk in combined in situ vaccination and cytokine therapy. Journal of the American Chemical Society, 147 (29), 25553-25570. doi: 10.1021/jacs.5c06120

Sono-destructive polymeric nanocapsules enable spatiotemporal orchestration of DC-T cell crosstalk in combined in situ vaccination and cytokine therapy

2025

Journal Article

Transdermal STING nano-agonists enhance multifaced functions of antigen-specific T cells triggered by sonodynamic cancer vaccination

Zhu, Anqi, Ren, Hongze, Li, Xiaolong, Yang, Wei, Han, Xiaoxia, Hou, Xiaodong, Zhang, Shen, Li, Shaoyue, Xie, Yujie, Yu, Meihua, Chen, Yu and Xu, Huixiong (2025). Transdermal STING nano-agonists enhance multifaced functions of antigen-specific T cells triggered by sonodynamic cancer vaccination. Nano Today, 61 102590. doi: 10.1016/j.nantod.2024.102590

Transdermal STING nano-agonists enhance multifaced functions of antigen-specific T cells triggered by sonodynamic cancer vaccination

2025

Journal Article

Advanced polymeric nanoparticles for cancer immunotherapy: materials engineering, immunotherapeutic mechanism and clinical translation

Jia, Wencong, Wu, Ye, Xie, Yujie, Yu, Meihua and Chen, Yu (2025). Advanced polymeric nanoparticles for cancer immunotherapy: materials engineering, immunotherapeutic mechanism and clinical translation. Advanced Materials, 37 (8) 2413603, 1-70. doi: 10.1002/adma.202413603

Advanced polymeric nanoparticles for cancer immunotherapy: materials engineering, immunotherapeutic mechanism and clinical translation

2025

Journal Article

One-dimensional nanosonosensitizer boosted multiple branches of immune responses against MHC-deficient immune-evasive urologic tumor

Yang, Wei, Di, Sichen, Yang, Zihuan, Cao, Jianwei, Fu, Qingqiao, Ren, Hongze, Cheng, Hui, Xie, Yujie, Jia, Wencong, Dai, Xinyue, Yu, Meihua, Chen, Yu and Cui, Xingang (2025). One-dimensional nanosonosensitizer boosted multiple branches of immune responses against MHC-deficient immune-evasive urologic tumor. Science Advances, 11 (5) eado7373, 1-23. doi: 10.1126/sciadv.ado7373

One-dimensional nanosonosensitizer boosted multiple branches of immune responses against MHC-deficient immune-evasive urologic tumor

2025

Journal Article

Catalytic biomaterials-activated in situ chemical reactions: Strategic modulation and enhanced disease treatment

Wang, Huijing, He, Wenjin, Liao, Jing, Wang, Shuangshuang, Dai, Xinyue, Yu, Meihua, Xie, Yujie and Chen, Yu (2025). Catalytic biomaterials-activated in situ chemical reactions: Strategic modulation and enhanced disease treatment. Advanced Materials, 37 (1) 2411967, 1-47. doi: 10.1002/adma.202411967

Catalytic biomaterials-activated in situ chemical reactions: Strategic modulation and enhanced disease treatment

2025

Journal Article

External stimuli-driven catalytic hydrogels for biomedical applications

Liao, Jing, Sun, Jijun, Jia, Wencong, He, Wenjin, Wang, Huijing, Huang, Weiyun, Wang, Yanmei, Yu, Meihua, Xie, Yujie and Chen, Yu (2025). External stimuli-driven catalytic hydrogels for biomedical applications. Chemical Communications, 61 (20), 3946-3966. doi: 10.1039/d4cc05256k

External stimuli-driven catalytic hydrogels for biomedical applications

2024

Journal Article

STING nanoagonist boosts antitumor immunity of therapeutic DNA vaccines

Jia, Wencong, Chandra, Janin, Teoh, Siok Min, Tolley, Lynn, Yang, Haotian, Tse, Brian W. C., Sokolowski, Kamil A., Liang, Xiaowen, Crawford, Darrell H. G., Steel, Jason C., Yu, Chengzhong, Roberts, Michael S., Frazer, Ian H., Chen, Yu, Wang, Haolu and Yu, Meihua (2024). STING nanoagonist boosts antitumor immunity of therapeutic DNA vaccines. Nano Letters, 24 (49), 1-10. doi: 10.1021/acs.nanolett.4c03846

STING nanoagonist boosts antitumor immunity of therapeutic DNA vaccines

2024

Journal Article

2D differential metallic immunopotentiators drive high diversity and capability of antigen-specific immunity against tumor

Ren, Hongze, Zhu, Anqi, Yang, Wei, Jia, Yiwen, Cheng, Hui, Wu, Ye, Tang, Zhengqi, Ye, Weifan, Sun, Mayu, Xie, Yujie, Yu, Meihua and Chen, Yu (2024). 2D differential metallic immunopotentiators drive high diversity and capability of antigen-specific immunity against tumor. Advanced Science, 11 (40) 2405729. doi: 10.1002/advs.202405729

2D differential metallic immunopotentiators drive high diversity and capability of antigen-specific immunity against tumor

2024

Journal Article

Immuno-nanocomplexes target heterogenous network of inflammation and immunity in myocardial infarction

Su, Fan, Ye, Weifan, Shen, Yi, Xie, Yujie, Zhang, Chong, Zhang, Qianyun, Tang, Zhengqi, Yu, Meihua, Chen, Yu and He, Bin (2024). Immuno-nanocomplexes target heterogenous network of inflammation and immunity in myocardial infarction. Advanced Science, 11 (36) 2402267. doi: 10.1002/advs.202402267

Immuno-nanocomplexes target heterogenous network of inflammation and immunity in myocardial infarction

2024

Journal Article

Immunogenic material vaccine for cancer immunotherapy by structure‐dependent immune cell trafficking and modulation

Yang, Wei, Cao, Jianwei, Di, Sichen, Chen, Wenjin, Cheng, Hui, Ren, Hongze, Xie, Yujie, Chen, Liang, Yu, Meihua, Chen, Yu and Cui, Xingang (2024). Immunogenic material vaccine for cancer immunotherapy by structure‐dependent immune cell trafficking and modulation. Advanced Materials, 36 (27) 2402580. doi: 10.1002/adma.202402580

Immunogenic material vaccine for cancer immunotherapy by structure‐dependent immune cell trafficking and modulation

2024

Journal Article

Engineering nanoprobes for magnetic resonance imaging of brain diseases

Zhang, Jingyi, Yu, Luodan, Yu, Meihua, Yu, Dehong, Chen, Yu and Zhang, Jun (2024). Engineering nanoprobes for magnetic resonance imaging of brain diseases. Chemical Engineering Journal, 481 148472, 1-29. doi: 10.1016/j.cej.2023.148472

Engineering nanoprobes for magnetic resonance imaging of brain diseases

2023

Journal Article

Regulation of antigen-specific immunotherapy with nanomaterials

Ye, Weifan, Jia, Yiwen, Ren, Hongze, Xie, Yujie, Yu, Meihua and Chen, Yu (2023). Regulation of antigen-specific immunotherapy with nanomaterials. Advanced NanoBiomed Research, 3 (12) 2300068, 1-21. doi: 10.1002/anbr.202300068

Regulation of antigen-specific immunotherapy with nanomaterials

2023

Journal Article

Engineering advanced nanomedicines against central nervous system diseases

Shi, Shuyu, Ren, Hongze, Xie, Yujie, Yu, Meihua, Chen, Yu and Yang, Liqun (2023). Engineering advanced nanomedicines against central nervous system diseases. Materials Today, 69, 355-392. doi: 10.1016/j.mattod.2023.08.005

Engineering advanced nanomedicines against central nervous system diseases

Funding

Past funding

  • 2018 - 2022
    A Nano-platform for Affordable and Ultra-sensitive Bio-marker Detection
    ARC Linkage Projects
    Open grant
  • 2018
    Assessment of Novel Nanoadjuvants for the Development of Potent Therapeutic Cancer Vaccines
    UQ Foundation
    Open grant
  • 2018
    Nanotechnology-medicated therapeutic HPV DNA vaccines
    UQ Early Career Researcher
    Open grant
  • 2017 - 2020
    Engineered Spiky Silica Nanoparticles as Effective Immune Adjuvants by Activating Inflammasome and Enhancing Cellular Uptake
    NHMRC Early Career Fellowships
    Open grant
  • 2016
    Advance Queensland Research Fellowship (Early): Nano-pollen encapsulated lysozyme: a safe alternative to antibiotics for livestock
    Advance Queensland Research Fellowships
    Open grant
  • 2012 - 2013
    A general platform technology for functional nanocomposites with advanced applications
    UWA-UQ Bilateral Research Collaboration Award
    Open grant

Supervision

Availability

Dr Meihua Yu is:
Available for supervision

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Supervision history

Completed supervision

Media

Enquiries

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