Overview
Background
Dr Meihua Yu is a NHMRC Early Career Fellow in Prof Ian Frazer’s lab, University Queensland Diamantina Institute (UQDI). She received her PhD degree in Biomedical Engineering from the Australian Institute for Bioengineering and Nanotechnology (AIBN), UQ in 2014, under the guidance of Prof Chengzhong (Michael) Yu.
Dr Yu’s current research focuses on developing nanotechnology vaccines for the treatment of diseases and cancers. She has extensive experience in development of sophisticated nanotechnology with controllable architecture, composition and functionality, and delivery of anticancer drugs, genetic molecules and therapeutic proteins for enhanced cancer treatment.
Dr Yu was awarded two prestigious fellowships (Advance Queensland Research Fellow in 2016 and a NHMRC Early Career Fellow in 2017). She has secured over $1.2 million in funding from internal and external funding agencies (UQ Early Career grant, ARC Linkage, Queensland Biomedical Assistance Fund). In recognition of her research achievements, she was awarded the prestigious 2017 UQ Foundation Research Excellence Award, the 2017 Monash Engineering Women Leader Award and the 2018 Frazer Family Foundation Travel Award.
Dr Yu has published 59 papers in international top refereed journals such as Journal of the American Chemical Society, Small, Chemical Communications, Nanoscale, and so on. Her innovative research has led to three patents. She has actively explored the potential of these discoveries in commercial translation by engaging with industry partners (e.g. Ridley, Ellume, Jingang Medicines).
Dr Yu is an invited reviewer for national grants (e.g. ARC DP and ARC DECRA) and 19 journals including Vaccines, ACS Omega, Biomaterials Science and Journal of Hazardous Materials.
Availability
- Dr Meihua Yu is:
- Available for supervision
Qualifications
- Doctor of Philosophy, The University of Queensland
Works
Search Professor Meihua Yu’s works on UQ eSpace
2021
Journal Article
Acquisition of murine splenic myeloid cells for protein and gene expression profiling by advanced flow cytometry and CITE-seq
Rødahl, Inga, Gotley, James, Andersen, Stacey B., Yu, Meihua, Mehdi, Ahmed M., Christ, Angelika N., Hamilton-Williams, Emma E., Frazer, Ian H., Lukowski, Samuel W. and Chandra, Janin (2021). Acquisition of murine splenic myeloid cells for protein and gene expression profiling by advanced flow cytometry and CITE-seq. STAR Protocols, 2 (4) 100842, 1-27. doi: 10.1016/j.xpro.2021.100842
2021
Journal Article
Insight into the double-edged role of ferroptosis in disease
Zhang, Lei, Jia, Ruohan, Li, Huizhen, Yu, Huarun, Ren, Keke, Jia, Shuangshuang, Li, Yanzhang and Wang, Qun (2021). Insight into the double-edged role of ferroptosis in disease. Biomolecules, 11 (12) 1790, 1-20. doi: 10.3390/biom11121790
2021
Journal Article
Editorial: Enhancing drug delivery and tumor penetration
Tang, Yuxia, Yu, Meihua, Su, Xiaodan, Teng, Zhaogang and Wang, Shouju (2021). Editorial: Enhancing drug delivery and tumor penetration. Frontiers in Oncology, 11 775001, 775001. doi: 10.3389/fonc.2021.775001
2021
Journal Article
Pressure-induced suppression of Jahn-Teller distortions and enhanced electronic properties in high-entropy oxide (Mg<sub>0.2</sub>Ni<sub>0.2</sub>Co<sub>0.2</sub>Zn<sub>0.2</sub>Cu<sub>0.2</sub>)O
Yan, Jiejuan, Zhang, Lingkong, Liu, Junxiu, Li, Nana, Tamura, Nobumichi, Chen, Bin, Lin, Yu, Mao, Wendy L. and Zhang, Hengzhong (2021). Pressure-induced suppression of Jahn-Teller distortions and enhanced electronic properties in high-entropy oxide (Mg0.2Ni0.2Co0.2Zn0.2Cu0.2)O. Applied Physics Letters, 119 (15) 151901, 1-6. doi: 10.1063/5.0067432
2021
Journal Article
Co-targeting Plk1 and DNMT3a in advanced prostate cancer
Zhang, Zhuangzhuang, Cheng, Lijun, Zhang, Qiongsi, Kong, Yifan, He, Daheng, Li, Kunyu, Rea, Matthew, Wang, Jianling, Wang, Ruixin, Liu, Jinghui, Li, Zhiguo, Yuan, Chongli, Liu, Enze, Fondufe-Mittendorf, Yvonne N., Li, Lang, Wang, Chi, Liu, Xiaoqi and Han, Tao (2021). Co-targeting Plk1 and DNMT3a in advanced prostate cancer. Advanced Science, 8 (13) 2101458, 1-16. doi: 10.1002/advs.202101458
2021
Journal Article
Prognostic factors to determine survivorship of meniscal allograft transplant: a systematic review
Wang, Ding-yu, Lee, Cassandra A., Li, Yan-zhang, Zhang, Bo, Li, Nan, Jiang, Dong and Yu, Jia-kuo (2021). Prognostic factors to determine survivorship of meniscal allograft transplant: a systematic review. Orthopaedic Journal of Sports Medicine, 9 (6), 1-8. doi: 10.1177/23259671211007215
2021
Journal Article
Impact and cost-effectiveness evaluation of a community-based rehabilitation intervention on quality of life among Chinese adults with hearing loss: study protocol for a randomized controlled trial
Ye, Xin, Zhu, Dawei, Chen, Siyuan, Shi, Xuefeng, Gong, Rui, Wang, Juncheng, Zuo, Huibin, Zhang, Mei and He, Ping (2021). Impact and cost-effectiveness evaluation of a community-based rehabilitation intervention on quality of life among Chinese adults with hearing loss: study protocol for a randomized controlled trial. Trials, 22 (1) 258, 1-9. doi: 10.1186/s13063-021-05228-2
2021
Journal Article
Absence of Batf3 reveals a new dimension of cell state heterogeneity within conventional dendritic cells
Lukowski, Samuel W., Rodahl, Inga, Kelly, Samuel, Yu, Meihua, Gotley, James, Zhou, Chenhao, Millard, Susan, Andersen, Stacey B., Christ, Angelika N., Belz, Gabrielle, Frazer, Ian H. and Chandra, Janin (2021). Absence of Batf3 reveals a new dimension of cell state heterogeneity within conventional dendritic cells. iScience, 24 (5) 102402, 1-21. doi: 10.1016/j.isci.2021.102402
2021
Journal Article
Immune-inhibitory gene expression is positively correlated with overall immune activity and predicts increased survival probability of cervical and head and neck cancer patients
Budhwani, Megha, Turrell, Gavin, Yu, Meihua, Frazer, Ian H., Mehdi, Ahmed M. and Chandra, Janin (2021). Immune-inhibitory gene expression is positively correlated with overall immune activity and predicts increased survival probability of cervical and head and neck cancer patients. Frontiers in Molecular Biosciences, 8 622643, 622643. doi: 10.3389/fmolb.2021.622643
2021
Journal Article
miR-653-5p suppresses the growth and migration of breast cancer cells by targeting MAPK6
Zhang, Mei, Wang, Hongwei, Zhang, Xiaomei and Liu, Fengping (2021). miR-653-5p suppresses the growth and migration of breast cancer cells by targeting MAPK6. Molecular Medicine Reports, 23 (3) 200, 1-7. doi: 10.3892/mmr.2021.11839
2021
Journal Article
Characterization of a Novel Bacteriophage Henu2 and Evaluation of the Synergistic Antibacterial Activity of Phage-Antibiotics
Li, Xianghui, Hu, Tongxin, Wei, Jiacun, He, Yuhua, Abdalla, Abualgasim Elgaili, Wang, Guoying, Li, Yanzhang and Teng, Tieshan (2021). Characterization of a Novel Bacteriophage Henu2 and Evaluation of the Synergistic Antibacterial Activity of Phage-Antibiotics. Antibiotics-Basel, 10 (2) 174, 174. doi: 10.3390/antibiotics10020174
2021
Journal Article
Manganese-doped silica-based nanoparticles promote the efficacy of antigen-specific immunotherapy
Chandra, Janin, Teoh, Siok Min, Kuo, Paula, Tolley, Lynn, Bashaw, Abate Assefa, Tuong, Zewen Kelvin, Liu, Yang, Chen, Zibin, Wells, James W., Yu, Chengzhong, Frazer, Ian H. and Yu, Meihua (2021). Manganese-doped silica-based nanoparticles promote the efficacy of antigen-specific immunotherapy. The Journal of Immunology, 206 (5), ji2000355-998. doi: 10.4049/jimmunol.2000355
2021
Journal Article
Rambutan-like silica nanoparticles at tailored particle sizes for plasmid DNA delivery
Hines, Elizabeth, Cheng, Dan, Wu, Weixi, Yu, Meihua, Xu, Chun, Song, Hao and Yu, Chengzhong (2021). Rambutan-like silica nanoparticles at tailored particle sizes for plasmid DNA delivery. Journal of Materials Science, 56 (9), 5830-5844. doi: 10.1007/s10853-020-05660-w
2021
Book Chapter
Therapeutic DNA Vaccine Against HPV16-Associated Cancer
Yu, Meihua and Chandra, Janin (2021). Therapeutic DNA Vaccine Against HPV16-Associated Cancer. DNA Vaccines. (pp. 241-252) New York, NY United States: Humana Press. doi: 10.1007/978-1-0716-0872-2_13
2020
Journal Article
Regulatory T-cells but not IL-10 impair cell-mediated immunity in HPV+ hyperplastic epithelium
Bashaw, Abate Assefa, Zhou, Chenhao, Yu, Meihua, Tolley, Lynn, Leggatt, Graham R., Frazer, Ian H. and Chandra, Janin (2020). Regulatory T-cells but not IL-10 impair cell-mediated immunity in HPV+ hyperplastic epithelium. The Journal of Investigative Dermatology, 141 (5), 1264-1273.e3. doi: 10.1016/j.jid.2020.10.011
2020
Journal Article
Sequential PDT and PTT using dual-modal single-walled carbon nanohorns synergistically promote systemic immune responses against tumor metastasis and relapse
Yang, Jingxing, Hou, Mengfei, Sun, Wenshe, Wu, Qinghe, Xu, Jia, Xiong, Liqin, Chai, Yimin, Liu, Yuxin, Yu, Meihua, Wang, Haolu, Xu, Zhi Ping, Liang, Xiaowen and Zhang, Chunfu (2020). Sequential PDT and PTT using dual-modal single-walled carbon nanohorns synergistically promote systemic immune responses against tumor metastasis and relapse. Advanced Science, 7 (16) 2001088, 2001088. doi: 10.1002/advs.202001088
2020
Journal Article
Pristine large pore benzene-bridged mesoporous organosilica nanoparticles as an adjuvant and co-delivery platform for eliciting potent antitumor immunity
Jambhrunkar, M., Yang, Y., Yu, M., Zhang, M., Abbaraju, P. L., Ghosh, T., Kalantari, M., Wang, Y., McMillan, N. A. J. and Yu, C. (2020). Pristine large pore benzene-bridged mesoporous organosilica nanoparticles as an adjuvant and co-delivery platform for eliciting potent antitumor immunity. Materials Today Advances, 6 100069, 100069. doi: 10.1016/j.mtadv.2020.100069
2020
Journal Article
IMCA induces ferroptosis mediated by SLC7A11 through the AMPK/mTOR pathway in colorectal cancer
Zhang, Lei, Liu, Wen, Liu, Fangyan, Wang, Qun, Song, Mengjiao, Yu, Qi, Tang, Kun, Teng, Tieshan, Wu, Dongdong, Wang, Xijing, Han, Wuqi and Li, Yanzhang (2020). IMCA induces ferroptosis mediated by SLC7A11 through the AMPK/mTOR pathway in colorectal cancer. Oxidative Medicine and Cellular Longevity, 2020 1675613, 1-14. doi: 10.1155/2020/1675613
2019
Journal Article
Residential mobility decreases the perception of social norm violations
Luo, Siyang, Kong, Qianting, Ke, Zijun, Huang, Liqin, Yu, Meihua, Zhu, Yiyi and Xu, Ying (2019). Residential mobility decreases the perception of social norm violations. Social Indicators Research, 148 (3), 961-986. doi: 10.1007/s11205-019-02224-7
2019
Journal Article
Yuanhuatine from Daphne genkwa selectively induces mitochondrial apoptosis in estrogen receptor α -positive breast cancer cells in vitro
Zhang, Ying-Ying, Shang, Xin-Yue, Hou, Xue-Wen, Li, Ling-Zhi, Wang, Wei, Hayashi, Toshihiko, Zhang, Yan, Yao, Guo-Dong and Song, Shao-Jiang (2019). Yuanhuatine from Daphne genkwa selectively induces mitochondrial apoptosis in estrogen receptor α -positive breast cancer cells in vitro. Planta Medica, 85 (16), 1275-1286. doi: 10.1055/a-1013-1439
Funding
Past funding
Supervision
Availability
- Dr Meihua Yu is:
- Available for supervision
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Supervision history
Completed supervision
-
2019
Doctor Philosophy
Development of a Mesoporous Silica Based Nanosystem for Safe and Efficient Therapeutic Delivery
Joint Principal Advisor
Other advisors: Professor Chengzhong Yu
-
2021
Master Philosophy
Development of Silica Based Nanoparticles for Plasmid DNA Delivery
Associate Advisor
Other advisors: Professor Chengzhong Yu
-
2020
Doctor Philosophy
Engineered iron-based nanomaterials for macrophage-centred anti-cancer application
Associate Advisor
Other advisors: Professor Chengzhong Yu
-
2019
Doctor Philosophy
Synthesis and characterization of novel silica nanoparticles for delivery applications
Associate Advisor
Other advisors: Professor Chengzhong Yu
-
2019
Doctor Philosophy
Optimised multifunctionality of Mesoporous Carbon Hollow Spheres (MCHS) nanocarriers using carbonization temperature
Associate Advisor
Other advisors: Professor Chengzhong Yu
-
2018
Doctor Philosophy
Synthesis of Novel Mesoporous Materials as High-performance Adsorbents
Associate Advisor
Other advisors: Professor Chengzhong Yu
-
2018
Doctor Philosophy
Engineering Nanomaterials as Safe and Effective Immune Adjuvants
Associate Advisor
Other advisors: Professor Chengzhong Yu
-
2018
Doctor Philosophy
Engineered Silica nanoparticles for efficient biomolecules delivery
Associate Advisor
Other advisors: Professor Chengzhong Yu
-
2017
Doctor Philosophy
Mesoporous silica nanoparticles for biomedical application
Associate Advisor
Other advisors: Professor Amirali Popat, Professor Chengzhong Yu
-
2016
Doctor Philosophy
Design of Mesoporous Silica Nanoparticles as Drug Carriers
Associate Advisor
Other advisors: Professor Chengzhong Yu
-
2016
Master Philosophy
Designed synthesis of large pore mesoporous silica nanoparticles as nano-carriers for bio-applications
Associate Advisor
Other advisors: Professor Chengzhong Yu
Media
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