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Dr Meihua Yu
Dr

Meihua Yu

Email: 

Overview

Background

Dr Meihua Yu is a NHMRC Early Career Fellow in Prof Ian Frazer’s lab, University Queensland Diamantina Institute (UQDI). She received her PhD degree in Biomedical Engineering from the Australian Institute for Bioengineering and Nanotechnology (AIBN), UQ in 2014, under the guidance of Prof Chengzhong (Michael) Yu.

Dr Yu’s current research focuses on developing nanotechnology vaccines for the treatment of diseases and cancers. She has extensive experience in development of sophisticated nanotechnology with controllable architecture, composition and functionality, and delivery of anticancer drugs, genetic molecules and therapeutic proteins for enhanced cancer treatment.

Dr Yu was awarded two prestigious fellowships (Advance Queensland Research Fellow in 2016 and a NHMRC Early Career Fellow in 2017). She has secured over $1.2 million in funding from internal and external funding agencies (UQ Early Career grant, ARC Linkage, Queensland Biomedical Assistance Fund). In recognition of her research achievements, she was awarded the prestigious 2017 UQ Foundation Research Excellence Award, the 2017 Monash Engineering Women Leader Award and the 2018 Frazer Family Foundation Travel Award.

Dr Yu has published 59 papers in international top refereed journals such as Journal of the American Chemical Society, Small, Chemical Communications, Nanoscale, and so on. Her innovative research has led to three patents. She has actively explored the potential of these discoveries in commercial translation by engaging with industry partners (e.g. Ridley, Ellume, Jingang Medicines).

Dr Yu is an invited reviewer for national grants (e.g. ARC DP and ARC DECRA) and 19 journals including Vaccines, ACS Omega, Biomaterials Science and Journal of Hazardous Materials.

Availability

Dr Meihua Yu is:
Available for supervision

Qualifications

  • Doctor of Philosophy, The University of Queensland

Works

Search Professor Meihua Yu’s works on UQ eSpace

95 works between 2006 and 2026

21 - 40 of 95 works

2023

Journal Article

Emerging nano-immunotherapeutic approaches to glioma

Nan, Jin, Yang, Wei, Xie, Yujie, Yu, Meihua, Chen, Yu and Zhang, Jun (2023). Emerging nano-immunotherapeutic approaches to glioma. Small Structures, 4 (8) 2300016. doi: 10.1002/sstr.202300016

Emerging nano-immunotherapeutic approaches to glioma

2023

Journal Article

Adjuvant physiochemistry and advanced nanotechnology for vaccine development

Ren, Hongze, Jia, Wencong, Xie, Yujie, Yu, Meihua and Chen, Yu (2023). Adjuvant physiochemistry and advanced nanotechnology for vaccine development. Chemical Society Reviews, 52 (15), 5172-5254. doi: 10.1039/d2cs00848c

Adjuvant physiochemistry and advanced nanotechnology for vaccine development

2023

Journal Article

Nanoformulations targeting immune cells for cancer therapy: mRNA therapeutics

Yang, Wei, Cao, Jianwei, Cheng, Hui, Chen, Liang, Yu, Meihua, Chen, Yu and Cui, Xingang (2023). Nanoformulations targeting immune cells for cancer therapy: mRNA therapeutics. Bioactive Materials, 23, 438-470. doi: 10.1016/j.bioactmat.2022.11.014

Nanoformulations targeting immune cells for cancer therapy: mRNA therapeutics

2022

Journal Article

Targeted cancer immunotherapy: nanoformulation engineering and clinical translation

Yu, Meihua, Yang, Wei, Yue, Wenwen and Chen, Yu (2022). Targeted cancer immunotherapy: nanoformulation engineering and clinical translation. Advanced Science, 9 (35) 2204335, 1-37. doi: 10.1002/advs.202204335

Targeted cancer immunotherapy: nanoformulation engineering and clinical translation

2022

Journal Article

Nanomedicine enables efficient CRISPR-Cas9 genome editing for disease treatment

Ma, Lifang, Dong, Caihong, Yu, Meihua, Song, Xinran, Yu, Yongchun and Chen, Yu (2022). Nanomedicine enables efficient CRISPR-Cas9 genome editing for disease treatment. Science Bulletin, 67 (6), 572-576. doi: 10.1016/j.scib.2021.11.016

Nanomedicine enables efficient CRISPR-Cas9 genome editing for disease treatment

2021

Journal Article

Acquisition of murine splenic myeloid cells for protein and gene expression profiling by advanced flow cytometry and CITE-seq

Rødahl, Inga, Gotley, James, Andersen, Stacey B., Yu, Meihua, Mehdi, Ahmed M., Christ, Angelika N., Hamilton-Williams, Emma E., Frazer, Ian H., Lukowski, Samuel W. and Chandra, Janin (2021). Acquisition of murine splenic myeloid cells for protein and gene expression profiling by advanced flow cytometry and CITE-seq. STAR Protocols, 2 (4) 100842, 1-27. doi: 10.1016/j.xpro.2021.100842

Acquisition of murine splenic myeloid cells for protein and gene expression profiling by advanced flow cytometry and CITE-seq

2021

Journal Article

Editorial: Enhancing drug delivery and tumor penetration

Tang, Yuxia, Yu, Meihua, Su, Xiaodan, Teng, Zhaogang and Wang, Shouju (2021). Editorial: Enhancing drug delivery and tumor penetration. Frontiers in Oncology, 11 775001, 775001. doi: 10.3389/fonc.2021.775001

Editorial: Enhancing drug delivery and tumor penetration

2021

Journal Article

Absence of Batf3 reveals a new dimension of cell state heterogeneity within conventional dendritic cells

Lukowski, Samuel W., Rodahl, Inga, Kelly, Samuel, Yu, Meihua, Gotley, James, Zhou, Chenhao, Millard, Susan, Andersen, Stacey B., Christ, Angelika N., Belz, Gabrielle, Frazer, Ian H. and Chandra, Janin (2021). Absence of Batf3 reveals a new dimension of cell state heterogeneity within conventional dendritic cells. iScience, 24 (5) 102402, 1-21. doi: 10.1016/j.isci.2021.102402

Absence of Batf3 reveals a new dimension of cell state heterogeneity within conventional dendritic cells

2021

Journal Article

Immune-inhibitory gene expression is positively correlated with overall immune activity and predicts increased survival probability of cervical and head and neck cancer patients

Budhwani, Megha, Turrell, Gavin, Yu, Meihua, Frazer, Ian H., Mehdi, Ahmed M. and Chandra, Janin (2021). Immune-inhibitory gene expression is positively correlated with overall immune activity and predicts increased survival probability of cervical and head and neck cancer patients. Frontiers in Molecular Biosciences, 8 622643, 622643. doi: 10.3389/fmolb.2021.622643

Immune-inhibitory gene expression is positively correlated with overall immune activity and predicts increased survival probability of cervical and head and neck cancer patients

2021

Journal Article

Manganese-doped silica-based nanoparticles promote the efficacy of antigen-specific immunotherapy

Chandra, Janin, Teoh, Siok Min, Kuo, Paula, Tolley, Lynn, Bashaw, Abate Assefa, Tuong, Zewen Kelvin, Liu, Yang, Chen, Zibin, Wells, James W., Yu, Chengzhong, Frazer, Ian H. and Yu, Meihua (2021). Manganese-doped silica-based nanoparticles promote the efficacy of antigen-specific immunotherapy. The Journal of Immunology, 206 (5), ji2000355-998. doi: 10.4049/jimmunol.2000355

Manganese-doped silica-based nanoparticles promote the efficacy of antigen-specific immunotherapy

2021

Journal Article

Rambutan-like silica nanoparticles at tailored particle sizes for plasmid DNA delivery

Hines, Elizabeth, Cheng, Dan, Wu, Weixi, Yu, Meihua, Xu, Chun, Song, Hao and Yu, Chengzhong (2021). Rambutan-like silica nanoparticles at tailored particle sizes for plasmid DNA delivery. Journal of Materials Science, 56 (9), 5830-5844. doi: 10.1007/s10853-020-05660-w

Rambutan-like silica nanoparticles at tailored particle sizes for plasmid DNA delivery

2021

Book Chapter

Therapeutic DNA Vaccine Against HPV16-Associated Cancer

Yu, Meihua and Chandra, Janin (2021). Therapeutic DNA Vaccine Against HPV16-Associated Cancer. DNA Vaccines. (pp. 241-252) New York, NY United States: Humana Press. doi: 10.1007/978-1-0716-0872-2_13

Therapeutic DNA Vaccine Against HPV16-Associated Cancer

2020

Journal Article

Regulatory T-cells but not IL-10 impair cell-mediated immunity in HPV+ hyperplastic epithelium

Bashaw, Abate Assefa, Zhou, Chenhao, Yu, Meihua, Tolley, Lynn, Leggatt, Graham R., Frazer, Ian H. and Chandra, Janin (2020). Regulatory T-cells but not IL-10 impair cell-mediated immunity in HPV+ hyperplastic epithelium. The Journal of Investigative Dermatology, 141 (5), 1264-1273.e3. doi: 10.1016/j.jid.2020.10.011

Regulatory T-cells but not IL-10 impair cell-mediated immunity in HPV+ hyperplastic epithelium

2020

Journal Article

Sequential PDT and PTT using dual-modal single-walled carbon nanohorns synergistically promote systemic immune responses against tumor metastasis and relapse

Yang, Jingxing, Hou, Mengfei, Sun, Wenshe, Wu, Qinghe, Xu, Jia, Xiong, Liqin, Chai, Yimin, Liu, Yuxin, Yu, Meihua, Wang, Haolu, Xu, Zhi Ping, Liang, Xiaowen and Zhang, Chunfu (2020). Sequential PDT and PTT using dual-modal single-walled carbon nanohorns synergistically promote systemic immune responses against tumor metastasis and relapse. Advanced Science, 7 (16) 2001088, 2001088. doi: 10.1002/advs.202001088

Sequential PDT and PTT using dual-modal single-walled carbon nanohorns synergistically promote systemic immune responses against tumor metastasis and relapse

2020

Journal Article

Pristine large pore benzene-bridged mesoporous organosilica nanoparticles as an adjuvant and co-delivery platform for eliciting potent antitumor immunity

Jambhrunkar, M., Yang, Y., Yu, M., Zhang, M., Abbaraju, P. L., Ghosh, T., Kalantari, M., Wang, Y., McMillan, N. A. J. and Yu, C. (2020). Pristine large pore benzene-bridged mesoporous organosilica nanoparticles as an adjuvant and co-delivery platform for eliciting potent antitumor immunity. Materials Today Advances, 6 100069, 100069. doi: 10.1016/j.mtadv.2020.100069

Pristine large pore benzene-bridged mesoporous organosilica nanoparticles as an adjuvant and co-delivery platform for eliciting potent antitumor immunity

2019

Journal Article

Engineering mesoporous silica microspheres as hyper-activation supports for continuous enzymatic biodiesel production

Kalantari, Mohammad, Yu, Meihua, Liu, Yang, Huang, Xiaodan and Yu, Chengzhong (2019). Engineering mesoporous silica microspheres as hyper-activation supports for continuous enzymatic biodiesel production. Materials Chemistry Frontiers, 3 (9), 1816-1822. doi: 10.1039/c9qm00375d

Engineering mesoporous silica microspheres as hyper-activation supports for continuous enzymatic biodiesel production

2018

Journal Article

Mesoporous carbon hollow spheres: carbonisation-temperature-dependent delivery of therapeutic proteins

Ghosh, Trisha, Mantri, Manasi, Gu, Zhengying, Kalantari, Mohammad, Yu, Meihua and Yu, Chengzhong (2018). Mesoporous carbon hollow spheres: carbonisation-temperature-dependent delivery of therapeutic proteins. Journal of Materials Chemistry B, 6 (5), 763-768. doi: 10.1039/c7tb02836a

Mesoporous carbon hollow spheres: carbonisation-temperature-dependent delivery of therapeutic proteins

2018

Journal Article

Room temperature synthesis of dendritic mesoporous silica nanoparticles with small sizes and enhanced mRNA delivery performance

Wang, Yue, Song, Hao, Yu, Meihua, Xu, Chun, Liu, Yang, Tang, Jie, Yang, Yannan and Yu, Chengzhong (2018). Room temperature synthesis of dendritic mesoporous silica nanoparticles with small sizes and enhanced mRNA delivery performance. Journal of Materials Chemistry B, 6 (24), 4089-4095. doi: 10.1039/c8tb00544c

Room temperature synthesis of dendritic mesoporous silica nanoparticles with small sizes and enhanced mRNA delivery performance

2018

Journal Article

Designed synthesis of organosilica nanoparticles for enzymatic biodiesel production

Kalantari, Mohammad, Yu, Meihua, Jambhrunkar, Manasi, Liu, Yang, Yang, Yannan, Huang, Xiaodan and Yu, Chengzhong (2018). Designed synthesis of organosilica nanoparticles for enzymatic biodiesel production. Materials Chemistry Frontiers, 2 (7), 1334-1342. doi: 10.1039/c8qm00078f

Designed synthesis of organosilica nanoparticles for enzymatic biodiesel production

2017

Journal Article

Plasmid DNA Delivery: Nanotopography Matters

Song, Hao, Yu, Meihua, Lu, Yao, Gu, Zhengying, Yang, Yannan, Zhang, Min, Fu, Jianye and Yu, Chengzhong (2017). Plasmid DNA Delivery: Nanotopography Matters. Journal of the American Chemical Society, 139 (50), 18247-18254. doi: 10.1021/jacs.7b08974

Plasmid DNA Delivery: Nanotopography Matters

Funding

Past funding

  • 2018 - 2022
    A Nano-platform for Affordable and Ultra-sensitive Bio-marker Detection
    ARC Linkage Projects
    Open grant
  • 2018
    Assessment of Novel Nanoadjuvants for the Development of Potent Therapeutic Cancer Vaccines
    UQ Foundation
    Open grant
  • 2018
    Nanotechnology-medicated therapeutic HPV DNA vaccines
    UQ Early Career Researcher
    Open grant
  • 2017 - 2020
    Engineered Spiky Silica Nanoparticles as Effective Immune Adjuvants by Activating Inflammasome and Enhancing Cellular Uptake
    NHMRC Early Career Fellowships
    Open grant
  • 2016
    Advance Queensland Research Fellowship (Early): Nano-pollen encapsulated lysozyme: a safe alternative to antibiotics for livestock
    Advance Queensland Research Fellowships
    Open grant
  • 2012 - 2013
    A general platform technology for functional nanocomposites with advanced applications
    UWA-UQ Bilateral Research Collaboration Award
    Open grant

Supervision

Availability

Dr Meihua Yu is:
Available for supervision

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Supervision history

Completed supervision

Media

Enquiries

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