Overview
Background
Transporters for Catecholamines and Serotonin. Science Education.
The overall theme of Lesley Lluka's research over 3 decades has been the structure and function of the noradrenaline transporter (NET) and the serotonin transporter (SERT). These transporters are important sites of action of drugs such as antidepressants.
More recently, Lesley Lluka's work has increasingly moved to Science Education, with a focus on areas such as student engagement in practical classes, innovative assessment practices to drive deep learning, and internationalization of the curriculum.
Availability
- Dr Lesley Lluka is:
- Not available for supervision
Fields of research
Qualifications
- Bachelor of Pharmacy, The University of Queensland
- Masters (Coursework), The University of Queensland
- Doctor of Philosophy, The University of Queensland
Research interests
-
Internationalisation of the curriculum in biomedical science
-
Role of tutor training in determining student learning outcomes
-
Vertically integrated practical curriculum in physiology
-
Active learning in lectures and 'lectorials'
Works
Search Professor Lesley Lluka’s works on UQ eSpace
2005
Conference Publication
Quantitative analysis of serotonin levels in the murine brain following treatment with serotonin reuptake inhibitor drugs
Williams, S. M., Bryan-Lluka, L. J. and Pow, D. V. (2005). Quantitative analysis of serotonin levels in the murine brain following treatment with serotonin reuptake inhibitor drugs. 25th Annual Meeting of the Australian Neuroscience Society (ANS), Perth, Australia, 30 January - 2 February 2005. Australia: ANS.
2005
Conference Publication
Pharmacological and substituded cysteine accessibility method (SCAM) analysis of transmembrane domain 5 (TMD5) of the human noradrenaline transporter
Khamu, T. and Lluka, L. J. (2005). Pharmacological and substituded cysteine accessibility method (SCAM) analysis of transmembrane domain 5 (TMD5) of the human noradrenaline transporter. The Australian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) - Australiasian Pharmaceutical Science Association (APSA) joint Annual Scientific Meeting 2005, Hilton on the Park, Melbourne, Australia, 4-7 December, 2005. Melbourne, Australia: Australian Society of Clinical and Experimental Pharmacologists Pharmacologists and Toxicologists.
2004
Journal Article
Nitric oxide donors inhibit 5-hydroxytryptamine (5-HT) uptake by the human 5-HT transporter (SERT)
Bryan-Lluka, Lesley J., Papacostas, Marisa H., Paczkowski, Filip A. and Wanstall, Janet C. (2004). Nitric oxide donors inhibit 5-hydroxytryptamine (5-HT) uptake by the human 5-HT transporter (SERT). British Journal of Pharmacology, 143 (1), 63-70. doi: 10.1038/sj.bjp.0705904
2004
Conference Publication
What is the role of transmembrane domain 2 (TMD2) in noradrenaline transporter (NET) function?
Sucic, S. and Lluka, L.J. (2004). What is the role of transmembrane domain 2 (TMD2) in noradrenaline transporter (NET) function?. 8th World Congress on Clinical Pharmacology & Therapeutics, Brisbane, Australia, 1-6 August 2004. Australia: Blackwell Publishing Asia Pty Ltd.
2004
Journal Article
Role of proline residues in the expression and function of the human noradrenaline transporter
Paczkowski, FA and Bryan-Lluka, LJ (2004). Role of proline residues in the expression and function of the human noradrenaline transporter. Journal of Neurochemistry, 88 (1), 203-211. doi: 10.1046/j.1471-4159.2003.02149.x
2004
Conference Publication
How do nitric oxide donors regulate the function of transporters for serotonin and noradrenaline?
Paczkowski, F. A., Wanstall, J. C. and Lluka, L.J. (2004). How do nitric oxide donors regulate the function of transporters for serotonin and noradrenaline?. 8th World Congress on Clinical Pharmacology & Therapeutics, Brisbane, Australia, 1-6 August 2004. Australia: Blackwell Publishing Asia Pty Ltd.
2003
Journal Article
χ-conopeptide MrIA partially overlaps desipramine and cocaine binding sites on the human norepinephrine transporter
Bryan-Lluka, Lesley J., Bonisch, Heinz and Lewis, Richard J. (2003). χ-conopeptide MrIA partially overlaps desipramine and cocaine binding sites on the human norepinephrine transporter. Journal of Biological Chemistry, 278 (41), 40324-40329. doi: 10.1074/jbc.M213101200
2003
Journal Article
5-Hydroxytryptamine and platelets: uptake and aggregation in hypoxic pulmonary hypertensive rats
Awabdy, Doreen, Bryan-Lluka, Lesley J. and Wanstall, Janet C. (2003). 5-Hydroxytryptamine and platelets: uptake and aggregation in hypoxic pulmonary hypertensive rats. European Journal of Pharmacology, 459 (1), 1-7. doi: 10.1016/S0014-2999(02)02734-6
2003
Conference Publication
Evidence for different, but overlapping, binding sites on the human noradrenaline transporter (hNET) for substrates, antidepressants and cocaine
Paczkowski, F. A., Sucic, S. and Bryan-Lluka, L. J. (2003). Evidence for different, but overlapping, binding sites on the human noradrenaline transporter (hNET) for substrates, antidepressants and cocaine. Summer Meeting of the British Association for Psychopharmacology, Cambridge, England, 20-23 July 2003. Oxford, United Kingdom: Sage Productions.
2003
Journal Article
An evaluation of factors affecting computer-based learning in haemostasis: A cultural experience
Overfield, J.A. and Lluka, L.J. (2003). An evaluation of factors affecting computer-based learning in haemostasis: A cultural experience. Bioscience Education E-Journal, 1 (1), 1-9.
2002
Journal Article
The role of conserved CXXXRXG motif in the expression and function of the human norepinephrine transporter
Sucic, Sonja and Bryan-Lluka, Lesley J. (2002). The role of conserved CXXXRXG motif in the expression and function of the human norepinephrine transporter. Molecular Brain Research, 108 (1-2), 40-50. doi: 10.1016/S0169-328X(02)00512-0
2002
Journal Article
Functional significance of a highly conserved glutamate residue of the human noradrenaline transportere
Sucic, Sonja, Paczkowski, Filip A., Runkel, Fabian, Bonisch, Heinz and Bryan-Lluka, Leslie J. (2002). Functional significance of a highly conserved glutamate residue of the human noradrenaline transportere. Journal of Neurochemistry, 81 (2), 344-354. doi: 10.1046/j.1471-4159.2002.00826.x
2002
Journal Article
Pharmacological properties of the naturally occurring Ala457Pro variant of the human norepinephrine transporter
Paczkowski, Filip A., Bonisch, Heinz and Bryan-Lluka, Lesley J. (2002). Pharmacological properties of the naturally occurring Ala457Pro variant of the human norepinephrine transporter. Pharmacogenetics, 12 (2), 165-173. doi: 10.1097/00008571-200203000-00010
2002
Journal Article
Amino Acids involved in differences in the pharmacological profiles of the rat and human noradrenaline transporters
Paczkowski, FA and Bryan-Lluka, LJ (2002). Amino Acids involved in differences in the pharmacological profiles of the rat and human noradrenaline transporters. Naunyn-Schmiedeberg's Archives of Pharmacology, 365 (4), 312-317. doi: 10.1007/s00210-002-0528-z
2001
Journal Article
Tyrosine residue 271 of the norepinephrine transporter is an important determinant of its pharmacology
Paczkowski, Filip A. and Bryan-Lluka, Lesley J. (2001). Tyrosine residue 271 of the norepinephrine transporter is an important determinant of its pharmacology. Molecular Brain Research, 97 (1), 32-42. doi: 10.1016/S0169-328X(01)00295-9
2001
Journal Article
Effects of short- and long-term exposure to c-AMP and c-GMP on the noradrenaline transporter
Bryan-Lluka, Lesley J., Paczkowski, Filip A. and Bonisch, Heinz (2001). Effects of short- and long-term exposure to c-AMP and c-GMP on the noradrenaline transporter. Neuropharmacology, 40 (4), 607-617. doi: 10.1016/S0028-3908(00)00201-X
2001
Conference Publication
5-hydroxytryptamine and platelet function in hypoxic pulmonary hypertensive rats: Studies on uptake and aggregation
Awabdy, D., Bryan-Lluka, L. J. and Wanstall, J. C. (2001). 5-hydroxytryptamine and platelet function in hypoxic pulmonary hypertensive rats: Studies on uptake and aggregation. ASCEPT Annual Scientific Meeting, University of Otago, Dunedin, New Zealand, 3-5 December, 2001. Victoria, Australia: ASCEPT.
2001
Conference Publication
Regulation of the norepinephrine transporter (NET) and the serotonin transporter (SERT) by second messengers and hormones
Bryan-Lluka, L. J., Dunner, E. M. and Papacostas, M. H. (2001). Regulation of the norepinephrine transporter (NET) and the serotonin transporter (SERT) by second messengers and hormones. 9th International Catecholamine Symposium, Kyoto, Japan/Kyoto International Conference Hall, 31 March - 5 April, 2001. Kyoto, Japan:
2001
Conference Publication
Similar effects of mutations in the first intracellular loop and fifth transmembrane domain of the human norepinephrine transporter
Paczkowski, F. A., Sucic, S. and Bryan-Lluka, L. J. (2001). Similar effects of mutations in the first intracellular loop and fifth transmembrane domain of the human norepinephrine transporter. The 9th International Catecholamine Symposium, Kyoto, Japan/Kyoto International Conference Hall, 31 March - 5 April 2001. Kyoto, Japan: N/A.
2001
Conference Publication
A naturally occurring human noradrenaline transporter mutation in transmembrane domain 9 causes differential changes in noradrenaline and cocaine affinities Abstracts of the . .
Bryan-Lluka, L. J., Bonisch, H. and Paczkowski, F. A. (2001). A naturally occurring human noradrenaline transporter mutation in transmembrane domain 9 causes differential changes in noradrenaline and cocaine affinities Abstracts of the . .. British Pharmacological Society Meeting, United Kingdom, 5-7 September, 2001. London, England:
Funding
Past funding
Supervision
Availability
- Dr Lesley Lluka is:
- Not available for supervision
Supervision history
Completed supervision
-
2014
Doctor Philosophy
A characterisation of the teaching approaches and practices used by casual academic tutors in undergraduate science laboratory-based practical classes
Principal Advisor
-
2009
Doctor Philosophy
The chronic effects of antipsychotic drugs on pyramidal cell structure in rat anterior cingulate cortex: with relevance to schizophrenia
Principal Advisor
-
2005
Doctor Philosophy
STRUCTURAL DETERMINANTS OF THE EXPRESSION, ASSEMBLY AND FUNCTION OF MONOAMINE NEUROTRANSMITTER TRANSPORTERS
Principal Advisor
Other advisors: Professor Alpha Yap
-
2003
Doctor Philosophy
STRUCTURE-ACTIVITY RELATIONSHIPS AND REGULATION OF THE NORADRENALINE TRANSPORTER
Principal Advisor
Media
Enquiries
For media enquiries about Dr Lesley Lluka's areas of expertise, story ideas and help finding experts, contact our Media team: