Dr Lesley Lluka
Dr

Lesley Lluka

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Background

Transporters for Catecholamines and Serotonin. Science Education.

The overall theme of Lesley Lluka's research over 3 decades has been the structure and function of the noradrenaline transporter (NET) and the serotonin transporter (SERT). These transporters are important sites of action of drugs such as antidepressants.

More recently, Lesley Lluka's work has increasingly moved to Science Education, with a focus on areas such as student engagement in practical classes, innovative assessment practices to drive deep learning, and internationalization of the curriculum.

Availability

Dr Lesley Lluka is:
Not available for supervision

Fields of research

Clinical sciences Pharmacology and pharmaceutical sciences

Qualifications

  • Bachelor of Pharmacy, The University of Queensland
  • Masters (Coursework), The University of Queensland
  • Doctor of Philosophy, The University of Queensland

Research interests

  • Internationalisation of the curriculum in biomedical science

  • Role of tutor training in determining student learning outcomes

  • Vertically integrated practical curriculum in physiology

  • Active learning in lectures and 'lectorials'

Search Professor Lesley Lluka’s works on UQ eSpace

90 works between 1991 and 2022
All (90) Journal Article (51) Conference Publication (38) Book (1)

61 - 80 of 90 works

2000

Journal Article

Specific uptake of 5-hydroxytryptamine is reduced in lungs from hypoxic pulmonary hypertensive rats

Jeffery, Trina K., Bryan-Lluka, Lesley J. and Wanstall, Janet C. (2000). Specific uptake of 5-hydroxytryptamine is reduced in lungs from hypoxic pulmonary hypertensive rats. European Journal of Pharmacology, 396 (2-3), 137-140. doi: 10.1016/S0014-2999(00)00252-1

Specific uptake of 5-hydroxytryptamine is reduced in lungs from hypoxic pulmonary hypertensive rats

2000

Conference Publication

Mutations in transmembrane domain (TMD) 5 of the human noradrenaline transporter (hNAT) cause increases in substrate affinities but decreases in inhibitor affinities

Bryan-Lluka, L. J. and Paczkowski, F. A. (2000). Mutations in transmembrane domain (TMD) 5 of the human noradrenaline transporter (hNAT) cause increases in substrate affinities but decreases in inhibitor affinities. Joint Meeting of ASCEPT and the British Pharmacological Society, Newcastle, Australia, 3 - 6 December, 2000. Melbourne, Australia: ASCEPT.

Mutations in transmembrane domain (TMD) 5 of the human noradrenaline transporter (hNAT) cause increases in substrate affinities but decreases in inhibitor affinities

2000

Conference Publication

Cell Type Dependent Regulation of the NA Transporter (NAT) and 5HT Transporter (SERT) by cAMP

Dunner, E. M. and Bryan-Lluka, L. J. (2000). Cell Type Dependent Regulation of the NA Transporter (NAT) and 5HT Transporter (SERT) by cAMP. The Australasian, Newcastle, Australia, 3 - 6 December, 2000. Melbourne, Australia: ASCEPT.

Cell Type Dependent Regulation of the NA Transporter (NAT) and 5HT Transporter (SERT) by cAMP

2000

Conference Publication

Role of two amino acids in pharmacological differences between human and rat NA transporters

Bryan-Lluka, L. J. and Paczkowski, F. A. (2000). Role of two amino acids in pharmacological differences between human and rat NA transporters. Joint Meeting of ASCEPT and the British Pharmacological Society, Melbourne, Australia, 25 - 28 April, 2000. Melbourne, Australia: ASCEPT.

Role of two amino acids in pharmacological differences between human and rat NA transporters

2000

Journal Article

Further characterisation of the interaction of haloperidol metabolites with neurotransmitter transporters in rat neuronal cultures and in transfected COS-7 cells

Siebert, G. A., Pond, S. M. and Bryan-Lluka, L. J. (2000). Further characterisation of the interaction of haloperidol metabolites with neurotransmitter transporters in rat neuronal cultures and in transfected COS-7 cells. Naunyn-Schmiedeberg's Archives of Pharmacology, 361 (3), 255-264. doi: 10.1007/s002109900202

Further characterisation of the interaction of haloperidol metabolites with neurotransmitter transporters in rat neuronal cultures and in transfected COS-7 cells

2000

Conference Publication

Importance of the first intracellular loop in the activity of the human noradrenaline transporter (hNAT)

Sucic, S. and Bryan-Lluka, L. J. (2000). Importance of the first intracellular loop in the activity of the human noradrenaline transporter (hNAT). Joint Meeting of ASCEPT and the British Pharmacological Society, Newcastle, Australia, 3 - 6 December, 2000. Melbourne, Australia: ASCEPT.

Importance of the first intracellular loop in the activity of the human noradrenaline transporter (hNAT)

1999

Journal Article

Potencies of haloperidol metabolites as inhibitors of the human noradrenaline, dopamine and serotonin transporters in transfected COS-7 cells

Bryan-Lluka, Lesley J., Siebert, Gerhard A. and Pond, Susan M. (1999). Potencies of haloperidol metabolites as inhibitors of the human noradrenaline, dopamine and serotonin transporters in transfected COS-7 cells. Naunyn-Schmiedeberg's Archives of Pharmacology, 360 (2), 109-115. doi: 10.1007/s002109900060

Potencies of haloperidol metabolites as inhibitors of the human noradrenaline, dopamine and serotonin transporters in transfected COS-7 cells

1999

Journal Article

Replacement and reduction of animal usage in teaching physiology and pharmacology at the University of Queensland

Lluka, Lesley and Oelrichs, Beverley A. (1999). Replacement and reduction of animal usage in teaching physiology and pharmacology at the University of Queensland. ANZCCART News, 12 (2), 4-7.

Replacement and reduction of animal usage in teaching physiology and pharmacology at the University of Queensland

1999

Conference Publication

Mechanism of 5-HT transporter (SERT) regulation by thyrosine

Papacostas, M. and Bryan-Lluka, L. J. (1999). Mechanism of 5-HT transporter (SERT) regulation by thyrosine. 33rd Annual Scientific Meeting of ASCEPT, Sydney Convention & Exhibition Cen., Sydney, 4 - 8 December, 1999. Melbourne: Blackwell Scientific Publications.

Mechanism of 5-HT transporter (SERT) regulation by thyrosine

1999

Conference Publication

Norepinephrine (NE) transporter (NET) and serotonin (5-HT) transporter (SERT) regulation by thyroxine (T4), angiotensin II (AII) and insulin (INS)

Bryan-Lluka, L. J. and Boyd, S. M. (1999). Norepinephrine (NE) transporter (NET) and serotonin (5-HT) transporter (SERT) regulation by thyroxine (T4), angiotensin II (AII) and insulin (INS). 42nd Annual Meeting of the Western Pharmacology Society, Maui, Hawwaii, USA, 30 Jan - 04 Feb, 1999. Seattle, USA: Western Pharacological Society.

Norepinephrine (NE) transporter (NET) and serotonin (5-HT) transporter (SERT) regulation by thyroxine (T4), angiotensin II (AII) and insulin (INS)

1999

Journal Article

Comparison of the pharmacological properties of cloned rat, human, and bovine norepinephrine transporters

Paczkowski, F. A., Bryan-Lluka, L. J., Porzgen, P., Bruss, M. and Bonisch, H. (1999). Comparison of the pharmacological properties of cloned rat, human, and bovine norepinephrine transporters. The Journal of Pharmacology and Experimental Therapeutics, 290 (2), 761-767.

Comparison of the pharmacological properties of cloned rat, human, and bovine norepinephrine transporters

1999

Conference Publication

Regulation of noradrenaline transporter (NAT) and 5-HT transporter (SERT) activity by inhibitors and substrates

Bryan-Lluka, L. J., Ha, L. D. Q. and Boyd, S. M. (1999). Regulation of noradrenaline transporter (NAT) and 5-HT transporter (SERT) activity by inhibitors and substrates. 33rd Annual Scientific Meeting of ASCEPT, Sydney Convention & Exhibition Cen., Sydney, 4 - 8 December, 1999. Melbourne: Blackwell Scientific Publications.

Regulation of noradrenaline transporter (NAT) and 5-HT transporter (SERT) activity by inhibitors and substrates

1999

Conference Publication

Interactions of Haloperidol (HP) Metabolites with transporters for Dopamine (DAT), Norepinephrine (NET) and Serotonin (SERT)

Siebert, G. A., Pond, S. M. and Bryan-Lluka, L. J. (1999). Interactions of Haloperidol (HP) Metabolites with transporters for Dopamine (DAT), Norepinephrine (NET) and Serotonin (SERT). 42nd Annual Meeting of the Western Pharmacology Society, Maui, Hawaii, USA, 30 Jan - 04 Feb, 1999. Seattle, USA: Western Pharmacological Society.

Interactions of Haloperidol (HP) Metabolites with transporters for Dopamine (DAT), Norepinephrine (NET) and Serotonin (SERT)

1999

Conference Publication

Effects of mutation of phenylalanine-531 on rat noradrenaline transporter activity

Paczkowski, F. A. and Bryan-Lluka, L. J. (1999). Effects of mutation of phenylalanine-531 on rat noradrenaline transporter activity. 33rd Annual Scientific Meeting of ASCEPT, Sydney, 4 - 8 December, 1999. Melbourne: Blackwell Scientific Publications.

Effects of mutation of phenylalanine-531 on rat noradrenaline transporter activity

1999

Conference Publication

Thyroxine causes cell type-dependent regulation of the serotonin and noradrenaline transporters

Bryan-Lluka, L. J., Boyd, S. M. and Papacostas, M. H. (1999). Thyroxine causes cell type-dependent regulation of the serotonin and noradrenaline transporters. British Pharmacological Society Meeting, University of Leeds, UK, 8 - 10 September, 1999. Hampshire, UK: Stockton Press - Div. of Macmillan Press Ltd.

Thyroxine causes cell type-dependent regulation of the serotonin and noradrenaline transporters

1998

Journal Article

Catecholamine uptake and metabolism in rat lungs

Bryan-Lluka, L. J., James, K. M., Bönisch, H., Pörzgen, P., Guice, K. S. and Oldham, K. T. (1998). Catecholamine uptake and metabolism in rat lungs. Advances in pharmacology (San Diego, Calif.), 42, 353-356.

Catecholamine uptake and metabolism in rat lungs

1997

Journal Article

The rat norepinephrine transporter: Molecular cloning from PC12 cells and functional expression

Brüss, Michael, Pörzgen, Peter, Bryan-Lluka, Lesley J. and Bönisch, Heinz (1997). The rat norepinephrine transporter: Molecular cloning from PC12 cells and functional expression. Molecular Brain Research, 52 (2), 257-262. doi: 10.1016/S0169-328X(97)00267-2

The rat norepinephrine transporter: Molecular cloning from PC12 cells and functional expression

1997

Journal Article

Catecholamine Uptake and Metabolism in Rat Lungs

Bryan-Lluka, Lesley J., James, Kristy M., Bönisch, Heinz, Pörzgen, Peter, Guice, Karen S. and Oldham, Keith T. (1997). Catecholamine Uptake and Metabolism in Rat Lungs. Advances in Pharmacology, 42 (C), 353-356. doi: 10.1016/S1054-3589(08)60763-2

Catecholamine Uptake and Metabolism in Rat Lungs

1997

Journal Article

Efflux studies allow further characterisation of the noradrenaline and 5-hydroxytryptamine transporters in rat lungs

James, K. M. and Bryan-Lluka, L. J. (1997). Efflux studies allow further characterisation of the noradrenaline and 5-hydroxytryptamine transporters in rat lungs. Naunyn-Schmiedeberg's Archives of Pharmacology, 356 (1), 126-133. doi: 10.1007/PL00005019

Efflux studies allow further characterisation of the noradrenaline and 5-hydroxytryptamine transporters in rat lungs

1996

Journal Article

Amezinium and debrisoquine are substrates of uptake1 and potent inhibitors of monoamine oxidase in perfused lungs of rats

Bryan-Lluka L.J., Seers H. and Sharpe I. (1996). Amezinium and debrisoquine are substrates of uptake1 and potent inhibitors of monoamine oxidase in perfused lungs of rats. Naunyn-Schmiedeberg's Archives of Pharmacology, 353 (5), 536-544. doi: 10.1007/BF00169173

Amezinium and debrisoquine are substrates of uptake1 and potent inhibitors of monoamine oxidase in perfused lungs of rats

Past funding

  • 2013 - 2016
    Development and implementation of MathBench for Australian universities to improve quantitative skills of science and mathematics students (OLT grant administered by Deakin University)
    Deakin University
    Open grant
  • 2009
    Liquid Scintillation Spectroscopy Facility
    UQ School/Centre Co-Funding
    Open grant
  • 2005 - 2007
    Determinants of Expression Assembly and Function of the Noradrenaline Transporter
    ARC Discovery Projects
    Open grant
  • 2003
    To Continue Established Collaboration With Professor Bonisch
    UQ Travel Grants Scheme
    Open grant
  • 2000 - 2002
    Molecular structure-function relationships of the moradrenaline transporter and drug action
    NHMRC Project Grant
    Open grant
  • 1998 - 2000
    Noradrenaline and Serotonin Transporter Regulation Implications for Therapy of Depression
    NHMRC Project Grant
    Open grant
  • 1996 - 1997
    Molecular identification and regulation of expression of monoamine transporters in pulmonary endothelial cells and other cell types - in collaboration with Professor H. Bonisch (Bonn, Germany) and Pro
    Quality Funds Round 3
    Open grant

Availability

Dr Lesley Lluka is:
Not available for supervision

Supervision history

Completed supervision

Enquiries

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communications@uq.edu.au