
Overview
Background
Senior Research Fellow
Room 7048, Level 7, Pharmacy Australia Centre of Excellence Phone:+61 7 334-61898; Fax: +61 7 334-61999 Email: a.hewavitharana@pharmacy.uq.edu.au
Amitha obtained her B.Sc. from the University of Colombo (Sri Lanka), M.Sc. from the university of Victoria (B.C., Canada) and PhD in analytical chemistry from the University of Alberta (Canada). Following that, she held brief research positions at the Massey University (New Zealand) and NZ Leather Research Institute. She then held a research scientist position at the NZ Dairy Research Institute (NZDRI, currently Fonterra Research) for 4 years before moving to Australia in 1997.
In Australia, she commenced her career as a lecturer in analytical chemistry at the University of Western Sydney, and then at Queensland University of Technology (QUT) until 2001. Following that, she held research positions in CSIRO (food science) and in QHSS (investigative chemistry) before joining the school of pharmacy in 2004.
Availability
- Dr Amitha Hewavitharana is:
- Not available for supervision
Fields of research
Qualifications
- Doctor of Philosophy, University of Alberta
Research interests
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Research Interests
Please refer to the complete list of publications, in the link below, to get an idea of Dr Hewavitharana's research focus: https://akhcv.wordpress.com Stemming from PhD in analytical chemistry, Dr Hewavitharana's research is focused on solving fundamental analytical problems as well as developing analytical methods for a variety of applications such as: metal speciation (free/ionized calcium, and magnesium) and metabolite analysis (eg. pseudouridine, paracetamols, endorphins, dynorphins) in biological fluids, water and waste water, nutrients (eg. vitamins), antinutrients (eg. lysiniolanine) and antioxidants (eg. carotenes, tocopherols, tocotrienols) in dairy foods and meat products, nutraceuticals in tropical fruits (eg. carotenes, quercetins, mangiferin, anticancer compounds) psychoactive compunds (THC), marker compounds such as isoprostanes, sinistrin, fluconazole, pindolol, p-amino hippuric acid and creatinine, drug discovery (antibiotics and anti-cancer compounds from marine sponge bacteria and tropical fruit), drug delivery (dendrimers) and drug assay (BAY-11-7082, paracetamol, endorphin), Disease markers (eg. Sarcosine in prostate cancer), Fat and Water soluble analogues of vitamin D, Trace metals in food, Ion suppression effects in mass spectrometry, Challenges in method validation. Over the past 31 years, her research outcomes were achieved using a wide variety of instrumentation such as, HPLC -MS-MS, -PDA, -fluorescence, -EC etc, IC, GC-MS, HPCE, AAS, NIR, FTIR, FIA. Her interests also include method validation and laboratory quality assurance in line with ISO 17025. She provides her expertise as a technical assessor to NATA and IANZ, in ISO accreditation of food and water laboratories in Australia and New Zealand.
Works
Search Professor Amitha Hewavitharana’s works on UQ eSpace
2013
Journal Article
Inaccuracies in the quantification of peptides - A case study using beta-endorphin assay
Herath, H. M. D. R., Kim, R-R., Cabot, P. J., Shaw, P. N. and Hewavitharana, A. K. (2013). Inaccuracies in the quantification of peptides - A case study using beta-endorphin assay. LCGC Europe, 26 (8), 435-437.
2013
Journal Article
Between fruit variability of the bioactive compounds, β-carotene and mangiferin, in mango (Mangifera indica)
Hewavitharana, Amitha K., Tan, Zhi W., Shimada, Ryo, Shaw, Paul N. and Flanagan, Bernadine M. (2013). Between fruit variability of the bioactive compounds, β-carotene and mangiferin, in mango (Mangifera indica). Nutrition and Dietetics, 70 (2), 158-163. doi: 10.1111/1747-0080.12009
2013
Journal Article
Current status of Vitamin D assays: are they reliable and sufficiently informative for clinical studies?
Hewavitharana, Amitha (2013). Current status of Vitamin D assays: are they reliable and sufficiently informative for clinical studies?. Bioanalysis, 5 (11), 1325-1327. doi: 10.4155/BIO.13.88
2013
Journal Article
Recent trends in the determination of vitamin D
Gomes, Fabio P., Shaw, P. Nicholas, Whitfield, Karen, Koorts, Pieter and Hewavitharana, Amitha K. (2013). Recent trends in the determination of vitamin D. Bioanalysis, 5 (24), 3063-3078. doi: 10.4155/bio.13.283
2013
Conference Publication
Liquid chromatography-mass spectrometry metabolomic profiling to explore inter-species diversity in the genus Salinispora
Bose, U., Hewavitharana, A. K., Vidgen, M. E., Shaw, P. N., Fuerst, J. A. and Hodson, M. P. (2013). Liquid chromatography-mass spectrometry metabolomic profiling to explore inter-species diversity in the genus Salinispora. FEMS 2013: 5th Congress of European Microbiologists, Leipzig, Germany, 21-25 July, 2013.
2013
Journal Article
Inaccuracies in the quantification of peptides - a case study using beta-endorphin assay
Herath, H. M. D. R., Kim, R. -R., Cabot, P. J., Shaw, P. N. and Hewavitharana, A. K. (2013). Inaccuracies in the quantification of peptides - a case study using beta-endorphin assay. LCGC North America, 31 (1), 58-61.
2013
Conference Publication
Intraspecific variability in secondary metabolites of the Great Barrier Reef sponge-associated marine bacteria "Salinispora pacifica"
Bose, Utpal, Hodson, Mark P., Shaw, P. Nicholas, Fuerst, John A. and Hewavitharana, Amitha K. (2013). Intraspecific variability in secondary metabolites of the Great Barrier Reef sponge-associated marine bacteria "Salinispora pacifica". IMBC 2013: 10th International Marine Biotechnology Conference, South Bank, QLD, Australia, 11-15 November, 2013.
2013
Conference Publication
Patterns of chemical diversity on sponge associated marine bacteria
Bose, Utpal, Hodson, Mark P., Vidgen, Miranda E., Shaw, P. Nicholas, Fuerst, John A. and Hewavitharana, Amitha K. (2013). Patterns of chemical diversity on sponge associated marine bacteria. 9th Annual Conference of the Metabolomics Society, Glasgow, Scotland, U.K., 1-4 July, 2013.
2013
Journal Article
Anticancer activity of Carica papaya: a review
Nguyen, Thao T. T., Shaw, Paul N., Parat, Marie-Odile and Hewavitharana, Amitha K. (2013). Anticancer activity of Carica papaya: a review. Molecular Nutrition and Food Research, 57 (1), 153-164. doi: 10.1002/mnfr.201200388
2013
Conference Publication
Biotransformation within inflamed tissue of beta-endorphin 1-31 and three major N-terminal fragments; beta-endorphin 1-17, beta-endorphin 1-13, and beta-endorphin 1-11
Asvadi, Naghmeh Hajarol, Morgan, Michael, Hewavitharana, Amitha, Shaw, P. Nicholas and Cabot, Peter J. (2013). Biotransformation within inflamed tissue of beta-endorphin 1-31 and three major N-terminal fragments; beta-endorphin 1-17, beta-endorphin 1-13, and beta-endorphin 1-11. HPLC 2013: 40th International Symposium on High Performance Liquid Phase Separations and Related Techniques, Hobart, TAS, Australia, 18-21 November, 2013. Royal Australian Chemical Institute (raci).
2013
Conference Publication
Discovering the hidden secondary metabolome of Salinispora arenicola: a study of intra-specific diversity
Bose, Utpal, Hodson, Mark P., Shaw, P. Nicholas, Fuerst, John A. and Hewavitharana, Amitha K. (2013). Discovering the hidden secondary metabolome of Salinispora arenicola: a study of intra-specific diversity. ICEC 2013: International Chemical Ecology Conference, Melbourne, VIC, Australia, 19-23 August, 2013.
2013
Conference Publication
The biotransformation of beta-endorphin in the rat brain after a single sedating dose of ethanol
Morgan, Michael, Holgate, Jan, Hewavitharana, Amitha K., Shaw, Nick, Cabot, Peter and Bartlett, Selena E. (2013). The biotransformation of beta-endorphin in the rat brain after a single sedating dose of ethanol. Australasian Professional Society on Alcohol and other Drugs Conference, Brisbane, QLD, Australia, 24-27 November 2013. Chichester, West Sussex, United Kingdom: Wiley-Blackwell. doi: 10.1111/dar.12077
2013
Journal Article
Developmental cycle and pharmaceutically relevant compounds of Salinospora actinbacteria isolated from Great Barrier Reef marine sponges
Ng, Yi Kai, Hewavitharana, Amitha K., Webb, Richard, Shaw, P. Nicholas and Fuerst, John A. (2013). Developmental cycle and pharmaceutically relevant compounds of Salinospora actinbacteria isolated from Great Barrier Reef marine sponges. Applied Microbiology and Biotechnology, 97 (7), 3097-3108. doi: 10.1007/s00253-012-4479-0
2013
Conference Publication
Chemical diversity of marine bacteria Salinispora arenicola and "Salinispora pacifica" associated with the host sponges Dercitus xanthus and Cinahyrella australiensis
Bose, Utpal, Hodson, Mark, Vidgen, M., Shaw, N., Fuerst, J. and Hewavitharana, A. (2013). Chemical diversity of marine bacteria Salinispora arenicola and "Salinispora pacifica" associated with the host sponges Dercitus xanthus and Cinahyrella australiensis. The 9th International Sponge Conference, Fremantle, WA, Australia, 2013.
2012
Journal Article
Monitoring potential prostate cancer biomarkers in urine by capillary electrophoresis-tandem mass spectrometry
Soliman, Laiel C., Hui, Yu, Hewavitharana, Amitha K. and Chen, David D. Y. (2012). Monitoring potential prostate cancer biomarkers in urine by capillary electrophoresis-tandem mass spectrometry. Journal of Chromatography A, 1267 (7), 162-169. doi: 10.1016/j.chroma.2012.07.021
2012
Journal Article
Dynorphin A 1–17 biotransformation in inflamed tissue, serum and trypsin solution analysed by liquid chromatography–tandem mass spectrometry
Morgan, M., Herath, H. M. D. R., Cabot, P. J., Shaw, P. N. and Hewavitharana, A. K. (2012). Dynorphin A 1–17 biotransformation in inflamed tissue, serum and trypsin solution analysed by liquid chromatography–tandem mass spectrometry. Analytical and Bioanalytical Chemistry, 404 (10), 3111-3121. doi: 10.1007/s00216-012-6406-8
2012
Journal Article
Study of beta endorphin metabolism in inflamed tissue, serum and trypsin solution by liquid chromatography-tandem mass spectrometric analysis
Dilanthi, H. M. D. R., Cabot, P. J., Shaw, P. N. and Hewavitharana, A. K. (2012). Study of beta endorphin metabolism in inflamed tissue, serum and trypsin solution by liquid chromatography-tandem mass spectrometric analysis. Analytical and Bioanalytical Chemistry, 402 (6), 2089-2100. doi: 10.1007/s00216-011-5686-8
2012
Conference Publication
Dependence of secondary metabolite profiles of Salinispora species on their geographical distribution
Hewavitharana, Amitha K. (2012). Dependence of secondary metabolite profiles of Salinispora species on their geographical distribution. 16th International Congress (PHYTOPHARM 2012), St Petersburg, Russia, 9-11 July 2012.
2011
Journal Article
Matrix matching in liquid chromatography-mass spectrometry with stable isotope labelled internal standards - Is it necessary?
Hewavitharana, Amitha K. (2011). Matrix matching in liquid chromatography-mass spectrometry with stable isotope labelled internal standards - Is it necessary?. Journal of Chromatography A, 1218 (2), 359-361. doi: 10.1016/j.chroma.2010.11.047
2011
Conference Publication
Identification of antimicrobial compounds in the crude extracts of the Australian macrofungi, Hohenbuehelia sp. and Ramaria sp., through bioassay-guided fractionation
Bala, Neeraj, Aitken, Elizabeth A.B., Hewavitharana, Amitha, Ross, Benjamin and Steadman, Kathryn (2011). Identification of antimicrobial compounds in the crude extracts of the Australian macrofungi, Hohenbuehelia sp. and Ramaria sp., through bioassay-guided fractionation. Australian Pharmaceutical Science Association Conference, Adelaide, Australia, 11-14 December 2011.
Funding
Past funding
Supervision
Availability
- Dr Amitha Hewavitharana is:
- Not available for supervision
Supervision history
Completed supervision
-
2017
Doctor Philosophy
Investigation of Selective Anti-Proliferative and Immunomodulatory Properties of Carica Papaya
Principal Advisor
Other advisors: Professor Peter Cabot, Professor Nick Shaw
-
2016
Doctor Philosophy
Development of an assay for total vitamin D content in milk and application to study the effect of pasteurisation in breastmilk
Principal Advisor
Other advisors: Professor Nick Shaw, Dr Karen Whitfield
-
2016
Doctor Philosophy
Investigation of bioactive compounds with anti-cancer potential in Carica papaya leaves
Principal Advisor
Other advisors: Professor Nick Shaw, Associate Professor Marie-Odile Parat
-
2014
Doctor Philosophy
Study of the chemical diversity of the actinobacteria genus Salinispora, isolated from Great Barrier Reef Sponges
Principal Advisor
Other advisors: Emeritus Professor John Fuerst, Professor Nick Shaw
-
2013
Doctor Philosophy
A study of the activity and efficacy of beta endorphin fragments in inflamed tissue
Principal Advisor
Other advisors: Professor Peter Cabot, Professor Nick Shaw
-
2018
Doctor Philosophy
Development of an assay for vitamin D in biological samples
Associate Advisor
Other advisors: Dr Karen Whitfield, Professor Nick Shaw
-
2017
Doctor Philosophy
Essential Trace Element Analysis of Human Breast Milk
Associate Advisor
Other advisors: Professor Nick Shaw, Dr Karen Whitfield
-
2015
Doctor Philosophy
Beta-Endorphin Biotransformation and Modulation of Inflammatory Signals
Associate Advisor
Other advisors: Professor Peter Cabot, Professor Nick Shaw
-
2013
Doctor Philosophy
Developmental cycle and the regulation of natural products in the antibiotic-producing actinobacterium Salinispora from marine sponges
Associate Advisor
Other advisors: Emeritus Professor John Fuerst, Professor Nick Shaw
-
2012
Doctor Philosophy
Genetic and chemical diversity of the actinobacterial genus Salinispora isolated from Great Barrier Reef sponges.
Associate Advisor
Other advisors: Emeritus Professor John Fuerst, Professor Nick Shaw
-
2010
Doctor Philosophy
The peripheral mechanisms of analgesia and the involvement of adhesion molecules - Development of a novel targeted drug delivery system to sites of inflammation and application to peripheral analgesia
Associate Advisor
Other advisors: Professor Peter Cabot, Professor Nick Shaw
Media
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