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Dr Amitha Hewavitharana
Dr

Amitha Hewavitharana

Email: 

Overview

Background

Senior Research Fellow

Room 7048, Level 7, Pharmacy Australia Centre of Excellence Phone:+61 7 334-61898; Fax: +61 7 334-61999 Email: a.hewavitharana@pharmacy.uq.edu.au

Amitha obtained her B.Sc. from the University of Colombo (Sri Lanka), M.Sc. from the university of Victoria (B.C., Canada) and PhD in analytical chemistry from the University of Alberta (Canada). Following that, she held brief research positions at the Massey University (New Zealand) and NZ Leather Research Institute. She then held a research scientist position at the NZ Dairy Research Institute (NZDRI, currently Fonterra Research) for 4 years before moving to Australia in 1997.

In Australia, she commenced her career as a lecturer in analytical chemistry at the University of Western Sydney, and then at Queensland University of Technology (QUT) until 2001. Following that, she held research positions in CSIRO (food science) and in QHSS (investigative chemistry) before joining the school of pharmacy in 2004.

Availability

Dr Amitha Hewavitharana is:
Not available for supervision

Qualifications

  • Doctor of Philosophy, University of Alberta

Research interests

  • Research Interests

    Please refer to the complete list of publications, in the link below, to get an idea of Dr Hewavitharana's research focus: https://akhcv.wordpress.com Stemming from PhD in analytical chemistry, Dr Hewavitharana's research is focused on solving fundamental analytical problems as well as developing analytical methods for a variety of applications such as: metal speciation (free/ionized calcium, and magnesium) and metabolite analysis (eg. pseudouridine, paracetamols, endorphins, dynorphins) in biological fluids, water and waste water, nutrients (eg. vitamins), antinutrients (eg. lysiniolanine) and antioxidants (eg. carotenes, tocopherols, tocotrienols) in dairy foods and meat products, nutraceuticals in tropical fruits (eg. carotenes, quercetins, mangiferin, anticancer compounds) psychoactive compunds (THC), marker compounds such as isoprostanes, sinistrin, fluconazole, pindolol, p-amino hippuric acid and creatinine, drug discovery (antibiotics and anti-cancer compounds from marine sponge bacteria and tropical fruit), drug delivery (dendrimers) and drug assay (BAY-11-7082, paracetamol, endorphin), Disease markers (eg. Sarcosine in prostate cancer), Fat and Water soluble analogues of vitamin D, Trace metals in food, Ion suppression effects in mass spectrometry, Challenges in method validation. Over the past 31 years, her research outcomes were achieved using a wide variety of instrumentation such as, HPLC -MS-MS, -PDA, -fluorescence, -EC etc, IC, GC-MS, HPCE, AAS, NIR, FTIR, FIA. Her interests also include method validation and laboratory quality assurance in line with ISO 17025. She provides her expertise as a technical assessor to NATA and IANZ, in ISO accreditation of food and water laboratories in Australia and New Zealand.

Works

Search Professor Amitha Hewavitharana’s works on UQ eSpace

109 works between 1988 and 2023

41 - 60 of 109 works

2013

Journal Article

Inaccuracies in the quantification of peptides - A case study using beta-endorphin assay

Herath, H. M. D. R., Kim, R-R., Cabot, P. J., Shaw, P. N. and Hewavitharana, A. K. (2013). Inaccuracies in the quantification of peptides - A case study using beta-endorphin assay. LCGC Europe, 26 (8), 435-437.

Inaccuracies in the quantification of peptides - A case study using beta-endorphin assay

2013

Journal Article

Between fruit variability of the bioactive compounds, β-carotene and mangiferin, in mango (Mangifera indica)

Hewavitharana, Amitha K., Tan, Zhi W., Shimada, Ryo, Shaw, Paul N. and Flanagan, Bernadine M. (2013). Between fruit variability of the bioactive compounds, β-carotene and mangiferin, in mango (Mangifera indica). Nutrition and Dietetics, 70 (2), 158-163. doi: 10.1111/1747-0080.12009

Between fruit variability of the bioactive compounds, β-carotene and mangiferin, in mango (Mangifera indica)

2013

Journal Article

Current status of Vitamin D assays: are they reliable and sufficiently informative for clinical studies?

Hewavitharana, Amitha (2013). Current status of Vitamin D assays: are they reliable and sufficiently informative for clinical studies?. Bioanalysis, 5 (11), 1325-1327. doi: 10.4155/BIO.13.88

Current status of Vitamin D assays: are they reliable and sufficiently informative for clinical studies?

2013

Journal Article

Recent trends in the determination of vitamin D

Gomes, Fabio P., Shaw, P. Nicholas, Whitfield, Karen, Koorts, Pieter and Hewavitharana, Amitha K. (2013). Recent trends in the determination of vitamin D. Bioanalysis, 5 (24), 3063-3078. doi: 10.4155/bio.13.283

Recent trends in the determination of vitamin D

2013

Conference Publication

Liquid chromatography-mass spectrometry metabolomic profiling to explore inter-species diversity in the genus Salinispora

Bose, U., Hewavitharana, A. K., Vidgen, M. E., Shaw, P. N., Fuerst, J. A. and Hodson, M. P. (2013). Liquid chromatography-mass spectrometry metabolomic profiling to explore inter-species diversity in the genus Salinispora. FEMS 2013: 5th Congress of European Microbiologists, Leipzig, Germany, 21-25 July, 2013.

Liquid chromatography-mass spectrometry metabolomic profiling to explore inter-species diversity in the genus Salinispora

2013

Journal Article

Inaccuracies in the quantification of peptides - a case study using beta-endorphin assay

Herath, H. M. D. R., Kim, R. -R., Cabot, P. J., Shaw, P. N. and Hewavitharana, A. K. (2013). Inaccuracies in the quantification of peptides - a case study using beta-endorphin assay. LCGC North America, 31 (1), 58-61.

Inaccuracies in the quantification of peptides - a case study using beta-endorphin assay

2013

Conference Publication

Intraspecific variability in secondary metabolites of the Great Barrier Reef sponge-associated marine bacteria "Salinispora pacifica"

Bose, Utpal, Hodson, Mark P., Shaw, P. Nicholas, Fuerst, John A. and Hewavitharana, Amitha K. (2013). Intraspecific variability in secondary metabolites of the Great Barrier Reef sponge-associated marine bacteria "Salinispora pacifica". IMBC 2013: 10th International Marine Biotechnology Conference, South Bank, QLD, Australia, 11-15 November, 2013.

Intraspecific variability in secondary metabolites of the Great Barrier Reef sponge-associated marine bacteria "Salinispora pacifica"

2013

Conference Publication

Patterns of chemical diversity on sponge associated marine bacteria

Bose, Utpal, Hodson, Mark P., Vidgen, Miranda E., Shaw, P. Nicholas, Fuerst, John A. and Hewavitharana, Amitha K. (2013). Patterns of chemical diversity on sponge associated marine bacteria. 9th Annual Conference of the Metabolomics Society, Glasgow, Scotland, U.K., 1-4 July, 2013.

Patterns of chemical diversity on sponge associated marine bacteria

2013

Journal Article

Anticancer activity of Carica papaya: a review

Nguyen, Thao T. T., Shaw, Paul N., Parat, Marie-Odile and Hewavitharana, Amitha K. (2013). Anticancer activity of Carica papaya: a review. Molecular Nutrition and Food Research, 57 (1), 153-164. doi: 10.1002/mnfr.201200388

Anticancer activity of Carica papaya: a review

2013

Conference Publication

Biotransformation within inflamed tissue of beta-endorphin 1-31 and three major N-terminal fragments; beta-endorphin 1-17, beta-endorphin 1-13, and beta-endorphin 1-11

Asvadi, Naghmeh Hajarol, Morgan, Michael, Hewavitharana, Amitha, Shaw, P. Nicholas and Cabot, Peter J. (2013). Biotransformation within inflamed tissue of beta-endorphin 1-31 and three major N-terminal fragments; beta-endorphin 1-17, beta-endorphin 1-13, and beta-endorphin 1-11. HPLC 2013: 40th International Symposium on High Performance Liquid Phase Separations and Related Techniques, Hobart, TAS, Australia, 18-21 November, 2013. Royal Australian Chemical Institute (raci).

Biotransformation within inflamed tissue of beta-endorphin 1-31 and three major N-terminal fragments; beta-endorphin 1-17, beta-endorphin 1-13, and beta-endorphin 1-11

2013

Conference Publication

Discovering the hidden secondary metabolome of Salinispora arenicola: a study of intra-specific diversity

Bose, Utpal, Hodson, Mark P., Shaw, P. Nicholas, Fuerst, John A. and Hewavitharana, Amitha K. (2013). Discovering the hidden secondary metabolome of Salinispora arenicola: a study of intra-specific diversity. ICEC 2013: International Chemical Ecology Conference, Melbourne, VIC, Australia, 19-23 August, 2013.

Discovering the hidden secondary metabolome of Salinispora arenicola: a study of intra-specific diversity

2013

Conference Publication

The biotransformation of beta-endorphin in the rat brain after a single sedating dose of ethanol

Morgan, Michael, Holgate, Jan, Hewavitharana, Amitha K., Shaw, Nick, Cabot, Peter and Bartlett, Selena E. (2013). The biotransformation of beta-endorphin in the rat brain after a single sedating dose of ethanol. Australasian Professional Society on Alcohol and other Drugs Conference, Brisbane, QLD, Australia, 24-27 November 2013. Chichester, West Sussex, United Kingdom: Wiley-Blackwell. doi: 10.1111/dar.12077

The biotransformation of beta-endorphin in the rat brain after a single sedating dose of ethanol

2013

Journal Article

Developmental cycle and pharmaceutically relevant compounds of Salinospora actinbacteria isolated from Great Barrier Reef marine sponges

Ng, Yi Kai, Hewavitharana, Amitha K., Webb, Richard, Shaw, P. Nicholas and Fuerst, John A. (2013). Developmental cycle and pharmaceutically relevant compounds of Salinospora actinbacteria isolated from Great Barrier Reef marine sponges. Applied Microbiology and Biotechnology, 97 (7), 3097-3108. doi: 10.1007/s00253-012-4479-0

Developmental cycle and pharmaceutically relevant compounds of Salinospora actinbacteria isolated from Great Barrier Reef marine sponges

2013

Conference Publication

Chemical diversity of marine bacteria Salinispora arenicola and "Salinispora pacifica" associated with the host sponges Dercitus xanthus and Cinahyrella australiensis

Bose, Utpal, Hodson, Mark, Vidgen, M., Shaw, N., Fuerst, J. and Hewavitharana, A. (2013). Chemical diversity of marine bacteria Salinispora arenicola and "Salinispora pacifica" associated with the host sponges Dercitus xanthus and Cinahyrella australiensis. The 9th International Sponge Conference, Fremantle, WA, Australia, 2013.

Chemical diversity of marine bacteria Salinispora arenicola and "Salinispora pacifica" associated with the host sponges Dercitus xanthus and Cinahyrella australiensis

2012

Journal Article

Monitoring potential prostate cancer biomarkers in urine by capillary electrophoresis-tandem mass spectrometry

Soliman, Laiel C., Hui, Yu, Hewavitharana, Amitha K. and Chen, David D. Y. (2012). Monitoring potential prostate cancer biomarkers in urine by capillary electrophoresis-tandem mass spectrometry. Journal of Chromatography A, 1267 (7), 162-169. doi: 10.1016/j.chroma.2012.07.021

Monitoring potential prostate cancer biomarkers in urine by capillary electrophoresis-tandem mass spectrometry

2012

Journal Article

Dynorphin A 1–17 biotransformation in inflamed tissue, serum and trypsin solution analysed by liquid chromatography–tandem mass spectrometry

Morgan, M., Herath, H. M. D. R., Cabot, P. J., Shaw, P. N. and Hewavitharana, A. K. (2012). Dynorphin A 1–17 biotransformation in inflamed tissue, serum and trypsin solution analysed by liquid chromatography–tandem mass spectrometry. Analytical and Bioanalytical Chemistry, 404 (10), 3111-3121. doi: 10.1007/s00216-012-6406-8

Dynorphin A 1–17 biotransformation in inflamed tissue, serum and trypsin solution analysed by liquid chromatography–tandem mass spectrometry

2012

Journal Article

Study of beta endorphin metabolism in inflamed tissue, serum and trypsin solution by liquid chromatography-tandem mass spectrometric analysis

Dilanthi, H. M. D. R., Cabot, P. J., Shaw, P. N. and Hewavitharana, A. K. (2012). Study of beta endorphin metabolism in inflamed tissue, serum and trypsin solution by liquid chromatography-tandem mass spectrometric analysis. Analytical and Bioanalytical Chemistry, 402 (6), 2089-2100. doi: 10.1007/s00216-011-5686-8

Study of beta endorphin metabolism in inflamed tissue, serum and trypsin solution by liquid chromatography-tandem mass spectrometric analysis

2012

Conference Publication

Dependence of secondary metabolite profiles of Salinispora species on their geographical distribution

Hewavitharana, Amitha K. (2012). Dependence of secondary metabolite profiles of Salinispora species on their geographical distribution. 16th International Congress (PHYTOPHARM 2012), St Petersburg, Russia, 9-11 July 2012.

Dependence of secondary metabolite profiles of Salinispora species on their geographical distribution

2011

Journal Article

Matrix matching in liquid chromatography-mass spectrometry with stable isotope labelled internal standards - Is it necessary?

Hewavitharana, Amitha K. (2011). Matrix matching in liquid chromatography-mass spectrometry with stable isotope labelled internal standards - Is it necessary?. Journal of Chromatography A, 1218 (2), 359-361. doi: 10.1016/j.chroma.2010.11.047

Matrix matching in liquid chromatography-mass spectrometry with stable isotope labelled internal standards - Is it necessary?

2011

Conference Publication

Identification of antimicrobial compounds in the crude extracts of the Australian macrofungi, Hohenbuehelia sp. and Ramaria sp., through bioassay-guided fractionation

Bala, Neeraj, Aitken, Elizabeth A.B., Hewavitharana, Amitha, Ross, Benjamin and Steadman, Kathryn (2011). Identification of antimicrobial compounds in the crude extracts of the Australian macrofungi, Hohenbuehelia sp. and Ramaria sp., through bioassay-guided fractionation. Australian Pharmaceutical Science Association Conference, Adelaide, Australia, 11-14 December 2011.

Identification of antimicrobial compounds in the crude extracts of the Australian macrofungi, Hohenbuehelia sp. and Ramaria sp., through bioassay-guided fractionation

Funding

Past funding

  • 2018
    Developing a method for measuring thiopurine drug and metabolites
    Research Donation Generic
    Open grant
  • 2010
    Analytical instrumentation enabling rapid compound separation and chemical structure analysis via mass fingerprinting
    UQ Major Equipment and Infrastructure
    Open grant

Supervision

Availability

Dr Amitha Hewavitharana is:
Not available for supervision

Supervision history

Completed supervision

Media

Enquiries

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