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Dr Amitha Hewavitharana
Dr

Amitha Hewavitharana

Email: 

Overview

Background

Senior Research Fellow

Room 7048, Level 7, Pharmacy Australia Centre of Excellence Phone:+61 7 334-61898; Fax: +61 7 334-61999 Email: a.hewavitharana@pharmacy.uq.edu.au

Amitha obtained her B.Sc. from the University of Colombo (Sri Lanka), M.Sc. from the university of Victoria (B.C., Canada) and PhD in analytical chemistry from the University of Alberta (Canada). Following that, she held brief research positions at the Massey University (New Zealand) and NZ Leather Research Institute. She then held a research scientist position at the NZ Dairy Research Institute (NZDRI, currently Fonterra Research) for 4 years before moving to Australia in 1997.

In Australia, she commenced her career as a lecturer in analytical chemistry at the University of Western Sydney, and then at Queensland University of Technology (QUT) until 2001. Following that, she held research positions in CSIRO (food science) and in QHSS (investigative chemistry) before joining the school of pharmacy in 2004.

Availability

Dr Amitha Hewavitharana is:
Not available for supervision

Qualifications

  • Doctor of Philosophy, University of Alberta

Research interests

  • Research Interests

    Please refer to the complete list of publications, in the link below, to get an idea of Dr Hewavitharana's research focus: https://akhcv.wordpress.com Stemming from PhD in analytical chemistry, Dr Hewavitharana's research is focused on solving fundamental analytical problems as well as developing analytical methods for a variety of applications such as: metal speciation (free/ionized calcium, and magnesium) and metabolite analysis (eg. pseudouridine, paracetamols, endorphins, dynorphins) in biological fluids, water and waste water, nutrients (eg. vitamins), antinutrients (eg. lysiniolanine) and antioxidants (eg. carotenes, tocopherols, tocotrienols) in dairy foods and meat products, nutraceuticals in tropical fruits (eg. carotenes, quercetins, mangiferin, anticancer compounds) psychoactive compunds (THC), marker compounds such as isoprostanes, sinistrin, fluconazole, pindolol, p-amino hippuric acid and creatinine, drug discovery (antibiotics and anti-cancer compounds from marine sponge bacteria and tropical fruit), drug delivery (dendrimers) and drug assay (BAY-11-7082, paracetamol, endorphin), Disease markers (eg. Sarcosine in prostate cancer), Fat and Water soluble analogues of vitamin D, Trace metals in food, Ion suppression effects in mass spectrometry, Challenges in method validation. Over the past 31 years, her research outcomes were achieved using a wide variety of instrumentation such as, HPLC -MS-MS, -PDA, -fluorescence, -EC etc, IC, GC-MS, HPCE, AAS, NIR, FTIR, FIA. Her interests also include method validation and laboratory quality assurance in line with ISO 17025. She provides her expertise as a technical assessor to NATA and IANZ, in ISO accreditation of food and water laboratories in Australia and New Zealand.

Works

Search Professor Amitha Hewavitharana’s works on UQ eSpace

109 works between 1988 and 2023

21 - 40 of 109 works

2016

Journal Article

Effect of pasteurisation on the concentrations of vitamin D compounds in donor breastmilk

Gomes, Fabio P., Shaw, P. Nicholas, Whitfield, Karen, Koorts, Pieter, McConachy, Helen and Hewavitharana, Amitha K. (2016). Effect of pasteurisation on the concentrations of vitamin D compounds in donor breastmilk. International Journal of Food Sciences and Nutrition, 67 (1), 16-19. doi: 10.3109/09637486.2015.1126566

Effect of pasteurisation on the concentrations of vitamin D compounds in donor breastmilk

2016

Journal Article

Determination of four sulfated vitamin D compounds in human biological fluids by liquid chromatography-tandem mass spectrometry

Gomes, Fabio P., Shaw, P. Nicholas and Hewavitharana, Amitha K. (2016). Determination of four sulfated vitamin D compounds in human biological fluids by liquid chromatography-tandem mass spectrometry. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 1009-1010, 80-86. doi: 10.1016/j.jchromb.2015.12.014

Determination of four sulfated vitamin D compounds in human biological fluids by liquid chromatography-tandem mass spectrometry

2016

Journal Article

The simultaneous analysis of eight essential trace elements in human milk by ICP-MS

Mohd-Taufek, Nor, Cartwright, David, Davies, Mark, Hewavitharana, Amitha K., Koorts, Pieter, Shaw, Paul N., Sumner, Ronald, Lee, Eugene and Whitfield, Karen (2016). The simultaneous analysis of eight essential trace elements in human milk by ICP-MS. Food Analytical Methods, 9 (7), 1-8. doi: 10.1007/s12161-015-0396-z

The simultaneous analysis of eight essential trace elements in human milk by ICP-MS

2016

Journal Article

Chemical characterization and in vitro cytotoxicity on squamous cell carcinoma cells of Carica papaya leaf extracts

Nguyen, Thao T., Parat, Marie-Odile, Hodson, Mark P., Pan, Jenny, Shaw, Paul N. and Hewavitharana, Amitha K. (2016). Chemical characterization and in vitro cytotoxicity on squamous cell carcinoma cells of Carica papaya leaf extracts. Toxins, 8 (1), 7.1-7.11. doi: 10.3390/toxins8010007

Chemical characterization and in vitro cytotoxicity on squamous cell carcinoma cells of Carica papaya leaf extracts

2016

Conference Publication

Medium polarity fraction of papaya leaf juice has selective antiproliferative effects on prostate cancer cells

Pandey, Saurabh, Walpole, Carina, Cabot, Peter J., Shaw, Paul N., Batra, Jyotsna and Hewavitharana, Amitha K. (2016). Medium polarity fraction of papaya leaf juice has selective antiproliferative effects on prostate cancer cells. 17th Asia-Pacific Prostate Cancer Conference, Melbourne, Australia, Aug 31-Sep 03, 2016. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/bju.13567

Medium polarity fraction of papaya leaf juice has selective antiproliferative effects on prostate cancer cells

2015

Journal Article

Breastmilk-saliva interactions boost innate immunity by regulating the oral microbiome in early infancy

Al-Shehri, Saad S., Knox, Christine L., Liley, Helen G., Cowley, David M., Wright, John R., Henman, Michael G., Hewavitharana, Amitha K., Charles, Bruce G., Shaw, Paul N., Sweeney, Emma L. and Duley, John A. (2015). Breastmilk-saliva interactions boost innate immunity by regulating the oral microbiome in early infancy. PLoS One, 10 (9) e0135047, e0135047.1-e0135047.19. doi: 10.1371/journal.pone.0135047

Breastmilk-saliva interactions boost innate immunity by regulating the oral microbiome in early infancy

2015

Conference Publication

Carica papaya leaf juice extracts have selective anti-proliferative responses in prostatic disease

Walpole, Carina, Pandey, Saurabh, Cabot, Peter J., Shaw, Paul N., Batra, Jyotsna and Hewavitharana, Amitha K. (2015). Carica papaya leaf juice extracts have selective anti-proliferative responses in prostatic disease. 2nd Prostate Cancer World Congress (PCWC), Cairns, QLD Australia, 17-21 August 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/bju.13198

Carica papaya leaf juice extracts have selective anti-proliferative responses in prostatic disease

2015

Journal Article

LC-MS-Based Metabolomics Study of Marine Bacterial Secondary Metabolite and Antibiotic Production in Salinispora arenicola.

Bose, Utpal, Hewavitharana, Amitha K., Ng, Yi Kai, Shaw, Paul Nicholas, Fuerst, John A. and Hodson, Mark P. (2015). LC-MS-Based Metabolomics Study of Marine Bacterial Secondary Metabolite and Antibiotic Production in Salinispora arenicola.. Marine Drugs, 13 (1), 249-266. doi: 10.3390/md13010249

LC-MS-Based Metabolomics Study of Marine Bacterial Secondary Metabolite and Antibiotic Production in Salinispora arenicola.

2015

Journal Article

Simultaneous quantitative analysis of eight vitamin D analogues in milk using liquid chromatographyetandem mass spectrometry

Gomes, Fabio P., Shaw, P. Nicholas, Whitfield, Karen and Hewavitharana, Amitha K. (2015). Simultaneous quantitative analysis of eight vitamin D analogues in milk using liquid chromatographyetandem mass spectrometry. Analytica Chimica Acta, 891 234099, 211-220. doi: 10.1016/j.aca.2015.08.017

Simultaneous quantitative analysis of eight vitamin D analogues in milk using liquid chromatographyetandem mass spectrometry

2015

Book Chapter

Cholecalciferol: Properties and Determination

Hewavitharana, A. K. and Gomes, F. P. (2015). Cholecalciferol: Properties and Determination. Encyclopedia of Food and Health. (pp. 42-46) Oxford, United Kingdom: Elsevier . doi: 10.1016/B978-0-12-384947-2.00148-3

Cholecalciferol: Properties and Determination

2015

Journal Article

Review of procedures used for the extraction of anti-cancer compounds from tropical plants

Pandey, Saurabh, Shaw, Paul N. and Hewavitharana, Amitha K. (2015). Review of procedures used for the extraction of anti-cancer compounds from tropical plants. Anti-Cancer Agents in Medicinal Chemistry, 15 (3), 314-326. doi: 10.2174/1871520614666141114202104

Review of procedures used for the extraction of anti-cancer compounds from tropical plants

2014

Journal Article

Effects of salinity on antibiotic production in sponge-derived Salinispora actinobacteria

Ng, Y. K., Hodson, M. P., Hewavitharana, A. K., Bose, U., Shaw, P. N. and Fuerst, J. A. (2014). Effects of salinity on antibiotic production in sponge-derived Salinispora actinobacteria. Journal of Applied Microbiology, 117 (1), 109-125. doi: 10.1111/jam.12507

Effects of salinity on antibiotic production in sponge-derived Salinispora actinobacteria

2014

Journal Article

Discovering the recondite secondary metabolome spectrum of Salinispora species: a study of inter-species diversity

Bose, Utpal, Hewavitharana, Amitha K., Vidgen, Miranda E., Ng, Yi Kai, Shaw, Nicholas, Fuerst, John A. and Hodson, Mark P. (2014). Discovering the recondite secondary metabolome spectrum of Salinispora species: a study of inter-species diversity. PLoS One, 9 (3) e91488, e91488.1-e91488.10. doi: 10.1371/journal.pone.0091488

Discovering the recondite secondary metabolome spectrum of Salinispora species: a study of inter-species diversity

2014

Journal Article

Bacterial production of the fungus-derived cholesterol-lowering agent mevinolin

Bose, Utpal, Hodson, Mark P., Shaw, P. Nicholas, Fuerst, John A. and Hewavitharana, Amitha K. (2014). Bacterial production of the fungus-derived cholesterol-lowering agent mevinolin. Biomedical Chromatography, 28 (9), 1163-1166. doi: 10.1002/bmc.3138

Bacterial production of the fungus-derived cholesterol-lowering agent mevinolin

2014

Journal Article

Biotransformation of beta-endorphin and possible therapeutic implications

Asvadi, Naghmeh H., Morgan, Michael, Hewavitharana, Amitha K., Shaw, P. Nicholas and Cabot, Peter J. (2014). Biotransformation of beta-endorphin and possible therapeutic implications. Frontiers in Pharmacology, 5 (Article 18) Article 18, 18. doi: 10.3389/fphar.2014.00018

Biotransformation of beta-endorphin and possible therapeutic implications

2014

Journal Article

Beta-Endorphin 1-31 Biotransformation and cAMP Modulation in Inflammation

Asvadi, Naghmeh Hajarol, Morgan, Michael, Herath, Herath M., Hewavitharana, Amitha K., Shaw, P. Nicholas and Cabot, Peter J. (2014). Beta-Endorphin 1-31 Biotransformation and cAMP Modulation in Inflammation. PLoS One, 9 (3) e90380, e90380.1-e90380.11. doi: 10.1371/journal.pone.0090380

Beta-Endorphin 1-31 Biotransformation and cAMP Modulation in Inflammation

2014

Journal Article

Two peptides, Cycloaspeptide A and Nazumamide A from a sponge associated marine Actinobacterium Salinispora sp

Bose, Utpal, Hodson, Mark P., Shaw, P. Nicholas, Fuerst, John A. and Hewavitharana, Amitha K. (2014). Two peptides, Cycloaspeptide A and Nazumamide A from a sponge associated marine Actinobacterium Salinispora sp. Natural Product Communications, 9 (4), 545-546. doi: 10.1177/1934578x1400900431

Two peptides, Cycloaspeptide A and Nazumamide A from a sponge associated marine Actinobacterium Salinispora sp

2014

Conference Publication

Investigation of compounds with cytotoxic activity in Carica papaya leaves

Nguyen, Thao, Parat, Marie-Odile, Hodson, Mark P., Shaw, P. Nicholas and Hewavitharana, Amitha K. (2014). Investigation of compounds with cytotoxic activity in Carica papaya leaves. ICDDT 2014: 6th International Conference on Drug Discovery and Therapy, Dubai, United Arab Emirates, February 2014. Saif Zone, Sharjah, UAE:

Investigation of compounds with cytotoxic activity in Carica papaya leaves

2014

Journal Article

Strategies for the detection and elimination of matrix effects in quantitative LC-MS analysis

Hewavitharana, Amitha K., Tan, Swee K. and Shaw, P. Nicholas (2014). Strategies for the detection and elimination of matrix effects in quantitative LC-MS analysis. LCGC North America, 32 (1), 54-64.

Strategies for the detection and elimination of matrix effects in quantitative LC-MS analysis

2014

Journal Article

Hydrophilic interaction liquid chromatography-tandem mass spectrometric determination of creatinine in human urine

Hewavitharana, Amitha K., Darch, Katherine M. and Shaw, P. Nicholas (2014). Hydrophilic interaction liquid chromatography-tandem mass spectrometric determination of creatinine in human urine. Analytical Letters, 47 (4), 689-696. doi: 10.1080/00032719.2013.848363

Hydrophilic interaction liquid chromatography-tandem mass spectrometric determination of creatinine in human urine

Funding

Past funding

  • 2018
    Developing a method for measuring thiopurine drug and metabolites
    Research Donation Generic
    Open grant
  • 2010
    Analytical instrumentation enabling rapid compound separation and chemical structure analysis via mass fingerprinting
    UQ Major Equipment and Infrastructure
    Open grant

Supervision

Availability

Dr Amitha Hewavitharana is:
Not available for supervision

Supervision history

Completed supervision

Media

Enquiries

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