
Overview
Background
Senior Research Fellow
Room 7048, Level 7, Pharmacy Australia Centre of Excellence Phone:+61 7 334-61898; Fax: +61 7 334-61999 Email: a.hewavitharana@pharmacy.uq.edu.au
Amitha obtained her B.Sc. from the University of Colombo (Sri Lanka), M.Sc. from the university of Victoria (B.C., Canada) and PhD in analytical chemistry from the University of Alberta (Canada). Following that, she held brief research positions at the Massey University (New Zealand) and NZ Leather Research Institute. She then held a research scientist position at the NZ Dairy Research Institute (NZDRI, currently Fonterra Research) for 4 years before moving to Australia in 1997.
In Australia, she commenced her career as a lecturer in analytical chemistry at the University of Western Sydney, and then at Queensland University of Technology (QUT) until 2001. Following that, she held research positions in CSIRO (food science) and in QHSS (investigative chemistry) before joining the school of pharmacy in 2004.
Availability
- Dr Amitha Hewavitharana is:
- Not available for supervision
Fields of research
Qualifications
- Doctor of Philosophy, University of Alberta
Research interests
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Research Interests
Please refer to the complete list of publications, in the link below, to get an idea of Dr Hewavitharana's research focus: https://akhcv.wordpress.com Stemming from PhD in analytical chemistry, Dr Hewavitharana's research is focused on solving fundamental analytical problems as well as developing analytical methods for a variety of applications such as: metal speciation (free/ionized calcium, and magnesium) and metabolite analysis (eg. pseudouridine, paracetamols, endorphins, dynorphins) in biological fluids, water and waste water, nutrients (eg. vitamins), antinutrients (eg. lysiniolanine) and antioxidants (eg. carotenes, tocopherols, tocotrienols) in dairy foods and meat products, nutraceuticals in tropical fruits (eg. carotenes, quercetins, mangiferin, anticancer compounds) psychoactive compunds (THC), marker compounds such as isoprostanes, sinistrin, fluconazole, pindolol, p-amino hippuric acid and creatinine, drug discovery (antibiotics and anti-cancer compounds from marine sponge bacteria and tropical fruit), drug delivery (dendrimers) and drug assay (BAY-11-7082, paracetamol, endorphin), Disease markers (eg. Sarcosine in prostate cancer), Fat and Water soluble analogues of vitamin D, Trace metals in food, Ion suppression effects in mass spectrometry, Challenges in method validation. Over the past 31 years, her research outcomes were achieved using a wide variety of instrumentation such as, HPLC -MS-MS, -PDA, -fluorescence, -EC etc, IC, GC-MS, HPCE, AAS, NIR, FTIR, FIA. Her interests also include method validation and laboratory quality assurance in line with ISO 17025. She provides her expertise as a technical assessor to NATA and IANZ, in ISO accreditation of food and water laboratories in Australia and New Zealand.
Works
Search Professor Amitha Hewavitharana’s works on UQ eSpace
2016
Journal Article
Effect of pasteurisation on the concentrations of vitamin D compounds in donor breastmilk
Gomes, Fabio P., Shaw, P. Nicholas, Whitfield, Karen, Koorts, Pieter, McConachy, Helen and Hewavitharana, Amitha K. (2016). Effect of pasteurisation on the concentrations of vitamin D compounds in donor breastmilk. International Journal of Food Sciences and Nutrition, 67 (1), 16-19. doi: 10.3109/09637486.2015.1126566
2016
Journal Article
Determination of four sulfated vitamin D compounds in human biological fluids by liquid chromatography-tandem mass spectrometry
Gomes, Fabio P., Shaw, P. Nicholas and Hewavitharana, Amitha K. (2016). Determination of four sulfated vitamin D compounds in human biological fluids by liquid chromatography-tandem mass spectrometry. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 1009-1010, 80-86. doi: 10.1016/j.jchromb.2015.12.014
2016
Journal Article
The simultaneous analysis of eight essential trace elements in human milk by ICP-MS
Mohd-Taufek, Nor, Cartwright, David, Davies, Mark, Hewavitharana, Amitha K., Koorts, Pieter, Shaw, Paul N., Sumner, Ronald, Lee, Eugene and Whitfield, Karen (2016). The simultaneous analysis of eight essential trace elements in human milk by ICP-MS. Food Analytical Methods, 9 (7), 1-8. doi: 10.1007/s12161-015-0396-z
2016
Journal Article
Chemical characterization and in vitro cytotoxicity on squamous cell carcinoma cells of Carica papaya leaf extracts
Nguyen, Thao T., Parat, Marie-Odile, Hodson, Mark P., Pan, Jenny, Shaw, Paul N. and Hewavitharana, Amitha K. (2016). Chemical characterization and in vitro cytotoxicity on squamous cell carcinoma cells of Carica papaya leaf extracts. Toxins, 8 (1), 7.1-7.11. doi: 10.3390/toxins8010007
2016
Conference Publication
Medium polarity fraction of papaya leaf juice has selective antiproliferative effects on prostate cancer cells
Pandey, Saurabh, Walpole, Carina, Cabot, Peter J., Shaw, Paul N., Batra, Jyotsna and Hewavitharana, Amitha K. (2016). Medium polarity fraction of papaya leaf juice has selective antiproliferative effects on prostate cancer cells. 17th Asia-Pacific Prostate Cancer Conference, Melbourne, Australia, Aug 31-Sep 03, 2016. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/bju.13567
2015
Journal Article
Breastmilk-saliva interactions boost innate immunity by regulating the oral microbiome in early infancy
Al-Shehri, Saad S., Knox, Christine L., Liley, Helen G., Cowley, David M., Wright, John R., Henman, Michael G., Hewavitharana, Amitha K., Charles, Bruce G., Shaw, Paul N., Sweeney, Emma L. and Duley, John A. (2015). Breastmilk-saliva interactions boost innate immunity by regulating the oral microbiome in early infancy. PLoS One, 10 (9) e0135047, e0135047.1-e0135047.19. doi: 10.1371/journal.pone.0135047
2015
Conference Publication
Carica papaya leaf juice extracts have selective anti-proliferative responses in prostatic disease
Walpole, Carina, Pandey, Saurabh, Cabot, Peter J., Shaw, Paul N., Batra, Jyotsna and Hewavitharana, Amitha K. (2015). Carica papaya leaf juice extracts have selective anti-proliferative responses in prostatic disease. 2nd Prostate Cancer World Congress (PCWC), Cairns, QLD Australia, 17-21 August 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/bju.13198
2015
Journal Article
LC-MS-Based Metabolomics Study of Marine Bacterial Secondary Metabolite and Antibiotic Production in Salinispora arenicola.
Bose, Utpal, Hewavitharana, Amitha K., Ng, Yi Kai, Shaw, Paul Nicholas, Fuerst, John A. and Hodson, Mark P. (2015). LC-MS-Based Metabolomics Study of Marine Bacterial Secondary Metabolite and Antibiotic Production in Salinispora arenicola.. Marine Drugs, 13 (1), 249-266. doi: 10.3390/md13010249
2015
Journal Article
Simultaneous quantitative analysis of eight vitamin D analogues in milk using liquid chromatographyetandem mass spectrometry
Gomes, Fabio P., Shaw, P. Nicholas, Whitfield, Karen and Hewavitharana, Amitha K. (2015). Simultaneous quantitative analysis of eight vitamin D analogues in milk using liquid chromatographyetandem mass spectrometry. Analytica Chimica Acta, 891 234099, 211-220. doi: 10.1016/j.aca.2015.08.017
2015
Book Chapter
Cholecalciferol: Properties and Determination
Hewavitharana, A. K. and Gomes, F. P. (2015). Cholecalciferol: Properties and Determination. Encyclopedia of Food and Health. (pp. 42-46) Oxford, United Kingdom: Elsevier . doi: 10.1016/B978-0-12-384947-2.00148-3
2015
Journal Article
Review of procedures used for the extraction of anti-cancer compounds from tropical plants
Pandey, Saurabh, Shaw, Paul N. and Hewavitharana, Amitha K. (2015). Review of procedures used for the extraction of anti-cancer compounds from tropical plants. Anti-Cancer Agents in Medicinal Chemistry, 15 (3), 314-326. doi: 10.2174/1871520614666141114202104
2014
Journal Article
Effects of salinity on antibiotic production in sponge-derived Salinispora actinobacteria
Ng, Y. K., Hodson, M. P., Hewavitharana, A. K., Bose, U., Shaw, P. N. and Fuerst, J. A. (2014). Effects of salinity on antibiotic production in sponge-derived Salinispora actinobacteria. Journal of Applied Microbiology, 117 (1), 109-125. doi: 10.1111/jam.12507
2014
Journal Article
Discovering the recondite secondary metabolome spectrum of Salinispora species: a study of inter-species diversity
Bose, Utpal, Hewavitharana, Amitha K., Vidgen, Miranda E., Ng, Yi Kai, Shaw, Nicholas, Fuerst, John A. and Hodson, Mark P. (2014). Discovering the recondite secondary metabolome spectrum of Salinispora species: a study of inter-species diversity. PLoS One, 9 (3) e91488, e91488.1-e91488.10. doi: 10.1371/journal.pone.0091488
2014
Journal Article
Bacterial production of the fungus-derived cholesterol-lowering agent mevinolin
Bose, Utpal, Hodson, Mark P., Shaw, P. Nicholas, Fuerst, John A. and Hewavitharana, Amitha K. (2014). Bacterial production of the fungus-derived cholesterol-lowering agent mevinolin. Biomedical Chromatography, 28 (9), 1163-1166. doi: 10.1002/bmc.3138
2014
Journal Article
Biotransformation of beta-endorphin and possible therapeutic implications
Asvadi, Naghmeh H., Morgan, Michael, Hewavitharana, Amitha K., Shaw, P. Nicholas and Cabot, Peter J. (2014). Biotransformation of beta-endorphin and possible therapeutic implications. Frontiers in Pharmacology, 5 (Article 18) Article 18, 18. doi: 10.3389/fphar.2014.00018
2014
Journal Article
Beta-Endorphin 1-31 Biotransformation and cAMP Modulation in Inflammation
Asvadi, Naghmeh Hajarol, Morgan, Michael, Herath, Herath M., Hewavitharana, Amitha K., Shaw, P. Nicholas and Cabot, Peter J. (2014). Beta-Endorphin 1-31 Biotransformation and cAMP Modulation in Inflammation. PLoS One, 9 (3) e90380, e90380.1-e90380.11. doi: 10.1371/journal.pone.0090380
2014
Journal Article
Two peptides, Cycloaspeptide A and Nazumamide A from a sponge associated marine Actinobacterium Salinispora sp
Bose, Utpal, Hodson, Mark P., Shaw, P. Nicholas, Fuerst, John A. and Hewavitharana, Amitha K. (2014). Two peptides, Cycloaspeptide A and Nazumamide A from a sponge associated marine Actinobacterium Salinispora sp. Natural Product Communications, 9 (4), 545-546. doi: 10.1177/1934578x1400900431
2014
Conference Publication
Investigation of compounds with cytotoxic activity in Carica papaya leaves
Nguyen, Thao, Parat, Marie-Odile, Hodson, Mark P., Shaw, P. Nicholas and Hewavitharana, Amitha K. (2014). Investigation of compounds with cytotoxic activity in Carica papaya leaves. ICDDT 2014: 6th International Conference on Drug Discovery and Therapy, Dubai, United Arab Emirates, February 2014. Saif Zone, Sharjah, UAE:
2014
Journal Article
Strategies for the detection and elimination of matrix effects in quantitative LC-MS analysis
Hewavitharana, Amitha K., Tan, Swee K. and Shaw, P. Nicholas (2014). Strategies for the detection and elimination of matrix effects in quantitative LC-MS analysis. LCGC North America, 32 (1), 54-64.
2014
Journal Article
Hydrophilic interaction liquid chromatography-tandem mass spectrometric determination of creatinine in human urine
Hewavitharana, Amitha K., Darch, Katherine M. and Shaw, P. Nicholas (2014). Hydrophilic interaction liquid chromatography-tandem mass spectrometric determination of creatinine in human urine. Analytical Letters, 47 (4), 689-696. doi: 10.1080/00032719.2013.848363
Funding
Past funding
Supervision
Availability
- Dr Amitha Hewavitharana is:
- Not available for supervision
Supervision history
Completed supervision
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2017
Doctor Philosophy
Investigation of Selective Anti-Proliferative and Immunomodulatory Properties of Carica Papaya
Principal Advisor
Other advisors: Professor Peter Cabot, Professor Nick Shaw
-
2016
Doctor Philosophy
Development of an assay for total vitamin D content in milk and application to study the effect of pasteurisation in breastmilk
Principal Advisor
Other advisors: Professor Nick Shaw, Dr Karen Whitfield
-
2016
Doctor Philosophy
Investigation of bioactive compounds with anti-cancer potential in Carica papaya leaves
Principal Advisor
Other advisors: Professor Nick Shaw, Associate Professor Marie-Odile Parat
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2014
Doctor Philosophy
Study of the chemical diversity of the actinobacteria genus Salinispora, isolated from Great Barrier Reef Sponges
Principal Advisor
Other advisors: Emeritus Professor John Fuerst, Professor Nick Shaw
-
2013
Doctor Philosophy
A study of the activity and efficacy of beta endorphin fragments in inflamed tissue
Principal Advisor
Other advisors: Professor Peter Cabot, Professor Nick Shaw
-
2018
Doctor Philosophy
Development of an assay for vitamin D in biological samples
Associate Advisor
Other advisors: Dr Karen Whitfield, Professor Nick Shaw
-
2017
Doctor Philosophy
Essential Trace Element Analysis of Human Breast Milk
Associate Advisor
Other advisors: Professor Nick Shaw, Dr Karen Whitfield
-
2015
Doctor Philosophy
Beta-Endorphin Biotransformation and Modulation of Inflammatory Signals
Associate Advisor
Other advisors: Professor Peter Cabot, Professor Nick Shaw
-
2013
Doctor Philosophy
Developmental cycle and the regulation of natural products in the antibiotic-producing actinobacterium Salinispora from marine sponges
Associate Advisor
Other advisors: Emeritus Professor John Fuerst, Professor Nick Shaw
-
2012
Doctor Philosophy
Genetic and chemical diversity of the actinobacterial genus Salinispora isolated from Great Barrier Reef sponges.
Associate Advisor
Other advisors: Emeritus Professor John Fuerst, Professor Nick Shaw
-
2010
Doctor Philosophy
The peripheral mechanisms of analgesia and the involvement of adhesion molecules - Development of a novel targeted drug delivery system to sites of inflammation and application to peripheral analgesia
Associate Advisor
Other advisors: Professor Peter Cabot, Professor Nick Shaw
Media
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