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Dr Amitha Hewavitharana
Dr

Amitha Hewavitharana

Email: 

Overview

Background

Senior Research Fellow

Room 7048, Level 7, Pharmacy Australia Centre of Excellence Phone:+61 7 334-61898; Fax: +61 7 334-61999 Email: a.hewavitharana@pharmacy.uq.edu.au

Amitha obtained her B.Sc. from the University of Colombo (Sri Lanka), M.Sc. from the university of Victoria (B.C., Canada) and PhD in analytical chemistry from the University of Alberta (Canada). Following that, she held brief research positions at the Massey University (New Zealand) and NZ Leather Research Institute. She then held a research scientist position at the NZ Dairy Research Institute (NZDRI, currently Fonterra Research) for 4 years before moving to Australia in 1997.

In Australia, she commenced her career as a lecturer in analytical chemistry at the University of Western Sydney, and then at Queensland University of Technology (QUT) until 2001. Following that, she held research positions in CSIRO (food science) and in QHSS (investigative chemistry) before joining the school of pharmacy in 2004.

Availability

Dr Amitha Hewavitharana is:
Not available for supervision

Qualifications

  • Doctor of Philosophy, University of Alberta

Research interests

  • Research Interests

    Please refer to the complete list of publications, in the link below, to get an idea of Dr Hewavitharana's research focus: https://akhcv.wordpress.com Stemming from PhD in analytical chemistry, Dr Hewavitharana's research is focused on solving fundamental analytical problems as well as developing analytical methods for a variety of applications such as: metal speciation (free/ionized calcium, and magnesium) and metabolite analysis (eg. pseudouridine, paracetamols, endorphins, dynorphins) in biological fluids, water and waste water, nutrients (eg. vitamins), antinutrients (eg. lysiniolanine) and antioxidants (eg. carotenes, tocopherols, tocotrienols) in dairy foods and meat products, nutraceuticals in tropical fruits (eg. carotenes, quercetins, mangiferin, anticancer compounds) psychoactive compunds (THC), marker compounds such as isoprostanes, sinistrin, fluconazole, pindolol, p-amino hippuric acid and creatinine, drug discovery (antibiotics and anti-cancer compounds from marine sponge bacteria and tropical fruit), drug delivery (dendrimers) and drug assay (BAY-11-7082, paracetamol, endorphin), Disease markers (eg. Sarcosine in prostate cancer), Fat and Water soluble analogues of vitamin D, Trace metals in food, Ion suppression effects in mass spectrometry, Challenges in method validation. Over the past 31 years, her research outcomes were achieved using a wide variety of instrumentation such as, HPLC -MS-MS, -PDA, -fluorescence, -EC etc, IC, GC-MS, HPCE, AAS, NIR, FTIR, FIA. Her interests also include method validation and laboratory quality assurance in line with ISO 17025. She provides her expertise as a technical assessor to NATA and IANZ, in ISO accreditation of food and water laboratories in Australia and New Zealand.

Works

Search Professor Amitha Hewavitharana’s works on UQ eSpace

109 works between 1988 and 2023

81 - 100 of 109 works

2006

Conference Publication

Identification and quantitation of intact beta-endorphin by LC-MS-MS

Cabot, P. J., Hewavitharana, A., Pham, U. and Shaw, P. N. (2006). Identification and quantitation of intact beta-endorphin by LC-MS-MS. BPC Science: British Pharmaceutical Conference, Manchester UK / Manchester International Convention Centre, 4-6 September 2006. West Sussex, U.K.: John Wiley & Sons. doi: 10.1211/002235706778251393

Identification and quantitation of intact beta-endorphin by LC-MS-MS

2006

Journal Article

Shortcomings of protein removal prior to high performance liquid chromatographic analysis - A case study using method development for BAY 11-7082

Hewavitharana, A. K., Hyde, C., Thomas, R. and Shaw, P. N. (2006). Shortcomings of protein removal prior to high performance liquid chromatographic analysis - A case study using method development for BAY 11-7082. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 834 (1-2), 93-97. doi: 10.1016/j.jchromb.2006.02.037

Shortcomings of protein removal prior to high performance liquid chromatographic analysis - A case study using method development for BAY 11-7082

2006

Journal Article

Discovery of a new source of rifamycin antibiotics in marine sponge actinobacteria by phylogenetic prediction

Kim, T. K., Hewavitharana, A. K., Shaw, P. N. and Fuerst, J. A. (2006). Discovery of a new source of rifamycin antibiotics in marine sponge actinobacteria by phylogenetic prediction. Applied And Environmental Microbiology, 72 (3), 2118-2125. doi: 10.1128/AEM.72.3.2118-2125.2006

Discovery of a new source of rifamycin antibiotics in marine sponge actinobacteria by phylogenetic prediction

2006

Conference Publication

Nutritional bioactives in tropical fruit

Wilkinson, A, Hewavitharana, A, Flanagan, B M, Dietzgen, R G, Monteith, G R, Shaw, P N, Roberts-Thomson, S J and Gidley, M (2006). Nutritional bioactives in tropical fruit. The 3rd Australian Health & Medical Research Congress, Melbourne Convention Centre, Melbourne, Australia, 26 November-1 December, 2006. Melbourne, Vic, Australia: National Health and Medical Research Council.

Nutritional bioactives in tropical fruit

2006

Conference Publication

Profiling acetaminophen metabolites in mouse urine by LC-MS-MS

Shaw, P N, Hewavitharana, A, Lee, S, Dawson, P A and Markovich, D (2006). Profiling acetaminophen metabolites in mouse urine by LC-MS-MS. British Pharmaceutical Conference, Manchester UK / Mancester International Convention Centre, 4-6 September 2006. Belfast, Northern Ireland: Pharmaceutical Press.

Profiling acetaminophen metabolites in mouse urine by LC-MS-MS

2006

Conference Publication

Profiling acetaminophen metabolites in mouse urine by LC-MS-MS

Shaw, P. N., Hewavitharana, A. K., Lee, S., Dawson, P. and Markovich, D. (2006). Profiling acetaminophen metabolites in mouse urine by LC-MS-MS. The British Pharmaceutical Conference, Manchester, England, 4-6 September 2006. West Sussex, England, U.K.: John Wiley & Sons Ltd.. doi: 10.1211/002235706778251375

Profiling acetaminophen metabolites in mouse urine by LC-MS-MS

2006

Conference Publication

Assessment of the presence of Rifamycin antibiotics in marine sponge bacterium Salinispora using LC-MS-MS

Hewavitharana, A, Shaw, P N, Kim, T. K. and Fuerst, J A (2006). Assessment of the presence of Rifamycin antibiotics in marine sponge bacterium Salinispora using LC-MS-MS. INTERACT 2006: Air, Water and Earth: INTERACT in Perth, Perth, Australia, 24-28 September 2006. Canning Bridge, Australia: Promaco Conventions.

Assessment of the presence of Rifamycin antibiotics in marine sponge bacterium Salinispora using LC-MS-MS

2005

Conference Publication

Effect of drug-protein interactions on drug assay

Hewavitharana, A., Shaw, N., Hyde, C. and Thomas, R. (2005). Effect of drug-protein interactions on drug assay. Joint Meeting of ASCEPT and APSA, Melbourne, Australia, 4-7 December 2005. Australia: Australasian Society of Clinical & Experimental Pharmacologists & Toxicologists.

Effect of drug-protein interactions on drug assay

2005

Journal Article

Enhancing the ratio of molecular ions to non-covalent compounds in the electrospray interface of LC-MS in quantitative analysis

Hewavitharana, AK and Shaw, PN (2005). Enhancing the ratio of molecular ions to non-covalent compounds in the electrospray interface of LC-MS in quantitative analysis. Analytical And Bioanalytical Chemistry, 382 (4), 1055-1059. doi: 10.1007/s00216-005-3236-y

Enhancing the ratio of molecular ions to non-covalent compounds in the electrospray interface of LC-MS in quantitative analysis

2005

Conference Publication

Development and application of a liposome delivery method to enhance the bioavailability of antioxidants and evaluate cytotoxicity in colon and breast cancer in vitro models

Sutherland, A., Hewavitharana, A., Flanagan, B. M., Monteith, G. R., Shaw, N., Roberts-Thomson, S. J. and Gidley, M. (2005). Development and application of a liposome delivery method to enhance the bioavailability of antioxidants and evaluate cytotoxicity in colon and breast cancer in vitro models. 29th Annual Scientific Meeting of Nutrition Society of Australia, Melbourne, Vic, Australia, 30 November-3 December, 2005. Clayton, Vic., Australia: Blackwell Science Asia.

Development and application of a liposome delivery method to enhance the bioavailability of antioxidants and evaluate cytotoxicity in colon and breast cancer in vitro models

2005

Conference Publication

Manipulation of the population of non-covalently bound species formed in the electrospray interface of LC-MS

Hewavitharana, A. and Shaw, N. (2005). Manipulation of the population of non-covalently bound species formed in the electrospray interface of LC-MS. Australian & New Zealand Society for Mass Spectrometry - 20th Conference, Adelaide, Australia, 30 Jan. - 3 Feb. 2005. Australia:

Manipulation of the population of non-covalently bound species formed in the electrospray interface of LC-MS

2005

Journal Article

Quantitative GG-MS analysis of Delta(9)-tetrahydrocannabinol in fiber hemp varieties

Hewavitharana, A.K., Golding, G., Tempany, G., King, G. and Holling, N. (2005). Quantitative GG-MS analysis of Delta(9)-tetrahydrocannabinol in fiber hemp varieties. Journal of Analytical Toxicology, 29 (4), 258-261. doi: 10.1093/jat/29.4.258

Quantitative GG-MS analysis of Delta(9)-tetrahydrocannabinol in fiber hemp varieties

2004

Conference Publication

A Feasibility Study of Fingerprinting Alcoholic Spirits Using SPME-GC-MS

Hewavitharana, A. K., Christensen, E., Golding, G. and Scheelings, P. (2004). A Feasibility Study of Fingerprinting Alcoholic Spirits Using SPME-GC-MS. Interact 2004, Gold Coast, Queensland, Australia, 4-8 July 2004.

A Feasibility Study of Fingerprinting Alcoholic Spirits Using SPME-GC-MS

2004

Journal Article

Simultaneous determination of Vitamin E homologs in chicken meat by liquid chromatography with fluorescence detection

Hewavitharana, A. K., Lanari, M. C. and Becu, C. (2004). Simultaneous determination of Vitamin E homologs in chicken meat by liquid chromatography with fluorescence detection. Journal of Chromatography A, 1025 (2), 313-317. doi: 10.1016/j.chroma.2003.10.052

Simultaneous determination of Vitamin E homologs in chicken meat by liquid chromatography with fluorescence detection

2004

Journal Article

Effect of dietary tocopherols and tocotrienols on the antioxidant status and lipid stability of chicken

Lanari, MC, Hewavitharana, AK, Becu, C and de Jong, S (2004). Effect of dietary tocopherols and tocotrienols on the antioxidant status and lipid stability of chicken. Meat Science, 68 (2), 155-162. doi: 10.1016/j.meatsci.2003.12.004

Effect of dietary tocopherols and tocotrienols on the antioxidant status and lipid stability of chicken

2003

Journal Article

Simultaneous determination of creatinine and pseudouridine concentrations in bovine plasma by reversed-phase liquid chromatography with photodiode array detection

Hewavitharana, AK and Bruce, HL (2003). Simultaneous determination of creatinine and pseudouridine concentrations in bovine plasma by reversed-phase liquid chromatography with photodiode array detection. Journal of Chromatography B-analytical Technologies In The Biomedical And Life Sciences, 784 (2), 275-281. doi: 10.1016/S1570-0232(02)00799-7

Simultaneous determination of creatinine and pseudouridine concentrations in bovine plasma by reversed-phase liquid chromatography with photodiode array detection

2003

Journal Article

Simple solutions to problems encountered in quantitative analysis of tocopherols and tocotrienols using silica columns

Hewavitharana, AK (2003). Simple solutions to problems encountered in quantitative analysis of tocopherols and tocotrienols using silica columns. Analytical Biochemistry, 313 (2) PII S0003-2697(02)00589-4, 342-344. doi: 10.1016/S0003-2697(02)00589-4

Simple solutions to problems encountered in quantitative analysis of tocopherols and tocotrienols using silica columns

2003

Conference Publication

Analysis of chicken meat for the influence of diet on tocopherol and tocotrienol compositions

Hewavitharana, A. K., Lanari, M.C. and Becu, C. U. (2003). Analysis of chicken meat for the influence of diet on tocopherol and tocotrienol compositions. 49th International Congress of Meat Science and Technology, Sao Paulo, Brazil, 31st August - 5th September 2003. Sao Paulo, Brazil: ICoMST.

Analysis of chicken meat for the influence of diet on tocopherol and tocotrienol compositions

2003

Journal Article

Simultaneous liquid chromatographic determination of creatinine and pseudouridine in bovine urine and the effect of sample pH on the analysis

Hewavitharana, A. K. and Bruce, H. L. (2003). Simultaneous liquid chromatographic determination of creatinine and pseudouridine in bovine urine and the effect of sample pH on the analysis. Journal of Agricultural And Food Chemistry, 51 (17), 4861-4865. doi: 10.1021/jf030095z

Simultaneous liquid chromatographic determination of creatinine and pseudouridine in bovine urine and the effect of sample pH on the analysis

1998

Journal Article

A rapid saponification procedure for the simultaneous HPLC determination of the natural levels of vitamins A, E and beta-carotene in milk

Hewavitharana, A. K. and Van Brakel, A. S. (1998). A rapid saponification procedure for the simultaneous HPLC determination of the natural levels of vitamins A, E and beta-carotene in milk. Milchwissenschaft-Milk Science International, 53 (1), 11-15.

A rapid saponification procedure for the simultaneous HPLC determination of the natural levels of vitamins A, E and beta-carotene in milk

Funding

Past funding

  • 2018
    Developing a method for measuring thiopurine drug and metabolites
    Research Donation Generic
    Open grant
  • 2010
    Analytical instrumentation enabling rapid compound separation and chemical structure analysis via mass fingerprinting
    UQ Major Equipment and Infrastructure
    Open grant

Supervision

Availability

Dr Amitha Hewavitharana is:
Not available for supervision

Supervision history

Completed supervision

Media

Enquiries

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