
Overview
Background
Senior Research Fellow
Room 7048, Level 7, Pharmacy Australia Centre of Excellence Phone:+61 7 334-61898; Fax: +61 7 334-61999 Email: a.hewavitharana@pharmacy.uq.edu.au
Amitha obtained her B.Sc. from the University of Colombo (Sri Lanka), M.Sc. from the university of Victoria (B.C., Canada) and PhD in analytical chemistry from the University of Alberta (Canada). Following that, she held brief research positions at the Massey University (New Zealand) and NZ Leather Research Institute. She then held a research scientist position at the NZ Dairy Research Institute (NZDRI, currently Fonterra Research) for 4 years before moving to Australia in 1997.
In Australia, she commenced her career as a lecturer in analytical chemistry at the University of Western Sydney, and then at Queensland University of Technology (QUT) until 2001. Following that, she held research positions in CSIRO (food science) and in QHSS (investigative chemistry) before joining the school of pharmacy in 2004.
Availability
- Dr Amitha Hewavitharana is:
- Not available for supervision
Fields of research
Qualifications
- Doctor of Philosophy, University of Alberta
Research interests
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Research Interests
Please refer to the complete list of publications, in the link below, to get an idea of Dr Hewavitharana's research focus: https://akhcv.wordpress.com Stemming from PhD in analytical chemistry, Dr Hewavitharana's research is focused on solving fundamental analytical problems as well as developing analytical methods for a variety of applications such as: metal speciation (free/ionized calcium, and magnesium) and metabolite analysis (eg. pseudouridine, paracetamols, endorphins, dynorphins) in biological fluids, water and waste water, nutrients (eg. vitamins), antinutrients (eg. lysiniolanine) and antioxidants (eg. carotenes, tocopherols, tocotrienols) in dairy foods and meat products, nutraceuticals in tropical fruits (eg. carotenes, quercetins, mangiferin, anticancer compounds) psychoactive compunds (THC), marker compounds such as isoprostanes, sinistrin, fluconazole, pindolol, p-amino hippuric acid and creatinine, drug discovery (antibiotics and anti-cancer compounds from marine sponge bacteria and tropical fruit), drug delivery (dendrimers) and drug assay (BAY-11-7082, paracetamol, endorphin), Disease markers (eg. Sarcosine in prostate cancer), Fat and Water soluble analogues of vitamin D, Trace metals in food, Ion suppression effects in mass spectrometry, Challenges in method validation. Over the past 31 years, her research outcomes were achieved using a wide variety of instrumentation such as, HPLC -MS-MS, -PDA, -fluorescence, -EC etc, IC, GC-MS, HPCE, AAS, NIR, FTIR, FIA. Her interests also include method validation and laboratory quality assurance in line with ISO 17025. She provides her expertise as a technical assessor to NATA and IANZ, in ISO accreditation of food and water laboratories in Australia and New Zealand.
Works
Search Professor Amitha Hewavitharana’s works on UQ eSpace
2006
Conference Publication
Identification and quantitation of intact beta-endorphin by LC-MS-MS
Cabot, P. J., Hewavitharana, A., Pham, U. and Shaw, P. N. (2006). Identification and quantitation of intact beta-endorphin by LC-MS-MS. BPC Science: British Pharmaceutical Conference, Manchester UK / Manchester International Convention Centre, 4-6 September 2006. West Sussex, U.K.: John Wiley & Sons. doi: 10.1211/002235706778251393
2006
Journal Article
Shortcomings of protein removal prior to high performance liquid chromatographic analysis - A case study using method development for BAY 11-7082
Hewavitharana, A. K., Hyde, C., Thomas, R. and Shaw, P. N. (2006). Shortcomings of protein removal prior to high performance liquid chromatographic analysis - A case study using method development for BAY 11-7082. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 834 (1-2), 93-97. doi: 10.1016/j.jchromb.2006.02.037
2006
Journal Article
Discovery of a new source of rifamycin antibiotics in marine sponge actinobacteria by phylogenetic prediction
Kim, T. K., Hewavitharana, A. K., Shaw, P. N. and Fuerst, J. A. (2006). Discovery of a new source of rifamycin antibiotics in marine sponge actinobacteria by phylogenetic prediction. Applied And Environmental Microbiology, 72 (3), 2118-2125. doi: 10.1128/AEM.72.3.2118-2125.2006
2006
Conference Publication
Nutritional bioactives in tropical fruit
Wilkinson, A, Hewavitharana, A, Flanagan, B M, Dietzgen, R G, Monteith, G R, Shaw, P N, Roberts-Thomson, S J and Gidley, M (2006). Nutritional bioactives in tropical fruit. The 3rd Australian Health & Medical Research Congress, Melbourne Convention Centre, Melbourne, Australia, 26 November-1 December, 2006. Melbourne, Vic, Australia: National Health and Medical Research Council.
2006
Conference Publication
Profiling acetaminophen metabolites in mouse urine by LC-MS-MS
Shaw, P N, Hewavitharana, A, Lee, S, Dawson, P A and Markovich, D (2006). Profiling acetaminophen metabolites in mouse urine by LC-MS-MS. British Pharmaceutical Conference, Manchester UK / Mancester International Convention Centre, 4-6 September 2006. Belfast, Northern Ireland: Pharmaceutical Press.
2006
Conference Publication
Profiling acetaminophen metabolites in mouse urine by LC-MS-MS
Shaw, P. N., Hewavitharana, A. K., Lee, S., Dawson, P. and Markovich, D. (2006). Profiling acetaminophen metabolites in mouse urine by LC-MS-MS. The British Pharmaceutical Conference, Manchester, England, 4-6 September 2006. West Sussex, England, U.K.: John Wiley & Sons Ltd.. doi: 10.1211/002235706778251375
2006
Conference Publication
Assessment of the presence of Rifamycin antibiotics in marine sponge bacterium Salinispora using LC-MS-MS
Hewavitharana, A, Shaw, P N, Kim, T. K. and Fuerst, J A (2006). Assessment of the presence of Rifamycin antibiotics in marine sponge bacterium Salinispora using LC-MS-MS. INTERACT 2006: Air, Water and Earth: INTERACT in Perth, Perth, Australia, 24-28 September 2006. Canning Bridge, Australia: Promaco Conventions.
2005
Conference Publication
Effect of drug-protein interactions on drug assay
Hewavitharana, A., Shaw, N., Hyde, C. and Thomas, R. (2005). Effect of drug-protein interactions on drug assay. Joint Meeting of ASCEPT and APSA, Melbourne, Australia, 4-7 December 2005. Australia: Australasian Society of Clinical & Experimental Pharmacologists & Toxicologists.
2005
Journal Article
Enhancing the ratio of molecular ions to non-covalent compounds in the electrospray interface of LC-MS in quantitative analysis
Hewavitharana, AK and Shaw, PN (2005). Enhancing the ratio of molecular ions to non-covalent compounds in the electrospray interface of LC-MS in quantitative analysis. Analytical And Bioanalytical Chemistry, 382 (4), 1055-1059. doi: 10.1007/s00216-005-3236-y
2005
Conference Publication
Development and application of a liposome delivery method to enhance the bioavailability of antioxidants and evaluate cytotoxicity in colon and breast cancer in vitro models
Sutherland, A., Hewavitharana, A., Flanagan, B. M., Monteith, G. R., Shaw, N., Roberts-Thomson, S. J. and Gidley, M. (2005). Development and application of a liposome delivery method to enhance the bioavailability of antioxidants and evaluate cytotoxicity in colon and breast cancer in vitro models. 29th Annual Scientific Meeting of Nutrition Society of Australia, Melbourne, Vic, Australia, 30 November-3 December, 2005. Clayton, Vic., Australia: Blackwell Science Asia.
2005
Conference Publication
Manipulation of the population of non-covalently bound species formed in the electrospray interface of LC-MS
Hewavitharana, A. and Shaw, N. (2005). Manipulation of the population of non-covalently bound species formed in the electrospray interface of LC-MS. Australian & New Zealand Society for Mass Spectrometry - 20th Conference, Adelaide, Australia, 30 Jan. - 3 Feb. 2005. Australia:
2005
Journal Article
Quantitative GG-MS analysis of Delta(9)-tetrahydrocannabinol in fiber hemp varieties
Hewavitharana, A.K., Golding, G., Tempany, G., King, G. and Holling, N. (2005). Quantitative GG-MS analysis of Delta(9)-tetrahydrocannabinol in fiber hemp varieties. Journal of Analytical Toxicology, 29 (4), 258-261. doi: 10.1093/jat/29.4.258
2004
Conference Publication
A Feasibility Study of Fingerprinting Alcoholic Spirits Using SPME-GC-MS
Hewavitharana, A. K., Christensen, E., Golding, G. and Scheelings, P. (2004). A Feasibility Study of Fingerprinting Alcoholic Spirits Using SPME-GC-MS. Interact 2004, Gold Coast, Queensland, Australia, 4-8 July 2004.
2004
Journal Article
Simultaneous determination of Vitamin E homologs in chicken meat by liquid chromatography with fluorescence detection
Hewavitharana, A. K., Lanari, M. C. and Becu, C. (2004). Simultaneous determination of Vitamin E homologs in chicken meat by liquid chromatography with fluorescence detection. Journal of Chromatography A, 1025 (2), 313-317. doi: 10.1016/j.chroma.2003.10.052
2004
Journal Article
Effect of dietary tocopherols and tocotrienols on the antioxidant status and lipid stability of chicken
Lanari, MC, Hewavitharana, AK, Becu, C and de Jong, S (2004). Effect of dietary tocopherols and tocotrienols on the antioxidant status and lipid stability of chicken. Meat Science, 68 (2), 155-162. doi: 10.1016/j.meatsci.2003.12.004
2003
Journal Article
Simultaneous determination of creatinine and pseudouridine concentrations in bovine plasma by reversed-phase liquid chromatography with photodiode array detection
Hewavitharana, AK and Bruce, HL (2003). Simultaneous determination of creatinine and pseudouridine concentrations in bovine plasma by reversed-phase liquid chromatography with photodiode array detection. Journal of Chromatography B-analytical Technologies In The Biomedical And Life Sciences, 784 (2), 275-281. doi: 10.1016/S1570-0232(02)00799-7
2003
Journal Article
Simple solutions to problems encountered in quantitative analysis of tocopherols and tocotrienols using silica columns
Hewavitharana, AK (2003). Simple solutions to problems encountered in quantitative analysis of tocopherols and tocotrienols using silica columns. Analytical Biochemistry, 313 (2) PII S0003-2697(02)00589-4, 342-344. doi: 10.1016/S0003-2697(02)00589-4
2003
Conference Publication
Analysis of chicken meat for the influence of diet on tocopherol and tocotrienol compositions
Hewavitharana, A. K., Lanari, M.C. and Becu, C. U. (2003). Analysis of chicken meat for the influence of diet on tocopherol and tocotrienol compositions. 49th International Congress of Meat Science and Technology, Sao Paulo, Brazil, 31st August - 5th September 2003. Sao Paulo, Brazil: ICoMST.
2003
Journal Article
Simultaneous liquid chromatographic determination of creatinine and pseudouridine in bovine urine and the effect of sample pH on the analysis
Hewavitharana, A. K. and Bruce, H. L. (2003). Simultaneous liquid chromatographic determination of creatinine and pseudouridine in bovine urine and the effect of sample pH on the analysis. Journal of Agricultural And Food Chemistry, 51 (17), 4861-4865. doi: 10.1021/jf030095z
1998
Journal Article
A rapid saponification procedure for the simultaneous HPLC determination of the natural levels of vitamins A, E and beta-carotene in milk
Hewavitharana, A. K. and Van Brakel, A. S. (1998). A rapid saponification procedure for the simultaneous HPLC determination of the natural levels of vitamins A, E and beta-carotene in milk. Milchwissenschaft-Milk Science International, 53 (1), 11-15.
Funding
Past funding
Supervision
Availability
- Dr Amitha Hewavitharana is:
- Not available for supervision
Supervision history
Completed supervision
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2017
Doctor Philosophy
Investigation of Selective Anti-Proliferative and Immunomodulatory Properties of Carica Papaya
Principal Advisor
Other advisors: Professor Peter Cabot, Professor Nick Shaw
-
2016
Doctor Philosophy
Development of an assay for total vitamin D content in milk and application to study the effect of pasteurisation in breastmilk
Principal Advisor
Other advisors: Professor Nick Shaw, Dr Karen Whitfield
-
2016
Doctor Philosophy
Investigation of bioactive compounds with anti-cancer potential in Carica papaya leaves
Principal Advisor
Other advisors: Professor Nick Shaw, Associate Professor Marie-Odile Parat
-
2014
Doctor Philosophy
Study of the chemical diversity of the actinobacteria genus Salinispora, isolated from Great Barrier Reef Sponges
Principal Advisor
Other advisors: Emeritus Professor John Fuerst, Professor Nick Shaw
-
2013
Doctor Philosophy
A study of the activity and efficacy of beta endorphin fragments in inflamed tissue
Principal Advisor
Other advisors: Professor Peter Cabot, Professor Nick Shaw
-
2018
Doctor Philosophy
Development of an assay for vitamin D in biological samples
Associate Advisor
Other advisors: Dr Karen Whitfield, Professor Nick Shaw
-
2017
Doctor Philosophy
Essential Trace Element Analysis of Human Breast Milk
Associate Advisor
Other advisors: Professor Nick Shaw, Dr Karen Whitfield
-
2015
Doctor Philosophy
Beta-Endorphin Biotransformation and Modulation of Inflammatory Signals
Associate Advisor
Other advisors: Professor Peter Cabot, Professor Nick Shaw
-
2013
Doctor Philosophy
Developmental cycle and the regulation of natural products in the antibiotic-producing actinobacterium Salinispora from marine sponges
Associate Advisor
Other advisors: Emeritus Professor John Fuerst, Professor Nick Shaw
-
2012
Doctor Philosophy
Genetic and chemical diversity of the actinobacterial genus Salinispora isolated from Great Barrier Reef sponges.
Associate Advisor
Other advisors: Emeritus Professor John Fuerst, Professor Nick Shaw
-
2010
Doctor Philosophy
The peripheral mechanisms of analgesia and the involvement of adhesion molecules - Development of a novel targeted drug delivery system to sites of inflammation and application to peripheral analgesia
Associate Advisor
Other advisors: Professor Peter Cabot, Professor Nick Shaw
Media
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