Overview
Background
Dr Keshvari is a postdoctoral research officer at Mater Research Institute-UQ. Her main research interest is to investigate the role of macrophages in metabolic disorders including acute and chronic liver diseases, obesity and type 2 diabetes. She was awarded her PhD titled “characterisation of two receptors for adiponectin” in 2016 and received the “2016 Dean’s Award for Outstanding Higher Degree by Research Theses”. She is the recipient of Australian Liver Foundation fellowship and is an NHMRC Emerging Leader Investigator. Her current project is focused on the beneficial effect of macrophage colony stimulating factor on resolving liver fibrosis and promoting liver regeneration and the role of macrophages on metabolic regulation in fat and endocrine system including pancreas.
Availability
- Dr Sahar Keshvari is:
- Available for supervision
Works
Search Professor Sahar Keshvari’s works on UQ eSpace
2022
Journal Article
A kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy has a dominant inhibitory impact on CSF1R signalling
Stables, Jennifer, Green, Emma K., Sehgal, Anuj, Patkar, Omkar L., Keshvari, Sahar, Taylor, Isis, Ashcroft, Maisie E., Grabert, Kathleen, Wollscheid-Lengeling, Evi, Szymkowiak, Stefan, McColl, Barry W., Adamson, Antony, Humphreys, Neil E., Mueller, Werner, Starobova, Hana, Vetter, Irina, Shabestari, Sepideh Kiani, Blurton-Jones, Matthew M., Summers, Kim M., Irvine, Katharine M., Pridans, Clare and Hume, David A. (2022). A kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy has a dominant inhibitory impact on CSF1R signalling. Development, 149 (8) dev200237. doi: 10.1242/dev.200237
2022
Other Outputs
Glucocorticoid activity regulates glucocorticoid receptor isoform expression and downstream gene transcription in humans
Lockett, Jack , Saif, Zarqa, Nolan, Brendan J., Keshvari, Sahar, Cesana-Nigro, Nicole, Ewing, Adam, Inder, Warrick J. and Clifton, Vicki L. (2022). Glucocorticoid activity regulates glucocorticoid receptor isoform expression and downstream gene transcription in humans. The University of Queensland. (Dataset) doi: 10.48610/ee0c38e
2022
Journal Article
Therapeutic potential of macrophage colony-stimulating factor (CSF1) in chronic liver disease
Keshvari, Sahar, Genz, Berit, Teakle, Ngari, Caruso, Melanie, Cestari, Michelle F., Patkar, Omkar L., Tse, Brian W. C., Sokolowski, Kamil A., Ebersbach, Hilmar, Jascur, Julia, MacDonald, Kelli P. A., Miller, Gregory, Ramm, Grant A., Pettit, Allison R., Clouston, Andrew D., Powell, Elizabeth E., Hume, David A. and Irvine, Katharine M. (2022). Therapeutic potential of macrophage colony-stimulating factor (CSF1) in chronic liver disease. Disease Models and Mechanisms, 15 (4) dmm049387, 1-15. doi: 10.1242/dmm.049387
2021
Journal Article
Pre-Diabetes Increases Tuberculosis Disease Severity, While High Body Fat Without Impaired Glucose Tolerance Is Protective
Sinha, Roma, Ngo, Minh Dao, Bartlett, Stacey, Bielefeldt-Ohmann, Helle, Keshvari, Sahar, Hasnain, Sumaira Z., Donovan, Meg L., Kling, Jessica C., Blumenthal, Antje, Chen, Chen, Short, Kirsty R. and Ronacher, Katharina (2021). Pre-Diabetes Increases Tuberculosis Disease Severity, While High Body Fat Without Impaired Glucose Tolerance Is Protective. Frontiers in Cellular and Infection Microbiology, 11 691823, 691823. doi: 10.3389/fcimb.2021.691823
2021
Journal Article
CSF1R-dependent macrophages control postnatal somatic growth and organ maturation
Keshvari, Sahar, Caruso, Melanie, Teakle, Ngari, Batoon, Lena, Sehgal, Anuj, Patkar, Omkar L., Ferrari-Cestari, Michelle, Snell, Cameron E., Chen, Chen, Stevenson, Alex, Davis, Felicity M., Bush, Stephen J., Pridans, Clare, Summers, Kim M., Pettit, Allison R., Irvine, Katharine M. and Hume, David A. (2021). CSF1R-dependent macrophages control postnatal somatic growth and organ maturation. PLoS Genetics, 17 (6) e1009605, e1009605. doi: 10.1371/journal.pgen.1009605
2021
Journal Article
The mononuclear phagocyte system of the rat
Hume, David A., Caruso, Melanie, Keshvari, Sahar, Patkar, Omkar L., Sehgal, Anuj, Bush, Stephen J., Summers, Kim M., Pridans, Clare and Irvine, Katharine M. (2021). The mononuclear phagocyte system of the rat. The Journal of Immunology, 206 (10), 2251-2263. doi: 10.4049/jimmunol.2100136
2021
Journal Article
Ex vivo glucocorticoid-induced secreted proteome approach for discovery of glucocorticoid-responsive proteins in human serum
Inder, Warrick J., Mohamed, Ahmed, Keshvari, Sahar, Barclay, Johanna L., Ruelcke, Jayde E., Stoll, Thomas, Nolan, Brendan J., Cesana-Nigro, Nicole and Hill, Michelle M. (2021). Ex vivo glucocorticoid-induced secreted proteome approach for discovery of glucocorticoid-responsive proteins in human serum. Proteomics - Clinical Applications, 15 (2-3) 2000078, 2000078. doi: 10.1002/prca.202000078
2021
Journal Article
Analysis of homozygous and heterozygous Csf1r knockout in the rat as a model for understanding microglial function in brain development and the impacts of human CSF1R mutations
Patkar, Omkar L., Caruso, Melanie, Teakle, Ngari, Keshvari, Sahar, Bush, Stephen J., Pridans, Clare, Belmer, Arnauld, Summers, Kim M., Irvine, Katharine M. and Hume, David A. (2021). Analysis of homozygous and heterozygous Csf1r knockout in the rat as a model for understanding microglial function in brain development and the impacts of human CSF1R mutations. Neurobiology of Disease, 151 105268, 105268. doi: 10.1016/j.nbd.2021.105268
2019
Journal Article
The effect of glucocorticoids on Thrombospondin-1, Osteocalcin and the Thrombospondin-1:Osteocalcin ratio in humans
Cesana-Nigro, Nicole, Keshvari, Sahar, Barclay, Johanna L., Sorbello, Jane, Upham, John W., Benham, Helen, Anderson, Stephen T., Steiger, Natasha, Prins, Johannes B. and Inder, Warrick J. (2019). The effect of glucocorticoids on Thrombospondin-1, Osteocalcin and the Thrombospondin-1:Osteocalcin ratio in humans. Clinical Endocrinology, 91 (6) cen.14108, 728-736. doi: 10.1111/cen.14108
2019
Journal Article
Analysis of the impact of CSF‐1 administration in adult rats using a novel Csf1r ‐mApple reporter gene
Irvine, Katharine M., Caruso, Melanie, Cestari, Michelle Ferrari, Davis, Gemma M., Keshvari, Sahar, Sehgal, Anuj, Pridans, Clare and Hume, David A. (2019). Analysis of the impact of CSF‐1 administration in adult rats using a novel Csf1r ‐mApple reporter gene. Journal of Leukocyte Biology, 107 (2) JLB.MA0519-149R, 221-235. doi: 10.1002/jlb.ma0519-149r
2018
Conference Publication
Body composition to estimate percentage fat mass: comparisons between common clinical methods and gold-standard air displacement plethysmography (BODPOD) in a cohort of university students
Akison, Lisa K., Gallo, Linda A., Barclay, Johanna L., Burgess, Danielle, Keshvari, Sahar, Fotheringham, Amelia K. and Moritz, Karen M. (2018). Body composition to estimate percentage fat mass: comparisons between common clinical methods and gold-standard air displacement plethysmography (BODPOD) in a cohort of university students. Joint Annual Scientific Meetings of Endocrine Society of Australia (ESA) and Society for Reproductive Biology (SRB), Perth, Australia, 27-30 August 2017. Chichester, West Sussex, United Kingdom: Wiley-Blackwell.
2017
Journal Article
Perinatal exposure to high dietary advanced glycation end products in transgenic NOD8.3 mice leads to pancreatic beta cell dysfunction
Borg, Danielle J., Yap, Felicia Y. T., Keshvari, Sahar, Simmons, David G., Gallo, Linda A., Fotheringham, Amelia K., Zhuang, Aowen, Slattery, Robyn M., Hasnain, Sumaira Z., Coughlan, Melinda T., Kantharidis, Phillip and Forbes, Josephine M. (2017). Perinatal exposure to high dietary advanced glycation end products in transgenic NOD8.3 mice leads to pancreatic beta cell dysfunction. Islets, 10 (1), 10-24. doi: 10.1080/19382014.2017.1405189
2017
Journal Article
Evolution of the magic bullet: Single chain antibody fragments for the targeted delivery of immunomodulatory proteins
Fercher, Christian, Keshvari, Sahar, McGuckin, Michael A and Barnard, Ross T (2017). Evolution of the magic bullet: Single chain antibody fragments for the targeted delivery of immunomodulatory proteins. Experimental biology and medicine (Maywood, N.J.), 243 (2), 166-183. doi: 10.1177/1535370217748575
2017
Journal Article
Muscle-specific overexpression of AdipoR1 or AdipoR2 gives rise to common and discrete local effects whilst AdipoR2 promotes additional systemic effects
Keshvari, Sahar, Henstridge, Darren C., Ng, Choaping, Febbraio, Mark A. and Whitehead, Jonathan P. (2017). Muscle-specific overexpression of AdipoR1 or AdipoR2 gives rise to common and discrete local effects whilst AdipoR2 promotes additional systemic effects. Scientific Reports, 7 (1) 41792, 41792. doi: 10.1038/srep41792
2016
Other Outputs
Molecular characterisation of the adiponectin receptors, AdipoR1 and AdipoR2
Keshvari, Sahar (2016). Molecular characterisation of the adiponectin receptors, AdipoR1 and AdipoR2. PhD Thesis, School of Medicine, The University of Queensland. doi: 10.14264/uql.2016.782
2016
Journal Article
Development of an enzyme-linked immunosorbent assay for thrombospondin-1 and comparison of human plasma and serum concentrations
Barclay, Johanna L., Keshvari, Sahar, Whitehead, Jonathan P. and Inder, Warrick J. (2016). Development of an enzyme-linked immunosorbent assay for thrombospondin-1 and comparison of human plasma and serum concentrations. Annals of Clinical Biochemistry, 53 (5), 606-610. doi: 10.1177/0004563216628891
2016
Journal Article
Effects of delayed sample processing on determination of total and high molecular weight (HMW) adiponectin in serum and plasma: a pilot study
Ng, Choaping, Rose, Felicity J., Keshvari, Sahar, Reeves, Marina M., Dimeski, Goce, Hickman, Ingrid J. and Whitehead, Jonathan P. (2016). Effects of delayed sample processing on determination of total and high molecular weight (HMW) adiponectin in serum and plasma: a pilot study. International Journal of Chemistry, 8 (3), 19-24. doi: 10.5539/ijc.v8n3p19
2016
Journal Article
Identification of carboxypeptidase X (CPX)-1 as a positive regulator of adipogenesis
Kim, Yu-Hee, Barclay, Johanna L., He, Jingjing, Luo, Xiao, O'Neill, Hayley M., Keshvari, Sahar, Webster, Julie A., Ng, Choaping, Hutley, Louise J., Prins, Johannes B. and Whitehead, Jonathan P. (2016). Identification of carboxypeptidase X (CPX)-1 as a positive regulator of adipogenesis. FASEB Journal, 30 (7), 2528-2540. doi: 10.1096/fj.201500107R
2016
Journal Article
Thrombospondin-1 is a glucocorticoid responsive protein in humans
Barclay, Johanna L., Petersons, Carolyn J., Keshvari, Sahar, Sorbello, Jane, Mangelsdorf, Brenda L., Thompson, Campbell H., Prins, Johannes B., Burt, Morton G., Whitehead, Jonathan P. and Inder, Warrick J. (2016). Thrombospondin-1 is a glucocorticoid responsive protein in humans. European Journal of Endocrinology, 174 (2), 193-201. doi: 10.1530/EJE-15-0964
2016
Conference Publication
Chronic treatment with cobalt protoporphyrin or hemin compromises adipogenesis and adiponectin production in a manner indenpendent of heme-oxygenase-1
Yang, M., Kimura, M., Ng, C., Keshvari, S., He, J., Barclay, J. L. and Whitehead, J. P. (2016). Chronic treatment with cobalt protoporphyrin or hemin compromises adipogenesis and adiponectin production in a manner indenpendent of heme-oxygenase-1. 52nd Annual Meeting of the European Association for the Study of Diabetes (EASD), Munich, Germany, Sep 12-16, 2016. Heidelberg, Germany: Springer. doi: 10.1007/s00125-016-4046-9
Supervision
Availability
- Dr Sahar Keshvari is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Available projects
-
Macrophage Therapeutic Potential in Metabolic Disease
- Explores how macrophages regulate metabolism in the liver, fat, and pancreas. Their activation maintains energy balance but also drives metabolic diseases, offering potential therapeutic targets.
Supervision history
Current supervision
-
Doctor Philosophy
Regulation of Resident Tissue Macrophage Development and Function
Associate Advisor
Other advisors: Professor David Hume, Dr Katharine Irvine
Completed supervision
-
2024
Doctor Philosophy
Macrophage colony-stimulating factor in the treatment of non-alcoholic fatty liver disease
Associate Advisor
Other advisors: Dr Katharine Irvine, Professor David Hume
-
2023
Doctor Philosophy
The role of macrophages in the regulation of systemic metabolism
Associate Advisor
Other advisors: Dr Katharine Irvine, Professor David Hume
Media
Enquiries
For media enquiries about Dr Sahar Keshvari's areas of expertise, story ideas and help finding experts, contact our Media team: