Overview
Background
Professor Peter Sly is the Director, Children's Health and Environment Program. Professor Sly is a NHMRC Leadership Fellow (L3) and an emeritus paediatric respiratory physician with extensive research experience in respiratory physiology, developmental immunology and children's environmental health. Professor Sly’s research aims to understand the mechanisms underlying chronic childhood lung diseases in order to improve clinical management and to delay or prevent their onset, with consequent reductions in adult lung diseases. A combination of basic science, longitudinal cohort studies and translation of research findings into clinical practice, including clinical trials, are included in three main areas: asthma, cystic fibrosis and children’s environmental health
Professor Sly is an advisor to the World Health Organisation Department of Public Health, Environmental and Social Determinants of Disease and currently serves on International Advisory Boards and committees, including: WHO network of Collaborating Centres in Children’s Environmental Health; Canadian Healthy Infant Longitudinal Development (CHILD) Study, Canada; the Infant Lung Health Study, Paarl, South Africa; and A SHARED Future: Achieving Strength, Health, and Autonomy, through Renewable Energy Development for the Future.
Availability
- Professor Peter Sly is:
- Not available for supervision
- Media expert
Fields of research
Qualifications
- Bachelor of Medicine and Surgery and Medical Science, University of Melbourne
- Doctoral Diploma of Medicine, University of Melbourne
- Doctoral Diploma of Science (Advanced), University of Western Australia
Research interests
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Asthma
Understanding mechanisms that underlie risks for developing asthma in susceptible children
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Cystic Fibrosis
Understanding the mechanisms underlying the development of lung disease early in life and why and how this progresses
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Impact of environmental exposures in early life
Improving methods of assessing environmental exposures during fetal development and in early postnatal life. Improving methods for assessing the effects of early life environmental exposures and understanding how these increase long-tern risk of chronic disease.
Research impacts
CI Sly’s research program changed thinking on how chronic respiratory disease develops; highlighting the impact of early life exposures increasing disease risk and showing early detection is the key to its reduction, developing tools for assessing early respiratory disease, revealing mechanisms underpinning disease onset and progression, and outlined intervention pathways to improve health outcomes. The paradigm-shifting Australian Respiratory Early Surveillance Team for Cystic Fibrosis CF (AREST CF), demonstrated infants can have significant lung disease with no clinical symptoms; defined risk factors for persistent bronchiectasis at 3 months of age; developing tools to assess early lung disease on chest CT scans showing early bronchiectasis was persistent and progressive; and resulted in the 1st clinical trial of primary prevention of bronchiectasis in infants with CF. Research and advocacy with the WHO led to the WHO program on e-Waste and contributions to WHO policy and Lancet commissions on Pollution and Health and Child Wellbeing. CI Sly has an established track record investigating infection and inflammation, and the underlying mechanisms of airway disease. He was one of the key persons in establishing and managing longitudinal birth cohorts to identify risk factors underlying the development of asthma. He also has a long track record in respiratory physiology and in developing and implementing new measurements of lung function. He has contributed to consensus statements in the area of standardization of lung function testing for infants and young children and has had substantial involvement in clinical trials, both investigator-initiated and pharma trials.
Works
Search Professor Peter Sly’s works on UQ eSpace
2020
Conference Publication
Characterization of lung function trajectories in the Raine Study
Sanna, Francesca, Locatelli, Francesca, Sly, Peter D., White, Elisha, Hall, Graham L. and Foong, Rachel E. (2020). Characterization of lung function trajectories in the Raine Study. International Congress of the European-Respiratory-Society (ERS), Electr Network, Sep 07-09, 2020. SHEFFIELD: EUROPEAN RESPIRATORY SOC JOURNALS LTD. doi: 10.1183/13993003.congress-2020.1678
2020
Conference Publication
Nusinersen stabilises respiratory function in paediatric spinal muscular atrophy
Chacko, Archana, Deegan, Sean, Gauld, Leanne and Sly, Peter (2020). Nusinersen stabilises respiratory function in paediatric spinal muscular atrophy. International Congress of the European-Respiratory-Society (ERS), Online, 7-9 September 2020. Sheffield, United Kingdom: European Respiratory Society. doi: 10.1183/13993003.congress-2020.1234
2020
Conference Publication
End of test (EOT) criteria for spirometry in preschool children
Enrique Busi, Luciano, David Sly, Peter and Gisel Fernandez, Sabrina (2020). End of test (EOT) criteria for spirometry in preschool children. International Congress of the European-Respiratory-Society (ERS), Electr Network, Sep 07-09, 2020. SHEFFIELD: EUROPEAN RESPIRATORY SOC JOURNALS LTD. doi: 10.1183/13993003.congress-2020.1224
2020
Journal Article
Prenatal phthalate exposure, oxidative stress-related genetic vulnerability and early life neurodevelopment: a birth cohort study
Ponsonby, Anne-Louise, Symeonides, Christos, Saffery, Richard, Mueller, Jochen F, O'Hely, Martin, Sly, Peter D, Wardrop, Nicole, Pezic, Angela, Mansell, Toby, Collier, Fiona, Burgner, David, Thompson, Kristie, Vijayasarathy, Soumini, Sugeng, Eva J., Dwyer, Terence, Ranganathan, Sarath, Anderson, Peter J, Anderson, Vicki and Vuillermin, Peter (2020). Prenatal phthalate exposure, oxidative stress-related genetic vulnerability and early life neurodevelopment: a birth cohort study. NeuroToxicology, 80, 20-28. doi: 10.1016/j.neuro.2020.05.006
2020
Journal Article
Neonatal genetics of gene expression reveal potential origins of autoimmune and allergic disease risk
Huang, Qin Qin, Tang, Howard H. F., Teo, Shu Mei, Mok, Danny, Ritchie, Scott C., Nath, Artika P., Brozynska, Marta, Salim, Agus, Bakshi, Andrew, Holt, Barbara J., Khor, Chiea Chuen, Sly, Peter D., Holt, Patrick G., Holt, Kathryn E. and Inouye, Michael (2020). Neonatal genetics of gene expression reveal potential origins of autoimmune and allergic disease risk. Nature Communications, 11 (1) 3761, 3761. doi: 10.1038/s41467-020-17477-x
2020
Journal Article
Assessing and mitigating environmental exposures in early life
Sly, Peter D. and Kayama, Fujio (2020). Assessing and mitigating environmental exposures in early life. Reviews on Environmental Health, 35 (3), 219-220. doi: 10.1515/reveh-2020-0082
2020
Journal Article
Author Correction: Increased susceptibility of airway epithelial cells from ataxia-telangiectasia to S. pneumoniae infection due to oxidative damage and impaired innate immunity
Yeo, Abrey J., Henningham, Anna, Fantino, Emmanuelle, Galbraith, Sally, Krause, Lutz, Wainwright, Claire E., Sly, Peter D. and Lavin, Martin F. (2020). Author Correction: Increased susceptibility of airway epithelial cells from ataxia-telangiectasia to S. pneumoniae infection due to oxidative damage and impaired innate immunity. Scientific Reports, 10 (1) 12742, 12742. doi: 10.1038/s41598-020-69649-w
2020
Journal Article
HMGB1 amplifies ILC2-induced type-2 inflammation and airway smooth muscle remodelling
Loh, Zhixuan, Simpson, Jennifer, Ullah, Ashik, Zhang, Vivian, Gan, Wan J., Lynch, Jason P., Werder, Rhiannon B., Sikder, Al Amin, Lane, Katie, Sim, Choon Boon, Porrello, Enzo, Mazzone, Stuart B., Sly, Peter D., Steptoe, Raymond J., Spann, Kirsten M., Sukkar, Maria B., Upham, John W. and Phipps, Simon (2020). HMGB1 amplifies ILC2-induced type-2 inflammation and airway smooth muscle remodelling. PLoS Pathogens, 16 (7) e1008651, 1-21. doi: 10.1371/journal.ppat.1008651
2020
Journal Article
Prenatal exposure to VOCs and NOx and lung function in preschoolers
Gutiérrez‐Delgado, Rosa I., Barraza‐Villarreal, Albino, Escamilla‐Núñez, María C., Hernandez‐Cadena, Leticia, Cortez‐Lugo, Marlene, Sly, Peter and Romieu, Isabelle (2020). Prenatal exposure to VOCs and NOx and lung function in preschoolers. Pediatric Pulmonology, 55 (8) ppul.24889, 2142-2149. doi: 10.1002/ppul.24889
2020
Conference Publication
Stabilisation of respiratory function in paediatric spinal muscular atrophy treated with nusinersen
Chacko, A., Sly, P., Deegan, S. and Gauld, L. (2020). Stabilisation of respiratory function in paediatric spinal muscular atrophy treated with nusinersen. TSANZSRS 2020 The Australia & New Zealand Society of Respiratory Science and The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ) Annual Scientific Meeting for Leaders in Lung Health & Respiratory Science, Melbourne, VIC Australia, 27-31 March 2020. Richmond, VIC Australia: John Wiley & Sons.
2020
Conference Publication
Stabilisation of respiratory function in paediatric spinal muscular atrophy treated with nusinersen
Chacko, A., Sly, P., Deegan, S. and Gauld, L. (2020). Stabilisation of respiratory function in paediatric spinal muscular atrophy treated with nusinersen. TSANZSRS 2020 The Australia & New Zealand Society of Respiratory Science and The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ) Annual Scientific Meeting for Leaders in Lung Health & Respiratory Science, Melbourne, VIC Australia, 27-31 March 2020. Richmond, VIC Australia: John Wiley & Sons.
2020
Conference Publication
Lung function trajectories from childhood to adulthood in the Raine study
Sanna, F., Locatelli, F., Sly, P., White, E., Hall, G. and Foong, R. (2020). Lung function trajectories from childhood to adulthood in the Raine study. The Australia & New Zealand Society of Respiratory Science and The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ) Annual Scientific Meeting for Leaders in Lung Health & Respiratory Science, Melbourne, VIC, Australia, 27–31 March 2020. Hoboken, NJ, United States: Wiley-Blackwell Publishing. doi: 10.1111/resp.13778
2020
Journal Article
Predictors with regard to ingestion, inhalation and dermal absorption of estimated phthalate daily intakes in pregnant women: The Barwon infant study
Sugeng, Eva J., Symeonides, Christos, O'Hely, Martin, Vuillermin, Peter, Sly, Peter D., Vijayasarathy, Soumini, Thompson, Kristie, Pezic, Angela, Mueller, Jochen F., Ponsonby, Anne-Louise and the Barwon Infant Study Investigator Group (2020). Predictors with regard to ingestion, inhalation and dermal absorption of estimated phthalate daily intakes in pregnant women: The Barwon infant study. Environment International, 139 105700, 105700. doi: 10.1016/j.envint.2020.105700
2020
Journal Article
Severe dioxin-like compound (DLC) contamination in e-waste recycling areas: an under-recognized threat to local health
Dai, Qingyuan, Xu, Xijin, Eskenazi, Brenda, Asante, Kwadwo Ansong, Chen, Aimin, Fobil, Julius, Bergman, Åke, Brennan, Lesley, Sly, Peter D., Nnorom, Innocent Chidi, Pascale, Antonio, Wang, Qihua, Zeng, Eddy Y., Zeng, Zhijun, Landrigan, Philip J., Bruné Drisse, Marie-Noel and Huo, Xia (2020). Severe dioxin-like compound (DLC) contamination in e-waste recycling areas: an under-recognized threat to local health. Environment International, 139 105731. doi: 10.1016/j.envint.2020.105731
2020
Journal Article
Association of maternal and social characteristics with age-standardised birthweight
Vilcins, Dwan, Baker, Peter, Jagals, Paul and Sly, Peter D. (2020). Association of maternal and social characteristics with age-standardised birthweight. Journal of Public Health, 30 (2), 373-383. doi: 10.1007/s10389-020-01292-1
2020
Journal Article
Campylobacter infection and household factors are associated with childhood growth in urban Bangladesh: an analysis of the MAL-ED study
Sanchez, J. Johanna, Alam, Ashraful, Stride, Christopher B., Haque, Ahshanul, Das, Subhasish, Mahfuz, Mustafa, Roth, Daniel E., Sly, Peter D., Long, Kurt Z. and Ahmed, Tahmeed (2020). Campylobacter infection and household factors are associated with childhood growth in urban Bangladesh: an analysis of the MAL-ED study. PLoS Neglected Tropical Diseases, 14 (5) e0008328, e0008328-15. doi: 10.1371/journal.pntd.0008328
2020
Journal Article
Green space and early childhood development: a systematic review
Islam, Mohammad Zahirul, Johnston, Jessika and Sly, Peter D. (2020). Green space and early childhood development: a systematic review. Reviews on Environmental Health, 35 (2), 189-200. doi: 10.1515/reveh-2019-0046
2020
Journal Article
Anti-inflammatory effects of lenabasum, a cannabinoid receptor type 2 agonist, on macrophages from cystic fibrosis
Tarique, Abdullah A., Evron, Tama, Zhang, George, Tepper, Mark A., Morshed, Mohammed M., Andersen, Isabella S.G., Begum, Nelufa, Sly, Peter D. and Fantino, Emmanuelle (2020). Anti-inflammatory effects of lenabasum, a cannabinoid receptor type 2 agonist, on macrophages from cystic fibrosis. Journal of Cystic Fibrosis, 19 (5), 823-829. doi: 10.1016/j.jcf.2020.03.015
2020
Journal Article
Maternal asthma, breastfeeding, and respiratory outcomes in the first year of life
Harvey, Soriah M., Murphy, Vanessa E., Gibson, Peter G., Collison, Adam, Robinson, Paul, Sly, Peter D., Mattes, Joerg and Jensen, Megan E. (2020). Maternal asthma, breastfeeding, and respiratory outcomes in the first year of life. Pediatric Pulmonology, 55 (7) ppul.24756, 1690-1696. doi: 10.1002/ppul.24756
2020
Journal Article
Early markers of cystic fibrosis structural lung disease: follow-up of the ACFBAL cohort
Wijker, Naomi E., Vidmar, Suzanna, Grimwood, Keith, Sly, Peter D., Byrnes, Catherine A., Carlin, John B., Cooper, Peter J., Robertson, Colin F., Massie, R. John, Kemner van de Corput, Mariette P. C., Cheney, Joyce, Tiddens, Harm A.W.M., Wainwright, Claire E. and for the Australasian Cystic Fibrosis Bronchoalveolar Lavage (ACFBAL) and Follow-up of the ACFBAL (CF-FAB) study groups (2020). Early markers of cystic fibrosis structural lung disease: follow-up of the ACFBAL cohort. European Respiratory Journal, 55 (4) 1901694, 1-12. doi: 10.1183/13993003.01694-2019
Funding
Current funding
Past funding
Supervision
Availability
- Professor Peter Sly is:
- Not available for supervision
Supervision history
Current supervision
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Doctor Philosophy
Role of airway obstruction in the development of asthma
Principal Advisor
Other advisors: Honorary Professor Zoltan Hantos, Dr Tamara Blake
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Doctor Philosophy
The Respiratory effects of Paediatric Spinal Muscular Atrophy
Principal Advisor
Other advisors: Dr Zephanie Tyack
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Doctor Philosophy
Impacts of early-life phthalate and bisphenol exposure on childhood asthma, allergy, and lung function
Principal Advisor
Other advisors: Dr Dwan Vilcins
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Doctor Philosophy
Providing evidence to guide public health messages during bushfire smoke events
Associate Advisor
Other advisors: Dr Dwan Vilcins
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Doctor Philosophy
Investigations into the importance of antimicrobial residues in the surveillance of antimicrobial resistance in peri-urban dairy farms of Nepal
Associate Advisor
Other advisors: Dr Deirdre Mikkelsen, Dr Nicholas Clark, Professor Ricardo Soares Magalhaes
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Doctor Philosophy
Improving detection of pulmonary graft-vs-host disease (pGVHD) post haematopoietic stem cell transplantation (HSCT)
Associate Advisor
Other advisors: Dr Tamara Blake, Professor Paul Robinson
Completed supervision
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2025
Doctor Philosophy
Characterizing the Environmental Burden and Health Impact of Electronic Waste (e-waste) in Bangladesh
Principal Advisor
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2023
Doctor Philosophy
Traffic-related air pollution: impact on respiratory health and attitudes to self-protective behaviours amongst urban Vietnamese children
Principal Advisor
Other advisors: Associate Professor Phong Thai, Associate Professor Dung Phung
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2020
Doctor Philosophy
Enteropathogen infection and Household Factors Associated with Linear Child Growth in Bangladesh
Principal Advisor
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2020
Doctor Philosophy
Novel green space measures and birthweight in Queensland, Australia
Principal Advisor
Other advisors: Dr Peter Baker
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2019
Doctor Philosophy
Incorporating Epidemiological Studies into Integrated Environmental Health Impact Assessment of Coal Mining
Principal Advisor
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2019
Doctor Philosophy
Evaluating the Effects of Atmospheric Environment on Children's Health in Hanoi, Vietnam
Principal Advisor
Other advisors: Associate Professor Phong Thai, Associate Professor Dung Phung
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2018
Doctor Philosophy
Improving the clinical utility of the Forced Oscillation Technique in preschool-aged children
Principal Advisor
Other advisors: Honorary Professor Zoltan Hantos
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2018
Doctor Philosophy
Assessing Exposure of Young Australian Children to Toxicants in the Home Environment using a Web-Based Questionnaire
Principal Advisor
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2025
Doctor Philosophy
Mitigating the health impacts of air pollution in Australia: From research to policy.
Associate Advisor
Other advisors: Professor Brian Head, Associate Professor Nina Lansbury
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2025
Doctor Philosophy
Epidemiological investigations into avian influenza virus environmental contamination in live bird markets of Dhaka's metropolitan area, Bangladesh
Associate Advisor
Other advisors: Dr Nicholas Clark, Professor Ricardo Soares Magalhaes
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2023
Doctor Philosophy
Trajectories of asthma symptom and their associations with family, neighbourhood, and psychosocial environmental factors among children in Australia
Associate Advisor
Other advisors: Professor Abdullah Mamun
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2023
Doctor Philosophy
Children's Environmental Health in Least Developed Countries: a modelling approach to support policy decisions
Associate Advisor
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2022
Master Philosophy
Investigating the molecular mechanisms of macrophage polarisation
Associate Advisor
Other advisors: Dr Abdullah Tarique
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2021
Doctor Philosophy
Assessing Early-life Human Exposure to Selected Pesticides Using Urinary Biomarkers
Associate Advisor
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2020
Doctor Philosophy
Statistical methods for analysing the health effects of prenatal exposure to mixtures of correlated endocrine-disrupting chemicals
Associate Advisor
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2020
Doctor Philosophy
Early Life Predictors of Peak Lung function at 21 years Findings from a Longitudinal Cohort Study
Associate Advisor
Other advisors: Professor Abdullah Mamun
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2019
Doctor Philosophy
Establishing a wound healing model in well differentiated cultures of primary human nasal epithelial cells
Associate Advisor
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2017
Doctor Philosophy
Assessing body burden of persistent organic pollutants (POPs) in infants/toddlers through analysis of faeces
Associate Advisor
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2016
Doctor Philosophy
The antiviral defects of the airway epithelium associated with wheeze and atopy in children and asthma in adults
Associate Advisor
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2016
Doctor Philosophy
Understanding the cellular and molecular processes that link RAGE gene-deletion with the development of pneumovirus-induced bronchiolitis and paucigranulocytic asthma
Associate Advisor
Other advisors: Honorary Professor John Upham
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2015
Doctor Philosophy
Immunomodulation of allergic airway inflammation by mesenchymal stem cells
Associate Advisor
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2014
Doctor Philosophy
Acute lower respiratory infections in infants in the tropics: Environmental drivers of seasonal epidemics
Associate Advisor
Other advisors: Emeritus Professor Gail Williams
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2014
Doctor Philosophy
Assessing environmental exposures in Australian children. A case study of bisphenol A
Associate Advisor
Media
Enquiries
Contact Professor Peter Sly directly for media enquiries about:
- Child health
- Children and environment
- Cystic fibrosis
- Paediatric asthma
- Respiratory physiology
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