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Professor Mark Smithers
Professor

Mark Smithers

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Overview

Background

Emeritus Professor Mark Smithers is a surgical oncologist who specialises in surgery for oesophago-gastric diseases, melanoma, advanced skin cancer and soft tissue sarcoma. He was the Director of the Upper GI and Soft Tissue Unit at the Princess Alexandra Hospital, in Brisbane, Australia from 1998 - 2023. Commencing his academic career with the University of Queensland in 1987, he progressed to be the Mayne Chair in Surgery and head of the Academy of Surgery. He is the second University of Queensland Medical graduate to be appointed to this role. His research has been focussed on the development and assessment of outcomes from minimally invasive upper GI surgery, and trials assessing the role of perioperative multidisciplinary therapy for esophageal and gastric cancer. As well he has led, or been involved with, clinical trials from phase I to III, for all stages of melanoma through his role as the Chair of the Queensland Melanoma Project. More recently he has been involved with the assessment of access to, and outcomes from, surgery for cancer in Queensland, Australia.

He has overseen the administration and development of the surgery curriculum, and the teaching, in the Academy of Surgery, in the UQ Faculty of Medicine. He was on a number of committees relevant to the implementation of the UQ MD design course. He has held various leadership and committee roles with the Royal Australasian College of Surgeons, as well as leadership roles, including the Presidency, in the Australian and New Zealand Oesophago Gastric Surgeons Association. He has also been on the committees of international organisations related to oesophageal and gastric surgery. He has published 250 articles, eight book chapters, and has been on the editorial board of a number of surgical journals.

He has been recognised for his clinical and academic roles by the award of Member of the Order of Australia (AM). The citation reads, "for service to medicine in the fields of gastro-intestinal and melanoma surgery, to medical education and to professional organisations". The Royal Australasian College of Surgeons awarded him the Sir Hugh Devine medal, for services to surgery and the community. This is the College’s highest honour. Internationally, he has been awarded an honorary fellowship of the Royal College of Surgeons of Edinburgh and recently, in the United States, he was elected as an Honarary Fellow of the American Surgical Association.

Availability

Professor Mark Smithers is:
Not available for supervision
Media expert

Qualifications

  • Bachelor of Medicine and Surgery and Medical Science, The University of Queensland
  • Honorary Fellow, American Surgical Association, American Surgical Association
  • Fellow, Royal Australasian College of Surgeons, Royal Australasian College of Surgeons
  • Fellow, Royal College of Surgeons of Edinburgh, Royal College of Surgeons of Edinburgh
  • Fellow, Royal College of Surgeons of England, Royal College of Surgeons of England

Research interests

  • Cutaneous Melanoma

    epidemiology, public health issues and management of all stages

  • Management of Oesophageal and Gastric Cancer

    Investigation and management of benign and malignant diseases of the oesophagus and the stomach.

Works

Search Professor Mark Smithers’s works on UQ eSpace

414 works between 1983 and 2025

381 - 400 of 414 works

1997

Journal Article

Relative dispersion of intravascular transit times during isolated human limb perfusions for recurrent melanoma

Roberts, MS, Wu, ZY, Rivory, LP, Smithers, BM, Egerton, WS and Weiss, M (1997). Relative dispersion of intravascular transit times during isolated human limb perfusions for recurrent melanoma. British Journal of Clinical Pharmacology, 44 (4), 347-351. doi: 10.1046/j.1365-2125.1997.t01-1-00593.x

Relative dispersion of intravascular transit times during isolated human limb perfusions for recurrent melanoma

1996

Journal Article

Laparoscopic nissen fundoplication and postoperative dysphagia - Can it be predicted?

Gotley, D. C., Smithers, B. M., Menzies, B., Branicki, F. J., Rhodes, M. and Nathanson, L. (1996). Laparoscopic nissen fundoplication and postoperative dysphagia - Can it be predicted?. Annals of the Academy of Medicine Singapore, 25 (5), 646-649.

Laparoscopic nissen fundoplication and postoperative dysphagia - Can it be predicted?

1996

Journal Article

Laparoscopic Nissen fundoplication - 200 consecutive cases

Gotley, D. C., Smithers, B. M., Rhodes, M., Menzies, B., Branicki, F. J. and Nathanson, L. (1996). Laparoscopic Nissen fundoplication - 200 consecutive cases. Gut, 38 (4), 487-491. doi: 10.1136/gut.38.4.487

Laparoscopic Nissen fundoplication - 200 consecutive cases

1996

Journal Article

Malignant sacrococcygeal germ cell tumour in an adult

Smithers, B. Mark, Theile, David E., Dickinson, Ian C., Thomson, Damien B. and Axelsen, Roy A. (1996). Malignant sacrococcygeal germ cell tumour in an adult. Australian and New Zeland Journal of Surgery, 66 (3), 185-189. doi: 10.1111/j.1445-2197.1996.tb01156.x

Malignant sacrococcygeal germ cell tumour in an adult

1996

Journal Article

Laparoscopic versus open appendectomy: Prospective randomized trial

Hansen, John Brendan, Smithers, Bernard Mark, Schache, David, Wall, Daryl Robert, Miller, Brian John and Menzies, Betty Lynette (1996). Laparoscopic versus open appendectomy: Prospective randomized trial. World Journal of Surgery, 20 (1), 17-21. doi: 10.1007/s002689900003

Laparoscopic versus open appendectomy: Prospective randomized trial

1995

Journal Article

High-performance liquid chromatographic assay for the measurement of melphalan and its hydrolysis products in perfusate and plasma and melphalan in tissues from human and rat isolated limb perfusions

Wu, Zhen-Yu, Thompson, Melanie J., Roberts, Michael S., Addison, Russell S., Cannell, Graeme R., Grabs, Anthony J. and Smithers, B. Mark (1995). High-performance liquid chromatographic assay for the measurement of melphalan and its hydrolysis products in perfusate and plasma and melphalan in tissues from human and rat isolated limb perfusions. Journal of Chromatography B: Biomedical Sciences and Applications, 673 (2), 267-279. doi: 10.1016/0378-4347(95)00277-5

High-performance liquid chromatographic assay for the measurement of melphalan and its hydrolysis products in perfusate and plasma and melphalan in tissues from human and rat isolated limb perfusions

1995

Journal Article

Radiation therapy for nodal disease in malignant melanoma

Burmeister, B. H., Smithers, B. M., Poulsen, M., McLeod, G. R., Bryant, G., Tripcony, L. and Thorpe, C. (1995). Radiation therapy for nodal disease in malignant melanoma. World Journal of Surgery, 19 (3), 369-371. doi: 10.1007/BF00299160

Radiation therapy for nodal disease in malignant melanoma

1995

Journal Article

Psychological responses to malignant melanoma: an investigation of traumatic stress rections to life-threatening illness

Raphael, Brian, Raphael, B., Smithers, Mark, Swanson, Cheryl, Reid, Carla, McLeod, Rod, Thomson, Damien and Walpole, Ewan (1995). Psychological responses to malignant melanoma: an investigation of traumatic stress rections to life-threatening illness. General Hospital Psychiatry, 17 (2), 126-134. doi: 10.1016/0163-8343(94)00098-X

Psychological responses to malignant melanoma: an investigation of traumatic stress rections to life-threatening illness

1995

Journal Article

Routine HIV testing before surgery

Selvey, L., Hogan, P., Frazer, I. H., Smithers, M. and Robinson, D. (1995). Routine HIV testing before surgery. Australian Journal of Public Health, 19 (1), 107-108.

Routine HIV testing before surgery

1995

Conference Publication

Laparoscopic nissen fundoplication - lessons learned from 200 consecutive cases

Rhodes, M., Gotley, D. C., Smithers, B. M., Menzies, B., Branicki, F. J. and Nathanson, L. (1995). Laparoscopic nissen fundoplication - lessons learned from 200 consecutive cases. Annual Meeting of the American Gastroenterological Association, San Diego, California, United States, 14–17 May 1995. Maryland Heights, MO, United States: W.B. Saunders. doi: 10.1016/0016-5085(95)23468-3

Laparoscopic nissen fundoplication - lessons learned from 200 consecutive cases

1994

Journal Article

Melphalan uptake, hyperthermic synergism and drug resistance in a human cell culture model for the isolated limb perfusion of melanoma

Clark, J., Grabs, A. J., Parsons, P. G., Smithers, B. M., Addison, R. S. and Roberts, M. S. (1994). Melphalan uptake, hyperthermic synergism and drug resistance in a human cell culture model for the isolated limb perfusion of melanoma. Melanoma Research, 4 (6), 365-370. doi: 10.1097/00008390-199412000-00004

Melphalan uptake, hyperthermic synergism and drug resistance in a human cell culture model for the isolated limb perfusion of melanoma

1994

Journal Article

Laparoscopic approach to the left kidney avoiding colonic mobilization

Nicol, D. L. and Smithers, B. M. (1994). Laparoscopic approach to the left kidney avoiding colonic mobilization. Journal of Urology, 152 (6), 1967-1969. doi: 10.1016/S0022-5347(17)32280-2

Laparoscopic approach to the left kidney avoiding colonic mobilization

1994

Journal Article

Percutaneous fluoroscopic gastrostomy. A safe option?

Laing, B., Smithers, M. and Harper, J. (1994). Percutaneous fluoroscopic gastrostomy. A safe option?. Medical Journal of Australia, 161 (5), 308-310. doi: 10.5694/j.1326-5377.1994.tb127451.x

Percutaneous fluoroscopic gastrostomy. A safe option?

1994

Journal Article

Laparoscopic nephrectomy for benign renal disease

Nicol, D. L., Winkle, D. C., Nathanson, L. K. and Smithers, B. M. (1994). Laparoscopic nephrectomy for benign renal disease. British Journal of Urology, 73 (3), 237-241. doi: 10.1111/j.1464-410X.1994.tb07511.x

Laparoscopic nephrectomy for benign renal disease

1993

Journal Article

Plasma concentrations of bupivacaine after wound infiltration of an 0.5% solution after inguinal herniorrhaphy: a preliminary study

Kastrissios, H., Triggs, E. J., Sinclair, F., Moran, P. and Smithers, M. (1993). Plasma concentrations of bupivacaine after wound infiltration of an 0.5% solution after inguinal herniorrhaphy: a preliminary study. European Journal of Clinical Pharmacology, 44 (6), 555-557. doi: 10.1007/BF02440858

Plasma concentrations of bupivacaine after wound infiltration of an 0.5% solution after inguinal herniorrhaphy: a preliminary study

1993

Journal Article

Videothoracoscopic primary repair of early distal oesophageal perforation

Nathanson, L. K., Gotley, D., Smithers, M. and Branicki, F. (1993). Videothoracoscopic primary repair of early distal oesophageal perforation. Australian and New Zealand Journal of Surgery, 63 (5), 399-403. doi: 10.1111/j.1445-2197.1993.tb00409.x

Videothoracoscopic primary repair of early distal oesophageal perforation

1993

Journal Article

Ultrastructure of human melanosis coli with reference to its pathogenesis

Walker, Neal I., Smith, Mary M. and Smithers, B. M. (1993). Ultrastructure of human melanosis coli with reference to its pathogenesis. Pathology, 25 (2), 120-123. doi: 10.3109/00313029309084783

Ultrastructure of human melanosis coli with reference to its pathogenesis

1993

Conference Publication

Plasma concentrations following wound infiltrations of 0.5-percent bupivacaine after inguinal herniorrhaphy

Kastrissios, H., Triggs, E. J., Sinclair, F., Smithers, M. and Moran, P. (1993). Plasma concentrations following wound infiltrations of 0.5-percent bupivacaine after inguinal herniorrhaphy. Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics, Honolulu, Hawaii, 24-26 March 1993. New York, NY, United States: Nature Publishing Group. doi: 10.1038/clpt.1993.20

Plasma concentrations following wound infiltrations of 0.5-percent bupivacaine after inguinal herniorrhaphy

1993

Conference Publication

Spleen slice grafts in mice as a model for producing donor-specific tolerance

Green, M. K., Walsh, M. and Smithers, B. M. (1993). Spleen slice grafts in mice as a model for producing donor-specific tolerance. International Congress on the Regulation of Leukocyte Production and Immune Function held at the Joint Meeting of the Australasian Society for Immunology and Society for Leukocyte Biology, Sydney, New South Wales, Australia, 1-5 December 1993. Bethesda, United States: Federation of American Societies for Experimental Biology.

Spleen slice grafts in mice as a model for producing donor-specific tolerance

1992

Journal Article

Desmoplastic melanoma: Patterns of recurrence

Smithers, B. Mark, McLeod, G. Roderick and Little, John H. (1992). Desmoplastic melanoma: Patterns of recurrence. World Journal of Surgery, 16 (2), 186-190. doi: 10.1007/BF02071519

Desmoplastic melanoma: Patterns of recurrence

Funding

Current funding

  • 2024 - 2025
    Optimising the Diagnosis and Management of Unilateral Primary Aldosteronism (MSH SERTA Grant led by Metro South HHS)
    Metro South Hospital and Health Service
    Open grant
  • 2023 - 2026
    iCare - An interactive online portal to improve health and wellbeing for people living with complex cancers, and their informal carers: a Phase II randomised controlled trial (Ex led Deakin MRFF CTA)
    Deakin University
    Open grant
  • 2021 - 2026
    AGITG TOP GEAR: A randomised phase II/III trial of preoperative chemoradiotherapy versus preoperative chemotherapy for resectable gastric cancer (CTCS: led by USyd)
    University of Sydney
    Open grant
  • 2019 - 2026
    A Randomised Phase II Trial of Adjuvant Avelumab in Patients with Early Stage Merkel Cell Carcinoma
    NHMRC MRFF - Rare Cancers, Rare Diseases and Unmet Need
    Open grant
  • 2019 - 2025
    Melanoma Margins Trial II - A Phase III, Multi-centre Randomised Controlled Trial Investigating 1cm v 2cm Wide Surgical Excision Margins.. (NHMRC Project Grant led by the University of Melbourne).
    University of Melbourne
    Open grant

Past funding

  • 2021 - 2024
    Advanced technological approach to predicting survival in patients diagnosed with locally invasive cutaneous melanoma
    Cancer Council Queensland
    Open grant
  • 2021 - 2024
    Establishing Australia's First Familial Melanoma Clinic (MSH RSS SERTA Program Grant led by Metro South Hospital and Health Service)
    Metro South Hospital and Health Service
    Open grant
  • 2020 - 2021
    Cancer Evolution Biobank
    PA Research Foundation
    Open grant
  • 2017 - 2019
    Predictors of mortality in thin melanomas
    Cancer Council Queensland
    Open grant
  • 2013 - 2015
    To identify and assess markers of prognosis, response and resistance to therapy in patients with Stage III metastatic melanoma
    Cancer Bequest Fund
    Open grant
  • 2011
    DOCetaxel with or without radiation Therapy for resectable Oesophageal adenocarcinoma based on early PET Response to induction chemotherapy (DOCTOR)
    NHMRC Project Grant
    Open grant
  • 2011 - 2013
    Effects of nevogenesis susceptibility genes and phenotypic correlation with dermoscopic characteristics of nevi
    NHMRC Project Grant
    Open grant
  • 2010 - 2014
    Comparison of pre- and perioperative immunonutrition in patients undergoing surgical resection of oesophageal cancer (NHMRC Project Grant administered by the University of Adelaide)
    University of Adelaide
    Open grant
  • 2001 - 2002
    The epidemiology of oesophageal cancer: Risk and molecular markers
    Queensland Cancer Fund
    Open grant
  • 2000
    The role of TAP and MHC class I expression in the response to melanoma immunotherapy using autologous dendritic cells
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 1999 - 2000
    A phase II clinical trial in patients with metastatic melanoma comparing autologous dendritic cells pulsed with autologous tumour peptides and melanoma associated peptides linked to the endoplasmic re
    Queensland Cancer Fund
    Open grant
  • 1998
    A Phase I/II Clinical Trial to Test Tumour Vaccines Comprising with Protein or Autologous Tumour Antigen Autologous Dandritic Cells Generated in a Closed Bag System Pulsed
    Mayne Bequest Fund
    Open grant
  • 1998
    Isolated limb infusion of melphalan and microdialysis technique in treatment of recurrent malignant melanoma
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 1998 - 2000
    Treatment of Recurrent Malignant Melanoma by Limb Infusion of Cytotoxic Drugs and Other Techniques
    NHMRC Project Grant
    Open grant
  • 1997 - 1998
    Pharmacokinetics of tumour necrosis factor (TNF) in isolated rat hindlimb perfusions and infusions related to melanoma therapy
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 1996 - 1997
    Targeting and monitoring drug delivery in specific tissues using iontophoresis and microdialysis
    Quality Funds Round 3
    Open grant
  • 1995 - 1997
    Pharmacokinetics of melphalan in isolated limb perfusion and infusion
    Queensland Cancer Fund
    Open grant

Supervision

Availability

Professor Mark Smithers is:
Not available for supervision

Supervision history

Current supervision

  • Master Philosophy

    Assessment of the impact of treating service characteristics on surgical and oncological outcomes for patients with Retroperitoneal and Inguinal Sarcomas in Queensland

    Principal Advisor

    Other advisors: Professor Andrew Barbour

  • Master Philosophy

    Factors Influencing Anastomotic Complications after Oesophagectomy

    Associate Advisor

  • Doctor Philosophy

    New tools for the multi-modal evaluation of pancreatic cancer and its precursor neoplasms.

    Associate Advisor

    Other advisors: Dr David Cavallucci

Completed supervision

Media

Enquiries

Contact Professor Mark Smithers directly for media enquiries about:

  • Advanced endoscopic surgery
  • Cancer surgery
  • Endoscopic surgery
  • General surgery
  • Melanoma
  • Surgery - cancer
  • Surgery - oesophageal, gastric cancer
  • Surgery - upper GI
  • Upper GI surgery

Need help?

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