Overview
Background
Jobichen Chacko is a structural biologist with extensive experience in protein structural biology, protein-ligand interaction, proteases and drug discovery. He completed his PhD from National University of Singapore in the area of structural and functional studies on bacterial protein secretion system. He is proficient in the areas of Cryo-Electron microscopy (Single Particle Analysis), protein structure analysis and X-ray crystallography. He has published more than 49 research articles in high level journals and has more than 850 citations. His research interests are in host-pathogen interaction, Antiphage defense, Toll-like receptor proteins, protein secretion system, snake venom toxins and proteases. Jobichen is a member of the editorial advisory board for FEBS-openbio journal and serves as a reviewer for various scientific journals.
Availability
- Dr Jobichen Chacko is:
- Available for supervision
Qualifications
- Doctor of Philosophy of Biological Sciences, National University of Singapore
Works
Search Professor Jobichen Chacko’s works on UQ eSpace
2026
Journal Article
Structural basis of canonical TIR-NLR activation in plant innate immunity
Natsumi Maruta, Weix Gu, Bryan Ying Jie Lim, Mitchell Sorbello, Dalton Heng Yong Ngu and Chacko Jobichen (2026). Structural basis of canonical TIR-NLR activation in plant innate immunity. doi: 10.64898/2026.02.03.703613
2026
Journal Article
Structural analysis of a motor with increased mechanical output reveals new transitions in kinesin microtubule motility
Shibata, Satoki, Wang, Matthew Y., Imasaki, Tsuyoshi, Shigematsu, Hideki, Ugarte La Torre, Diego, Wei, Yuanyuan, Jobichen, Chacko, Hagio, Hajime, Sivaraman, J., Sugita, Yuji, Endow, Sharyn A. and Nitta, Ryo (2026). Structural analysis of a motor with increased mechanical output reveals new transitions in kinesin microtubule motility. Scientific Reports, 16 (1) 487. doi: 10.1038/s41598-025-28573-7
2026
Journal Article
AccA from <i>Neisseria gonorrhoeae</i> provides a new framework for understanding periplasmic copper metallochaperones
Firth, Samantha, Earl, William, Thaqi, Denis, Hong, YoungJin, O'Hern, Charlotte, Luscombe, Gemma, Ngu, Dalton, Luo, Zhenyao, Jobichen, Chacko, Kobe, Bostjan, McEwan, Alastair G and Djoko, Karrera (2026). AccA from Neisseria gonorrhoeae provides a new framework for understanding periplasmic copper metallochaperones. Chemical Science. doi: 10.1039/d5sc08738d
2025
Other Outputs
Natural variation in an NLR pair confers thermostable resistance to a devastating bacterial pathogen
Nathalie Aoun,, Mandeep Singh and Chacko Jobichen (2025). Natural variation in an NLR pair confers thermostable resistance to a devastating bacterial pathogen. doi: 10.64898/2025.12.15.694456
2025
Journal Article
Resolving the structure and assembly of the honeybee silk heterotetrameric coiled coil
Johnston, Caitlin L., Jobichen, Chacko, Briggs, Lyndall J., Michie, Michelle, Liu, Jian‐Wei, Morton, Craig J., Warden, Andrew C. and Sutherland, Tara D. (2025). Resolving the structure and assembly of the honeybee silk heterotetrameric coiled coil. Protein Science, 34 (8) e70230, e70230. doi: 10.1002/pro.70230
2025
Journal Article
Cryo-EM structure provides insights into the unusual heptameric assembly of rice (Oryza sativa L.) ClpB1 AAA+ ATPase
Jobichen, Chacko, Saharan, Ketul, Samal, Archana, Choong, Yeu Khai, Jagdev, Manas Kumar, Mohapatra, Chinmayee, Jian, Shi, Babbar, Richa, Dobson, Renwick C.J., Grover, Anil, Vasudevan, Dileep and Sivaraman, J. (2025). Cryo-EM structure provides insights into the unusual heptameric assembly of rice (Oryza sativa L.) ClpB1 AAA+ ATPase. International Journal of Biological Macromolecules, 311 (Pt 3) 143917, 1-8. doi: 10.1016/j.ijbiomac.2025.143917
2024
Journal Article
Structure, dynamics and evolution of the Candida albicans multi-drug resistance ABC transporter CDR1
Shin, Jeeeun, Jin, Ruitao, Gall, Barnabas, Jobichen, Chacko, Jackson, Colin, Rug, Melanie, Corry, Ben and Brock, Joseph (2024). Structure, dynamics and evolution of the Candida albicans multi-drug resistance ABC transporter CDR1. doi: 10.1101/2024.10.28.620768
2024
Other Outputs
Structural transitions in kinesin minus-end directed microtubule motility
Shibata, Satoki, Wang, Matthew Y., Imasaki, Tsuyoshi, Shigematsu, Hideki, Wei, Yuanyuan, Jobichen, Chacko, Hagio, Hajime, Sivaraman, J., Endow, Sharyn A. and Nitta, Ryo (2024). Structural transitions in kinesin minus-end directed microtubule motility. doi: 10.1101/2024.07.29.605428
2024
Journal Article
Sensing for survival: specialised regulatory mechanisms of Type III secretion systems in Gram-negative pathogens
Manisha, Yadav, Srinivasan, Mahalashmi, Jobichen, Chacko, Rosenshine, Ilan and Sivaraman, J. (2024). Sensing for survival: specialised regulatory mechanisms of Type III secretion systems in Gram-negative pathogens. Biological Reviews, 99 (3), 837-863. doi: 10.1111/brv.13047
2023
Journal Article
Bacterioferritin nanocage structures uncover the biomineralization process in ferritins
Jobichen, Chacko, Chong, Tan Ying, Rattinam, Rajesh, Basak, Sandip, Srinivasan, Mahalashmi, Choong, Yeu Khai, Pandey, Kannu Priya, Tran Bich Ngoc,, Shi, Jian, Angayarkanni, Jayaraman and Sivaraman, J. (2023). Bacterioferritin nanocage structures uncover the biomineralization process in ferritins. PNAS Nexus, 2 (7) pgad235, pgad235. doi: 10.1093/pnasnexus/pgad235
2023
Journal Article
Structural understanding of fungal terpene synthases for the formation of linear or cyclic terpene products
Rehka, T., Sharma, Deepti, Lin, Fu, Choong, Yeu Khai, Lim, Chinchin, Jobichen, Chacko and Zhang, Congqiang (2023). Structural understanding of fungal terpene synthases for the formation of linear or cyclic terpene products. ACS Catalysis, 13 (7), 4949-4959. doi: 10.1021/acscatal.2c05598
2023
Journal Article
Structures of apo Cas12a and its complex with crRNA and DNA reveal the dynamics of ternary complex formation and target DNA cleavage
Li, Jianwei, Jobichen, Chacko, Machida, Satoru, Meng, Sun, Read, Randy J., Chen, Hongying, Jian, Shi, Yuan, Yuren Adam and Sivaraman, J. (2023). Structures of apo Cas12a and its complex with crRNA and DNA reveal the dynamics of ternary complex formation and target DNA cleavage. Plos Biology, 21 (3) e3002023, e3002023. doi: 10.1371/journal.pbio.3002023
2022
Journal Article
A novel allosteric site employs a conserved inhibition mechanism in human kidney-type glutaminase
Shankar, Srihari, Ramachandran, Sarath, Tulsian, Nikhil, Radhakrishnan, Sridhar, Jobichen, Chacko and Sivaraman, J. (2022). A novel allosteric site employs a conserved inhibition mechanism in human kidney-type glutaminase. The FEBS Journal, 290 (9), 2437-2448. doi: 10.1111/febs.16658
2022
Book Chapter
Proteases as therapeutic targets: a structural biology perspective
Choong, Yeu Khai, Srinivasan, Mahalashmi and Jobichen, Chacko (2022). Proteases as therapeutic targets: a structural biology perspective. Therapeutic protein targets for drug discovery and clinical evaluation: bio-crystallography and drug design. (pp. 103-121) edited by Velmurugan, D, Bhattacharjee, Atanu and Gayath, D. Singapore: World Scientific Publishing Co.. doi: 10.1142/9789811254796_0005
2022
Journal Article
Structural and functional insights into fungal glutaminase using a computational approach
Amobonye, Ayodeji, Singh, Samayaditya, Mukherjee, Koel, Jobichen, Chacko, Qureshi, Insaf Ahmed and Pillai, Santhosh (2022). Structural and functional insights into fungal glutaminase using a computational approach. Process Biochemistry, 117, 76-89. doi: 10.1016/j.procbio.2022.03.019
2022
Journal Article
Bacterial antagonism of Chromobacterium haemolyticum and characterization of its putative type VI secretion system
Zwe, Ye Htut, Yadav, Manisha, Ten, Michelle Mei Zhen, Srinivasan, Mahalashmi, Jobichen, Chacko, Sivaraman, J. and Li, Dan (2022). Bacterial antagonism of Chromobacterium haemolyticum and characterization of its putative type VI secretion system. Research in Microbiology, 173 (3) 103918, 103918. doi: 10.1016/j.resmic.2021.103918
2021
Journal Article
Structure of Aedes aegypti carboxypeptidase B1-inhibitor complex uncover the disparity between mosquito and non-mosquito insect carboxypeptidase inhibition mechanism
Gavor, Edem, Choong, Yeu Khai, Jobichen, Chacko, Mok, Yu Keung, Kini, R. Manjunatha and Sivaraman, J. (2021). Structure of Aedes aegypti carboxypeptidase B1-inhibitor complex uncover the disparity between mosquito and non-mosquito insect carboxypeptidase inhibition mechanism. Protein Science, 30 (12), 2445-2456. doi: 10.1002/pro.4212
2021
Journal Article
Crystal structure of Aedes aegypti trypsin inhibitor in complex with μ-plasmin reveals role for scaffold stability in Kazal-type serine protease inhibitor
Walvekar, Varsha Ashok, Ramesh, Karthik, Jobichen, Chacko, Kannan, Muthu, Sivaraman, J., Kini, R. Manjunatha and Mok, Yu Keung (2021). Crystal structure of Aedes aegypti trypsin inhibitor in complex with μ-plasmin reveals role for scaffold stability in Kazal-type serine protease inhibitor. Protein Science, 31 (2), 470-484. doi: 10.1002/pro.4245
2021
Journal Article
Structural and mechanistic insight into stem-loop RNA processing by yeast Pichia stipitis Dicer
Chan, JingRu, Qinqin, Fu, Jianwei, Li, Ying, Chen, Machida, Satoru, Wei, Chen, Yuan, Yuren Adam and Jobichen, Chacko (2021). Structural and mechanistic insight into stem-loop RNA processing by yeast Pichia stipitis Dicer. Protein Science, 30 (6), 1210-1220. doi: 10.1002/pro.4086
2021
Journal Article
Structural basis for p50RhoGAP BCH domain-mediated regulation of Rho inactivation
Chichili, Vishnu Priyanka Reddy, Chew, Ti Weng, Shankar, Srihari, Er, Shi Yin, Chin, Cheen Fei, Jobichen, Chacko, Pan, Catherine Qiurong, Zhou, Yiting, Yeong, Foong May, Low, Boon Chuan and Sivaraman, J. (2021). Structural basis for p50RhoGAP BCH domain-mediated regulation of Rho inactivation. National Academy of Sciences. Proceedings, 118 (21) e2014242118, 1-12. doi: 10.1073/pnas.2014242118
Funding
Past funding
Supervision
Availability
- Dr Jobichen Chacko is:
- Available for supervision
Looking for a supervisor? Read our advice on how to choose a supervisor.
Supervision history
Current supervision
-
Doctor Philosophy
Structural and functional characterisation of TIR domain-containing proteins
Associate Advisor
Other advisors: Professor Bostjan Kobe
-
Doctor Philosophy
Structural and functional analysis of bat MyD88
Associate Advisor
Other advisors: Professor Bostjan Kobe
-
Doctor Philosophy
Structural basis of plant immune receptor signaling
Associate Advisor
Other advisors: Dr Natsumi Maruta, Professor Bostjan Kobe
Media
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