Overview
Background
Jobichen Chacko is a structural biologist with extensive experience in protein structural biology, protein-ligand interaction, proteases and drug discovery. He completed his PhD from National University of Singapore in the area of structural and functional studies on bacterial protein secretion system. He is proficient in the areas of Cryo-Electron microscopy (Single Particle Analysis), protein structure analysis and X-ray crystallography. He has published more than 40 research articles in high level journals and has more than 700 citations. His research interests are in host-pathogen interaction, protein secretion system, snake venom toxins and proteases. Jobichen is a member of the editorial advisory board for FEBS-openbio journal and serves as a reviewer for various scientific journals.
Availability
- Dr Jobichen Chacko is:
- Available for supervision
Qualifications
- Doctor of Philosophy of Biological Sciences, National University of Singapore
Works
Search Professor Jobichen Chacko’s works on UQ eSpace
2024
Journal Article
Structure, dynamics and evolution of the Candida albicans multi-drug resistance ABC transporter CDR1
Shin, Jeeeun, Jin, Ruitao, Gall, Barnabas, Jobichen, Chacko, Jackson, Colin, Rug, Melanie, Corry, Ben and Brock, Joseph (2024). Structure, dynamics and evolution of the Candida albicans multi-drug resistance ABC transporter CDR1. doi: 10.1101/2024.10.28.620768
2024
Journal Article
Structural transitions in kinesin minus-end directed microtubule motility
Shibata, Satoki, Wang, Matthew Y., Imasaki, Tsuyoshi, Shigematsu, Hideki, Wei, Yuanyuan, Jobichen, Chacko, Hagio, Hajime, Sivaraman, J., Endow, Sharyn A. and Nitta, Ryo (2024). Structural transitions in kinesin minus-end directed microtubule motility.
2024
Journal Article
Sensing for survival: specialised regulatory mechanisms of Type III secretion systems in Gram-negative pathogens
Manisha, Yadav, Srinivasan, Mahalashmi, Jobichen, Chacko, Rosenshine, Ilan and Sivaraman, J. (2024). Sensing for survival: specialised regulatory mechanisms of Type III secretion systems in Gram-negative pathogens. Biological Reviews, 99 (3), 837-863. doi: 10.1111/brv.13047
2023
Journal Article
Bacterioferritin nanocage structures uncover the biomineralization process in ferritins
Jobichen, Chacko, Chong, Tan Ying, Rattinam, Rajesh, Basak, Sandip, Srinivasan, Mahalashmi, Choong, Yeu Khai, Pandey, Kannu Priya, Tran Bich Ngoc,, Shi, Jian, Angayarkanni, Jayaraman and Sivaraman, J. (2023). Bacterioferritin nanocage structures uncover the biomineralization process in ferritins. PNAS Nexus, 2 (7) pgad235, pgad235. doi: 10.1093/pnasnexus/pgad235
2023
Journal Article
Structural understanding of fungal terpene synthases for the formation of linear or cyclic terpene products
Rehka, T., Sharma, Deepti, Lin, Fu, Choong, Yeu Khai, Lim, Chinchin, Jobichen, Chacko and Zhang, Congqiang (2023). Structural understanding of fungal terpene synthases for the formation of linear or cyclic terpene products. ACS Catalysis, 13 (7), 4949-4959. doi: 10.1021/acscatal.2c05598
2023
Journal Article
Structures of apo Cas12a and its complex with crRNA and DNA reveal the dynamics of ternary complex formation and target DNA cleavage
Li, Jianwei, Jobichen, Chacko, Machida, Satoru, Meng, Sun, Read, Randy J., Chen, Hongying, Jian, Shi, Yuan, Yuren Adam and Sivaraman, J. (2023). Structures of apo Cas12a and its complex with crRNA and DNA reveal the dynamics of ternary complex formation and target DNA cleavage. Plos Biology, 21 (3) e3002023, e3002023. doi: 10.1371/journal.pbio.3002023
2022
Journal Article
A novel allosteric site employs a conserved inhibition mechanism in human kidney-type glutaminase
Shankar, Srihari, Ramachandran, Sarath, Tulsian, Nikhil, Radhakrishnan, Sridhar, Jobichen, Chacko and Sivaraman, J. (2022). A novel allosteric site employs a conserved inhibition mechanism in human kidney-type glutaminase. The FEBS Journal, 290 (9), 2437-2448. doi: 10.1111/febs.16658
2022
Book Chapter
Proteases as therapeutic targets: a structural biology perspective
Choong, Yeu Khai, Srinivasan, Mahalashmi and Jobichen, Chacko (2022). Proteases as therapeutic targets: a structural biology perspective. Therapeutic protein targets for drug discovery and clinical evaluation: bio-crystallography and drug design. (pp. 103-121) edited by Velmurugan, D, Bhattacharjee, Atanu and Gayath, D. Singapore: World Scientific Publishing Co.. doi: 10.1142/9789811254796_0005
2022
Journal Article
Structural and functional insights into fungal glutaminase using a computational approach
Amobonye, Ayodeji, Singh, Samayaditya, Mukherjee, Koel, Jobichen, Chacko, Qureshi, Insaf Ahmed and Pillai, Santhosh (2022). Structural and functional insights into fungal glutaminase using a computational approach. Process Biochemistry, 117, 76-89. doi: 10.1016/j.procbio.2022.03.019
2022
Journal Article
Bacterial antagonism of Chromobacterium haemolyticum and characterization of its putative type VI secretion system
Zwe, Ye Htut, Yadav, Manisha, Ten, Michelle Mei Zhen, Srinivasan, Mahalashmi, Jobichen, Chacko, Sivaraman, J. and Li, Dan (2022). Bacterial antagonism of Chromobacterium haemolyticum and characterization of its putative type VI secretion system. Research in Microbiology, 173 (3) 103918, 103918. doi: 10.1016/j.resmic.2021.103918
2021
Journal Article
Structure of Aedes aegypti carboxypeptidase B1-inhibitor complex uncover the disparity between mosquito and non-mosquito insect carboxypeptidase inhibition mechanism
Gavor, Edem, Choong, Yeu Khai, Jobichen, Chacko, Mok, Yu Keung, Kini, R. Manjunatha and Sivaraman, J. (2021). Structure of Aedes aegypti carboxypeptidase B1-inhibitor complex uncover the disparity between mosquito and non-mosquito insect carboxypeptidase inhibition mechanism. Protein Science, 30 (12), 2445-2456. doi: 10.1002/pro.4212
2021
Journal Article
Crystal structure of Aedes aegypti trypsin inhibitor in complex with μ-plasmin reveals role for scaffold stability in Kazal-type serine protease inhibitor
Walvekar, Varsha Ashok, Ramesh, Karthik, Jobichen, Chacko, Kannan, Muthu, Sivaraman, J., Kini, R. Manjunatha and Mok, Yu Keung (2021). Crystal structure of Aedes aegypti trypsin inhibitor in complex with μ-plasmin reveals role for scaffold stability in Kazal-type serine protease inhibitor. Protein Science, 31 (2), 470-484. doi: 10.1002/pro.4245
2021
Journal Article
Structural and mechanistic insight into stem-loop RNA processing by yeast Pichia stipitis Dicer
Chan, JingRu, Qinqin, Fu, Jianwei, Li, Ying, Chen, Machida, Satoru, Wei, Chen, Yuan, Yuren Adam and Jobichen, Chacko (2021). Structural and mechanistic insight into stem-loop RNA processing by yeast Pichia stipitis Dicer. Protein Science, 30 (6), 1210-1220. doi: 10.1002/pro.4086
2021
Journal Article
Structural basis for p50RhoGAP BCH domain-mediated regulation of Rho inactivation
Chichili, Vishnu Priyanka Reddy, Chew, Ti Weng, Shankar, Srihari, Er, Shi Yin, Chin, Cheen Fei, Jobichen, Chacko, Pan, Catherine Qiurong, Zhou, Yiting, Yeong, Foong May, Low, Boon Chuan and Sivaraman, J. (2021). Structural basis for p50RhoGAP BCH domain-mediated regulation of Rho inactivation. National Academy of Sciences. Proceedings, 118 (21) e2014242118, 1-12. doi: 10.1073/pnas.2014242118
2021
Journal Article
The autocatalytic cleavage domain is not required for the activity of scpc, a virulence protease from streptococcus pyogenes: a structural insight
Jobichen, Chacko, Chong, Tan Ying, Ling, Tai Hui and Sivaraman, J. (2021). The autocatalytic cleavage domain is not required for the activity of scpc, a virulence protease from streptococcus pyogenes: a structural insight. Biochemistry, 60 (19), 1564-1568. doi: 10.1021/acs.biochem.1c00185
2020
Journal Article
Unusual quaternary structure of a homodimeric synergistic-type toxin from mamba snake venom defines its molecular evolution
Aoki-Shioi, Narumi, Jobichen, Chacko, Sivaraman, J. and Kini, R. Manjunatha (2020). Unusual quaternary structure of a homodimeric synergistic-type toxin from mamba snake venom defines its molecular evolution. Biochemical Journal, 477 (20), 3951-3962. doi: 10.1042/BCJ20200529
2020
Journal Article
Structural basis for the inhibition mechanism of ecotin against neutrophil elastase by targeting the active site and secondary binding site
Jobichen, Chacko, Prabhakar, Mahalakshmi Tirumuru, Loh, Su Ning and Sivaraman, J. (2020). Structural basis for the inhibition mechanism of ecotin against neutrophil elastase by targeting the active site and secondary binding site. Biochemistry, 59 (30), 2788-2795. doi: 10.1021/acs.biochem.0c00493
2020
Journal Article
SYNCRIP, a new player in pri-let-7a processing
Chen, Ying, Chan, Jingru, Chen, Wei, Li, Jianwei, Sun, Meng, Kannan, Gayathiri Sathyamoorthy, Mok, Yu-Keung, Yuan, Yuren Adam and Jobichen, Chacko (2020). SYNCRIP, a new player in pri-let-7a processing. RNA, 26 (3), 290-305. doi: 10.1261/rna.072959.119
2020
Journal Article
AtFKBP53: a chimeric histone chaperone with functional nucleoplasmin and PPIase domains
Singh, Ajit Kumar, Datta, Aritreyee, Jobichen, Chacko, Luan, Sheng and Vasudevan, Dileep (2020). AtFKBP53: a chimeric histone chaperone with functional nucleoplasmin and PPIase domains. Nucleic Acids Research, 48 (3), 1531-1550. doi: 10.1093/nar/gkz1153
2020
Journal Article
Fulditoxin, representing a new class of dimeric snake toxins, defines novel pharmacology at nicotinic ACh receptors
Foo, Chun Shin, Jobichen, Chacko, Hassan-Puttaswamy, Varuna, Dekan, Zoltan, Tae, Han-Shen, Bertrand, Daniel, Adams, David J., Alewood, Paul F., Sivaraman, J., Nirthanan, Selvanayagam and Kini, R. Manjunatha (2020). Fulditoxin, representing a new class of dimeric snake toxins, defines novel pharmacology at nicotinic ACh receptors. British Journal of Pharmacology, 177 (8), 1822-1840. doi: 10.1111/bph.14954
Supervision
Availability
- Dr Jobichen Chacko is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Supervision history
Current supervision
-
Doctor Philosophy
Structural basis of plant immune receptor signaling
Associate Advisor
Other advisors: Dr Natsumi Maruta, Professor Bostjan Kobe
Media
Enquiries
For media enquiries about Dr Jobichen Chacko's areas of expertise, story ideas and help finding experts, contact our Media team: