Dr Jobichen Chacko
Dr

Jobichen Chacko

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Background

Jobichen Chacko is a structural biologist with extensive experience in protein structural biology, protein-ligand interaction, proteases and drug discovery. He completed his PhD from National University of Singapore in the area of structural and functional studies on bacterial protein secretion system. He is proficient in the areas of Cryo-Electron microscopy (Single Particle Analysis), protein structure analysis and X-ray crystallography. He has published more than 40 research articles in high level journals and has more than 700 citations. His research interests are in host-pathogen interaction, protein secretion system, snake venom toxins and proteases. Jobichen is a member of the editorial advisory board for FEBS-openbio journal and serves as a reviewer for various scientific journals.

Availability

Dr Jobichen Chacko is:
Available for supervision

Qualifications

  • Doctor of Philosophy of Biological Sciences, National University of Singapore

Search Professor Jobichen Chacko’s works on UQ eSpace

46 works between 2006 and 2025
All (46) Journal Article (44) Book Chapter (2)

21 - 40 of 46 works

2020

Journal Article

Fulditoxin, representing a new class of dimeric snake toxins, defines novel pharmacology at nicotinic ACh receptors

Foo, Chun Shin, Jobichen, Chacko, Hassan-Puttaswamy, Varuna, Dekan, Zoltan, Tae, Han-Shen, Bertrand, Daniel, Adams, David J., Alewood, Paul F., Sivaraman, J., Nirthanan, Selvanayagam and Kini, R. Manjunatha (2020). Fulditoxin, representing a new class of dimeric snake toxins, defines novel pharmacology at nicotinic ACh receptors. British Journal of Pharmacology, 177 (8), 1822-1840. doi: 10.1111/bph.14954

Fulditoxin, representing a new class of dimeric snake toxins, defines novel pharmacology at nicotinic ACh receptors

2019

Journal Article

Identification of a α-helical molten globule intermediate and structural characterization of β-cardiotoxin, an all β-sheet protein isolated from the venom of Ophiophagus hannah (king cobra)

Roy, Amrita, Sun Qingxiang,, Alex, Chapeaurouge, Rajagopalan, Nandhakishore, Jobichen, Chacko, Sivaraman, J. and Kini, R. Manjunatha (2019). Identification of a α-helical molten globule intermediate and structural characterization of β-cardiotoxin, an all β-sheet protein isolated from the venom of Ophiophagus hannah (king cobra). Protein Science, 28 (5), 952-963. doi: 10.1002/pro.3605

Identification of a α-helical molten globule intermediate and structural characterization of β-cardiotoxin, an all β-sheet protein isolated from the venom of Ophiophagus hannah (king cobra)

2019

Book Chapter

Role of plant volatiles, pest-resistant varieties and transgenics in tri-trophic interactions

Jobichen, Chacko and Selvanarayanan, V. (2019). Role of plant volatiles, pest-resistant varieties and transgenics in tri-trophic interactions. Experimental techniques in host-plant resistance. (pp. 245-252) edited by Akshay Kumar Chakravarthy and Venkatesan Selvanarayanan. Singapore: Springer. doi: 10.1007/978-981-13-2652-3_25

Role of plant volatiles, pest-resistant varieties and transgenics in tri-trophic interactions

2018

Journal Article

Structural basis for the pathogenesis of Campylobacter jejuni Hcp1, a structural and effector protein of the Type VI Secretion System

Noreen, Zobia, Jobichen, Chacko, Abbasi, Rashda, Seetharaman, Jayaraman, Sivaraman, J. and Bokhari, Habib (2018). Structural basis for the pathogenesis of Campylobacter jejuni Hcp1, a structural and effector protein of the Type VI Secretion System. FEBS Journal, 285 (21), 4060-4070. doi: 10.1111/febs.14650

Structural basis for the pathogenesis of Campylobacter jejuni Hcp1, a structural and effector protein of the Type VI Secretion System

2018

Journal Article

Structure of ScpC, a virulence protease from Streptococcus pyogenes, reveals the functional domains and maturation mechanism

Jobichen, Chacko, Tan, Ying Chong, Prabhakar, Mahalakshmi Tirumuru, Nayak, Digant, Biswas, Debabrata, Pannu, Navraj S., Hanski, Emanuel and Sivaraman, J. (2018). Structure of ScpC, a virulence protease from Streptococcus pyogenes, reveals the functional domains and maturation mechanism. Biochemical Journal, 475 (17), 2847-2860. doi: 10.1042/bcj20180145

Structure of ScpC, a virulence protease from Streptococcus pyogenes, reveals the functional domains and maturation mechanism

2018

Journal Article

Proteobacterial origin of protein arginine methylation and regulation of complex I assembly by MidA

Hameed, Umar F. Shahul, Sanislav, Oana, Lay, Sui T., Annesley, Sarah J., Jobichen, Chacko, Fisher, Paul R., Swaminathan, Kunchithapadam and Arold, Stefan T. (2018). Proteobacterial origin of protein arginine methylation and regulation of complex I assembly by MidA. Cell Reports, 24 (8), 1996-2004. doi: 10.1016/j.celrep.2018.07.075

Proteobacterial origin of protein arginine methylation and regulation of complex I assembly by MidA

2018

Journal Article

Targeting cancer addiction for SALL4 by shifting its transcriptome with a pharmacologic peptide

Liu, Bee Hui, Jobichen, Chacko, Chia, C. S. Brian, Chan, Tim Hon Man, Tang, Jing Ping, Chung, Theodora X. Y., Li, Jia, Poulsen, Anders, Hung, Alvin W., Koh-Stenta, Xiaoying, Tan, Yaw Sing, Verma, Chandra S., Tan, Hong Kee, Wu, Chan-Shuo, Li, Feng, Hill, Jeffrey, Joy, Joma, Yang, Henry, Chai, Li, Sivaraman, J. and Tenen, Daniel G. (2018). Targeting cancer addiction for SALL4 by shifting its transcriptome with a pharmacologic peptide. National Academy of Sciences. Proceedings, 115 (30), E7119-E7128. doi: 10.1073/pnas.1801253115

Targeting cancer addiction for SALL4 by shifting its transcriptome with a pharmacologic peptide

2018

Journal Article

Biophysical studies and modelling indicate the binding preference of TAZ WW domain for LATS1 PPxY motif

Verma, Apoorva, Lin, Fu, Tan, Ying Chong, Hidayat, Muhammad Nur, Jobichen, Chacko, Fan, Hao and Sivaraman, J. (2018). Biophysical studies and modelling indicate the binding preference of TAZ WW domain for LATS1 PPxY motif. Biochemical and Biophysical Research Communications, 502 (3), 307-312. doi: 10.1016/j.bbrc.2018.05.127

Biophysical studies and modelling indicate the binding preference of TAZ WW domain for LATS1 PPxY motif

2017

Journal Article

Avathrin: a novel thrombin inhibitor derived from a multicopy precursor in the salivary glands of the ixodid tick, Amblyomma variegatum

Iyer, Janaki Krishnamoorthy, Koh, Cho Yeow, Kazimirova, Maria, Roller, Ladislav, Jobichen, Chacko, Swaminathan, Kunchithapadam, Mizuguchi, Jun, Iwanaga, Sadaaki, Nuttall, Patricia A., Chan, Mark Y. and Kini, R. Manjunatha (2017). Avathrin: a novel thrombin inhibitor derived from a multicopy precursor in the salivary glands of the ixodid tick, Amblyomma variegatum. The FASEB Journal, 31 (7), 2981-2995. doi: 10.1096/fj.201601216R

Avathrin: a novel thrombin inhibitor derived from a multicopy precursor in the salivary glands of the ixodid tick, Amblyomma variegatum

2016

Journal Article

Ringhalexin from Hemachatus haemachatus: A novel inhibitor of extrinsic tenase complex

Barnwal, Bhaskar, Jobichen, Chacko, Girish, Vallerinteavide Mavelli, Foo, Chun Shin, Sivaraman, J. and Kini, R. Manjunatha (2016). Ringhalexin from Hemachatus haemachatus: A novel inhibitor of extrinsic tenase complex. Scientific Reports, 6 25935, 1-13. doi: 10.1038/srep25935

Ringhalexin from Hemachatus haemachatus: A novel inhibitor of extrinsic tenase complex

2015

Journal Article

Structural basis of mapping the spontaneous mutations with 5-flurouracil in uracil phosphoribosyltransferase from Mycobacterium tuberculosis

Ghode, Pramila, Jobichen, Chacko, Ramachandran, Sarath, Bifani, Pablo and Sivaraman, J. (2015). Structural basis of mapping the spontaneous mutations with 5-flurouracil in uracil phosphoribosyltransferase from Mycobacterium tuberculosis. Biochemical and Biophysical Research Communications, 467 (3), 577-582. doi: 10.1016/j.bbrc.2015.09.133

Structural basis of mapping the spontaneous mutations with 5-flurouracil in uracil phosphoribosyltransferase from Mycobacterium tuberculosis

2015

Journal Article

Structural basis for a unique ATP synthase core complex from Nanoarcheaum equitans

Mohanty, Soumya, Jobichen, Chacko, Chichili, Vishnu Priyanka Reddy, Velazquez-Campoy, Adrian, Low, Boon Chuan, Hogue, Christopher W. V. and Sivaraman, J. (2015). Structural basis for a unique ATP synthase core complex from Nanoarcheaum equitans. Journal of Biological Chemistry, 290 (45), 27280-27296. doi: 10.1074/jbc.M115.677492

Structural basis for a unique ATP synthase core complex from Nanoarcheaum equitans

2015

Journal Article

Structure of AcrH-AopB chaperone-translocator complex reveals a role for membrane hairpins in type III secretion system translocon assembly

Nguyen, Van Sang, Jobichen, Chacko, Tan, Kang Wei, Tan, Yih Wan, Chan, Siew Leong, Ramesh, Karthik, Yuan, Yongming, Hong, Yunhan, Seetharaman, Jayaraman, Leung, Ka Yin, Sivaraman, J. and Mok, Yu Keung (2015). Structure of AcrH-AopB chaperone-translocator complex reveals a role for membrane hairpins in type III secretion system translocon assembly. Structure, 23 (11), 2022-2031. doi: 10.1016/j.str.2015.08.014

Structure of AcrH-AopB chaperone-translocator complex reveals a role for membrane hairpins in type III secretion system translocon assembly

2015

Journal Article

Extended loop region of Hcp1 is critical for the assembly and function of type VI secretion system in Burkholderia pseudomallei

Lim, Yan Ting, Jobichen, Chacko, Wong, Jocelyn, Limmathurotsakul, Direk, Li, Shaowei, Chen, Yahua, Raida, Manfred, Srinivasan, Nalini, MacAry, Paul Anthony, Sivaraman, J. and Gan, Yunn-Hwen (2015). Extended loop region of Hcp1 is critical for the assembly and function of type VI secretion system in Burkholderia pseudomallei. Scientific Reports, 5 8235, 1-10. doi: 10.1038/srep08235

Extended loop region of Hcp1 is critical for the assembly and function of type VI secretion system in Burkholderia pseudomallei

2014

Journal Article

Molecular replacement with a large number of molecules in the asymmetric unit

Jobichen, Chacko and Swaminathan, Kunchithapadam (2014). Molecular replacement with a large number of molecules in the asymmetric unit. Acta Crystallographica Section F-Structural Biology Communications, 70 (9), 1296-1302. doi: 10.1107/S2053230X14014381

Molecular replacement with a large number of molecules in the asymmetric unit

2014

Journal Article

Dimerization of VirD2 binding protein is essential for Agrobacterium induced tumor formation in plants

Padavannil, Abhilash, Jobichen, Chacko, Yang Qinghua,, Seetharaman, Jayaraman, Velazquez-Campoy, Adrian, Yang, Liu, Pan, Shen Q. and Sivaraman, J. (2014). Dimerization of VirD2 binding protein is essential for Agrobacterium induced tumor formation in plants. PLoS Pathogens, 10 (3) e1003948, 1-12. doi: 10.1371/journal.ppat.1003948

Dimerization of VirD2 binding protein is essential for Agrobacterium induced tumor formation in plants

2013

Journal Article

Structure of GrlR-GrlA complex that prevents GrlA activation of virulence genes

Padavannil, Abhilash, Jobichen, Chacko, Mills, Erez, Velazquez-Campoy, Adrian, Li, Mo, Leung, Ka Yin, Mok, Yu Keung, Rosenshine, Ilan and Sivaraman, J. (2013). Structure of GrlR-GrlA complex that prevents GrlA activation of virulence genes. Nature Communications, 4 2546, 1-10. doi: 10.1038/ncomms3546

Structure of GrlR-GrlA complex that prevents GrlA activation of virulence genes

2013

Journal Article

Computer aided design of FtsZ targeting oligopeptides

Pieraccini, Stefano, Rendine, Stefano, Jobichen, Chacko, Domadia, Prerna, Sivaraman, J., Francescato, Pierangelo, Speranza, Giovanna and Sironi, Maurizio (2013). Computer aided design of FtsZ targeting oligopeptides. RSC Advances, 3 (6), 1739-1743. doi: 10.1039/c2ra21886k

Computer aided design of FtsZ targeting oligopeptides

2012

Journal Article

Crystal structure of mouse RhoA:GTPcS complex in a centered lattice

Jobichen, Chacko, Pal, Kuntal and Swaminathan, Kunchithapadam (2012). Crystal structure of mouse RhoA:GTPcS complex in a centered lattice. Journal of Structural and Functional Genomics, 13 (4), 241-245. doi: 10.1007/s10969-012-9143-5

Crystal structure of mouse RhoA:GTPcS complex in a centered lattice

2012

Journal Article

Identification and structural characterization of a new three-finger toxin Hemachatoxin from Hemachatus haemachatus venom

Girish, Vallerinteavide Mavelli, Kumar, Sundramurthy, Joseph, Lissa, Jobichen, Chacko, Kini, R. Manjunatha and Sivaraman, J. (2012). Identification and structural characterization of a new three-finger toxin Hemachatoxin from Hemachatus haemachatus venom. PLoS One, 7 (10) e48112, 1-9. doi: 10.1371/journal.pone.0048112

Identification and structural characterization of a new three-finger toxin Hemachatoxin from Hemachatus haemachatus venom

Availability

Dr Jobichen Chacko is:
Available for supervision

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Supervision history

Current supervision

Enquiries

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