Overview
Background
Dr Fernando's current research interests include developing needle-free, pain-free, skin patch vaccines. Influenza and human papilloma virus vaccines are used as model vaccines in these studies.
Dr Germain Fernando completed PhD at the University of Arizona, USA, and did post-doctoral research at the Baylor College of Medicine, Houston, Texas, USA, before joining the University of Queensland in 1989. He has been working in the field of vaccinology for the last 28 years. He has a H-Index of 36.
He is a Senior Consultant at Vaxxas Pty. Ltd, Brisbane, Australia
Publications and Citation Metrics are available at the following website:
http://www.researcherid.com/rid/C-3733-2009
Availability
- Dr Germain Fernando is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Bachelor (Honours) of Science (Advanced), Institution to be confirmed
- Doctor of Philosophy, Arizona State University
Research interests
-
Vaccinations using a novel needle-free, pain-free, skin patch.
Although effective vaccines are available for combating diseases such as flu and cervical cancer, some people are reluctant to get vaccinated because of the fear of the needle. The needle and syringe first invented in 1853 is still being used because of the convenience to the person administering the vaccine. However this method has many disadvantages: Fear of the needle and the pain of injection, especially among children. Furthermore injection into muscle is less efficient than delivering the vaccine directly to immunologically active cells in the skin. We have designed a skin patch to overcome these disadvantages. We have recently published data to show potent immunity can be induced using very low doses of vaccine delivered by the skin patch. Reference: Fernando et al PLoS One 2010 April 21:5(4), e 10266.
Works
Search Professor Germain Fernando’s works on UQ eSpace
2008
Conference Publication
Micro-nanoprojection array patches for targeted vaccine delivery to skin: investigation of mechanical penetration interactions
Chen, X., Crichton, M. L., Fernando, G. J. P., Kendall, M. A. F. and Prow, T. W. (2008). Micro-nanoprojection array patches for targeted vaccine delivery to skin: investigation of mechanical penetration interactions. Engineering and Physical Sciences in Medicine and the Australian Biomedical Engineering Conference, Christchurch, New Zealand, 16-20 November 2008.
2008
Conference Publication
Novel coating of Micro-nanoprojection patches for targeted vaccine delivery to skin
Xianfeng Chen, Tarl Prow, Michael Crichton, Fernando, Germain J. and Kendall, Mark A. (2008). Novel coating of Micro-nanoprojection patches for targeted vaccine delivery to skin. 2008 International Conference on Nanoscience and Nanotechnology, Melbourne , Australia, February 25-29, 2008. New York , U.S.A.: IEEE. doi: 10.1109/ICONN.2008.4639257
2005
Journal Article
A model of peripheral CD8(+) T cell tolerance against skin antigen
Narayan, S., Fernando, G., Frazer, I. H. and Leggatt, G. (2005). A model of peripheral CD8(+) T cell tolerance against skin antigen. Tissue Antigens, 66 (5), 501-501. doi: 10.1111/j.1399-0039.2005.00523.x
2005
Journal Article
Local inflammation is crucial for T cell mediated rejection of skin graft expressing foreign antigen
Zhong, J., De Kluyver, R., Leggatt, G. R., Fernando, G. J. and Frazer, I. H. (2005). Local inflammation is crucial for T cell mediated rejection of skin graft expressing foreign antigen. Tissue Antigens, 66 (5), 600-600.
2005
Journal Article
The role of TH cells in memory CTL mediated tumor protection
Gao, Feng-Guang, Fernando, Germain J. P. and Liu, Wen-Jun (2005). The role of TH cells in memory CTL mediated tumor protection. Chinese Journal of Microbiology and Immunology, 25 (4), 286-291.
2005
Journal Article
Overcoming original antigenic sin to generate effective immune responses in antigen primed host
Liu, X., Leggatt, G., Fernando, G. J. and Frazer, I. H. (2005). Overcoming original antigenic sin to generate effective immune responses in antigen primed host. Tissue Antigens, 66 (5), 481-481.
2004
Journal Article
Changes to peptide structure, not concentration, contribute to expansion of the lowest avidity cytotoxic T lymphocytes
Leggatt, Graham R., Narayan, Sharmal, Fernando, Germain J. P. and Frazer, Ian H. (2004). Changes to peptide structure, not concentration, contribute to expansion of the lowest avidity cytotoxic T lymphocytes. Journal of Leukocyte Biology, 76 (4), 787-795. doi: 10.1189/jlb.0104026
2001
Other Outputs
Subunit papilloma virus vaccine and peptides for use therein
Tindle, Robert, Fernando, Germain and Frazer, Ian (2001). Subunit papilloma virus vaccine and peptides for use therein. US6183745B1.
2000
Journal Article
Immune responses induced by BCG recombinant for human papillomavirus L1 and E7 proteins
Abdul Jabbar, I., Fernando, G. J., Saunders, N. A., Aldovini, A., Young, R., Malcolm, K. M. and Frazer, I. H. (2000). Immune responses induced by BCG recombinant for human papillomavirus L1 and E7 proteins. Vaccine, 18 (22), 2444-2453. doi: 10.1016/S0264-410X(99)00550-2
1999
Book Chapter
Safety and Immunogenicity of HPV16 E7/Algammulin
Frazer, I. H., Tindle, R. W., Fernando, G. J., Malcolm, K. M., Herd, K. A., McFadyen, S. M., Cooper, P. D. and Ward, B. G. (1999). Safety and Immunogenicity of HPV16 E7/Algammulin. Vaccines for Human Papillomavirus Infection and Anogenital Disease. (pp. 91-104) edited by R. W. Tindle. Austin, USA: R.G. Landes Company.
1995
Conference Publication
Hpv16 E7 Transgenic Skin Is Not Rejected in E7 Immunized Mice
Frazer, I. H., Dunn, L. A., Fernando, G. J., Tindle, R. W., Leippe, D. M. and Lambert, P. F. (1995). Hpv16 E7 Transgenic Skin Is Not Rejected in E7 Immunized Mice. Keystone Symposia on Molecular & Cellular Biology, Keystone, CO United States, 16-23 January 1995 . NEW YORK: Wiley-Blackwell.
1994
Journal Article
Cell-Mediated Immune-Responses to E7 Peptides of Human Papillomavirus (hpv) Type-16 Are Dependent On the Hpv Type Infecting the Cervix Whereas Serological Reactivity Is Not Type-Specific
Kadish, A. S., Romney, S. L., Ledwidge, R., Tindle, R., Fernando, G. J. P., Zee, S. Y., Vanranst, M. A. and Burk, R. D. (1994). Cell-Mediated Immune-Responses to E7 Peptides of Human Papillomavirus (hpv) Type-16 Are Dependent On the Hpv Type Infecting the Cervix Whereas Serological Reactivity Is Not Type-Specific. Journal of General Virology, 75, 2277-2284. doi: 10.1099/0022-1317-75-9-2277
1994
Journal Article
Cell-mediated immune responses to E7 peptides of human papillomavirus (HPV) type 16 are dependent on the HPV type infecting the cervix whereas serological reactivity is not type-specific
Kadish, Anna S., Romney, Seymour L., Ledwidge, Richard, Tindle, Robert, Fernando, Germain J. P., Zee, Sui Y., Van Ranst, Marc A. and Burk, Robert D. (1994). Cell-mediated immune responses to E7 peptides of human papillomavirus (HPV) type 16 are dependent on the HPV type infecting the cervix whereas serological reactivity is not type-specific. Journal of General Virology, 75 (9), 2277-2284. doi: 10.1099/0022-1317-75-9-2277
1994
Conference Publication
A Transgenic Mouse Model of the Immunobiology of Hpv16 Induced Cervical-Cancer
Frazer, I. H., Lieppe, D., Lambert, P., Griep, A., Dunn, L., Tindle, R. W. and Fernando, G. (1994). A Transgenic Mouse Model of the Immunobiology of Hpv16 Induced Cervical-Cancer. Keystone Symposia on Molecular & Cellular Biology, Taos, New Mexico , 13 - 20 February 1994. NEW YORK: Wiley-Blackwell.
1994
Conference Publication
Small Synthetic Peptides as Vaccines - a Model Peptide Iscom Construct From Cancer-Associated Human Papillomavirus
Fernando, G. J. P., Tindle, R. W., Frazer, I. H., Stenzel, D. J., Merza, M. S. and Morein, B. (1994). Small Synthetic Peptides as Vaccines - a Model Peptide Iscom Construct From Cancer-Associated Human Papillomavirus. 11th Annual Meeting on Modern Approaches to New Vaccines, Cold Spring Harbor, NY United States, September 1993. PLAINVIEW: COLD SPRING HARBOR LABORATORY PRESS.
1993
Conference Publication
Adjuvants Can Bias to Th1 or Th2 the Immune-Response to Hpv E7 Protein in Mice
Fernando, G. J., Zhou, J., Tindle, R. W. and Frazer, I. H. (1993). Adjuvants Can Bias to Th1 or Th2 the Immune-Response to Hpv E7 Protein in Mice. -, -, 1993. BETHESDA: Wiley-Blackwell.
1993
Conference Publication
An Improved Immunoassay for the E7 Protein of Hpv16
Dunn, L. A., Tindle, R. W., Fernando, G. J. and Frazer, I. H. (1993). An Improved Immunoassay for the E7 Protein of Hpv16. -, -, 1993. BETHESDA: Wiley-Blackwell.
1993
Conference Publication
A Transgenic Mouse Model of the Immunobiology of Hpv16 Induced Cervical-Cancer
Frazer, I. H., Lieppe, D., Lambert, P., Griep, A., Tindle, R. W. and Fernando, G. (1993). A Transgenic Mouse Model of the Immunobiology of Hpv16 Induced Cervical-Cancer. -, -, 1993. BETHESDA: FEDERATION AMER SOC EXP BIOL.
1992
Journal Article
Humoral immune response to the E7 open reading frame protein of human papillomavirus genotype 16 in subjects with anogenital papillomavirus infection and controls
Tindle, Robert W., Murray, Barbara, Herd, Karen, Kennedy, Lynn, O'Connor, Dan T., Fernando, Germain J. P. and Frazer, Ian H. (1992). Humoral immune response to the E7 open reading frame protein of human papillomavirus genotype 16 in subjects with anogenital papillomavirus infection and controls. Immunology and Infections Diseases, 2, 223-228.
1992
Journal Article
The vaccinia virus K2L gene encodes a serine protease inhibitor which inhibits cell-cell fusion
Zhou, J., Sun, X. Y., Fernando, G. J. P. and Frazer, I. H. (1992). The vaccinia virus K2L gene encodes a serine protease inhibitor which inhibits cell-cell fusion. Virology, 189 (2), 678-686. doi: 10.1016/0042-6822(92)90591-C
Funding
Supervision
Availability
- Dr Germain Fernando is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Available projects
-
Development of needle-free pain-free skin patch vaccines
1). Delivering of vaccines using a novel skin patch that is needle-free and pain-free which induces potent immune responses. Study of mechanisms.
2). Developing Universal Influenza Vaccines that protect people from new strains of virus.
3). Translating the skin patch vaccine delivery system from animal models to human clinical testing.
Supervision history
Completed supervision
-
2017
Doctor Philosophy
Systems Vaccinology studies on the biomolecular basis of physical adjuvantation in skin when vaccinated with a high density microprojection array
Associate Advisor
-
2012
Doctor Philosophy
Dissolving Nanopatches for Targeted Vaccine Delivery to the Skin
Associate Advisor
Media
Enquiries
Contact Dr Germain Fernando directly for media enquiries about:
- Anti-cancer Vaccines
- Antibody
- Biochemistry
- Drug Delivery
- Immunisation
- Immunology
- Influenza vaccines
- Lipid Chemistry
- Lipoproteins
- Medical Devices
- Nanopatch
- Needle-free vaccination
- Papillomavirus Vaccines
- Protein Chemistry
- Skin - vaccinations
- Systems Vaccinology
- T-Cells
- Vaccination
- Vaccine Adjuvants
- Vaccine delivery
- Vaccines
- Vaccines and genes
- Viral Vaccines
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