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2024 Journal Article EGFR targeting of liposomal doxorubicin improves recognition and suppression of non-small cell lung cancerMoles, Ernest, Chang, David, Mansfeld, Friederike, Duly, Alastair, Kimpton, Kathleen, Logan, Amy, Howard, Christopher, Thurecht, Kristofer and Kavallaris, Maria (2024). EGFR targeting of liposomal doxorubicin improves recognition and suppression of non-small cell lung cancer. International Journal of Nanomedicine, 2024 (19), 3623-3639. doi: 10.2147/ijn.s450534 |
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2024 Journal Article Influence of chirality on protein corona formation of low-fouling chiral poly(2-oxazoline) coated nanoparticlesPizzi, David, Nandakumar, Aparna, Morrow, Joshua P., Humphries, James, Siddiqui, Ghizal, Creek, Darren J., Quinn, John.F., Yin, Jialiang, Shi, Qianqian, Cheng, Wenlong, Thurecht, Kristofer J. and Kempe, Kristian (2024). Influence of chirality on protein corona formation of low-fouling chiral poly(2-oxazoline) coated nanoparticles. European Polymer Journal, 210 112964, 1-12. doi: 10.1016/j.eurpolymj.2024.112964 |
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2024 Journal Article Targeted delivery of polo-like kinase 1 siRNA nanoparticles using an EGFR-PEG bispecific antibody inhibits proliferation of high-risk neuroblastomaLogan, Amy, Howard, Christopher B., Huda, Pie, Kimpton, Kathleen, Ma, Zerong, Thurecht, Kristofer J., McCarroll, Joshua A., Moles, Ernest and Kavallaris, Maria (2024). Targeted delivery of polo-like kinase 1 siRNA nanoparticles using an EGFR-PEG bispecific antibody inhibits proliferation of high-risk neuroblastoma. Journal of Controlled Release, 367, 806-820. doi: 10.1016/j.jconrel.2024.02.007 |
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2024 Journal Article Biodegradable mPEG-b-poly(MDO-co-vinyl esters) block copolymers as a viable nanocarrier platform with tuneable disassemblyBalaji, Arunpandian, Prior, Amber R., O'Reilly, Rachel K., Dove, Andrew P., Thurecht, Kristofer J. and Bell, Craig A. (2024). Biodegradable mPEG-b-poly(MDO-co-vinyl esters) block copolymers as a viable nanocarrier platform with tuneable disassembly. Polymer Chemistry, 15 (12), 1152-1165. doi: 10.1039/d4py00049h |
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2023 Journal Article Self-cyclisation as a general and efficient platform for peptide and protein macrocyclisationJia, Xinying, Chin, Yanni K.-Y., Zhang, Alan H., Crawford, Theo, Zhu, Yifei, Fletcher, Nicholas L., Zhou, Zihan, Hamilton, Brett R., Stroet, Martin, Thurecht, Kristofer J. and Mobli, Mehdi (2023). Self-cyclisation as a general and efficient platform for peptide and protein macrocyclisation. Communications Chemistry, 6 (1) 48, 1-10. doi: 10.1038/s42004-023-00841-5 |
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2023 Conference Publication A HER2 targeted polylysine dendrimer nanoparticle radiotheranostic demonstrates excellent tumor accumulation, rapid clearance from circulation, and promising performance in PET-CT imagingJohnstone, Cameron N., Heery, Graham P., Kelly, Brian D, Humphries, James, Akhter, Dewan T., Thurecht, Kristofer J., Yuen, Daniel, Giannis, Michael, Yong, Ken, Chadwick, Gareth, Barker, Helena, Cargill, Anne, Eglezos, Anthony, Castellarnau, Alex, Paull, Jeremy R. A. and Hufton, Richard (2023). A HER2 targeted polylysine dendrimer nanoparticle radiotheranostic demonstrates excellent tumor accumulation, rapid clearance from circulation, and promising performance in PET-CT imaging. AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, Boston, MA United States, 11-15 October 2023. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1535-7163.targ-23-a147 |
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2023 Journal Article Targeted hyperbranched nanoparticles for delivery of doxorubicin in breast cancer brain metastasisLim, Malcolm, Fletcher, Nicholas L., Saunus, Jodi M., McCart Reed, Amy E., Chittoory, Haarika, Simpson, Peter T., Thurecht, Kristofer J. and Lakhani, Sunil R. (2023). Targeted hyperbranched nanoparticles for delivery of doxorubicin in breast cancer brain metastasis. Molecular Pharmaceutics, 20 (12), 6169-6183. doi: 10.1021/acs.molpharmaceut.3c00558 |
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2023 Journal Article An immunomodulating peptide with potential to suppress tumour growth and autoimmunityAgrez, Michael, Chandler, Christopher, Thurecht, Kristofer J., Fletcher, Nicholas L., Liu, Feifei, Subramaniam, Gayathri, Howard, Christopher B., Blyth, Benjamin, Parker, Stephen, Turner, Darryl, Rzepecka, Justyna, Knox, Gavin, Nika, Anastasia, Hall, Andrew M., Gooding, Hayley and Gallagher, Laura (2023). An immunomodulating peptide with potential to suppress tumour growth and autoimmunity. Scientific Reports, 13 (1) 19741, 19741. doi: 10.1038/s41598-023-47229-y |
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2023 Journal Article Exploring the impact of severity in hepatic fibrosis disease on the intrahepatic distribution of novel biodegradable nanoparticles targeted towards different disease biomarkersBalaji, Arunpandian, Bell, Craig A., Houston, Zachary H., Bridle, Kim R., Genz, Berit, Fletcher, Nicholas L., Ramm, Grant A. and Thurecht, Kristofer J. (2023). Exploring the impact of severity in hepatic fibrosis disease on the intrahepatic distribution of novel biodegradable nanoparticles targeted towards different disease biomarkers. Biomaterials, 302 122318, 1-18. doi: 10.1016/j.biomaterials.2023.122318 |
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2023 Journal Article Click‐on antibody fragments for customisable targeted nanomedicines – site‐specific tetrazine and azide functionalisation through non‐canonical amino acid incorporationHuda, Pie, Humphries, James, Fletcher, Nicholas L., Howard, Christopher B., Thurecht, Kristofer J. and Bell, Craig A. (2023). Click‐on antibody fragments for customisable targeted nanomedicines – site‐specific tetrazine and azide functionalisation through non‐canonical amino acid incorporation. Chemistry–Methods, 4 (2) e202300036. doi: 10.1002/cmtd.202300036 |
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2023 Journal Article An immunomodulating peptide to counteract solar radiation-induced immunosuppression and DNA damageAgrez, Michael, Rybchyn, Mark Stephen, De Silva, Warusavithana Gunawardena Manori, Mason, Rebecca Sara, Chandler, Christopher, Piva, Terrence J., Thurecht, Kristofer, Fletcher, Nicholas, Liu, Feifei, Subramaniam, Gayathri, Howard, Christopher B., Blyth, Benjamin, Parker, Stephen, Turner, Darryl, Rzepecka, Justyna, Knox, Gavin, Nika, Anastasia, Hall, Andrew, Gooding, Hayley and Gallagher, Laura (2023). An immunomodulating peptide to counteract solar radiation-induced immunosuppression and DNA damage. Scientific Reports, 13 (1) 11702, 1-19. doi: 10.1038/s41598-023-38890-4 |
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2023 Conference Publication Dox- loaded mpeg nanoparticles as a promising treatment in a humanized mouse model for breast cancer bone metastasisFrankenbach, Tina, Landgraf, Marietta, Fletcher, Nicholas, Howard, Christopher, Ravichandran, Akhilandeshwari, Akhter, Dewan, Shafiee, Abbas, Holzapfel, Boris M., Thurecht, Kristofer, McGovern, Jacqui and Hutmacher, Dietmar W. (2023). Dox- loaded mpeg nanoparticles as a promising treatment in a humanized mouse model for breast cancer bone metastasis. Tissue Engineering and Regenerative Medicine International Society (TERMIS), Krakow, Poland, 28 June - 1 July 2022. New Rochelle, NY United States: Mary Ann Liebert. |
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2023 Journal Article RAFT polymer–antibody conjugation: squaramide ester chemistry leads to conjugates with a therapeutic anti-EGFR antibody with full retention of activity and increased tumor uptake in vivoArdana, Aditya, Ghosh, Saikat, Huda, Pie, Fletcher, Nicholas L., Thurecht, Kristofer J. and Williams, Charlotte C. (2023). RAFT polymer–antibody conjugation: squaramide ester chemistry leads to conjugates with a therapeutic anti-EGFR antibody with full retention of activity and increased tumor uptake in vivo. Molecular Pharmaceutics, 20 (6), 3073-3087. doi: 10.1021/acs.molpharmaceut.3c00085 |
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2023 Journal Article Delivery of PEGylated liposomal doxorubicin by bispecific antibodies improves treatment in models of high-risk childhood leukemiaMoles, Ernest, Howard, Christopher B., Huda, Pie, Karsa, Mawar, McCalmont, Hannah, Kimpton, Kathleen, Duly, Alastair, Chen, Yongjuan, Huang, Yizhou, Tursky, Melinda L., Ma, David, Bustamante, Sonia, Pickford, Russell, Connerty, Patrick, Omari, Sofia, Jolly, Christopher J., Joshi, Swapna, Shen, Sylvie, Pimanda, John E., Dolnikov, Alla, Cheung, Laurence C., Kotecha, Rishi S., Norris, Murray D., Haber, Michelle, de Bock, Charles E., Somers, Klaartje, Lock, Richard B., Thurecht, Kristofer J. and Kavallaris, Maria (2023). Delivery of PEGylated liposomal doxorubicin by bispecific antibodies improves treatment in models of high-risk childhood leukemia. Science Translational Medicine, 15 (696) abm1262, 1-17. doi: 10.1126/scitranslmed.abm1262 |
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2023 Journal Article Development and validation of a targeted treatment for brain tumors using a multi-drug loaded, relapse-resistant polymeric theranosticChu, Weijing, Houston, Zachary H., Fletcher, Nicholas L., Huda, Pie, Ahamed, Muneer, Lim, Ting Xiang, Day, Bryan W., Pinkham, Mark and Thurecht, Kristofer J. (2023). Development and validation of a targeted treatment for brain tumors using a multi-drug loaded, relapse-resistant polymeric theranostic. Biomacromolecules, 24 (6), 2674-2690. doi: 10.1021/acs.biomac.3c00138 |
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2023 Journal Article Efficient delivery of Temozolomide using ultrasmall large-pore silica nanoparticles for glioblastomaJanjua, Taskeen Iqbal, Cao, Yuxue, Ahmed-Cox, Aria, Raza, Aun, Moniruzzaman, Md, Akhter, Dewan Taslima, Fletcher, Nicholas L., Kavallaris, Maria, Thurecht, Kristofer J. and Popat, Amirali (2023). Efficient delivery of Temozolomide using ultrasmall large-pore silica nanoparticles for glioblastoma. Journal of Controlled Release, 357, 161-174. doi: 10.1016/j.jconrel.2023.03.040 |
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2023 Journal Article Combination of chemotherapy and mild hyperthermia using targeted nanoparticles: a potential treatment modality for breast cancerKaur, Ishdeep, Tieu, Terence, Deepagan, Veerasikku G., Ali, Muhammad A., Alsunaydih, Fahad, Rudd, David, Moghaddam, Maliheh A., Bourgeois, Laure, Adams, Timothy E., Thurecht, Kristofer J., Yuce, Mehmet, Cifuentes-Rius, Anna and Voelcker, Nicolas H. (2023). Combination of chemotherapy and mild hyperthermia using targeted nanoparticles: a potential treatment modality for breast cancer. Pharmaceutics, 15 (5) 1389, 1-23. doi: 10.3390/pharmaceutics15051389 |
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2023 Journal Article Homochiral poly(2‐oxazoline)‐based membrane for efficient enantioselective separationWang, Fanmengjing, Pizzi, David, Lu, Yizhihao, He, Kaiqiang, Thurecht, Kristofer J., Hill, Matthew R., Marriott, Philip, Holl, Mark M. Banaszak, Kempe, Kristian and Wang, Huanting (2023). Homochiral poly(2‐oxazoline)‐based membrane for efficient enantioselective separation. Angewandte Chemie International Edition, 62 (8) e202212139, 1-6. doi: 10.1002/anie.202212139 |
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2023 Journal Article Pharmacokinetics and Biodistribution of Zr-Miltuximab and Its Antibody Fragments as Glypican-1 Targeting Immuno-PET Agents in GlioblastomaGhosh, Saikat, Fletcher, Nicholas L., Huda, Pie, Houston, Zachary H., Howard, Christopher B., Lund, Maria E., Lu, Yanling, Campbell, Douglas H., Walsh, Bradley J. and Thurecht, Kristofer J. (2023). Pharmacokinetics and Biodistribution of Zr-Miltuximab and Its Antibody Fragments as Glypican-1 Targeting Immuno-PET Agents in Glioblastoma. Molecular pharmaceutics, 20 (3), 1549-1563. doi: 10.1021/acs.molpharmaceut.2c00760 |
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2023 Journal Article Enhanced drug delivery to cancer cells through a pH-sensitive polycarbonate platformArno, Maria C., Simpson, Joshua D., Blackman, Lewis D., Brannigan, Ruairí P., Thurecht, Kristofer J. and Dove, Andrew P. (2023). Enhanced drug delivery to cancer cells through a pH-sensitive polycarbonate platform. Biomaterials Science, 11 (3), 908-915. doi: 10.1039/d2bm01626e |
