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2016

Journal Article

The in vitro and in vivo antiviral properties of combined monoterpene alcohols against West Nile virus infection

Pliego Zamora, Adriana, Edmonds, Judith H., Reynolds, Maxwell J., Khromykh, Alexander A. and Ralph, Stephen J. (2016). The in vitro and in vivo antiviral properties of combined monoterpene alcohols against West Nile virus infection. Virology, 495, 18-32. doi: 10.1016/j.virol.2016.04.021

The in vitro and in vivo antiviral properties of combined monoterpene alcohols against West Nile virus infection

2016

Journal Article

Human miRNA miR-532-5p exhibits antiviral activity against West Nile virus via suppression of host genes SESTD1 and TAB3 required for virus replication

Slonchak, Andrii, Shannon, Rory P, Pali, Gabor and Khromykh, Alexander A (2016). Human miRNA miR-532-5p exhibits antiviral activity against West Nile virus via suppression of host genes SESTD1 and TAB3 required for virus replication. Journal of Virology, 90 (5), 2388-2402. doi: 10.1128/JVI.02608-15

Human miRNA miR-532-5p exhibits antiviral activity against West Nile virus via suppression of host genes SESTD1 and TAB3 required for virus replication

2015

Journal Article

Functional non-coding RNAs derived from the flavivirus 3' untranslated region

Clarke, B. D., Roby, J. A., Slonchak, A. and Khromykh, A. A. (2015). Functional non-coding RNAs derived from the flavivirus 3' untranslated region. Virus Research, 206, 53-61. doi: 10.1016/j.virusres.2015.01.026

Functional non-coding RNAs derived from the flavivirus 3' untranslated region

2015

Journal Article

The I22V and L72S substitutions in West Nile virus prM protein promote enhanced prM/E heterodimerisation and nucleocapsid incorporation

Setoh, Yin Xiang, Tan, Cindy Si En, Prow, Natalie A., Hobson-Peters, Jody, Young, Paul R., Khromykh, Alexander A. and Hall, Roy A. (2015). The I22V and L72S substitutions in West Nile virus prM protein promote enhanced prM/E heterodimerisation and nucleocapsid incorporation. Virology Journal, 12 (1) 72, 72.1-72.5. doi: 10.1186/s12985-015-0303-7

The I22V and L72S substitutions in West Nile virus prM protein promote enhanced prM/E heterodimerisation and nucleocapsid incorporation

2015

Journal Article

Last 20 aa of the West Nile virus NS1' protein are responsible for its retention in cells and the formation of unique heat-stable dimers.

Young, Lucy B., Melian, Ezequiel Balmori, Setoh, Yin Xiang, Young, Paul R. and Khromykh, Alexander A. (2015). Last 20 aa of the West Nile virus NS1' protein are responsible for its retention in cells and the formation of unique heat-stable dimers.. Journal of General Virology, 96 (5), 1042-1054. doi: 10.1099/vir.0.000053

Last 20 aa of the West Nile virus NS1' protein are responsible for its retention in cells and the formation of unique heat-stable dimers.

2015

Journal Article

Viral RNA intermediates as targets for detection and discovery of novel and emerging mosquito-borne viruses

O'Brien, Caitlin A., Hobson-Peters, Jody, Yam, Alice Wei Yee, Colmant, Agathe M. G., McLean, Breeanna J., Prow, Natalie A., Watterson, Daniel, Hall-Mendelin, Sonja, Warrilow, David, Ng, Mah-Lee, Khromykh, Alexander A. and Hall, Roy A. (2015). Viral RNA intermediates as targets for detection and discovery of novel and emerging mosquito-borne viruses. PLoS Neglected Tropical Diseases, 9 (3) e0003629, 1-27. doi: 10.1371/journal.pntd.0003629

Viral RNA intermediates as targets for detection and discovery of novel and emerging mosquito-borne viruses

2015

Journal Article

A Kunjin replicon virus-like particle vaccine provides protection against ebola virus infection in nonhuman primates

Pyankov, Oleg V., Bodnev, Sergey A., Pyankova, Olga G., Solodkyi, Vladislav V., Pyankov, Stepan A., Setoh, Yin Xiang, Volchkova, Valentina A., Suhrbier, Andreas, Volchkov, Viktor V., Agafonov, Alexander A. and Khromykh, Alexander A. (2015). A Kunjin replicon virus-like particle vaccine provides protection against ebola virus infection in nonhuman primates. Journal of Infectious Diseases, 212 (Supp.), S1-S4. doi: 10.1093/infdis/jiv019

A Kunjin replicon virus-like particle vaccine provides protection against ebola virus infection in nonhuman primates

2015

Journal Article

Comparison of attenuated and virulent West Nile virus strains in human monocyte-derived dendritic cells as a model of initial human infection

Rawle, Daniel J., Setoh, Yin Xiang, Edmonds, Judith H. and Khromykh, Alexander A. (2015). Comparison of attenuated and virulent West Nile virus strains in human monocyte-derived dendritic cells as a model of initial human infection. Virology Journal, 12 (1) 46, 46.1-46.5. doi: 10.1186/s12985-015-0279-3

Comparison of attenuated and virulent West Nile virus strains in human monocyte-derived dendritic cells as a model of initial human infection

2015

Journal Article

Post-translational regulation and modifications of flavivirus structural proteins

Roby, Justin A., Setoh, Yin Xiang, Hall, Roy A. and Khromykh, Alexander A. (2015). Post-translational regulation and modifications of flavivirus structural proteins. Journal of General Virology, 96 (7), 1551-1569. doi: 10.1099/vir.0.000097

Post-translational regulation and modifications of flavivirus structural proteins

2015

Journal Article

Systematic analysis of viral genes responsible for differential virulence between American and Australian West Nile virus strains

Setoh, Yin Xiang, Prow, Natalie A., Rawle, Daniel J., Tan, Cindy Si En, Edmonds, Judith H., Hall, Roy A. and Khromykh, Alexander A. (2015). Systematic analysis of viral genes responsible for differential virulence between American and Australian West Nile virus strains. Journal of General Virology, 96 (Pt 6), 1297-1308. doi: 10.1099/vir.0.000069

Systematic analysis of viral genes responsible for differential virulence between American and Australian West Nile virus strains

2014

Journal Article

Multiple immune factors are involved in controlling acute and chronic chikungunya virus infection

Poo, Yee Suan, Rudd, Penny A., Gardner, Joy, Wilson, Jane A. C., Larcher, Thibaut, Colle, Marie-Anne, Le, Thuy T., Nakaya, Helder I., Warrilow, David, Allcock, Richard, Bielefeldt-Ohmann, Helle, Schroder, Wayne A., Khromykh, Alexander A., Lopez, Jose A. and Suhrbier, Andreas (2014). Multiple immune factors are involved in controlling acute and chronic chikungunya virus infection. PLoS Neglected Tropical Diseases, 8 (12) e3354, 1-15. doi: 10.1371/journal.pntd.0003354

Multiple immune factors are involved in controlling acute and chronic chikungunya virus infection

2014

Journal Article

Programmed ribosomal frameshift alters expression of West Nile virus genes and facilitates virus replication in birds and mosquitoes

Melian, Ezequiel Balmori, Hall-Mendelin, Sonja, Du, Fangyao, Owens, Nick, Bosco-Lauth, Angela M., Nagasaki, Tomoko, Rudd, Stephen, Brault, Aaron C., Bowen, Richard A., Hall, Roy A., van den Hurk, Andrew F. and Khromykh, Alexander A. (2014). Programmed ribosomal frameshift alters expression of West Nile virus genes and facilitates virus replication in birds and mosquitoes. PLoS Pathogens, 10 (11) e1004447, e1004447.1-e1004447.18. doi: 10.1371/journal.ppat.1004447

Programmed ribosomal frameshift alters expression of West Nile virus genes and facilitates virus replication in birds and mosquitoes

2014

Journal Article

The increased expression of capsid protein in trans enhances production of single-round infectious particles by West Nile virus DNA vaccine candidate

Roby, Justin A., Bielefeldt-Ohmann, Helle, Prow, Natalie A., Chang, David C., Hall, Roy A. and Khromykh, Alexander A. (2014). The increased expression of capsid protein in trans enhances production of single-round infectious particles by West Nile virus DNA vaccine candidate. Journal of General Virology, 95 (10), 2176-2191. doi: 10.1099/vir.0.064121-0

The increased expression of capsid protein in trans enhances production of single-round infectious particles by West Nile virus DNA vaccine candidate

2014

Journal Article

Expression of mosquito microRNA aae-miR-2940-5p is down-regulated in response to West Nile Virus infection to restrict viral replication

Slonchak, Andrii, Hussain, Mazhar, Torres Morales, Shessy, Asgari, Sassan and Khromykh, Alexander (2014). Expression of mosquito microRNA aae-miR-2940-5p is down-regulated in response to West Nile Virus infection to restrict viral replication. Journal of Virology, 88 (15), 8457-8467. doi: 10.1128/JVI.00317-14

Expression of mosquito microRNA aae-miR-2940-5p is down-regulated in response to West Nile Virus infection to restrict viral replication

2014

Journal Article

Wolbachia infection modifies the profile, shuttling and structure of MicroRNAs in a mosquito cell line

Mayoral, Jamie G., Etebari, Kayvan, Hussain, Mazhar, Khromykh, Alexander A. and Asgari, Sassan (2014). Wolbachia infection modifies the profile, shuttling and structure of MicroRNAs in a mosquito cell line. PLoS One, 9 (4) e96107, e96107. doi: 10.1371/journal.pone.0096107

Wolbachia infection modifies the profile, shuttling and structure of MicroRNAs in a mosquito cell line

2014

Journal Article

Loop de loop: viral RNA evades IFIT1 targeting

Roby, Justin A., Clarke, Brian D. and Khromykh, Alexander A. (2014). Loop de loop: viral RNA evades IFIT1 targeting. Trends In Microbiology, 22 (4), 171-173. doi: 10.1016/j.tim.2014.02.014

Loop de loop: viral RNA evades IFIT1 targeting

2014

Journal Article

Internal ribosome entry site-based attenuation of a flavivirus candidate vaccine and evaluation of the effect of beta interferon coexpression on vaccine properties

Frese, Michael, Lee, Eva, Larena, Maximilian, Lim, Pek Siew, Rao, Sudha, Matthaei, Klaus I., Khromykh, Alexander, Ramshaw, Ian and Lobigs, Mario (2014). Internal ribosome entry site-based attenuation of a flavivirus candidate vaccine and evaluation of the effect of beta interferon coexpression on vaccine properties. Journal of Virology, 88 (4), 2056-2070. doi: 10.1128/JVI.03051-13

Internal ribosome entry site-based attenuation of a flavivirus candidate vaccine and evaluation of the effect of beta interferon coexpression on vaccine properties

2014

Journal Article

Noncoding subgenomic flavivirus RNA: multiple functions in West Nile Virus pathogenesis and modulation of host responses

Roby, Justin A., Pijlman, Gorben P., Wilusz, Jeffrey and Khromykh, Alexander A. (2014). Noncoding subgenomic flavivirus RNA: multiple functions in West Nile Virus pathogenesis and modulation of host responses. Viruses, 6 (2), 404-427. doi: 10.3390/v6020404

Noncoding subgenomic flavivirus RNA: multiple functions in West Nile Virus pathogenesis and modulation of host responses

2014

Journal Article

The West Nile virus assembly process evades the conserved antiviral mechanism of the interferon-induced MxA protein

Hoenen, Antje, Gillespie, Leah, Morgan, Garry, van der Heide, Peter, Khromykh, Alexander and Mackenzie, Jason (2014). The West Nile virus assembly process evades the conserved antiviral mechanism of the interferon-induced MxA protein. Virology, 448, 104-116. doi: 10.1016/j.virol.2013.10.005

The West Nile virus assembly process evades the conserved antiviral mechanism of the interferon-induced MxA protein

2013

Journal Article

West Nile virus genome with glycosylated envelope protein and deletion of alpha helixes 1, 2 and 4 in the capsid gene is non-infectious and efficiently secretes sub-viral particles

Roby, Justin A., Hall, Roy A. and Khromykh, Alexander A. (2013). West Nile virus genome with glycosylated envelope protein and deletion of alpha helixes 1, 2 and 4 in the capsid gene is non-infectious and efficiently secretes sub-viral particles. Journal of Virology, 87 (23), 13063-13069. doi: 10.1128/JVI.01552-13

West Nile virus genome with glycosylated envelope protein and deletion of alpha helixes 1, 2 and 4 in the capsid gene is non-infectious and efficiently secretes sub-viral particles