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2016 Journal Article Genetic coding variant in GPR65 alters lysosomal pH and links lysosomal dysfunction with colitis riskLassen, Kara G., McKenzie, Craig I., Mari, Muriel, Murano, Tatsuro, Begun, Jakob, Baxt, Leigh A., Goel, Gautam, Villablanca, Eduardo J., Kuo, Szu-Yu, Huang, Hailiang, Macia, Laurence, Bhan, Atul K., Batten, Marcel, Daly, Mark J., Reggiori, Fulvio, Mackay, Charles R. and Xavier, Ramnik J. (2016). Genetic coding variant in GPR65 alters lysosomal pH and links lysosomal dysfunction with colitis risk. Immunity, 44 (6), 1392-1405. doi: 10.1016/j.immuni.2016.05.007 |
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2016 Conference Publication Inflammatory bowel disease in the clinic: escalation and de-escalation of therapy: a longitudinal case-based discussionBegun, Jakob (2016). Inflammatory bowel disease in the clinic: escalation and de-escalation of therapy: a longitudinal case-based discussion. The Takeda Symposium, Sydney, NSW Australia, 13-14 February 2016. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.13348 |
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2016 Conference Publication Bacterial activation of thioguanine results in lymphocyte independent improvement in murine colitisOancea, I., Das, I., de Carcer, D. Aguirre, Movva, R., Schreiber, V., Yang, Y., Proctor, M., Wang, R., Sheng, Y., Lobb, M., Cuiv, P. O., Duley, J. A., Begun, J. and Florin, T. H. J. (2016). Bacterial activation of thioguanine results in lymphocyte independent improvement in murine colitis. 11th Congress of ECCO - European Crohn’s and Colitis Organisation, Amsterdam, Netherlands, 16-19 March 2016. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/ecco-jcc/jjw019.177 |
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2016 Journal Article Towards an integrated understanding of the therapeutic utility of exclusive enteral nutrition in the treatment of Crohn's diseaseO Cuiv, Paraic, Begun, Jake, Keely, Simon, Lewindon, Peter and Morrison, Mark (2016). Towards an integrated understanding of the therapeutic utility of exclusive enteral nutrition in the treatment of Crohn's disease. Food and Function, 7 (4), 1741-1751. doi: 10.1039/C5FO01196E |
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2016 Conference Publication Clinical presentation of IBD diagnosed after age 60Shukla, D., Begun, J. and Florin, T. (2016). Clinical presentation of IBD diagnosed after age 60. Gastroenterological Society of Australia, Australian Gastroenterology Week 2016, Adelaide, South Australia, Australia, 10–12 October 2016. HOBOKEN: WILEY-BLACKWELL. doi: 10.1111/jgh.13522 |
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2016 Conference Publication Severe bacterial infections with vedolizumab therapy: 3 illustrative casesSzetoo, S. W., Hume, G., De Cruz, P. and Begun, J. (2016). Severe bacterial infections with vedolizumab therapy: 3 illustrative cases. Gastroenterological Society of Australia, Australian Gastroenterology Week 2016, Adelaide, South Australia, Australia, 10–12 October 2016. HOBOKEN: WILEY-BLACKWELL. doi: 10.1111/jgh.13522 |
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2016 Conference Publication An inhibitor of Wnt protein production improves host control of Listeria monocytogenesTran, T. T., Andrades, M. G., Nguyen, T. T. K., Wyer, O., Kling, J. C., Begun, J. and Blumenthal, A. (2016). An inhibitor of Wnt protein production improves host control of Listeria monocytogenes. ICI 2016 International Congress of Immunology, Melbourne, VIC, Australia, 21-26 August 2016. Weinheim, Germany: Wiley - VCH Verlag. doi: 10.1002/eji.201670200 |
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2016 Conference Publication The burden of illness among adolescents and young adults with inflammatory bowel diseaseDuffy, K. and Begun, J. (2016). The burden of illness among adolescents and young adults with inflammatory bowel disease. Gastroenterological Society of Australia, Australian Gastroenterology Week 2016, Adelaide, South Australia, Australia, 10–12 October 2016. HOBOKEN: WILEY-BLACKWELL. doi: 10.1111/jgh.13522 |
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2016 Conference Publication High fat diets induce colonic epithelial cell stress and inflammation that is reversed by IL-22Gulhane, M., Lourie, R., Tong, H., Kang, A., Schreiber, V., Magor, G., Denman, S., Begun, J., Florin, T., Perkins, A., O Cuiv, P., Mcguckin, M. and Hasnain, S. Z. (2016). High fat diets induce colonic epithelial cell stress and inflammation that is reversed by IL-22. ICI 2016 International Congress of Immunology, Melbourne, Australia, 21–26 August 2016. Weinheim, Germany: Wiley. doi: 10.1002/eji.201670200 |
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2016 Conference Publication Alleviation of Acute Drug-Induced Liver Injury Following Acetaminophen Overdose by Therapeutic Blockade of E-Selectin in Preclinical Mouse ModelOancea, Iulia, Barbier, Valerie, Chee, David, Lourie, Rohan, Movva, Ramya, Proctor, Martina A., Begun, Jakob, Magnani, John L., Florin, Timothy H. and Winkler, Ingrid (2016). Alleviation of Acute Drug-Induced Liver Injury Following Acetaminophen Overdose by Therapeutic Blockade of E-Selectin in Preclinical Mouse Model. 57th Annual Meeting and Residents Fellow Conference of the Society for Surgery of the Alimentary Tract (SSAT) / 52nd Annual Meeting on Digestive Disease Week (DDW) / Meeting of the American-Gastroenterological-Association (AGA), San Diego, CA United States, 21-24 May 2016. Philadelphia, PA United States: Elsevier. doi: 10.1016/s0016-5085(16)33483-7 |
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2016 Conference Publication The incidence of 30-day adverse events after colonoscopy in an IBD populationAn, Y. K., Wong, J., You, I. S., Mortimore, M., Hewett, D. G., Appleyard, M. N. and Begun, J. (2016). The incidence of 30-day adverse events after colonoscopy in an IBD population. Gastroenterological Society of Australia, Australian Gastroenterology Week 2016, Adelaide, South Australia, Australia, 10–12 October 2016. HOBOKEN: WILEY-BLACKWELL. doi: 10.1111/jgh.13522 |
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2016 Conference Publication Thiopurine Mediated Chemoprevention of Colitis-Associated Colorectal DysplasiaJose, Beulah, Lourie, Rohan, Schreiber, Veronika, Florin, Timothy H., Oancea, Iulia and Begun, Jakob (2016). Thiopurine Mediated Chemoprevention of Colitis-Associated Colorectal Dysplasia. 57th Annual Meeting and Residents Fellow Conference of the Society for Surgery of the Alimentary Tract (SSAT) / 52nd Annual Meeting on Digestive Disease Week (DDW) / Meeting of the American Gastroenterological Association (AGA57th Annual Meeting and Residents Fellow Conference of the Society for Surgery of the Alimentary Tract (SSAT) / 52nd Annual Meeting on Digestive Disease Week (DDW) / Meeting of the American-Gastroenterological-Association (AGA), San Diego, CA United States, 21-24 May 2016. Philadelphia, PA United States: Elsevier. doi: 10.1016/s0016-5085(16)33291-7 |
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2015 Conference Publication Malnutrition and quality of life among inflammatory bowel disease outpatientsPulley, J., Todd, A., Flatley, C. and Begun, J. (2015). Malnutrition and quality of life among inflammatory bowel disease outpatients. Gastro 2015 GESA‐AGW and WGO International Congress, Gastroenterological Society of Australia Australian Gastroenterology Week 2015, Brisbane, QLD Australia, 28 September‐2 October 2015. Richmond, VIC Australia: John Wiley and Sons. doi: 10.1111/jgh.13096 |
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2015 Journal Article Integrated genomics of crohn's disease risk variant identifies a role for CLEC12A in antibacterial autophagyBegun, Jakob, Lassen, Kara G., Jijon, Humberto B., Baxt, Leigh A., Goel, Gautam, Heath, Robert J., Ng, Aylwin, Tam, Jenny M., Kuo, Szu-Yu, Villablanca, Eduardo J., Fagbami, Lola, Oosting, Marije, Kumar, Vinod, Schenone, Monica, Carr, Steven A., Joosten, Leo A. B., Vyas, Jatin M., Daly, Mark J., Netea, Mihai G., Brown, Gordon D., Wijmenga, Cisca and Xavier, Ramnik J. (2015). Integrated genomics of crohn's disease risk variant identifies a role for CLEC12A in antibacterial autophagy. Cell Reports, 11 (12), 1905-1918. doi: 10.1016/j.celrep.2015.05.045 |
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2015 Journal Article Enteroliths in a Kock continent ileostomy: case report and review of the literatureMoattar, Hadi, Begun, Jakob and Florin, Timothy (2015). Enteroliths in a Kock continent ileostomy: case report and review of the literature. Endoscopy, 47 (S 01), E200-E201. doi: 10.1055/s-0034-1391302 |
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2014 Journal Article IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humansde Luca, Antonella, Smeekens, Sanne P., Casagrande, Andrea, Iannitti, Rossana, Conway, Kara L., Gresnigt, Mark. S., Begun, Jakob, Plantinga, Theo S., Joosten, Leo A. B., van der Meer, Jos W. M., Chamilos, Georgios, Netea, Mihai G., Xavier, Ramnik J., Dinarello, Charles A., Romani, Luigina and van de Veerdonk, Frank L. (2014). IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans. Proceedings of the National Academy of Sciences of the United States of America, 111 (9), 3526-3531. doi: 10.1073/pnas.1322831111 |
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2013 Journal Article Autophagy at the crossroads of metabolism and cellular defenseBegun, Jakob and Xavier, Ramnik J. (2013). Autophagy at the crossroads of metabolism and cellular defense. Current Opinion in Gastroenterology, 29 (6), 588-596. doi: 10.1097/MOG.0b013e328365d34d |
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2013 Journal Article Deep resequencing of GWAS loci identifies rare variants in CARD9, IL23R and RNF186 that are associated with ulcerative colitisBeaudoin, Melissa, Goyette, Philippe, Boucher, Gabrielle, Lo, Ken Sin, Rivas, Manuel A., Stevens, Christine, Alikashani, Azadeh, Ladouceur, Martin, Ellinghaus, David, Torkvist, Leif, Goel, Gautam, Lagace, Caroline, Annese, Vito, Bitton, Alain, Begun, Jakob, Brant, Steve R., Bresso, Francesca, Cho, Judy H., Duerr, Richard H., Halfvarson, Jonas, McGovern, Dermot P. B., Radford-Smith, Graham, Schreiber, Stefan, Schumm, Philip L., Sharma, Yashoda, Silverberg, Mark S., Weersma, Rinse K., D'Amato, Mauro, Vermeire, Severine ... Rioux, John D. (2013). Deep resequencing of GWAS loci identifies rare variants in CARD9, IL23R and RNF186 that are associated with ulcerative colitis. PLoS Genetics, 9 (9) e1003723, e1003723.1-e1003723.11. doi: 10.1371/journal.pgen.1003723 |
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2012 Journal Article The LRR and RING domain protein LRSAM1 is an E3 ligase crucial for ubiquitin-dependent autophagy of intracellular salmonella typhimuriumHuett, Alan, Heath, Robert J., Begun, Jakob, Sassi, Slim O., Baxt, Leigh A., Vyas, Jatin M., Goldberg, Marcia B. and Xavier, Ramnik J. (2012). The LRR and RING domain protein LRSAM1 is an E3 ligase crucial for ubiquitin-dependent autophagy of intracellular salmonella typhimurium. Cell Host and Microbe, 12 (6), 778-790. doi: 10.1016/j.chom.2012.10.019 |
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2012 Journal Article ATG16L1 T300A dependent differential gene expression identifies genes required for anti-bacterial autophagy : P-227 YIBegun, Jakob, Ng, Aylwin and Xavier, Ramnik (2012). ATG16L1 T300A dependent differential gene expression identifies genes required for anti-bacterial autophagy : P-227 YI. Inflammatory Bowel Diseases, 18, S103. doi: 10.1097/00054725-201212001-00260 |
