Overview
Background
Dr María Patricia Hernández Mitre (Patty Mitre) is Postdoctoral Research Fellow in the Antimicrobial Optimisation Group led by Professor Jason Roberts and a member of the CRE-RESPOND (Centre of Research Excellence - REduce the burden of antimicrobial reSistance through oPtimal persONalised Dosing) team at the University of Queensland Centre for Clinical Research, located on the Royal Brisbane and Women's Hospital campus at Herston in Brisbane, Queensland, Australia.
She is certified in non-compartmental analysis (NCA) using Phoenix® WinNonlin™ and conducts NCA for Phase 1 clinical trials under NATA ISO 17025-accredited processes, preparing regulatory reports for submission to agencies such as the FDA. In addition, she develops and validates population pharmacokinetic models using Monolix®, Pmetrics™, and NONMEM® to optimise drug therapy and support therapeutic drug monitoring.
Dr Hernández Mitre is leading the individual pharmacokinetic analyses of antifungal therapies from the Screening Anti-Fungal Exposure in Intensive Care Units (SAFE-ICU) study. She also mentors students and clinicians, delivers training in pharmacokinetic modelling, and participates actively in university committees. She is experienced in clinical trial monitoring, regulatory writing, and electronic research data management.
Availability
- Dr Patty Mitre is:
- Available for supervision
Fields of research
Qualifications
- Bachelor of Chemistry, Universidad Autónoma de San Luis Potosí
- Masters (Research) of Pharmacy and Biology, Universidad Autónoma de San Luis Potosí
- Doctor of Philosophy of Pharmacy and Biology, Universidad Autónoma de San Luis Potosí
Works
Search Professor Patty Mitre’s works on UQ eSpace
2026
Journal Article
Plasma and subcutaneous interstitial fluid vancomycin and gentamicin concentrations in three patients undergoing open abdominal aortic aneurysm repair
Ryan, Rochelle, Jarrett, Paul, Lassig-Smith, Melissa, Wallis, Steven C., van Zundert, Andre, Ordonez, Jenny, Won, Hayoung, Lipman, Jeffrey, Hernandez-Mitre, Maria Patricia and Roberts, Jason A. (2026). Plasma and subcutaneous interstitial fluid vancomycin and gentamicin concentrations in three patients undergoing open abdominal aortic aneurysm repair. International Journal of Antimicrobial Agents, 67 (6) 107796, 107796. doi: 10.1016/j.ijantimicag.2026.107796
2026
Journal Article
Nimodipine dosing and pharmacokinetic variability in subarachnoid hemorrhage patients
Bellapart, Judith, Hernández-Mitre, María Patricia, Wu, Xiaolin, Wallis, Steven C., Smith, Melissa-Lassig, Stuart, Janine, Fourie, Cheryl, Livermore, Amelia and Roberts, Jason A. (2026). Nimodipine dosing and pharmacokinetic variability in subarachnoid hemorrhage patients. Journal of Clinical Neuroscience, 147 111940, 111940. doi: 10.1016/j.jocn.2026.111940
2026
Journal Article
Population pharmacokinetics of cefazolin and metronidazole in patients undergoing elective colorectal surgery
Ryan, Rochelle, McDonald, Scott, Wallis, Steven C, van Zundert, Andre, Wu, Xiolin, Won, Hayoung, Lipman, Jeffrey, Hernandez-Mitre, Maria Patricia and Roberts, Jason A. (2026). Population pharmacokinetics of cefazolin and metronidazole in patients undergoing elective colorectal surgery. International Journal of Antimicrobial Agents, 67 (5) 107742, 107742-5. doi: 10.1016/j.ijantimicag.2026.107742
2026
Journal Article
Population pharmacokinetics of polymyxin B in critically ill patients with multidrug-resistant (MDR) Acinetobacter baumannii and Pseudomonas aeruginosa infections
Zamri, Puteri Juanita, Wölky, Saskia A., Hernandez-Mitre, Maria P., Liu, Xin, Hasan, M. Shahnaz, Shariff, Izyani Md, Sulaiman, Helmi, Wallis, Steven C., Sumi, Chandra Datta, Parker, Suzanne L., Sime, Fekade Bruck, Roberts, Jason A. and Abdul-Aziz, Mohd Hafiz (2026). Population pharmacokinetics of polymyxin B in critically ill patients with multidrug-resistant (MDR) Acinetobacter baumannii and Pseudomonas aeruginosa infections. International Journal of Antimicrobial Agents 107816, 107816. doi: 10.1016/j.ijantimicag.2026.107816
2026
Journal Article
A pharmacokinetic/pharmacodynamic analysis of intravenous tranexamic acid in adult patients undergoing elective total hip arthroplasty (ORACLE)
Gurunathan, Usha, Medcalf, Robert L., Chiang, Lily, Liu, Zikou, Liu, Xin, Keragala, Charithani B., Hernandez-Mitre, Maria Patricia, Brady, Paul, Wallis, Steven C., Roberts, Jason A., Mullany, Daniel, Nandurkar, Harshal, Eley, Victoria and Parker, Suzanne L. (2026). A pharmacokinetic/pharmacodynamic analysis of intravenous tranexamic acid in adult patients undergoing elective total hip arthroplasty (ORACLE). British Journal of Anaesthesia, 136 (4), 1157-1165. doi: 10.1016/j.bja.2024.12.004
2026
Journal Article
Can Model-Informed Precision Dosing of Beta-Lactams in Critical Care Improve Clinical Outcomes?
Oakley, Robert, Ulldemolins, Marta, Hernández Mitre, Maria Patricia, Colmenero, Manuel, Roberts, Natasha, Roberts, Jason, Lipman, Jeffrey and Heffernan, Aaron (2026). Can Model-Informed Precision Dosing of Beta-Lactams in Critical Care Improve Clinical Outcomes?. Chemotherapy, 1-23. doi: 10.1159/000550822
2025
Journal Article
A pharmacokinetic analysis of intravenous fluconazole in adult patients undergoing mechanical circulatory support device implantation
Cairns, Kelly A., Hernandez-Mitre, Maria Patricia, Peel, Trisha N., Abbott, Iain J., Kaye, David M., Marasco, Silvana, Daly, David, Warner, Victoria, Coldham, Anna, Pope, Jeffrey D., Schneider, Hans G, Dooley, Michael J., Liu, Xin, Roberts, Jason A. and Udy, Andrew A. (2025). A pharmacokinetic analysis of intravenous fluconazole in adult patients undergoing mechanical circulatory support device implantation. Clinical Pharmacokinetics, 65 (3), 395-404. doi: 10.1007/s40262-025-01607-z
2025
Journal Article
Population pharmacokinetics and optimized dosing of piperacillin-tazobactam in hematological patients with febrile neutropenia
Laporte-Amargos, Julia, Ulldemolins, Marta, Hernández-Mitre, María Patricia, Roberts, Jason A., Rigo-Bonnin, Raul, Carmona-Torre, Francisco, Huguet, Maria, Puerta-Alcalde, Pedro, Arnan, Montserrat, del Pozo, Jose Luis, Torrent, Anna, García-Vidal, Carolina, Sureda, Anna, Bergas, Alba, Sastre-Escolà, Enric, Carratalà, Jordi and Gudiol, Carlota (2025). Population pharmacokinetics and optimized dosing of piperacillin-tazobactam in hematological patients with febrile neutropenia. Antimicrobial Agents and Chemotherapy, 70 (1) e01253-25, 1-13. doi: 10.1128/aac.01253-25
2025
Journal Article
Phase 1, randomized, double-blind, placebo-controlled, ascending single- and multiple-dose study of the safety, tolerability, and pharmacokinetics of intravenous xeruborbactam (QPX7728) in healthy adult subjects
Hernandez-Mitre, Maria Patricia, Wallis, Steven C., Loutit, Jeffery S., Griffith, David C. and Roberts, Jason A. (2025). Phase 1, randomized, double-blind, placebo-controlled, ascending single- and multiple-dose study of the safety, tolerability, and pharmacokinetics of intravenous xeruborbactam (QPX7728) in healthy adult subjects. Antimicrobial Agents and Chemotherapy, 69 (10) e00784-25, 1-11. doi: 10.1128/aac.00784-25
2025
Journal Article
Optimizing ICU antifungal therapy: overcoming pharmacokinetic limitations with combination strategies—author's reply
Hernández-Mitre, María Patricia, Roberts, Jason A. and Roger, Claire (2025). Optimizing ICU antifungal therapy: overcoming pharmacokinetic limitations with combination strategies—author's reply. Intensive Care Medicine, 51 (4), 1-2. doi: 10.1007/s00134-025-07872-7
2025
Journal Article
Are contemporary antifungal doses sufficient for critically ill patients? Outcomes from an international, multicenter pharmacokinetics study for Screening Antifungal Exposure in Intensive Care Units—the SAFE-ICU study
Roberts, Jason A., Sime, Fekade B., Lipman, Jeffrey, Hernández-Mitre, María Patricia, Baptista, João Pedro, Brüggemann, Roger J., Darvall, Jai, De Waele, Jan J., Dimopoulos, George, Lefrant, Jean-Yves, Mat Nor, Mohd Basri, Rello, Jordi, Seoane, Leonardo, Slavin, Monica A., Valkonen, Miia, Venditti, Mario, Ceccarelli, Giancarlo, Wong, Wai Tat, Zeitlinger, Markus and Roger, Claire (2025). Are contemporary antifungal doses sufficient for critically ill patients? Outcomes from an international, multicenter pharmacokinetics study for Screening Antifungal Exposure in Intensive Care Units—the SAFE-ICU study. Intensive Care Medicine, 51 (2), 1-16. doi: 10.1007/s00134-025-07793-5
2025
Journal Article
Propofol and fentanyl pharmacokinetics and pharmacodynamics in extracorporeal membrane oxygenation
Morales Castro, Diana, Balzani, Eleonora, Abdul-Aziz, M. Hafiz, Hernandez-Mitre, Maria Patricia, Wong, Irene, Turgeon, Julien, Tisminetzky, Manuel, Jurado-Camacho, Felipe, Morris, Idunn, Dresser, Linda, Granton, John, Uetrecht, Jack, Pang, K. Sandy, Chen, Eric, Shekar, Kiran and Fan, Eddy (2025). Propofol and fentanyl pharmacokinetics and pharmacodynamics in extracorporeal membrane oxygenation. Annals of the American Thoracic Society, 22 (1), 121-129. doi: 10.1513/annalsats.202407-795oc
2025
Journal Article
Erratum to ‘TMPRSS2 inhibitors for the treatment of COVID-19 in adults: a systematic review and meta-analysis of randomized clinical trials of nafamostat and camostat mesylate’ [Clin Microbiol Infect (30) (2024) 743–754, (S1198743X24000557), (10.1016/j.cmi.2024.01.029)]
Hernández-Mitre, María Patricia, Morpeth, Susan C., Venkatesh, Balasubramanian, Hills, Thomas E., Davis, Joshua, Mahar, Robert K., McPhee, Grace, Jones, Mark, Totterdell, James, Tong, Steven Y.C. and Roberts, Jason A. (2025). Erratum to ‘TMPRSS2 inhibitors for the treatment of COVID-19 in adults: a systematic review and meta-analysis of randomized clinical trials of nafamostat and camostat mesylate’ [Clin Microbiol Infect (30) (2024) 743–754, (S1198743X24000557), (10.1016/j.cmi.2024.01.029)]. Clinical Microbiology and Infection, 31 (1) 141, 141-141. doi: 10.1016/j.cmi.2024.08.005
2024
Journal Article
Population pharmacokinetics of prophylactic cefoxitin in elective bariatric surgery patients: a prospective monocentric study
Novy, Emmanuel, Liu, Xin, Hernandez-Mitre, Maria Patricia, Belveyre, Thibaut, Scala-Bertola, Julien, Roberts, Jason A. and Parker, Suzanne L. (2024). Population pharmacokinetics of prophylactic cefoxitin in elective bariatric surgery patients: a prospective monocentric study. Anaesthesia Critical Care and Pain Medicine, 43 (3) 101376, 1-8. doi: 10.1016/j.accpm.2024.101376
2024
Journal Article
TMPRSS2 inhibitors for the treatment of COVID-19 in adults: a systematic review and meta-analysis of randomized clinical trials of nafamostat and camostat mesylate
Hernández-Mitre, María Patricia, Morpeth, Susan C., Venkatesh, Balasubramanian, Hills, Thomas E., Davis, Joshua, Mahar, Robert K., McPhee, Grace, Jones, Mark, Totterdell, James, Tong, Steven Y. C. and Roberts, Jason A. (2024). TMPRSS2 inhibitors for the treatment of COVID-19 in adults: a systematic review and meta-analysis of randomized clinical trials of nafamostat and camostat mesylate. Clinical Microbiology and Infection, 30 (6), 743-754. doi: 10.1016/j.cmi.2024.01.029
2023
Journal Article
A phase I, randomized, double-blind, placebo-controlled, ascending single- and multiple-dose study of the pharmacokinetics, safety, and tolerability of oral ceftibuten in healthy adult subjects
Hernández-Mitre, María Patricia, Wallis, Steven C., Morgan, Elizabeth E., Dudley, Michael N., Loutit, Jeffery S., Griffith, David C. and Roberts, Jason A. (2023). A phase I, randomized, double-blind, placebo-controlled, ascending single- and multiple-dose study of the pharmacokinetics, safety, and tolerability of oral ceftibuten in healthy adult subjects. Antimicrobial Agents and Chemotherapy, 68 (1) e0109923, 1-12. doi: 10.1128/aac.01099-23
2023
Journal Article
Stability of nafamostat in intravenous infusion solutions, human whole blood and extracted plasma: implications for clinical effectiveness studies
Hernández-Mitre, María Patricia, Won, Hayoung, Wallis, Steven C., Parker, Suzanne L. and Roberts, Jason A. (2023). Stability of nafamostat in intravenous infusion solutions, human whole blood and extracted plasma: implications for clinical effectiveness studies. Bioanalysis, 15 (12), 673-681. doi: 10.4155/bio-2023-0040
2023
Journal Article
A protocol for an international, multicentre pharmacokinetic study for Screening Antifungal Exposure in Intensive Care Units: The SAFE-ICU study
Roberts, Jason A., Sime, Fekade, Lipman, Jeffrey, Hernández-Mitre, Maria Patricia, Baptista, João Pedro, Brüggemann, Roger J., Darvall, Jai, De Waele, Jan J., Dimopoulos, George, Lefrant, Jean-Yves, Mat Nor, Mohd Basri, Rello, Jordi, Seoane, Leonardo, Slavin, Monica A., Valkonen, Miia, Venditti, Mario, Wong, Wai Tat, Zeitlinger, Markus and Roger, Claire (2023). A protocol for an international, multicentre pharmacokinetic study for Screening Antifungal Exposure in Intensive Care Units: The SAFE-ICU study. Critical Care and Resuscitation, 25 (1), 1-5. doi: 10.1016/j.ccrj.2023.04.002
2023
Other Outputs
TMPRSS2 inhibitors for the treatment of COVID-19 in adults: a systematic review and meta-analysis of nafamostat and camostat mesylate randomised clinical trials
Hernández-Mitre, María Patricia, Morpeth, Susan C., Venkatesh, Balasubramanian, Hills, Thomas E., Davis, Joshua, Mahar, Robert K., McPhee, Grace, Jones, Mark, Totterdell, James, Tong, Steven Y. C. and Roberts, Jason A. (2023). TMPRSS2 inhibitors for the treatment of COVID-19 in adults: a systematic review and meta-analysis of nafamostat and camostat mesylate randomised clinical trials. Middletown, DE, United States: INPLASY: International Platform of Registered Systematic Review and Meta-analysis Protocols. doi: 10.37766/inplasy2023.2.0120
2022
Conference Publication
Pharmacokinetics of polymyxin B and the pharmacokinetic/pharmacodynamic target attainment in hospitalised adult patients with multidrug-resistant gram-negative infections
Zamri, Puteri Juanita, Abdul-Aziz, Mohd-Hafiz, Hernandez-Mitre, Maria Patricia, Hasan, Mohd Shahnaz, Shariff, Izyani Md, Sulaiman, Helmi, Wallis, Steve, Sumi, Chandra Datta, Sime, Fekade Bruck and Roberts, Jason A (2022). Pharmacokinetics of polymyxin B and the pharmacokinetic/pharmacodynamic target attainment in hospitalised adult patients with multidrug-resistant gram-negative infections. 32nd International Congress of Antimicrobial Chemotherapy (ICC), Perth, Australia, 27-30 November 2022. Amsterdam, Netherlands: Elsevier . doi: 10.1016/s2213-7165(22)00339-3
Funding
Past funding
Supervision
Availability
- Dr Patty Mitre is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Paediatric antibiotic pharmacokinetics and micro-sampling utility and in the paediatric intensive care
Associate Advisor
Other advisors: Dr Mark Coulthard, Emeritus Professor Jeffrey Lipman, Dr Xin Liu, Professor Jason Roberts
-
Doctor Philosophy
Peri-Operative Pharmacokinetics of Surgical Antimicrobial Prophylaxis.
Associate Advisor
Other advisors: Emeritus Professor Jeffrey Lipman, Adjunct Professor Andre Van Zundert, Professor Jason Roberts
Media
Enquiries
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