Overview
Background
Dr Leon Hugo is a medical entomologist conducting research into the biology of mosquitoes, host-parasite interactions and the development of novel control strategies against arthropod-borne viruses (arboviruses). Dr Hugo is an Honorary Associate Professor through the School of Biomedical Sciences and is also the Academic Lead of the Mosquito Control Laboratory at QIMR Berghofer medical research institute, Brisbane. Dr Hugo has developed and applied experimental mosquito models of arbovirus infection for over 15 years to establish the risk of arbovirus transmission in Australia and new biological controls. Dr Hugo works with physical containment/biosecurity level (PC/BSL) 2 and 3 arboviruses, including dengue, Zika, Japanese encephalitis and chikungunya viruses and performs fundamental research on Wolbachia bacteria and Insect-specific virus (ISV) microbial control agents. Dr Hugo has published 60+ research articles with over 160 collaborators, from academic, medical, government and corporate sectors, across 18 countries. Topic areas his publications have had greatest impact were Japanese Encephalitis and Socioeconomic Impact, Wolbachia’s Role in Mosquito Population Replacement and Insecticide Resistance Mechanisms in Aedes aegypti.
Dr Hugo’s team maintains a living library of native and exotic mosquito species and conducts infection and transmission studies in state-of-the-art PC2 and PC3 insectaries. Research themes including mosquito vector competence, climate change impacts on mosquito-borne disease transmission risk, mosquito and arbovirus surveillance and genomics and novel control strategies, including biological control and the use of endectocides.
Availability
- Dr Leon Hugo is:
- Available for supervision
Qualifications
- Doctor of Philosophy, The University of Queensland
Research impacts
Seven of Dr Hugo's publications have attracted over 40 citations in policy documents across 8+ countries from agencies including the WHO, State of Hawaii and the OECD.
Works
Search Professor Leon Hugo’s works on UQ eSpace
2025
Journal Article
Fitness compatibility and dengue virus Inhibition in a Bangladeshi strain of Aedes aegypti infected with the Wolbachia strain wAlbB
Al-Amin, Hasan Mohammad, Gyawali, Narayan, Graham, Melissa, Alam, Mohammad Shafiul, Lenhart, Audrey, Xi, Zhiyong, Rašić, Gordana, Beebe, Nigel W., Hugo, Leon E. and Devine, Gregor J. (2025). Fitness compatibility and dengue virus Inhibition in a Bangladeshi strain of Aedes aegypti infected with the Wolbachia strain wAlbB. Scientific Reports, 15 (1) 13425, 1-18. doi: 10.1038/s41598-025-98093-x
2025
Journal Article
Transcriptomic response of mosquitoes to Japanese encephalitis virus and identification of its potential entry factors
Hussain, Mazhar, Etebari, Kayvan, Parry, Rhys H., Khromykh, Alexander A., Hugo, Leon E. and Asgari, Sassan (2025). Transcriptomic response of mosquitoes to Japanese encephalitis virus and identification of its potential entry factors. npj Viruses, 3 (1) 68, 68-1. doi: 10.1038/s44298-025-00151-8
2025
Journal Article
Assessment of the transmission of live-attenuated chikungunya virus vaccine VLA1553 by Aedes albopictus mosquitoes
Fritzer, Andrea, Suhrbier, Andreas, Hugo, Leon E., Tang, Bing, Devine, Greg, Jost, Sandra and Meinke, Andreas L. (2025). Assessment of the transmission of live-attenuated chikungunya virus vaccine VLA1553 by Aedes albopictus mosquitoes. Parasites & Vectors, 18 (1) 171. doi: 10.1186/s13071-025-06789-w
2024
Journal Article
Unleashing nature’s allies: comparing the vertical transmission dynamics of insect-specific and vertebrate-infecting flaviviruses in mosquitoes
Peterson, Alyssa J., Hall, Roy A., Harrison, Jessica J., Hobson-Peters, Jody and Hugo, Leon E. (2024). Unleashing nature’s allies: comparing the vertical transmission dynamics of insect-specific and vertebrate-infecting flaviviruses in mosquitoes. Viruses, 16 (9) 1499, 1499. doi: 10.3390/v16091499
2024
Journal Article
Estimation of population age structure, daily survival rates, and potential to support dengue virus transmission for Florida Keys Aedes aegypti via transcriptional profiling
Pruszynski, Catherine A., Buckner, Eva A., Burkett-Cadena, Nathan D., Hugo, Leon E., Leal, Andrea L. and Caragata, Eric P. (2024). Estimation of population age structure, daily survival rates, and potential to support dengue virus transmission for Florida Keys Aedes aegypti via transcriptional profiling. PLoS Neglected Tropical Diseases, 18 (8) e0012350. doi: 10.1371/journal.pntd.0012350
2024
Journal Article
Generating prophylactic immunity against arboviruses in vertebrates and invertebrates
Rawle, Daniel J., Hugo, Leon E., Cox, Abigail L., Devine, Gregor J. and Suhrbier, Andreas (2024). Generating prophylactic immunity against arboviruses in vertebrates and invertebrates. Nature Reviews Immunology, 24 (9), 621-636. doi: 10.1038/s41577-024-01016-6
2024
Journal Article
Rapid low-resource detection of Plasmodium falciparum in infected Anopheles mosquitoes
Hugo, Leon E., van Huyssteen, Karla, Oloniniyi, Olamide, Donnelly, Laura, Conn, Anna, Collins, Katharine A., Mitchell, Hayley, McCarthy, James S. and Macdonald, Joanne (2024). Rapid low-resource detection of Plasmodium falciparum in infected Anopheles mosquitoes. Frontiers in Tropical Diseases, 5 1287025. doi: 10.3389/fitd.2024.1287025
2023
Journal Article
Statement in Support of: “Virology under the Microscope—a Call for Rational Discourse”
Speck, Peter, Mackenzie, Jason, Bull, Rowena A., Slobedman, Barry, Drummer, Heidi, Fraser, Johanna, Herrero, Lara, Helbig, Karla, Londrigan, Sarah, Moseley, Gregory, Prow, Natalie, Hansman, Grant, Edwards, Robert, Ahlenstiel, Chantelle, Abendroth, Allison, Tscharke, David, Hobson-Peters, Jody, Kriiger-Loterio, Robson, Parry, Rhys, Marsh, Glenn, Harding, Emma, Jacques, David A., Gartner, Matthew J., Lee, Wen Shi, McAuley, Julie, Vaz, Paola, Sainsbury, Frank, Tate, Michelle D., Sinclair, Jane ... Young, Paul (2023). Statement in Support of: “Virology under the Microscope—a Call for Rational Discourse”. mSphere, 8 (3) e0016523, 1-3. doi: 10.1128/msphere.00165-23
2023
Journal Article
Statement in Support of: “Virology under the Microscope—a Call for Rational Discourse”
Speck, Peter, Mackenzie, Jason, Bull, Rowena A., Slobedman, Barry, Drummer, Heidi, Fraser, Johanna, Herrero, Lara, Helbig, Karla, Londrigan, Sarah, Moseley, Gregory, Prow, Natalie, Hansman, Grant, Edwards, Robert, Ahlenstiel, Chantelle, Abendroth, Allison, Tscharke, David, Hobson-Peters, Jody, Kriiger-Loterio, Robson, Parry, Rhys, Marsh, Glenn, Harding, Emma, Jacques, David A., Gartner, Matthew J., Lee, Wen Shi, McAuley, Julie, Vaz, Paola, Sainsbury, Frank, Tate, Michelle D., Sinclair, Jane ... Young, Paul (2023). Statement in Support of: “Virology under the Microscope—a Call for Rational Discourse”. Journal of Virology, 97 (5) e0045123, 1-3. doi: 10.1128/jvi.00451-23
2023
Journal Article
Statement in Support of: “Virology under the Microscope—a Call for Rational Discourse”
Speck, Peter, Mackenzie, Jason, Bull, Rowena A., Slobedman, Barry, Drummer, Heidi, Fraser, Johanna, Herrero, Lara, Helbig, Karla, Londrigan, Sarah, Moseley, Gregory, Prow, Natalie, Hansman, Grant, Edwards, Robert, Ahlenstiel, Chantelle, Abendroth, Allison, Tscharke, David, Hobson-Peters, Jody, Kriiger-Loterio, Robson, Parry, Rhys, Marsh, Glenn, Harding, Emma, Jacques, David A., Gartner, Matthew J., Lee, Wen Shi, McAuley, Julie, Vaz, Paola, Sainsbury, Frank, Tate, Michelle D., Sinclair, Jane ... Young, Paul (2023). Statement in Support of: “Virology under the Microscope—a Call for Rational Discourse”. mBio, 14 (3) e0081523, 1-3. doi: 10.1128/mbio.00815-23
2023
Journal Article
Insecticide resistance compromises the control of Aedes aegypti in Bangladesh
Al‐Amin, Hasan Mohammad, Gyawali, Narayan, Graham, Melissa, Alam, Mohammad Shafiul, Lenhart, Audrey, Hugo, Leon E., Rašić, Gordana, Beebe, Nigel W. and Devine, Gregor J. (2023). Insecticide resistance compromises the control of Aedes aegypti in Bangladesh. Pest Management Science, 79 (8), 2846-2861. doi: 10.1002/ps.7462
2023
Journal Article
Immunogenicity of a single fractional intradermal dose of Japanese encephalitis live attenuated chimeric vaccine
Furuya-Kanamori, Luis, Gyawali, Narayan, Mills, Deborah J., Mills, Christine, Hugo, Leon E, Devine, Gregor J. and Lau, Colleen L. (2023). Immunogenicity of a single fractional intradermal dose of Japanese encephalitis live attenuated chimeric vaccine. Journal of Travel Medicine, 30 (2) taac122, 1-8. doi: 10.1093/jtm/taac122
2023
Journal Article
Statement in Support of: “Virology under the Microscope-a Call for Rational Discourse”
Speck, Peter, Mackenzie, Jason, Bull, Rowena A., Slobedman, Barry, Drummer, Heidi, Fraser, Johanna, Herrero, Lara, Helbig, Karla, Londrigan, Sarah, Moseley, Gregory, Prow, Natalie, Hansman, Grant, Edwards, Robert, Ahlenstiel, Chantelle, Abendroth, Allison, Tscharke, David, Hobson-Peters, Jody, Kriiger-Loterio, Robson, Parry, Rhys, Marsh, Glenn, Harding, Emma, Jacques, David A., Gartner, Matthew J., Lee, Wen Shi, McAuley, Julie, Vaz, Paola, Sainsbury, Frank, Tate, Michelle D., Sinclair, Jane ... Young, Paul (2023). Statement in Support of: “Virology under the Microscope-a Call for Rational Discourse”. Journal of Virology, 97 (5). doi: 10.1128/jvi.00451-23
2022
Journal Article
Rapid molecular assays for the detection of the four dengue viruses in infected mosquitoes
Ahmed, Madeeha, Pollak, Nina M., Hugo, Leon E., van den Hurk, Andrew F., Hobson-Peters, Jody and Macdonald, Joanne (2022). Rapid molecular assays for the detection of the four dengue viruses in infected mosquitoes. Gates Open Research, 6 81, 1-20. doi: 10.12688/gatesopenres.13534.2
2022
Journal Article
Detection of Dengue Virus 2 with single infected mosquito resolution using yeast affinity bionanofragments and plasmonic SERS nanoboxes
Farokhinejad, Fahimeh, Li, Junrong, Hugo, Leon E., Howard, Christopher B., Wuethrich, Alain and Trau, Matt (2022). Detection of Dengue Virus 2 with single infected mosquito resolution using yeast affinity bionanofragments and plasmonic SERS nanoboxes. Analytical Chemistry, 94 (41), 14177-14184. doi: 10.1021/acs.analchem.2c02012
2022
Journal Article
Japanese encephalitis emergence in Australia: the potential population at risk
Yakob, Laith, Hu, Wenbiao, Frentiu, Francesca D, Gyawali, Narayan, Hugo, Leon E, Johnson, Brian, Lau, Colleen, Furuya-Kanamori, Luis, Magalhaes, Ricardo Soares and Devine, Gregor (2022). Japanese encephalitis emergence in Australia: the potential population at risk. Clinical Infectious Diseases, 76 (2), 335-337. doi: 10.1093/cid/ciac794
2022
Journal Article
Rapid detection of kdr mutation F1534C in Aedes aegypti using recombinase polymerase amplification and lateral flow dipsticks
Ahmed, Madeeha, Nath, Nisa Suraj, Hugo, Leon E., Devine, Gregor J., Macdonald, Joanne and Pollak, Nina M. (2022). Rapid detection of kdr mutation F1534C in Aedes aegypti using recombinase polymerase amplification and lateral flow dipsticks. Pesticide Biochemistry and Physiology, 187 105209, 1-7. doi: 10.1016/j.pestbp.2022.105209
2022
Journal Article
Wolbachia wAlbB inhibit dengue and Zika infection in the mosquito Aedes aegypti with an Australian background
Hugo, Leon E., Rašić, Gordana, Maynard, Andrew J., Ambrose, Luke, Liddington, Catherine, Thomas, Callum J. E., Nath, Nisa Suraj, Graham, Melissa, Winterford, Clay, Wimalasiri-Yapa, B M C Randika, Xi, Zhiyong, Beebe, Nigel W. and Devine, Gregor J. (2022). Wolbachia wAlbB inhibit dengue and Zika infection in the mosquito Aedes aegypti with an Australian background. PLoS Neglected Tropical Diseases, 16 (10) e0010786, e0010786. doi: 10.1371/journal.pntd.0010786
2022
Journal Article
Analysis of Aedes aegypti microRNAs in response to Wolbachia wAlbB infection and their potential role in mosquito longevity
Bishop, Cameron, Hussain, Mazhar, Hugo, Leon E. and Asgari, Sassan (2022). Analysis of Aedes aegypti microRNAs in response to Wolbachia wAlbB infection and their potential role in mosquito longevity. Scientific Reports, 12 (1) 15245, 1-17. doi: 10.1038/s41598-022-19574-x
2022
Journal Article
Reporter flaviviruses as tools to demonstrate homologous and heterologous superinfection exclusion
Torres, Francisco J., Parry, Rhys, Hugo, Leon E., Slonchak, Andrii, Newton, Natalee D., Vet, Laura J., Modhiran, Naphak, Pullinger, Brody, Wang, Xiaohui, Potter, James, Winterford, Clay, Hobson-Peters, Jody, Hall, Roy A. and Khromykh, Alexander A. (2022). Reporter flaviviruses as tools to demonstrate homologous and heterologous superinfection exclusion. Viruses, 14 (7) 1501, 1501. doi: 10.3390/v14071501
Supervision
Availability
- Dr Leon Hugo is:
- Available for supervision
Looking for a supervisor? Read our advice on how to choose a supervisor.
Supervision history
Current supervision
-
Doctor Philosophy
Insect-specific viruses as tools for the downregulation of mosquito vector competence for arboviruses
Principal Advisor
Other advisors: Associate Professor Jody Peters
-
Doctor Philosophy
Investigation of factors affecting the maternal transmission of Insect-specific viruses by mosquitoes
Principal Advisor
Other advisors: Associate Professor Jody Peters
-
Doctor Philosophy
Engineering chimeric viruses as protective and safe vaccines against mosquito-borne viral disease
Associate Advisor
Other advisors: Professor Alexander Khromykh, Dr Andrii Slonchak, Associate Professor Jody Peters
-
Doctor Philosophy
Exploring the development of a malaria refractory Anopheles farauti
Associate Advisor
Other advisors: Professor Sassan Asgari, Professor Nigel Beebe
Completed supervision
-
2023
Doctor Philosophy
New tools for managing Aedes-borne diseases in Bangladesh
Associate Advisor
Other advisors: Professor Nigel Beebe
-
2021
Doctor Philosophy
The biological costs and benefits associated with a pyrethroid-resistant genotype of Aedes aegypti
Associate Advisor
Other advisors: Professor Nigel Beebe
-
2020
Doctor Philosophy
Interaction between flaviviruses and the vector Aedes aegypti, an overview into replication and microRNAs
Associate Advisor
Other advisors: Professor Nigel Beebe, Professor Sassan Asgari
-
2020
Doctor Philosophy
Characterization of Wolbachia infections from native Australian mosquitoes
Associate Advisor
Other advisors: Professor Sassan Asgari
Media
Enquiries
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