Overview
Background
David Evans is an NHMRC Leadership Fellow and Professor of Statistical Genetics at the University of Queensland Institute for Molecular Bioscience. He is a winner of the NHMRC Marshall and Warren Award.
He completed his PhD in Statistical Genetics at the University of Queensland in 2003, before undertaking a four-year post-doctoral fellowship at the Wellcome Trust Centre for Human Genetics, University of Oxford where he worked as part of the The International HapMap Consortium and co-led the analysis of four diseases within the first Wellcome Trust Case Control Consortium. In 2007 he moved to take up a Senior Lecturer position at the University of Bristol where he led much of the genome-wide association studies work in the Avon Longitudinal Study of Parents and Children (ALSPAC). In 2013 he returned to take up a chair at the University of Queensland whilst continuing to lead an MRC Programme in statistical genetics at the University of Bristol.
His research interests include the genetic mapping of complex traits and diseases (including birthweight and other perinatal traits, osteoporosis, ankylosing spondylitis, sepsis, laterality) and the development of statistical methodologies in genetic epidemiology including approaches for gene mapping, individual risk prediction, causal modelling and dissecting the genetic architecture of complex traits. He has a particular interest in Mendelian randomization and has used it and other causal methods to investigate the Developmental Origins of Health and Disease (DOHaD)- the idea that adverse intrauterine exposures lead to increased risk of disease in later life.
He is Academic Codirector at the NIH funded International Workshop on Statistical Genetics Methods and is faculty on the European Programme in Educational Epidemiology.
He is Associate Editor at the International Journal of Epidemiology and Behavior Genetics journals.
Availability
- Professor David Evans is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Bachelor (Honours), The University of Queensland
- Doctor of Philosophy, The University of Queensland
Research interests
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Mendelian randomization
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Genome-wide association studies
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Causal Modeling
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Developmental Origins of Health and Disease (DOHaD)
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Laterality
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Sepsis
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Osteoporosis
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Ankylosing Spondylitis
Works
Search Professor David Evans’s works on UQ eSpace
2016
Journal Article
Genome-wide associations for birth weight and correlations with adult disease
Horikoshi, Momoko, Beaumont, Robin N., Day, Felix R., Warrington, Nicole M., Kooijman, Marjolein N., Fernandez-Tajes, Juan, Feenstra, Bjarke, van Zuydam, Natalie R., Gaulton, Kyle J., Grarup, Niels, Bradfield, Jonathan P., Strachan, David P., Li-Gao, Ruifang, Ahluwalia, Tarunveer S., Kreiner, Eskil, Rueedi, Rico, Lyytikainen, Leo-Pekka, Cousminer, Diana L., Wu, Ying, Thiering, Elisabeth, Wang, Carol A., Have, Christian T., Hottenga, Jouke-Jan, Vilor-Tejedor, Natalia, Joshi, Peter K., Boh, Eileen Tai Hui, Ntalla, Ioanna, Pitkanen, Niina, Mahajan, Anubha ... Freathy, Rachel M. (2016). Genome-wide associations for birth weight and correlations with adult disease. Nature, 538 (7624), 248-252. doi: 10.1038/nature19806
2016
Journal Article
Using Mendelian randomization to investigate a possible causal relationship between adiposity and increased bone mineral density at different skeletal sites in children
Kemp, John P., Sayers, Adrian, Smith, George Davey, Tobias, Jonathan H. and Evans, David M. (2016). Using Mendelian randomization to investigate a possible causal relationship between adiposity and increased bone mineral density at different skeletal sites in children. International Journal of Epidemiology, 45 (5), 1560-1572. doi: 10.1093/ije/dyw079
2016
Journal Article
Heritability and genome-wide association analyses of sleep duration in children: the EAGLE consortium
Marinelli, Marcella, Pappa, Irene, Bustamante, Mariona, Bonilla, Carolina, Suarez, Anna, Tiesler, Carla M., Vilor-Tejedor, Natalia, Zafarmand, Mohammad Hadi, Alvarez-Pedrerol, Mar, Andersson, Sture, Bakermans-Kranenburg, Marian J., Estivill, Xavier, Evans, David M., Flexeder, Claudia, Forns, Joan, Gonzalez, Juan R., Guxens, Monica, Huss, Anke, van IJzendoorn, Marinus H., Jaddoe, Vincent W. V., Julvez, Jordi, Lahti, Jari, Lopez-Vicente, Monica, Lopez-Espinosa, Maria-Jose, Manz, Judith, Mileva-Seitz, Viara R., Perola, Markus, Pesonen, Anu-Katriina, Rivadeneira, Fernando ... Sunyer, Jordi (2016). Heritability and genome-wide association analyses of sleep duration in children: the EAGLE consortium. Sleep, 39 (10), 1859-1869. doi: 10.5665/sleep.6170
2016
Journal Article
A genome-wide association meta-analysis of attention-deficit/hyperactivity disorder symptoms in population-based pediatric cohorts
Middeldorp, Christel M., Hammerschlag, Anke R., Ouwens, Klaasjan G., Groen-Blokhuis, Maria M., St Pourcain, Beate, Greven, Corina U., Pappa, Irene, Tiesler, Carla M. T., Ang, Wei, Nolte, Ilja M., Vilor-Tejedor, Natalia, Bacelis, Jonas, Ebejer, Jane L., Zhao, Huiying, Davies, Gareth E., Ehli, Erik A., Evans, David M., Fedko, Iryna O., Guxens, Monica, Hottenga, Jouke-Jan, Hudziak, James J., Jugessur, Astanand, Kemp, John P., Krapohl, Eva, Martin, Nicholas G., Murcia, Mario, Myhre, Ronny, Ormel, Johan, Ring, Susan M. ... Boomsma, Dorret I. (2016). A genome-wide association meta-analysis of attention-deficit/hyperactivity disorder symptoms in population-based pediatric cohorts. Journal of the American Academy of Child and Adolescent Psychiatry, 55 (10), 896-905.e6. doi: 10.1016/j.jaac.2016.05.025
2016
Journal Article
Why internal weights should be avoided (not only) in MR-Egger regression response
Kemp, John P., Sayers, Adrian, Smith, George Davey, Tobias, Jonathan H. and Evans, David M. (2016). Why internal weights should be avoided (not only) in MR-Egger regression response. International Journal of Epidemiology, 45 (5), 1678-1679. doi: 10.1093/ije/dyw241
2016
Journal Article
A genome-wide association meta-analysis of diarrhoeal disease in young children identifies FUT2 locus and provides plausible biological pathways
Bustamante, Mariona, Standl, Marie, Bassat, Quique, Vilor-Tejedor, Natalia, Medina-Gomez, Carolina, Bonilla, Carolina, Ahluwalia, Tarunveer S., Bacelis, Jonas, Bradfield, Jonathan P., Tiesler, Carla M. T., Rivadeneira, Fernando, Ring, Susan, Vissing, Nadja H., Fink, Nadia R., Jugessur, Astanand, Mentch, Frank D., Ballester, Ferran, Kriebel, Jennifer, Kiefte-de Jong, Jessica C., Wolsk, Helene M., Llop, Sabrina, Thiering, Elisabeth, Beth, Systke A., Timpson, Nicholas J., Andersen, Josefine, Schulz, Holger, Jaddoe, Vincent W. V., Evans, David M., Waage, Johannes ... Sunyer, Jordi (2016). A genome-wide association meta-analysis of diarrhoeal disease in young children identifies FUT2 locus and provides plausible biological pathways. Human Molecular Genetics, 25 (18), 4127-4142. doi: 10.1093/hmg/ddw264
2016
Journal Article
Genome-wide association study of copy number variation with lung function identifies a novel signal of association near BANP for forced vital capacity
Shrine, Nick, Tobin, Martin D., Schurmann, Claudia, Artigas, Maria Soler, Hui, Jennie, Lehtimaki, Terho, Raitakari, Olli T., Pennell, Craig E., Ang, Qi Wei, Strachan, David P., Homuth, Georg, Glaeser, Sven, Felix, Stephan B., Evans, David M., Henderson, John, Granell, Raquel, Palmer, Lyle J., Huffman, Jennifer, Hayward, Caroline, Scotland, Generation, Malarstig, Anders, Musk, Bill, James, Alan L. and Wain, Louise V. (2016). Genome-wide association study of copy number variation with lung function identifies a novel signal of association near BANP for forced vital capacity. BMC Genetics, 17 (1) 116, 1-8. doi: 10.1186/s12863-016-0423-0
2016
Journal Article
Erratum to: Heritability and genome-wide analyses of problematic peer relationships during childhood and adolescence
Pourcain, Beate St, Haworth, C. M. A., Davis, O. S. P., Wang, Kai, Timpson, Nicholas J., Evans, David M., Kemp, John P., Ronald, Angelica, Price, Tom, Meaburn, Emma, Ring, Susan M., Golding, Jean, Hakonarson, Hakon, Plomin, R. and Smith, George Davey (2016). Erratum to: Heritability and genome-wide analyses of problematic peer relationships during childhood and adolescence. Human Genetics, 135 (8), 965-965. doi: 10.1007/s00439-016-1695-1
2016
Journal Article
Joint developmental trajectories of internalizing and externalizing disorders between childhood and adolescence
Nivard, Michel G., Lubke, Gitta H., Dolan, Conor V., Evans, David M., St. Pourcain, Beate, Munafo, Marcus R. and Middeldorp, Christel M. (2016). Joint developmental trajectories of internalizing and externalizing disorders between childhood and adolescence. Development and Psychopathology, 29 (3), 1-10. doi: 10.1017/S0954579416000572
2016
Journal Article
International genome-wide association study consortium identifies novel loci associated with blood pressure in children and adolescents
Parmar, Priyakumari Ganesh, Taal, H. Rob, Timpson, Nicholas J., Thiering, Elisabeth, Lehtimaki, Terho, Marinelli, Marcella, Lind, Penelope A., Howe, Laura D., Verwoert, Germaine, Aalto, Ville, Uitterlinden, Andre G., Briollais, Laurent, Evans, Dave M., Wright, Margie J., Newnham, John P., Whitfield, John B., Lyytikainen, Leo-Pekka, Rivadeneira, Fernando, Boomsma, Dorrett I., Viikari, Jorma, Gillman, Matthew W., St Pourcain, Beate, Hottenga, Jouke-Jan, Montgomery, Grant W., Hofman, Albert, Kahonen, Mika, Martin, Nicholas G., Tobin, Martin D., Raitakari, Ollie ... Palmer, Lyle J. (2016). International genome-wide association study consortium identifies novel loci associated with blood pressure in children and adolescents. Circulation: Cardiovascular Genetics, 9 (3), 266-278. doi: 10.1161/CIRCGENETICS.115.001190
2016
Journal Article
The case for genome-wide association studies of bone acquisition in paediatric and adolescent populations
Kemp, John P, Medina-Gomez, Carolina, Tobias, Jonathan H, Rivadeneira, Fernando and Evans, David M (2016). The case for genome-wide association studies of bone acquisition in paediatric and adolescent populations. BoneKEy reports, 5, 796. doi: 10.1038/bonekey.2016.23
2016
Journal Article
Childhood gene-environment interactions and age-dependent effects of genetic variants associated with refractive error and myopia: the CREAM Consortium
Fan, Qiao, Guo, Xiaobo, Tideman, J. Willem L., Williams, Katie M., Yazar, Seyhan, Hosseini, S. Mohsen, Howe, Laura D., St Pourcain, Beate, Evans, David M., Timpson, Nicholas J., McMahon, George, Hysi, Pirro G., Krapohl, Eva, Wang, Ya Xing, Jonas, Jost B., Baird, Paul Nigel, Wang, Jie Jin, Cheng, Ching-Yu, Teo, Yik-Ying, Wong, Tien-Yin, Ding, Xiaohu, Wojciechowski, Robert, Young, Terri L., Parssinen, Olavi, Oexle, Konrad, Pfeiffer, Norbert, Bailey-Wilson, Joan E., Paterson, Andrew D., Klaver, Caroline C. W. ... Guggenheim, Jeremy A. (2016). Childhood gene-environment interactions and age-dependent effects of genetic variants associated with refractive error and myopia: the CREAM Consortium. Scientific Reports, 6 (1) 25853, 25853. doi: 10.1038/srep25853
2016
Journal Article
Genome-wide association study identifies 74 loci associated with educational attainment
Okbay, Aysu, Beauchamp, Jonathan P., Fontana, Mark Alan, Lee, James J., Pers, Tune H., Rietveld, Cornelius A., Turley, Patrick, Chen, Guo-Bo, Emilsson, Valur, Meddens, S. Fleur W., Oskarsson, Sven, Pickrell, Joseph K., Thom, Kevin, Timshel, Pascal, de Vlaming, Ronald, Abdellaoui, Abdel, Ahluwalia, Tarunveer S., Bacelis, Jonas, Baumbach, Clemens, Bjornsdottir, Gyda, Brandsma, Johannes H., Concas, Maria Pina, Derringer, Jaime, Furlotte, Nicholas A., Galesloot, Tessel E., Girotto, Giorgia, Gupta, Richa, Hall, Leanne M., Harris, Sarah E. ... Benjamin, Daniel J. (2016). Genome-wide association study identifies 74 loci associated with educational attainment. Nature, 533 (7604), 539-542. doi: 10.1038/nature17671
2016
Journal Article
Exome-wide study of ankylosing spondylitis demonstrates additional shared genetic background with inflammatory bowel disease
Robinson, Philip C., Leo, Paul J, Pointon, Jennifer J., Harris, Jessica, Cremin, Katie, Bradbury, Linda A., Stebbings, Simon, Harrison, Andrew A., Australian Osteoporosis Genetics Consortium, Wellcome Trust Case Control Consortium, Management Committee, Data and Analysis Group, DNA, Genotyping, Data QC and Informatics Group, Publications Committee, Duncan, Emma L., Evans, David M., Wordsworth, Paul B. and Brown, Matthew A. (2016). Exome-wide study of ankylosing spondylitis demonstrates additional shared genetic background with inflammatory bowel disease. NPJ Genomic Medicine, 1 (1) 16008, 16008-6. doi: 10.1038/npjgenmed.2016.8
2016
Journal Article
Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population
Robinson, Elise B., St Pourcain, Beate, Anttila, Verneri, Kosmicki, Jack A., Bulik-Sullivan, Brendan, Grove, Jakob, Maller, Julian, Samocha, Kaitlin E., Sanders, Stephan J., Ripke, Stephan, Martin, Joanna, Hollegaard, Mads V., Werge, Thomas, Hougaard, David M., Neale, Benjamin M., Evans, David M., Skuse, David, Mortensen, Preben Bo, Børglum, Anders D., Ronald, Angelica, Smith, George Davey and Daly, Mark J. (2016). Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population. Nature Genetics, 48 (5), 552-555. doi: 10.1038/ng.3529
2016
Journal Article
Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error
Fan, Qiao, Verhoeven, Virginie J. M., Wojciechowski, Robert, Barathi, Veluchamy A., Hysi, Pirro G., Guggenheim, Jeremy A., Hoehn, Rene, Vitart, Veronique, Khawaja, Anthony P., Yamashiro, Kenji, Hosseini, S. Mohsen, Lehtimaki, Terho, Lu, Yi, Haller, Toomas, Xie, Jing, Delcourt, Cecile, Pirastu, Mario, Wedenoja, Juho, Gharahkhani, Puya, Venturini, Cristina, Miyake, Masahiro, Hewitt, Alex W., Guo, Xiaobo, Mazur, Johanna, Huffman, Jenifer E., Williams, Katie M., Polasek, Ozren, Campbell, Harry, Rudan, Igor ... Makela, Kari Matti (2016). Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error. Nature Communications, 7 (1) 11008, 11008-11008. doi: 10.1038/ncomms11008
2016
Journal Article
Common genetic variants influence whorls in fingerprint patterns
Ho, Yvonne Y. W., Evans, David M., Montgomery, Grant W., Henders, Anjali K., Kemp, John P., Timpson, Nicholas J., Pourcain, Beate St., Heath, Andrew C., Madden, Pamela A. F., Loesch, Danuta Z., McNevin, Dennis, Daniel, Runa, Davey-Smith, George, Martin, Nicholas G. and Medland, Sarah E. (2016). Common genetic variants influence whorls in fingerprint patterns. Journal of Investigative Dermatology, 136 (4), 859-862. doi: 10.1016/j.jid.2015.10.062
2016
Journal Article
Systematic identification of genetic influences on methylation across the human life course
Gaunt, Tom R., Shihab, Hashem A., Hemani, Gibran, Min, Josine L., Woodward, Geoff, Lyttleton, Oliver, Zheng, Jie, Duggirala, Aparna, McArdle, Wendy L., Ho, Karen, Ring, Susan M., Evans, David M., Smith, George Davey and Relton, Caroline L. (2016). Systematic identification of genetic influences on methylation across the human life course. Genome Biology, 17 (1) 61, 61. doi: 10.1186/s13059-016-0926-z
2016
Journal Article
Genetic evidence for causal relationships between maternal obesity-related traits and birth weight
Tyrrell, Jessica, Richmond, Rebecca C., Palmer, Tom M., Feenstra, Bjarke, Rangarajan, Janani, Metrustry, Sarah, Cavadino, Alana, Paternoster, Lavinia, Armstrong, Loren L., De Silva, N. Maneka G., Wood, Andrew R., Horikoshi, Momoko, Geller, Frank, Myhre, Ronny, Bradfield, Jonathan P., Kreiner-Moller, Eskil, Huikari, Ville, Painter, Jodie N., Hottenga, Jouke-Jan, Allard, Catherine, Berry, Diane J., Bouchard, Luigi, Das, Shikta, Evans, David M., Hakonarson, Hakon, Hayes, M. Geoffrey, Heikkinen, Jani, Hofman, Albert, Knight, Bridget ... Freathy, Rachel M. (2016). Genetic evidence for causal relationships between maternal obesity-related traits and birth weight. Journal of the American Medical Association, 315 (11), 1129-1140. doi: 10.1001/jama.2016.1975
2016
Journal Article
Association of forced vital capacity with the developmental gene NCOR2
Minelli, Cosetta, Dean, Charlotte H., Hind, Matthew, Alves, Alexessander Couto, Amaral, Andre F. S., Siroux, Valerie, Huikari, Ville, Artigas, Maria Soler, Evans, David M., Loth, Daan W., Bosse, Yohan, Postma, Dirkje S., Sin, Don, Thompson, John, Demenais, Florence, Henderson, John, Bouzigon, Emmanuelle, Jarvis, Deborah, Jarvelin, Marjo-Riitta and Burney, Peter (2016). Association of forced vital capacity with the developmental gene NCOR2. Plos One, 11 (2) e0147388, e0147388-e0147388. doi: 10.1371/journal.pone.0147388
Funding
Current funding
Supervision
Availability
- Professor David Evans is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Available projects
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Sometimes Correlation does Equal Causation: Developing Statistical Methods to Determine Causality Using Genetic Data
There is a well-known mantra that correlation does not necessarily equal causation. This is why randomized controlled trials in which participants are physically randomized into treatment and placebo groups are the gold standard for assessing causality in epidemiological investigations. However, what is less appreciated is that strong evidence for causality can sometimes be obtained using observational data only. In particular, genotypes are randomly transmitted from parents to their offspring independent of the environment and other confounding factors, meaning that genotypes associated with particular traits can be used like natural “randomized controlled trials” to examine whether these traits causally affect risk of disease.
The aim of this PhD project is to develop statistical methods to assess causality using observational data alone. The successful candidate will gain experience across a wide range of advanced statistical genetics methodologies including Mendelian randomization (a way of using genetic variants to investigate putatively causal relationships), structural equation modelling, genome-wide association analysis (GWAS), genetic restricted maximum likelihood (G-REML) analysis of genome-wide data which can be used to partition variation in phenotypes into genetic and environmental sources of variation, and instrumental variables analysis (using natural “experiments” to obtain information on causality from observational data). The candidate will apply the new statistical methods that they develop to large genetically informative datasets like the UK Biobank (500,000 individuals with genome-wide SNP data).
Supervision history
Current supervision
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Doctor Philosophy
Developing and Applying Statistical Genetics Methods to Elucidate the Developmental Origins of Health and Disease
Principal Advisor
Other advisors: Dr Nicole Warrington
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Doctor Philosophy
Investigating the association between maternal and fetal HLA-KIR genotypes and offspring birth weight
Principal Advisor
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Doctor Philosophy
Understanding the genetic epidemiology of women's reproductive health
Principal Advisor
Other advisors: Dr Gunn-Helen Moen
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Doctor Philosophy
Harnessing Genetically Informative Within-Family Research Designs for Deeper Insights into the Intrauterine Developmental Period and Downstream Effects on Offspring Neurodevelopmental Outcomes
Principal Advisor
Other advisors: Dr Daniel Hwang, Dr Gunn-Helen Moen
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Doctor Philosophy
Multi-omic Approaches to Understanding Septic Shock
Principal Advisor
Other advisors: Dr Daniel Hwang
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Doctor Philosophy
Using multi-omics approaches to characterise determinants of early growth trajectories and their consequences on later life health
Associate Advisor
Other advisors: Honorary Professor Jake Gratten, Dr Nicole Warrington
Completed supervision
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2023
Doctor Philosophy
Using Genetics to Understand the Relationship Between the Intrauterine Environment and Future Offspring Cardiometabolic Risk
Principal Advisor
Other advisors: Dr Nicole Warrington
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2019
Doctor Philosophy
Detecting and Quantifying the Effect of Assortative mating and Maternal Effects on Statistical Genetics Analyses
Principal Advisor
Other advisors: Dr Nicole Warrington
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Media
Enquiries
Contact Professor David Evans directly for media enquiries about:
- Genetics
- Genome-wide association
- Mendelian randomization
- Twin Studies
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