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2020

Journal Article

RelB suppresses type I Interferon signaling in dendritic cells

Saha, Irene, Jaiswal, Hemant, Mishra, Richa, Nel, Hendrik J., Schreuder, Jaring, Kaushik, Monika, Singh Chauhan, Kuldeep, Singh Rawat, Bhupendra, Thomas, Ranjeny, Naik, Shalin, Kumar, Himanshu and Tailor, Prafullakumar (2020). RelB suppresses type I Interferon signaling in dendritic cells. Cellular Immunology, 349 104043, 104043. doi: 10.1016/j.cellimm.2020.104043

RelB suppresses type I Interferon signaling in dendritic cells

2020

Journal Article

Regulatory T cells induced by single-peptide liposome immunotherapy suppress islet-Specific T cell responses to multiple antigens and protect from autoimmune diabetes

Bergot, Anne-Sophie, Buckle, Irina, Cikaluru, Sumana, Naranjo, Jennifer Loaiza, Wright, Casey Maree, Zheng, Guoliang, Talekar, Meghna, Hamilton-Williams, Emma E. and Thomas, Ranjeny (2020). Regulatory T cells induced by single-peptide liposome immunotherapy suppress islet-Specific T cell responses to multiple antigens and protect from autoimmune diabetes. Journal of Immunology, 204 (7), ji1901128-1797. doi: 10.4049/jimmunol.1901128

Regulatory T cells induced by single-peptide liposome immunotherapy suppress islet-Specific T cell responses to multiple antigens and protect from autoimmune diabetes

2020

Journal Article

Mortality is increased in patients with rheumatoid arthritis or diabetes compared to the general population – the Nord-Trøndelag health study

Houge, Ingrid Sæther, Hoff, Mari, Thomas, Ranjeny and Videm, Vibeke (2020). Mortality is increased in patients with rheumatoid arthritis or diabetes compared to the general population – the Nord-Trøndelag health study. Scientific Reports, 10 (1) 3593, 3593. doi: 10.1038/s41598-020-60621-2

Mortality is increased in patients with rheumatoid arthritis or diabetes compared to the general population – the Nord-Trøndelag health study

2019

Journal Article

MHC class II antigen presentation by the intestinal epithelium initiates graft-versus-host disease and is influenced by the microbiota

Koyama, Motoko, Mukhopadhyay, Pamela, Schuster, Iona S., Henden, Andrea S., Hülsdünker, Jan, Varelias, Antiopi, Vetizou, Marie, Kuns, Rachel D., Robb, Renee J., Zhang, Ping, Blazar, Bruce B., Thomas, Ranjeny, Begun, Jakob, Waddell, Nicola, Trinchieri, Giorgio, Zeiser, Robert, Clouston, Andrew D., Degli-Esposti, Mariapia A. and Hill, Geoffrey R. (2019). MHC class II antigen presentation by the intestinal epithelium initiates graft-versus-host disease and is influenced by the microbiota. Immunity, 51 (5), 885-898. doi: 10.1016/j.immuni.2019.08.011

MHC class II antigen presentation by the intestinal epithelium initiates graft-versus-host disease and is influenced by the microbiota

2019

Journal Article

PD-L1 and calcitriol dependent liposomal antigen-specific regulation of systemic inflammatory autoimmune disease

Galea, Ryan, Nel, Hendrik, Talekar, Meghna, Liu, Xiao, Ooi, Joshua D., Huynh, Megan, Hadjigol, Sara, Robson, Kate J., Ting, Yi Tian, Cole, Suzanne, Cochlin, Karyn, Hitchcock, Shannon, Zeng, Bijun, Yekollu, Suman, Boks, Martine, Goh, Natalie, Roberts, Helen, Rossjohn, Jamie, Reid, Hugh H., Boyd, Ben J., Malaviya, Ravi, Shealy, David J., Baker, Daniel G., Madakamutil, Loui, Kitching, A. Richard, O’Sullivan, Brendan J. and Thomas, Ranjeny (2019). PD-L1 and calcitriol dependent liposomal antigen-specific regulation of systemic inflammatory autoimmune disease. JCI Insight, 4 (18) e126025. doi: 10.1172/jci.insight.126025

PD-L1 and calcitriol dependent liposomal antigen-specific regulation of systemic inflammatory autoimmune disease

2019

Conference Publication

COMPARISON OF MORTALITY IN RHEUMATOID ARTHRITIS AND DIABETES - THE HUNT POPULATION-BASED STUDY

Houge, Ingrid Saether, Hoff, Mari, Thomas, Ranjeny and Videm, Vibeke (2019). COMPARISON OF MORTALITY IN RHEUMATOID ARTHRITIS AND DIABETES - THE HUNT POPULATION-BASED STUDY. Annual European Congress of Rheumatology (EULAR), Madrid Spain, Jun 12-15, 2019. LONDON: BMJ PUBLISHING GROUP. doi: 10.1136/annrheumdis-2019-eular.1781

COMPARISON OF MORTALITY IN RHEUMATOID ARTHRITIS AND DIABETES - THE HUNT POPULATION-BASED STUDY

2019

Journal Article

Regulation of tolerogenic features on dexamethasone-modulated MPLA-activated dendritic cells by MYC

Garcia-Gonzalez, Paulina A., Maggi, Jaxaira, Schinnerling, Katina, Sepulveda-Gutierrez, Alejandro, Soto, Lilian, Neire, Oscar, Mehdi, Ahmed M., Nel, Hendrik J., Pesce, Barbara, Aravena, Octavio, Carmen Molina, Maria, Catalan, Diego, Thomas, Ranjeny, Verdugo, Ricardo A. and Carlos Aguillon, Juan (2019). Regulation of tolerogenic features on dexamethasone-modulated MPLA-activated dendritic cells by MYC. Frontiers in Immunology, 10 (MAY) 1171, 1171. doi: 10.3389/fimmu.2019.01171

Regulation of tolerogenic features on dexamethasone-modulated MPLA-activated dendritic cells by MYC

2019

Journal Article

NKT cell-driven enhancement of antitumor immunity induced by Clec9a-targeted tailorable nanoemulsion

Lam, Pui Yeng, Kobayashi, Takumi, Soon, Megan, Zeng, Bijun, Dolcetti, Riccardo, Leggatt, Graham, Thomas, Ranjeny and Mattarollo, Stephen R. (2019). NKT cell-driven enhancement of antitumor immunity induced by Clec9a-targeted tailorable nanoemulsion. Cancer Immunology Research, 7 (6), 952-962. doi: 10.1158/2326-6066.cir-18-0650

NKT cell-driven enhancement of antitumor immunity induced by Clec9a-targeted tailorable nanoemulsion

2019

Conference Publication

Immune responses to the microbiome tune MHC class II antigen presentation by the intestinal epithelium to control gut pathology

Koyama, Motoko, Mukhopadhyay, Pamela, Schuster, Iona S., Henden, Andrea S., Hülsdünker, Jan, Varelias, Antiopi, Vetizou, Marie, Kuns, Rachel D., Robb, Renee J., Zhang, Ping, Blazar, Bruce R., Thomas, Ranjeny, Begun, Jakob, Waddell, Nicola, Trinchieri, Giorgio, Zeiser, Robert, Clouston, Andrew D., Degli-Esposti, Mariapia A. and Hill, Geoffrey R. (2019). Immune responses to the microbiome tune MHC class II antigen presentation by the intestinal epithelium to control gut pathology. Immunology 2019™ Meeting, San Diego, CA United States, 9-13 May 2019. Rockville, MD United States: American Association of Immunologists. doi: 10.4049/jimmunol.202.supp.69.38

Immune responses to the microbiome tune MHC class II antigen presentation by the intestinal epithelium to control gut pathology

2019

Journal Article

A microfluidic-SERSplatform for isolation and immuno-phenotyping of antigen specific T-cells

Dey, Shuvashis, Vaidyanathan, Ramanathan, Reza, K. Kamil, Wang, Jing, Wang, Yuling, Nel, Hendrik J., Law, Soi-Cheng, Tyler, Jennifer, Rossjohn, Jamie, Reid, Hugh H., Ibn Sina, Abu Ali, Thomas, Ranjeny and Trau, Matt (2019). A microfluidic-SERSplatform for isolation and immuno-phenotyping of antigen specific T-cells. Sensors and Actuators B: Chemical, 284, 281-288. doi: 10.1016/j.snb.2018.12.099

A microfluidic-SERSplatform for isolation and immuno-phenotyping of antigen specific T-cells

2019

Journal Article

Humanized mouse models of rheumatoid arthritis for studies on immunopathogenesis and preclinical testing of cell-based therapies

Schinnerling, Katina, Rosas, Carlos, Soto, Lilian, Thomas, Ranjeny and Carlos Aguillon, Juan (2019). Humanized mouse models of rheumatoid arthritis for studies on immunopathogenesis and preclinical testing of cell-based therapies. Frontiers in Immunology, 10 (FEB) 203, 203. doi: 10.3389/fimmu.2019.00203

Humanized mouse models of rheumatoid arthritis for studies on immunopathogenesis and preclinical testing of cell-based therapies

2019

Journal Article

Cardiorespiratory fitness in patients with rheumatoid arthritis is associated with the patient global assessment but not with objective measurements of disease activity

Liff, Marthe Halsan, Hoff, Mari, Fremo, Thomas, Wisløff, Ulrik, Thomas, Ranjeny and Videm, Vibeke (2019). Cardiorespiratory fitness in patients with rheumatoid arthritis is associated with the patient global assessment but not with objective measurements of disease activity. RMD Open, 5 (1) e000912, e000912. doi: 10.1136/rmdopen-2019-000912

Cardiorespiratory fitness in patients with rheumatoid arthritis is associated with the patient global assessment but not with objective measurements of disease activity

2019

Journal Article

IL-23 favours outgrowth of spondyloarthritis-associated pathobionts and suppresses host support for homeostatic microbiota

Rehaume, Linda M., Matigian, Nicholas, Mehdi, Ahmed M., Lachner, Nancy, Bowerman, Kate L., Daly, Joshua, Lê Cao, Kim-Anh, Hugenholtz, Philip and Thomas, Ranjeny (2019). IL-23 favours outgrowth of spondyloarthritis-associated pathobionts and suppresses host support for homeostatic microbiota. Annals of the Rheumatic Diseases, 78 (4), 494-503. doi: 10.1136/annrheumdis-2018-214381

IL-23 favours outgrowth of spondyloarthritis-associated pathobionts and suppresses host support for homeostatic microbiota

2019

Journal Article

Altered composition and phenotype of mucosal-associated invariant T cells in early untreated rheumatoid arthritis

Koppejan, Hester, Jansen, Diahann T. S. L., Hameetman, Marjolijn, Thomas, Ranjeny, Toes, Rene E. M. and van Gaalen, Floris A. (2019). Altered composition and phenotype of mucosal-associated invariant T cells in early untreated rheumatoid arthritis. Arthritis Research and Therapy, 21 (1) 3, 3. doi: 10.1186/s13075-018-1799-1

Altered composition and phenotype of mucosal-associated invariant T cells in early untreated rheumatoid arthritis

2019

Conference Publication

A phase I, randomized, double-blind, placebo-controlled, single center, single-dose escalation to investigate the safety, tolerability, and pharmacodynamics of subcutaneously administered DEN-181 in adult patients with ACPA plus rheumatoid arthritis on stable methotrexate

Sonigra, Amee, Nel, Hendrik, Ramnoruth, Nishta, Talekar, Meghna, Tesiram, Joanne, Stuurman, Frederik, Proctor, Lavinia, Roberts, Helen, Thurmond, Robin, Vecchio, Phillip, Gourley, Ian, Rigby, Mark, Felix, Nathan, Becart, Stephane, Campbell, Kim and Thomas, Ranjeny (2019). A phase I, randomized, double-blind, placebo-controlled, single center, single-dose escalation to investigate the safety, tolerability, and pharmacodynamics of subcutaneously administered DEN-181 in adult patients with ACPA plus rheumatoid arthritis on stable methotrexate. 2019 ACR/ARP Annual Meeting, Atlanta, GA, United States, 8 - 13 November 2019. Hoboken, NJ, United States: John Wiley & Sons.

A phase I, randomized, double-blind, placebo-controlled, single center, single-dose escalation to investigate the safety, tolerability, and pharmacodynamics of subcutaneously administered DEN-181 in adult patients with ACPA plus rheumatoid arthritis on stable methotrexate

2019

Conference Publication

CD4+CD25+CD127HI cells correlate with length of remission in type 1 diabetes: validated in a multi-site study

Narsale, A., Moya, R., Robertson, H., Payne, D., Lu, T. T., Geoffery, R., Buchanan, K., Harris, M., Bergot, A. S., Thomas, R., Hessner, M., Battaglia, M., Serti, E. and Davies, J. (2019). CD4+CD25+CD127HI cells correlate with length of remission in type 1 diabetes: validated in a multi-site study. International Conference on Lymphocyte Engineering (ICLE), London, United Kingdom, 13-15 September 2019. New Rochelle, NY United States: Mary Ann Liebert. doi: 10.1089/hum.2019.29091.abstracts

CD4+CD25+CD127HI cells correlate with length of remission in type 1 diabetes: validated in a multi-site study

2018

Journal Article

An improved clinical model to predict stimulated C-peptide in children with recent-onset type 1 diabetes

Buchanan, Kerry, Mehdi, Ahmed M, Hughes, Ian, Cotterill, Andrew, Le Cao, Kim-Anh, Thomas, Ranjeny and Harris, Mark (2018). An improved clinical model to predict stimulated C-peptide in children with recent-onset type 1 diabetes. Pediatric Diabetes, 20 (2), 166-171. doi: 10.1111/pedi.12808

An improved clinical model to predict stimulated C-peptide in children with recent-onset type 1 diabetes

2018

Journal Article

Dendritic cells, T cells and their interaction in rheumatoid arthritis : Dendritic cells, T cells and their interaction

Wehr, P., Purvis, H., Law, S.-C. and Thomas, R. (2018). Dendritic cells, T cells and their interaction in rheumatoid arthritis : Dendritic cells, T cells and their interaction. Clinical and Experimental Immunology, 196 (1), 12-27. doi: 10.1111/cei.13256

Dendritic cells, T cells and their interaction in rheumatoid arthritis : Dendritic cells, T cells and their interaction

2018

Journal Article

The SKG model of spondyloarthritis

Rahman, M. Arifur and Thomas, Ranjeny (2018). The SKG model of spondyloarthritis. Best Practice and Research: Clinical Rheumatology, 30 (6), 1-15. doi: 10.1016/j.berh.2018.07.004

The SKG model of spondyloarthritis

2018

Journal Article

Pro-inflammatory CX3CR1 CD59 TL1A IL-23 monocytes are expanded in patients with Ankylosing Spondylitis and modulate ILC3 immune functions

Ciccia, Francesco, Guggino, Giuliana, Zeng, Michael, Thomas, Ranjeny, Ranganathan, Vidya, Rahman, Arifur, Alessandro, Riccardo, Rizzo, Aroldo, Saieva, Laura, Macaluso, Federica, Peralta, Sergio, Di Liberto, Diana, Dieli, Francesco, Cipriani, Paola, Giacomelli, Roberto, Baeten, Dominique and Haroon, Nigil (2018). Pro-inflammatory CX3CR1 CD59 TL1A IL-23 monocytes are expanded in patients with Ankylosing Spondylitis and modulate ILC3 immune functions. Arthritis & Rheumatology, 70 (12), 2003-2013. doi: 10.1002/art.40582

Pro-inflammatory CX3CR1 CD59 TL1A IL-23 monocytes are expanded in patients with Ankylosing Spondylitis and modulate ILC3 immune functions