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2018 Journal Article Macrophage colony-stimulating factor increases hepatic macrophage content, liver growth, and lipid accumulation in neonatal ratsPridans, Clare, Sauter, Kristin A., Irvine, Katharine M., Davis, Gemma M., Lefevre, Lucas, Raper, Anna, Rojo, Rocio, Nirmal, Ajit J., Beard, Philippa, Cheeseman, Michael and Hume, David A. (2018). Macrophage colony-stimulating factor increases hepatic macrophage content, liver growth, and lipid accumulation in neonatal rats. American Journal of Physiology - Gastrointestinal and Liver Physiology, 314 (3), G388-G398. doi: 10.1152/ajpgi.00343.2017 |
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2018 Journal Article Shared activity patterns arising at genetic susceptibility loci reveal underlying genomic and cellular architecture of human diseaseBaillie, J. Kenneth, Bretherick, Andrew, Haley, Christopher S., Clohisey, Sara, Gray, Alan, Neyton, Lucile P. A., Barrett, Jeffrey, Stahl, Eli A., Tenesa, Albert, Andersson, Robin, Brown, J. Ben, Faulkner, Geoffrey J., Lizio, Marina, Schaefer, Ulf, Daub, Carsten, Itoh, Masayoshi, Kondo, Naoto, Lassmann, Timo, Kawai, Jun, IIBDGC Consortium, Mole, Damian, Bajic, Vladimir B., Heutink, Peter, Rehli, Michael, Kawaji, Hideya, Sandelin, Albin, Suzuki, Harukazu, Satsangi, Jack, Wells, Christine A. ... Hume, David A. (2018). Shared activity patterns arising at genetic susceptibility loci reveal underlying genomic and cellular architecture of human disease. PL o S Computational Biology, 14 (3) e1005934, e1005934. doi: 10.1371/journal.pcbi.1005934 |
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2018 Journal Article Effects of anti-inflammatory drugs on the expression of tryptophan-metabolism genes by human macrophagesRegan, Tim, Gill, Andrew C., Clohisey, Sara M., Barnett, Mark W., Pariante, Carmine M., Harrison, Neil A., Hume, David A., Bullmore, Edward T. and Freeman, Tom C. (2018). Effects of anti-inflammatory drugs on the expression of tryptophan-metabolism genes by human macrophages. Journal of Leukocyte Biology, 103 (4), 681-692. doi: 10.1002/JLB.3A0617-261R |
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2018 Journal Article Replicable and coupled changes in innate and adaptive immune gene expression in two case-control studies of blood microarrays in major depressive disorderLeday, Gwenaël G.R., Vértes, Petra E., Richardson, Sylvia, Greene, Jonathan R., Regan, Tim, Khan, Shahid, Henderson, Robbie, Freeman, Tom C., Pariante, Carmine M., Harrison, Neil A., Perry, V. Hugh, Drevets, Wayne C., Wittenberg, Gayle M., Bullmore, Edward T., MRC Immunopsychiatry Consortium, Bullmore, Edward, Vertes, Petra, Cardinal, Rudolf, Richardson, Sylvia, Leday, Gwenael, Freeman, Tom, Regan, Tim, Hume, David, Wu, Zhaozong, Pariante, Carmine, Cattaneo, Annamaria, Zunszain, Patricia, Borsini, Alessandra, Stewart, Robert ... Henderson, Robbie (2018). Replicable and coupled changes in innate and adaptive immune gene expression in two case-control studies of blood microarrays in major depressive disorder. Biological Psychiatry, 83 (1), 70-80. doi: 10.1016/j.biopsych.2017.01.021 |
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2018 Journal Article Species-specific transcriptional regulation of genes involved in nitric oxide production and arginine metabolism in macrophagesYoung, Rachel, Bush, Stephen J., Lefevre, Lucas, McCulloch, Mary E.B., Lisowski, Zofia M., Muriuki, Charity, Waddell, Lindsey A., Sauter, Kristin A., Pridans, Clare, Clark, Emily L. and Hume, David A. (2018). Species-specific transcriptional regulation of genes involved in nitric oxide production and arginine metabolism in macrophages. ImmunoHorizons, 2 (1), 27-37. doi: 10.4049/immunohorizons.1700073 |
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2017 Journal Article Glucocorticoid Receptor Binding Induces Rapid and Prolonged Large-Scale Chromatin Decompaction at Multiple Target LociJubb, Alasdair W., Boyle, Shelagh, Hume, David A. and Bickmore, Wendy A. (2017). Glucocorticoid Receptor Binding Induces Rapid and Prolonged Large-Scale Chromatin Decompaction at Multiple Target Loci. Cell Reports, 21 (11), 3022-3031. doi: 10.1016/j.celrep.2017.11.053 |
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2017 Journal Article The evolution of the macrophage-specific enhancer (Fms intronic regulatory element) within the CSF1R locus of vertebratesHume, David A., Wollscheid-Lengeling, Evi, Rojo, Rocio and Pridans, Clare (2017). The evolution of the macrophage-specific enhancer (Fms intronic regulatory element) within the CSF1R locus of vertebrates. Scientific Reports, 7 (1) 17115, 1-10. doi: 10.1038/s41598-017-15999-x |
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2017 Journal Article CCR2-dependent monocyte-derived macrophages resolve inflammation and restore gut motility in postoperative ileusFarro, Giovanna, Stakenborg, Michelle, Gomez-Pinilla, Pedro J., Labeeuw, Evelien, Goverse, Gera, Giovangiulio, Martina Di, Stakenborg, Nathalie, Meroni, Elisa, D'Errico, Francesca, Elkrim, Yvon, Laoui, Damya, Lisowski, Zofia M., Sauter, Kristin A., Hume, David A., Van Ginderachter, Jo A., Boeckxstaens, Guy E. and Matteoli, Gianluca (2017). CCR2-dependent monocyte-derived macrophages resolve inflammation and restore gut motility in postoperative ileus. Gut, 66 (12), 2098-2109. doi: 10.1136/gutjnl-2016-313144 |
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2017 Journal Article Groups with no coarse embeddings into hyperbolic groupsHume, David and Sisto, Alessandro (2017). Groups with no coarse embeddings into hyperbolic groups. New York Journal of Mathematics, 23, 1657-1670. doi: 10.48550/arXiv.1702.03789 |
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2017 Journal Article CD169+ macrophages are critical for osteoblast maintenance and promote intramembranous and endochondral ossification during bone repairBatoon, Lena, Millard, Susan Marie, Wullschleger, Martin Eduar, Preda, Corina, Wu, Andy Chiu-Ku, Kaur, Simranpreet, Tseng, Hsu-Wen, Hume, David Arthur, Levesque, Jean-Pierre, Raggatt, Liza Jane and Pettit, Allison Robyn (2017). CD169+ macrophages are critical for osteoblast maintenance and promote intramembranous and endochondral ossification during bone repair. Biomaterials, 196, 51-66. doi: 10.1016/j.biomaterials.2017.10.033 |
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2017 Journal Article Effects of Eimeria tenella infection on chicken caecal microbiome diversity, exploring variation associated with severity of pathologyMacdonald, Sarah E., Nolan, Matthew J., Harman, Kimberley, Boulton, Kay, Hume, David A., Tomley, Fiona M., Stabler, Richard A. and Blake, Damer P. (2017). Effects of Eimeria tenella infection on chicken caecal microbiome diversity, exploring variation associated with severity of pathology. PLoS ONE, 12 (9) e0184890, 1-17. doi: 10.1371/journal.pone.0184890 |
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2017 Journal Article A high resolution atlas of gene expression in the domestic sheep (Ovis aries)Clark, Emily L., Bush, Stephen J., McCulloch, Mary E. B., Farquhar, Iseabail L., Young, Rachel, Lefevre, Lucas, Pridans, Clare, Tsang, Hiu, Wu, Chunlei, Afrasiabi, Cyrus, Watson, Mick, Whitelaw, C. Bruce, Freeman, Tom C., Summers, Kim M., Archibald, Alan L. and Hume, David A. (2017). A high resolution atlas of gene expression in the domestic sheep (Ovis aries). PLoS Genetics, 13 (9) e1006997, e1006997. doi: 10.1371/journal.pgen.1006997 |
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2017 Journal Article The genomic architecture of mastitis resistance in dairy sheepBanos, G., Bramis, G., Bush, S. J., Clark, E. L., McCulloch, M. E. B., Smith, J., Schulze, G., Arsenos, G., Hume, D. A. and Psifidi, A. (2017). The genomic architecture of mastitis resistance in dairy sheep. BMC Genomics, 18 (1) 624, 1-18. doi: 10.1186/s12864-017-3982-1 |
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2017 Journal Article Repeated exposure to systemic inflammation and risk of new depressive symptoms among older adultsBell, J. A., Kivimäki, M., Bullmore, E. T., Steptoe, A., Carvalho, L. A., Vértes, Petra E., Cardinal, Rudolf, Richardson, Sylvia, Leday, Gwenael, Freeman, Tom, Hume, David, Regan, Tim, Wu, Zhaozong, Pariante, Carmine, Cattaneo, Annamaria, Zuszain, Patricia, Borsini, Alessandra, Stewart, Robert, Chandran, David, Souza-Teodoro, Luis Henrique, Perry, Hugh, Harrison, Neil, Janssen, Wayne Drevets, Wittenberg, Gayle M., Sun, Yu, Jones, Declan, Bullmore, Edward, Khan, Shahid, Stylianou, Annie and Henderson, Robert B. (2017). Repeated exposure to systemic inflammation and risk of new depressive symptoms among older adults. Translational Psychiatry, 7 (8) e1208, e1208-e1208. doi: 10.1038/tp.2017.155 |
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2017 Journal Article FANTOM5 CAGE profiles of human and mouse samplesNoguchi, Shuhei, Arakawa, Takahiro, Fukuda, Shiro, Furuno, Masaaki, Hasegawa, Akira, Hori, Fumi, Ishikawa-Kato, Sachi, Kaida, Kaoru, Kaiho, Ai, Kanamori-Katayama, Mutsumi, Kawashima, Tsugumi, Kojima, Miki, Kubosaki, Atsutaka, Manabe, Ri-ichiroh, Murata, Mitsuyoshi, Nagao-Sato, Sayaka, Nakazato, Kenichi, Ninomiya, Noriko, Nishiyori-Sueki, Hiromi, Noma, Shohei, Saijyo, Eri, Saka, Akiko, Sakai, Mizuho, Simon, Christophe, Suzuki, Naoko, Tagami, Michihira, Watanabe, Shoko, Yoshida, Shigehiro, Arner, Peter ... Hayashizaki, Yoshihide (2017). FANTOM5 CAGE profiles of human and mouse samples. Scientific Data, 4 (1) 170112, 170112. doi: 10.1038/sdata.2017.112 |
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2017 Journal Article Transcriptional mechanisms that control expression of the macrophage colony-stimulating factor receptor locusRojo, Rocio, Pridans, Clare, Langlais, David and Hume, David A. (2017). Transcriptional mechanisms that control expression of the macrophage colony-stimulating factor receptor locus. Clinical Science, 131 (16), 2161-2182. doi: 10.1042/CS20170238 |
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2017 Journal Article Identification of the macrophage-specific promoter signature in FANTOM5 mouse embryo developmental time course dataSummers, Kim M. and Hume, David A. (2017). Identification of the macrophage-specific promoter signature in FANTOM5 mouse embryo developmental time course data. Journal of Leukocyte Biology, 102 (4), 1081-1092. doi: 10.1189/jlb.1A0417-150RR |
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2017 Journal Article Integration of quantitated expression estimates from polyA-selected and rRNA-depleted RNA-seq librariesBush, Stephen J., McCulloch, Mary E.B., Summers, Kim M., Hume, David A. and Clark, Emily L. (2017). Integration of quantitated expression estimates from polyA-selected and rRNA-depleted RNA-seq libraries. BMC Bioinformatics, 18 (1) 301, 1-12. doi: 10.1186/s12859-017-1714-9 |
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2017 Journal Article Jmjd6, a JmjC dioxygenase with many interaction partners and pleiotropic functionsKwok, Janice, O'Shea, Marie, Hume, David A. and Lengeling, Andreas (2017). Jmjd6, a JmjC dioxygenase with many interaction partners and pleiotropic functions. Frontiers in Genetics, 8 (MAR) 32. doi: 10.3389/fgene.2017.00032 |
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2017 Journal Article Analysis of the human monocyte-derived macrophage transcriptome and response to lipopolysaccharide provides new insights into genetic aetiology of inflammatory bowel diseaseBaillie, J. Kenneth, Arner, Erik, Daub, Carsten, De Hoon, Michiel, Itoh, Masayoshi, Kawaji, Hideya, Lassmann, Timo, Carninci, Piero, Forrest, Alistair R. R., Hayashizaki, Yoshihide, Faulkner, Geoffrey J., Wells, Christine A., Rehli, Michael, Pavli, Paul, Summers, Kim M., Hume, David A. and FANTOM Consortium (2017). Analysis of the human monocyte-derived macrophage transcriptome and response to lipopolysaccharide provides new insights into genetic aetiology of inflammatory bowel disease. PLoS Genetics, 13 (3) e1006641, 1-36. doi: 10.1371/journal.pgen.1006641 |
