Dr Yosephine Gumulya
Dr

Yosephine Gumulya

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Background

Yosephine Gumulya has a degree in Food Technology (2004) from Bogor Agricultural University (Indonesia) and a Master of Biotechnology (2007) from Technical University Hamburg Harburg (Germany). She completed her PhD in 2010 at Max Planck Institute for Coal Research (Germany), where she learned how to mimic the natural evolution in laboratory and use this technique to generate novel enzymes for biotechnology applications. After spending 1.5 years working for food industry in Spain, in October 2012, she decided to pursue an academic career by doing postdoctoral research in the lab of Prof Elizabeth Gillam and A.Prof. Mikael Boden. Her research has focused on protein engineering and ancestral sequence reconstruction. This knowledge is essential for understanding the protein evolutionary histroy as well for creating robust yet promiscous enzymes for industrial applications.

Availability

Dr Yosephine Gumulya is:
Available for supervision

Qualifications

  • Doctor of Philosophy of Natural Sciences, Ruhr University Bochum

Research interests

  • Protein Engineering / Directed evolution

    Mimicking the natural evolution in the laboratory can create biocatalysts with suitable properties for industrial applications (e.g. selectivity, activity, stability)

  • Ancestral protein reconstruction

    Hypothesising that the Earth was hot in ancient times, resurrecting ancestral proteins in the laboratory can generate robust proteins that useful for industrial applications.

  • Simulated Microgravity/Space Technology

    Using space-based platforms and extreme microbial biology to inform the design of synthetic biology solutions on Earth and beyond.

Research impacts

A major limitation of industrial process development is the lack of robust enzymes with novel functions or suitable properties for industrial application. With laboratory-based methods (protein engineering and ancestral sequence reconstruction), we have generated stable yet promiscuous enzymes that can be used to generate drug metabolites. As a result, it will significantly speed up the drug development pipeline and, more importantly, reduce the cost of overall drug discovery process.

Search Professor Yosephine Gumulya’s works on UQ eSpace

41 works between 2008 and 2026
All (41) Journal Article (39) Conference Publication (1) Book Chapter (1)

41 - 41 of 41 works

2008

Journal Article

Improved PCR method for the creation of saturation mutagenesis libraries in directed evolution: application to difficult-to-amplify templates

Sanchis, Joaquin, Fernandez, Layla, Carballeira, J. Daniel, Drone, Jullien, Gumulya, Yosephine, Hoebenreich, Horst, Kahakeaw, Daniel, Kille, Sabrina, Lohmer, Renate, Peyralans, Jerome J. -P., Podtetenieff, John, Prasad, Shreenath, Soni, Pankaj, Taglieber, Andreas, Wu, Sheng, Zilly, Felipe E. and Reetz, Manfred T. (2008). Improved PCR method for the creation of saturation mutagenesis libraries in directed evolution: application to difficult-to-amplify templates. Applied Microbiology and Biotechnology, 81 (2), 387-397. doi: 10.1007/s00253-008-1678-9

Improved PCR method for the creation of saturation mutagenesis libraries in directed evolution: application to difficult-to-amplify templates

Current funding

  • 2025 - 2028
    Learning from the past to design drugs for the future
    NHMRC IDEAS Grants
    Open grant
  • 2023 - 2028
    Biosustainability Hub: Paving the way to net zero using biological strategies
    Woodside Energy Technologies Pty Ltd
    Open grant

Availability

Dr Yosephine Gumulya is:
Available for supervision

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Supervision history

Current supervision

Completed supervision

Enquiries

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