Overview
Background
Dr Yinghong Zhou leads the ImmunoEngineering for Regenerative Dentistry research team at the School of Dentistry. Her research interests extend across several transdisciplinary research projects, all with the central theme of biomedical engineering and bone/periodontal tissue regeneration. Her high-quality research leads the field in (a) hypoxia-mimicking bioscaffolds for bone regeneration (field-weighted citation impact=13.15), (b) trace element-mediated biomineralization (recognised by the Tissue Engineering and Regenerative Medicine International Society (TERMIS) Young Investigator Award, given only to two emerging researchers in the whole Asia-Pacific region in 2021), and (c) immunoengineering approaches for periodontal regeneration (introduced into the tertiary learning sector as the world-first Master of Philosophy (Materiobiology) Program at QUT). Dr Zhou has been awarded prestigious fellowships including the Endeavour Research Fellowship (2017), NHMRC Early Career Fellowship (2016-2020), and the BridgeTech Industry Fellowship (2021).
Availability
- Dr Yinghong Zhou is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy of Biomedical Engineering, Queensland University of Technology
Research interests
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Immunoengineered titanium implants towards soft tissue integration
Peri-implantitis is a site-specific infectious disease that causes an inflammatory process in soft tissues, and bone loss surrounding dental implants. The long-term success of titanium (Ti) dental implants therefore relies on a superior transmucosal “seal” to prevent bacteria invasion and subsequent inflammation. It is known that the Ti implant surface topography and chemistry play a key role in controlling the long-standing connective tissue seal. Yet, none of the existing surface coating systems takes into consideration of the initial blood clot formation and immune cell-material interactions. This project, therefore, aims to develop a new generation of multifunctional surface coatings on Ti implants that can fight off bacteria, orchestrate blood clot formation and regulate immune responses to achieve optimal soft tissue integration.
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In vitro modelling to mimic cellular crosstalk in periodontitis
The prevalence of periodontitis (infection-induced inflammatory gum disease) remains relatively high today, reaching to over 50% of the global population. If left untreated, the disease can trigger systemic diseases such as cardiovascular disease, diabetes, and adverse pregnancy outcomes. Till date, the exact interplay between the oral microbiome, immune cells and the surrounding microenvironment remains unclear in the pathogenesis of periodontitis. In vitro platforms can be ideal to systematically pair up key factors in periodontal pathophysiology which is helpful in further understanding of the disease progression and their associated systemic influences. However, the re-creation of heterogenous microenvironments that can support cultures of both oral microbiome (in lower oxygen tension) and the neighbouring macrophages/periodontal ligament cells (in normal oxygen tension) within the same platform without relying on highly specialised equipment remains a key engineering challenge today. Our team has previously formulated functionalise-able hydrogels to locally control the oxygen level which could be used as a medium to support co-culture of bacteria and macrophages/periodontal ligament cells whilst mimicking the heterogenous oxygen level within the oral cavity. This project aims to establish the framework on tuning and characterising the hydrogels’ capability to support the culture of gram-negative anaerobic bacteria critical to periodontal pathogenesis such as Porphyromonas gingivalis (Pg).
Works
Search Professor Yinghong Zhou’s works on UQ eSpace
Featured
2022
Journal Article
LiCl-induced immunomodulatory periodontal regeneration via the activation of the Wnt/β-catenin signaling pathway
Zheng, Xiumei, Wang, Shengfang, Xiao, Lan, Han, Pingping, Xie, Kunke, Ivanovski, Saso, Xiao, Yin and Zhou, Yinghong (2022). LiCl-induced immunomodulatory periodontal regeneration via the activation of the Wnt/β-catenin signaling pathway. Journal of Periodontal Research, 57 (4), 835-848. doi: 10.1111/jre.13022
2024
Journal Article
Hyperuricemia and elevated uric acid/creatinine ratio are associated with stages III/IV periodontitis: a population-based cross-sectional study (NHANES 2009–2014)
Chen, Yueqi, Lu, Peipei, Lin, Chuyin, Li, Song, Zhu, Yufan, Tan, Jiaying, Zhou, Yinghong and Yu, Ting (2024). Hyperuricemia and elevated uric acid/creatinine ratio are associated with stages III/IV periodontitis: a population-based cross-sectional study (NHANES 2009–2014). BMC Oral Health, 24 (1) 1389. doi: 10.1186/s12903-024-05173-x
2024
Journal Article
A low-kiloelectronvolt focused ion beam strategy for processing low-thermal-conductance materials with nanoampere currents
Wolff, Annalena, Klingner, Nico, Thompson, William, Zhou, Yinghong, Lin, Jinying and Xiao, Yin (2024). A low-kiloelectronvolt focused ion beam strategy for processing low-thermal-conductance materials with nanoampere currents. Beilstein Journal of Nanotechnology, 15, 1197-1207. doi: 10.3762/bjnano.15.97
2024
Journal Article
Modelling periodontitis in vitro: engineering strategies and biofilm model development
Wang, Cong, Xu, Tian, Seneviratne, Chaminda Jayampath, Ong, Louis Jun Ye and Zhou, Yinghong (2024). Modelling periodontitis in vitro: engineering strategies and biofilm model development. Frontiers in Biomaterials Science, 3 1380153. doi: 10.3389/fbiom.2024.1380153
2024
Journal Article
Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches: Position paper
Welsh, Joshua A., Goberdhan, Deborah C. I., O'Driscoll, Lorraine, Buzas, Edit I., Blenkiron, Cherie, Bussolati, Benedetta, Cai, Houjian, Di Vizio, Dolores, Driedonks, Tom A. P., Erdbrugger, Uta, Falcon-Perez, Juan M., Fu, Qing-Ling, Hill, Andrew F., Lenassi, Metka, Lim, Sai Kiang, Mahoney, My G., Mohanty, Sujata, Moller, Andreas, Nieuwland, Rienk, Ochiya, Takahiro, Sahoo, Susmita, Torrecilhas, Ana C., Zheng, Lei, Zijlstra, Andries, Abuelreich, Sarah, Bagabas, Reem, Bergese, Paolo, Bridges, Esther M., Brucale, Marco ... Guanzon, Dominic (2024). Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches: Position paper. Journal of Extracellular Vesicles, 13 (2) e12404, 1-84. doi: 10.1002/jev2.12404
2023
Journal Article
TNF-α and OSX mRNA of salivary small extracellular vesicles in periodontitis: a pilot study
Han, Pingping, Jiao, Kexin, Moran, Corey S., Liaw, Andrew, Zhou, Yinghong, Salomon, Carlos and Ivanovski, Saso (2023). TNF-α and OSX mRNA of salivary small extracellular vesicles in periodontitis: a pilot study. Tissue Engineering. Part C. Methods, 29 (7), 298-306. doi: 10.1089/ten.tec.2023.0051
2023
Journal Article
An optimized method for µCT analysis of trabecular parameters of metal scaffolds for bone ingrowth
Li, Zhengmao, Zhang, Qing, Yang, Shuang, Li, Yuncang, Atrens, Andrej, Kanwar, Jagat Rakesh, Zhong, Wen, Lin, Bingpeng, Wen, Cuie, Zhou, Yinghong and Xiao, Yin (2023). An optimized method for µCT analysis of trabecular parameters of metal scaffolds for bone ingrowth. Tissue Engineering Part C: Methods (ja), 276-283. doi: 10.1089/ten.tec.2023.0076
2023
Journal Article
Plasma‐activated medium triggers immunomodulation and autophagic activity for periodontal regeneration
Wang, Shengfang, Wang, Peiyu, Thompson, Rik, Ostrikov, Kostya, Xiao, Yin and Zhou, Yinghong (2023). Plasma‐activated medium triggers immunomodulation and autophagic activity for periodontal regeneration. Bioengineering and Translational Medicine, 8 (4) e10528, e10528. doi: 10.1002/btm2.10528
2023
Journal Article
Editorial for Special Issue on Biomaterials and Cell Strategies for Regenerative Dentistry
Ji, Wei, Zhou, Yinghong and Jansen, John A. (2023). Editorial for Special Issue on Biomaterials and Cell Strategies for Regenerative Dentistry. Tissue engineering. Part C, Methods, 29 (5), 161-162. doi: 10.1089/ten.tec.2023.29037.editorial
2023
Journal Article
Association between periodontitis and uric acid levels in blood and oral fluids: a systematic review and meta-analysis
Ye, Lu-Wen, Zhao, Li, Mei, Ze-Song, Zhou, Ying-Hong and Yu, Ting (2023). Association between periodontitis and uric acid levels in blood and oral fluids: a systematic review and meta-analysis. BMC Oral Health, 23 (1) 178, 1-16. doi: 10.1186/s12903-023-02900-8
2023
Journal Article
Immunomodulatory nanotherapeutic approaches for periodontal tissue regeneration
Xu, Tian, Xie, Kunke, Wang, Cong, Ivanovski, Sašo and Zhou, Yinghong (2023). Immunomodulatory nanotherapeutic approaches for periodontal tissue regeneration. Nanoscale, 15 (13), 5992-6008. doi: 10.1039/d2nr06149j
2023
Journal Article
Osteoimmunomodulatory nanoparticles for bone regeneration
Wen, Jingyi, Cai, Donglin, Gao, Wendong, He, Ruiying, Li, Yulin, Zhou, Yinghong, Klein, Travis, Xiao, Lan and Xiao, Yin (2023). Osteoimmunomodulatory nanoparticles for bone regeneration. Nanomaterials, 13 (4) 692, 1-21. doi: 10.3390/nano13040692
2023
Journal Article
Bioceramic micro-fillers reinforce antibiofilm and remineralization properties of clear aligner attachment materials
Jiang, Wenhui, Wang, Zhejun, Zhou, Yinghong, Shen, Ya and Zou, Bingshuang (2023). Bioceramic micro-fillers reinforce antibiofilm and remineralization properties of clear aligner attachment materials. Frontiers in Bioengineering and Biotechnology, 11 1346959, 1-11. doi: 10.3389/fbioe.2023.1346959
2023
Journal Article
Osteo-immunomodulatory role of interleukin-4-immobilized plasma immersion ion implantation membranes for bone regeneration
Wei, Fei, Mu, Yuqing, Tan, Richard P., Wise, Steven G., Bilek, Marcela M., Zhou, Yinghong and Xiao, Yin (2023). Osteo-immunomodulatory role of interleukin-4-immobilized plasma immersion ion implantation membranes for bone regeneration. ACS Applied Materials and Interfaces, 15 (2), 2590-2601. doi: 10.1021/acsami.2c17005
2023
Book Chapter
Clinical usage of dental stem cells and their derived extracellular vesicles
Zhou, Yinghong, Xu, Tian, Wang, Cong, Han, Pingping and Ivanovski, Sašo (2023). Clinical usage of dental stem cells and their derived extracellular vesicles. Stem cell in medicine. (pp. 297-326) San Diego, CA, United States: Academic Press. doi: 10.1016/bs.pmbts.2023.03.005
2023
Journal Article
Metal–organic framework glass composites
Lin, Rijia, Chai, Milton, Zhou, Yinghong, Chen, Vicki, Bennett, Thomas D. and Hou, Jingwei (2023). Metal–organic framework glass composites. Chemical Society Reviews, 52 (13), 4149-4172. doi: 10.1039/d2cs00315e
2023
Journal Article
Physiological and pathological/ectopic mineralization: from composition to microstructure
Mu, Yuqing, Gao, Wendong, Zhou, Yinghong, Xiao, Lan and Xiao, Yin (2023). Physiological and pathological/ectopic mineralization: from composition to microstructure. Microstructures, 3 (4) 2023030. doi: 10.20517/microstructures.2023.05
2023
Journal Article
Micro/nano-modified titanium surfaces accelerate osseointegration via Rab7-dependent mitophagy
Tang, Cuizhu, Deng, Jiali, Xu, Ruogu, Li, Jingping, Yin, Chengcheng, Yang, Yang, Zhou, Yinghong and Deng, Feilong (2023). Micro/nano-modified titanium surfaces accelerate osseointegration via Rab7-dependent mitophagy. Biomaterials Science, 11 (2), 666-677. doi: 10.1039/d2bm01528e
2023
Book Chapter
Preface
Higuchi, Akon, Zhou, Yinghong and Chiou, Shih-Hwa (2023). Preface. Stem Cell in Medicine Preface. (pp. XIX-XXII) edited by Akon Higuchi, Yinghong Zhou and Shih-Hwa Chiou. San Diego, CA, United States: Elsevier.
2023
Book Chapter
Engineered adult stem cells: current clinical trials status of disease treatment
Han, Pingping, Moran, Corey Stephan, Liu, Chun, Griffiths, Rebecca, Zhou, Yinghong and Ivanovski, Sašo (2023). Engineered adult stem cells: current clinical trials status of disease treatment. Stem Cell in Medicine. (pp. 33-62) San Diego, CA United States: Academic Press. doi: 10.1016/bs.pmbts.2023.02.007
Funding
Current funding
Past funding
Supervision
Availability
- Dr Yinghong Zhou is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Biomimetic nanoplatform enhances bone regeneration through immunomodulation
Principal Advisor
Other advisors: Professor Saso Ivanovski, Dr Pingping Han
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Doctor Philosophy
Novel nanomaterials of cerium-doped ZIF-62 for periodontal tissue regeneration
Principal Advisor
Other advisors: Professor Saso Ivanovski
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Doctor Philosophy
Development of an oral biofilm-oral epithelial cells co-culture model based on jammed-packed microgel
Principal Advisor
Other advisors: Dr Jaya Seneviratne
Media
Enquiries
Contact Dr Yinghong Zhou directly for media enquiries about:
- biomaterials
- bone tissue engineering
- regenerative dentistry
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