Overview
Background
Dr Yinghong Zhou leads the ImmunoEngineering for Regenerative Dentistry research team at the School of Dentistry. Her research interests extend across several transdisciplinary research projects, all with the central theme of biomedical engineering and bone/periodontal tissue regeneration. Her high-quality research leads the field in (a) hypoxia-mimicking bioscaffolds for bone regeneration (field-weighted citation impact=13.15), (b) trace element-mediated biomineralization (recognised by the Tissue Engineering and Regenerative Medicine International Society (TERMIS) Young Investigator Award, given only to two emerging researchers in the whole Asia-Pacific region in 2021), and (c) immunoengineering approaches for periodontal regeneration (introduced into the tertiary learning sector as the world-first Master of Philosophy (Materiobiology) Program at QUT). Dr Zhou has been awarded prestigious fellowships including the Endeavour Research Fellowship (2017), NHMRC Early Career Fellowship (2016-2020), and the BridgeTech Industry Fellowship (2021).
Availability
- Dr Yinghong Zhou is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy of Biomedical Engineering, Queensland University of Technology
Research interests
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Immunoengineered titanium implants towards soft tissue integration
Peri-implantitis is a site-specific infectious disease that causes an inflammatory process in soft tissues, and bone loss surrounding dental implants. The long-term success of titanium (Ti) dental implants therefore relies on a superior transmucosal “seal” to prevent bacteria invasion and subsequent inflammation. It is known that the Ti implant surface topography and chemistry play a key role in controlling the long-standing connective tissue seal. Yet, none of the existing surface coating systems takes into consideration of the initial blood clot formation and immune cell-material interactions. This project, therefore, aims to develop a new generation of multifunctional surface coatings on Ti implants that can fight off bacteria, orchestrate blood clot formation and regulate immune responses to achieve optimal soft tissue integration.
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In vitro modelling to mimic cellular crosstalk in periodontitis
The prevalence of periodontitis (infection-induced inflammatory gum disease) remains relatively high today, reaching to over 50% of the global population. If left untreated, the disease can trigger systemic diseases such as cardiovascular disease, diabetes, and adverse pregnancy outcomes. Till date, the exact interplay between the oral microbiome, immune cells and the surrounding microenvironment remains unclear in the pathogenesis of periodontitis. In vitro platforms can be ideal to systematically pair up key factors in periodontal pathophysiology which is helpful in further understanding of the disease progression and their associated systemic influences. However, the re-creation of heterogenous microenvironments that can support cultures of both oral microbiome (in lower oxygen tension) and the neighbouring macrophages/periodontal ligament cells (in normal oxygen tension) within the same platform without relying on highly specialised equipment remains a key engineering challenge today. Our team has previously formulated functionalise-able hydrogels to locally control the oxygen level which could be used as a medium to support co-culture of bacteria and macrophages/periodontal ligament cells whilst mimicking the heterogenous oxygen level within the oral cavity. This project aims to establish the framework on tuning and characterising the hydrogels’ capability to support the culture of gram-negative anaerobic bacteria critical to periodontal pathogenesis such as Porphyromonas gingivalis (Pg).
Works
Search Professor Yinghong Zhou’s works on UQ eSpace
2015
Conference Publication
A Novel Approach to Study The Immunoregulatory Effect of Exogenous Factors on Macrophages
Huang, R., Zhou, Y. and Xiao, Y. (2015). A Novel Approach to Study The Immunoregulatory Effect of Exogenous Factors on Macrophages. 4th TERMIS World Congress, Boston, MA United States, 8-11 September 2015. New Rochelle, NY United States: Mary Ann Liebert.
2015
Journal Article
Stimulation of osteogenesis and angiogenesis of hBMSCs by delivering Si ions and functional drug from mesoporous silica nanospheres
Shi, Mengchao, Zhou, Yinghong, Shao, Jin, Chen, Zetao, Song, Botao, Chang, Jiang, Wu, Chengtie and Xiao, Yin (2015). Stimulation of osteogenesis and angiogenesis of hBMSCs by delivering Si ions and functional drug from mesoporous silica nanospheres. Acta Biomaterialia, 21, 178-189. doi: 10.1016/j.actbio.2015.04.019
2015
Journal Article
Implantation of osteogenic differentiated donor mesenchymal stem cells causes recruitment of host cells
Zhou, Yinghong, Fan, Wei, Prasadam, Indira, Crawford, Ross and Xiao, Yin (2015). Implantation of osteogenic differentiated donor mesenchymal stem cells causes recruitment of host cells. Journal of Tissue Engineering and Regenerative Medicine, 9 (2), 118-126. doi: 10.1002/term.1619
2014
Journal Article
Role of dentin matrix protein 1 in cartilage redifferentiation and osteoarthritis
Prasadam, Indira, Zhou, Yinghong, Shi, Wei, Crawford, Ross and Xiao, Yin (2014). Role of dentin matrix protein 1 in cartilage redifferentiation and osteoarthritis. Rheumatology, 53 (12), 2280-2287. doi: 10.1093/rheumatology/keu262
2014
Journal Article
Stimulation of osteogenic and angiogenic ability of cells on polymers by pulsed laser deposition of uniform akermanite-glass nanolayer
Wu, Chengtie, Zhai, Dong, Ma, Hongshi, Li, Xiaomin, Zhang, Yali, Zhou, Yinghong, Luo, Yongxiang, Wang, Yueyue, Xiao, Yin and Chang, Jiang (2014). Stimulation of osteogenic and angiogenic ability of cells on polymers by pulsed laser deposition of uniform akermanite-glass nanolayer. Acta Biomaterialia, 10 (7), 3295-3306. doi: 10.1016/j.actbio.2014.03.035
2014
Journal Article
The effect of hypoxia on the stemness and differentiation capacity of PDLC and DPC
Zhou, Yinghong, Fan, Wei and Xiao, Yin (2014). The effect of hypoxia on the stemness and differentiation capacity of PDLC and DPC. BioMed Research International, 2014 890675, 1-7. doi: 10.1155/2014/890675
2014
Journal Article
Silicate-based bioceramics for periodontal regeneration
Zhou, Yinghong, Wu, Chengtie and Xiao, Yin (2014). Silicate-based bioceramics for periodontal regeneration. Journal of Materials Chemistry B, 2 (25), 3907-3910. doi: 10.1039/c4tb00377b
2014
Journal Article
Osteocyte-induced angiogenesis via VEGF-MAPK-dependent pathways in endothelial cells
Prasadam, Indira, Zhou, Yinghong, Du, Zhibin, Chen, Jiezhong, Crawford, Ross and Xiao, Yin (2014). Osteocyte-induced angiogenesis via VEGF-MAPK-dependent pathways in endothelial cells. Molecular and Cellular Biochemistry, 386 (1-2), 15-25. doi: 10.1007/s11010-013-1840-2
2013
Journal Article
Delivery of dimethyloxallyl glycine in mesoporous bioactive glass scaffolds to improve angiogenesis and osteogenesis of human bone marrow stromal cells
Wu, Chengtie, Zhou, Yinghong, Chang, Jiang and Xiao, Yin (2013). Delivery of dimethyloxallyl glycine in mesoporous bioactive glass scaffolds to improve angiogenesis and osteogenesis of human bone marrow stromal cells. Acta Biomaterialia, 9 (11), 9159-9168. doi: 10.1016/j.actbio.2013.06.026
2013
Journal Article
The ionic products from bredigite bioceramics induced cementogenic differentiation of periodontal ligament cells via activation of the Wnt/β-catenin signalling pathway
Zhou, Yinghong, Wu, Chengtie, Zhang, Xufang, Han, Pingping and Xiao, Yin (2013). The ionic products from bredigite bioceramics induced cementogenic differentiation of periodontal ligament cells via activation of the Wnt/β-catenin signalling pathway. Journal of Materials Chemistry B, 1 (27), 3380-3389. doi: 10.1039/c3tb20445f
2013
Journal Article
Nagelschmidtite bioceramics with osteostimulation properties: material chemistry activating osteogenic genes and WNT signalling pathway of human bone marrow stromal cells
Wu, Chengtie, Han, Pingping, Xu, Mengchi, Zhang, Xufang, Zhou, Yinghong, Xue, Guangda, Chang, Jiang and Xiao, Yin (2013). Nagelschmidtite bioceramics with osteostimulation properties: material chemistry activating osteogenic genes and WNT signalling pathway of human bone marrow stromal cells. Journal of Materials Chemistry B, 1 (6), 876-885. doi: 10.1039/c2tb00391k
2013
Journal Article
Mesenchymal stem cells and nano-structured surfaces
Zhou, Yinghong, Chakravorty, Nishant, Xiao, Yin and Gu, Wenyi (2013). Mesenchymal stem cells and nano-structured surfaces. Methods in Molecular Biology, 1058, 133-48. doi: 10.1007/7651_2013_30
2013
Book Chapter
Mesenchymal stem cells and nano-structured surfaces
Zhou, Yinghong, Chakravorty, Nishant, Xiao, Yin and Gu, Wenyi (2013). Mesenchymal stem cells and nano-structured surfaces. Stem Cell Nanotechnology: Methods and Protocols. (pp. 133-148) edited by Turksen, K. New York, NY, United States: Humana Press. doi: 10.1007/7651_2013_30
2013
Journal Article
Preparation and characterization of magnetic mesoporous bioactive glass/carbon composite scaffolds
Zhu, Min, Zhang, Jianhua, Zhou, Yinghong, Liu, Yunfei, He, Xing, Tao, Cuilian and Zhu, Yufang (2013). Preparation and characterization of magnetic mesoporous bioactive glass/carbon composite scaffolds. Journal of Chemistry, 2013 (1) 893479, 1-11. doi: 10.1155/2013/893479
2013
Journal Article
Copper-containing mesoporous bioactive glass scaffolds with multifunctional properties of angiogenesis capacity, osteostimulation and antibacterial activity
Wu, Chengtie, Zhou, Yinghong, Xu, Mengchi, Han, Pingping, Chen, Lei, Chang, Jiang and Xiao, Yin (2013). Copper-containing mesoporous bioactive glass scaffolds with multifunctional properties of angiogenesis capacity, osteostimulation and antibacterial activity. Biomaterials, 34 (2), 422-433. doi: 10.1016/j.biomaterials.2012.09.066
2012
Journal Article
Strontium-containing mesoporous bioactive glass scaffolds with improved osteogenic/cementogenic differentiation of periodontal ligament cells for periodontal tissue engineering
Wu, Chengtie, Zhou, Yinghong, Lin, Chucheng, Chang, Jiang and Xiao, Yin (2012). Strontium-containing mesoporous bioactive glass scaffolds with improved osteogenic/cementogenic differentiation of periodontal ligament cells for periodontal tissue engineering. Acta Biomaterialia, 8 (10), 3805-3815. doi: 10.1016/j.actbio.2012.06.023
2012
Conference Publication
Biomaterials for the stabilization of Hypoxia Inducible Factor 1 (HIF-1) in stem cell recruitment and vascularization
Xiao, Y., Shi, W., Wu, C., Fan, W. and Zhou, Y. (2012). Biomaterials for the stabilization of Hypoxia Inducible Factor 1 (HIF-1) in stem cell recruitment and vascularization. 3rd TERMIS World Congress 2012, Vienna, Austria, 5‐8 September 2012. Hoboken, NJ United States: Wiley-Blackwell.
2012
Journal Article
Oral health related quality of life among older adults in Central China
Zhou, Y., Zhang, M., Jiang, H., Wu, B. and Du, M. (2012). Oral health related quality of life among older adults in Central China. Community Dental Health, 29 (3), 219-223. doi: 10.1922/CDH_2783Du05
2012
Journal Article
Oral health related quality of life among older adults in Central China
Zhou, Y., Zhang, M., Jiang, H., Wu, B. and Du, M. (2012). Oral health related quality of life among older adults in Central China. Community Dental Health, 29 (3), 219-223. doi: 10.1922/CDH_2783Du05
2012
Conference Publication
VEGF induced CXCL12/CXCR4 axis in the recruitment of mesenchymal stem cells (MSCs) by osteogenic differentiated bone marrow stromal cells (O-BMSCs)
Zhou, Y., Fan, W., Prasadam, I., Crawford, R. and Xiao, Y. (2012). VEGF induced CXCL12/CXCR4 axis in the recruitment of mesenchymal stem cells (MSCs) by osteogenic differentiated bone marrow stromal cells (O-BMSCs). 3rd TERMIS World Congress 2012, Vienna, Austria, 5‐8 September 2012. Hoboken, NJ United States: Wiley-Blackwell.
Funding
Current funding
Past funding
Supervision
Availability
- Dr Yinghong Zhou is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Biomimetic nanoplatform enhances bone regeneration through immunomodulation
Principal Advisor
Other advisors: Professor Saso Ivanovski, Dr Pingping Han
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Doctor Philosophy
Novel nanomaterials of cerium-doped ZIF-62 for periodontal tissue regeneration
Principal Advisor
Other advisors: Professor Saso Ivanovski
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Doctor Philosophy
Development of an oral biofilm-oral epithelial cells co-culture model based on jammed-packed microgel
Principal Advisor
Other advisors: Associate Professor Jaya Seneviratne
Media
Enquiries
Contact Dr Yinghong Zhou directly for media enquiries about:
- biomaterials
- bone tissue engineering
- regenerative dentistry
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