Overview
Background
Dr Yinghong Zhou leads the ImmunoEngineering for Regenerative Dentistry research team at the School of Dentistry. Her research interests extend across several transdisciplinary research projects, all with the central theme of biomedical engineering and bone/periodontal tissue regeneration. Her high-quality research leads the field in (a) hypoxia-mimicking bioscaffolds for bone regeneration (field-weighted citation impact=13.15), (b) trace element-mediated biomineralization (recognised by the Tissue Engineering and Regenerative Medicine International Society (TERMIS) Young Investigator Award, given only to two emerging researchers in the whole Asia-Pacific region in 2021), and (c) immunoengineering approaches for periodontal regeneration (introduced into the tertiary learning sector as the world-first Master of Philosophy (Materiobiology) Program at QUT). Dr Zhou has been awarded prestigious fellowships including the Endeavour Research Fellowship (2017), NHMRC Early Career Fellowship (2016-2020), and the BridgeTech Industry Fellowship (2021).
Availability
- Dr Yinghong Zhou is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy of Biomedical Engineering, Queensland University of Technology
Research interests
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Immunoengineered titanium implants towards soft tissue integration
Peri-implantitis is a site-specific infectious disease that causes an inflammatory process in soft tissues, and bone loss surrounding dental implants. The long-term success of titanium (Ti) dental implants therefore relies on a superior transmucosal “seal” to prevent bacteria invasion and subsequent inflammation. It is known that the Ti implant surface topography and chemistry play a key role in controlling the long-standing connective tissue seal. Yet, none of the existing surface coating systems takes into consideration of the initial blood clot formation and immune cell-material interactions. This project, therefore, aims to develop a new generation of multifunctional surface coatings on Ti implants that can fight off bacteria, orchestrate blood clot formation and regulate immune responses to achieve optimal soft tissue integration.
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In vitro modelling to mimic cellular crosstalk in periodontitis
The prevalence of periodontitis (infection-induced inflammatory gum disease) remains relatively high today, reaching to over 50% of the global population. If left untreated, the disease can trigger systemic diseases such as cardiovascular disease, diabetes, and adverse pregnancy outcomes. Till date, the exact interplay between the oral microbiome, immune cells and the surrounding microenvironment remains unclear in the pathogenesis of periodontitis. In vitro platforms can be ideal to systematically pair up key factors in periodontal pathophysiology which is helpful in further understanding of the disease progression and their associated systemic influences. However, the re-creation of heterogenous microenvironments that can support cultures of both oral microbiome (in lower oxygen tension) and the neighbouring macrophages/periodontal ligament cells (in normal oxygen tension) within the same platform without relying on highly specialised equipment remains a key engineering challenge today. Our team has previously formulated functionalise-able hydrogels to locally control the oxygen level which could be used as a medium to support co-culture of bacteria and macrophages/periodontal ligament cells whilst mimicking the heterogenous oxygen level within the oral cavity. This project aims to establish the framework on tuning and characterising the hydrogels’ capability to support the culture of gram-negative anaerobic bacteria critical to periodontal pathogenesis such as Porphyromonas gingivalis (Pg).
Works
Search Professor Yinghong Zhou’s works on UQ eSpace
2019
Journal Article
Immunoregulatory role of exosomes derived from differentiating mesenchymal stromal cells on inflammation and osteogenesis
Wei, Fei, Li, Zhengmao, Crawford, Ross, Xiao, Yin and Zhou, Yinghong (2019). Immunoregulatory role of exosomes derived from differentiating mesenchymal stromal cells on inflammation and osteogenesis. Journal of Tissue Engineering and Regenerative Medicine, 13 (11), 1978-1991. doi: 10.1002/term.2947
2019
Journal Article
Focused ion beams in biology: how the helium ion microscope and FIB/SEMs help reveal nature's tiniest structures
Wolff, Annalena, Klingner, Nico, Thompson, William, Zhou, Yinghong, Lin, Jinying, Peng, Yong Y, Ramshaw, John A.M. and Xiao, Yin (2019). Focused ion beams in biology: how the helium ion microscope and FIB/SEMs help reveal nature's tiniest structures. Microscopy and Microanalysis, 25 (S2), 864-865. doi: 10.1017/s1431927619005051
2019
Journal Article
S1P-S1PR1 signaling: the "Sphinx"in osteoimmunology
Xiao, Lan, Zhou, Yinghong, Friis, Thor, Beagley, Kenneth and Xiao, Yin (2019). S1P-S1PR1 signaling: the "Sphinx"in osteoimmunology. Frontiers in Immunology, 10 (JUN) 1409. doi: 10.3389/fimmu.2019.01409
2019
Journal Article
Exosome-integrated titanium oxide nanotubes for targeted bone regeneration
Wei, Fei, Li, Mengting, Crawford, Ross, Zhou, Yinghong and Xiao, Yin (2019). Exosome-integrated titanium oxide nanotubes for targeted bone regeneration. Acta Biomaterialia, 86, 480-492. doi: 10.1016/j.actbio.2019.01.006
2019
Book Chapter
Interaction between mesenchymal stem cells and immune cells in tissue engineering
Huang, Rong, Zhou, Yinghong and Xiao, Yin (2019). Interaction between mesenchymal stem cells and immune cells in tissue engineering. Encyclopedia of biomedical engineering. (pp. 249-256) edited by R. Narayan. Amsterdam, Netherlands: Elsevier. doi: 10.1016/b978-0-12-801238-3.99877-5
2018
Journal Article
The bidirectional interactions between inflammation and coagulation in fracture hematoma
Ma, Yaping, Zhou, Yinghong, Wu, Fujun, Ji, Wenjun, Zhang, Jun and Wang, Xin (2018). The bidirectional interactions between inflammation and coagulation in fracture hematoma. Tissue Engineering Part B - Reviews, 25 (1), 46-54. doi: 10.1089/ten.teb.2018.0157
2018
Journal Article
SPHK1-S1PR1-RANKL axis regulates the interactions between macrophages and BMSCs in inflammatory bone loss
Xiao, Lan, Zhou, Yinghong, Zhu, Lingxin, Yang, Shasha, Huang, Rong, Shi, Wei, Peng, Bin and Xiao, Yin (2018). SPHK1-S1PR1-RANKL axis regulates the interactions between macrophages and BMSCs in inflammatory bone loss. Journal of Bone and Mineral Research, 33 (6), 1090-1104. doi: 10.1002/jbmr.3396
2018
Journal Article
The immunomodulatory role of BMP-2 on macrophages to accelerate osteogenesis
Wei, Fei, Zhou, Yinghong, Wang, Jing, Liu, Changsheng and Xiao, Yin (2018). The immunomodulatory role of BMP-2 on macrophages to accelerate osteogenesis. Tissue Engineering Part A, 24 (7-8), 584-594. doi: 10.1089/ten.tea.2017.0232
2018
Journal Article
Notch expressed by osteocytes plays a critical role in mineralisation
Shao, Jin, Zhou, Yinghong, Lin, Jinying, Trung Dung Nguyen, , Huang, Rong, Gu, Yuantong, Friis, Thor, Crawford, Ross and Xiao, Yin (2018). Notch expressed by osteocytes plays a critical role in mineralisation. Journal of Molecular Medicine, 96 (3-4), 333-347. doi: 10.1007/s00109-018-1625-x
2018
Journal Article
The regulatory roles of Notch in osteocyte differentiation via the crosstalk with canonical Wnt pathways during the transition of osteoblasts to osteocytes
Shao, Jin, Zhou, Yinghong and Xiao, Yin (2018). The regulatory roles of Notch in osteocyte differentiation via the crosstalk with canonical Wnt pathways during the transition of osteoblasts to osteocytes. Bone, 108, 165-178. doi: 10.1016/j.bone.2018.01.010
2018
Journal Article
Accelerated host angiogenesis and immune responses by ion release from mesoporous bioactive glass
Zhou, Yinghong, Han, Shengwei, Xiao, Lan, Han, Pingping, Wang, Shengfang, He, Jie, Chang, Jiang, Wu, Chengtie and Xiao, Yin (2018). Accelerated host angiogenesis and immune responses by ion release from mesoporous bioactive glass. Journal of Materials Chemistry B, 6 (20), 3274-3284. doi: 10.1039/c8tb00683k
2018
Journal Article
Mesenchymal stromal cells regulate the cell mobility and the immune response during osteogenesis through secretion of vascular endothelial growth factor A
Zhou, Yinghong, Huang, Rong, Fan, Wei, Prasadam, Indira, Crawford, Ross and Xiao, Yin (2018). Mesenchymal stromal cells regulate the cell mobility and the immune response during osteogenesis through secretion of vascular endothelial growth factor A. Journal of Tissue Engineering and Regenerative Medicine, 12 (1), E566-E578. doi: 10.1002/term.2327
2017
Journal Article
RANKL-induced M1 macrophages are involved in bone formation
Huang, Rong, Wang, Xin, Zhou, Yinghong and Xiao, Yin (2017). RANKL-induced M1 macrophages are involved in bone formation. Bone Research, 5 (1) 17019. doi: 10.1038/boneres.2017.19
2017
Journal Article
Strategies to direct vascularisation using mesoporous bioactive glass-based biomaterials for bone regeneration
Zhou, Yinghong, Shi, Mengchao, Jones, Julian R., Chen, Zetao, Chang, Jiang, Wu, Chengtie and Xiao, Yin (2017). Strategies to direct vascularisation using mesoporous bioactive glass-based biomaterials for bone regeneration. International Materials Reviews, 62 (7), 392-414. doi: 10.1080/09506608.2016.1266744
2016
Journal Article
The impact of Wnt signalling and hypoxia on osteogenic and cementogenic differentiation in human periodontal ligament cells
Li, Shuigen, Shao, Jin, Zhou, Yinghong, Friis, Thor, Yao, Jiangwu, Shi, Bin and Xiao, Yin (2016). The impact of Wnt signalling and hypoxia on osteogenic and cementogenic differentiation in human periodontal ligament cells. Molecular Medicine Reports, 14 (6), 4975-4982. doi: 10.3892/mmr.2016.5909
2016
Journal Article
Special collection: cell-based therapy for bone regeneration
Zhou, Yinghong and van den Beucken, Jeroen J. J. P. (2016). Special collection: cell-based therapy for bone regeneration. Tissue Engineering - Part A, 22 (19-20), 1127-1128. doi: 10.1089/ten.tea.2016.0249
2016
Journal Article
Blood clot formed on rough titanium surface induces early cell recruitment
Yang, Jin, Zhou, Yinghong, Wei, Fei and Xiao, Yin (2016). Blood clot formed on rough titanium surface induces early cell recruitment. Clinical Oral Implants Research, 27 (8), 1031-1038. doi: 10.1111/clr.12672
2016
Journal Article
Multi-elemental profiling of tibial and maxillary trabecular bone in ovariectomised rats
Han, Pingping, Lu, Shifeier, Zhou, Yinghong, Moromizato, Karine, Du, Zhibin, Friis, Thor and Xiao, Yin (2016). Multi-elemental profiling of tibial and maxillary trabecular bone in ovariectomised rats. International Journal of Molecular Sciences, 17 (6) 977, 977. doi: 10.3390/ijms17060977
2016
Journal Article
Bifunctional bioceramics stimulating osteogenic differentiation of a gingival fibroblast and inhibiting plaque biofilm formation
Shen, Ya, Wang, Zhejun, Wang, Jiao, Zhou, Yinghong, Chen, Hui, Wu, Chengtie and Haapasalo, Markus (2016). Bifunctional bioceramics stimulating osteogenic differentiation of a gingival fibroblast and inhibiting plaque biofilm formation. Biomaterials Science, 4 (4), 639-651. doi: 10.1039/c5bm00534e
2015
Journal Article
Biophysical response of living cells to boron nitride nanoparticles: uptake mechanism and bio-mechanical characterization
Rasel, Md. Alim Iftekhar, Li, Tong, Trung Dung Nguyen, , Singh, Sanjleena, Zhou, Yinghong, Xiao, Yin and Gu, YuanTong (2015). Biophysical response of living cells to boron nitride nanoparticles: uptake mechanism and bio-mechanical characterization. Journal of Nanoparticle Research, 17 (11) 441. doi: 10.1007/s11051-015-3248-2
Funding
Current funding
Past funding
Supervision
Availability
- Dr Yinghong Zhou is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Biomimetic nanoplatform enhances bone regeneration through immunomodulation
Principal Advisor
Other advisors: Professor Saso Ivanovski, Dr Pingping Han
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Doctor Philosophy
Novel nanomaterials of cerium-doped ZIF-62 for periodontal tissue regeneration
Principal Advisor
Other advisors: Professor Saso Ivanovski
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Doctor Philosophy
Development of an oral biofilm-oral epithelial cells co-culture model based on jammed-packed microgel
Principal Advisor
Other advisors: Associate Professor Jaya Seneviratne
Media
Enquiries
Contact Dr Yinghong Zhou directly for media enquiries about:
- biomaterials
- bone tissue engineering
- regenerative dentistry
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