Overview
Background
Dr Yinghong Zhou leads the ImmunoEngineering for Regenerative Dentistry research team at the School of Dentistry. Her research interests extend across several transdisciplinary research projects, all with the central theme of biomedical engineering and bone/periodontal tissue regeneration. Her high-quality research leads the field in (a) hypoxia-mimicking bioscaffolds for bone regeneration (field-weighted citation impact=13.15), (b) trace element-mediated biomineralization (recognised by the Tissue Engineering and Regenerative Medicine International Society (TERMIS) Young Investigator Award, given only to two emerging researchers in the whole Asia-Pacific region in 2021), and (c) immunoengineering approaches for periodontal regeneration (introduced into the tertiary learning sector as the world-first Master of Philosophy (Materiobiology) Program at QUT). Dr Zhou has been awarded prestigious fellowships including the Endeavour Research Fellowship (2017), NHMRC Early Career Fellowship (2016-2020), and the BridgeTech Industry Fellowship (2021).
Availability
- Dr Yinghong Zhou is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy of Biomedical Engineering, Queensland University of Technology
Research interests
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Immunoengineered titanium implants towards soft tissue integration
Peri-implantitis is a site-specific infectious disease that causes an inflammatory process in soft tissues, and bone loss surrounding dental implants. The long-term success of titanium (Ti) dental implants therefore relies on a superior transmucosal “seal” to prevent bacteria invasion and subsequent inflammation. It is known that the Ti implant surface topography and chemistry play a key role in controlling the long-standing connective tissue seal. Yet, none of the existing surface coating systems takes into consideration of the initial blood clot formation and immune cell-material interactions. This project, therefore, aims to develop a new generation of multifunctional surface coatings on Ti implants that can fight off bacteria, orchestrate blood clot formation and regulate immune responses to achieve optimal soft tissue integration.
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In vitro modelling to mimic cellular crosstalk in periodontitis
The prevalence of periodontitis (infection-induced inflammatory gum disease) remains relatively high today, reaching to over 50% of the global population. If left untreated, the disease can trigger systemic diseases such as cardiovascular disease, diabetes, and adverse pregnancy outcomes. Till date, the exact interplay between the oral microbiome, immune cells and the surrounding microenvironment remains unclear in the pathogenesis of periodontitis. In vitro platforms can be ideal to systematically pair up key factors in periodontal pathophysiology which is helpful in further understanding of the disease progression and their associated systemic influences. However, the re-creation of heterogenous microenvironments that can support cultures of both oral microbiome (in lower oxygen tension) and the neighbouring macrophages/periodontal ligament cells (in normal oxygen tension) within the same platform without relying on highly specialised equipment remains a key engineering challenge today. Our team has previously formulated functionalise-able hydrogels to locally control the oxygen level which could be used as a medium to support co-culture of bacteria and macrophages/periodontal ligament cells whilst mimicking the heterogenous oxygen level within the oral cavity. This project aims to establish the framework on tuning and characterising the hydrogels’ capability to support the culture of gram-negative anaerobic bacteria critical to periodontal pathogenesis such as Porphyromonas gingivalis (Pg).
Works
Search Professor Yinghong Zhou’s works on UQ eSpace
2023
Book Chapter
Engineered adult stem cells: current clinical trials status of disease treatment
Han, Pingping, Moran, Corey Stephan, Liu, Chun, Griffiths, Rebecca, Zhou, Yinghong and Ivanovski, Sašo (2023). Engineered adult stem cells: current clinical trials status of disease treatment. Stem Cell in Medicine. (pp. 33-62) San Diego, CA United States: Academic Press. doi: 10.1016/bs.pmbts.2023.02.007
2022
Journal Article
Current advances in 3D dynamic cell culture systems
Huang, Xin, Huang, Zhengxiang, Gao, Weidong, Gao, Wendong, He, Ruiying, Li, Yulin, Crawford, Ross, Zhou, Yinghong, Xiao, Lan and Xiao, Yin (2022). Current advances in 3D dynamic cell culture systems. Gels, 8 (12) 829, 1-20. doi: 10.3390/gels8120829
2022
Journal Article
Inflammatory macrophages interrupt osteocyte maturation and mineralization via regulating the Notch signaling pathway
Wang, Shengfang, Xiao, Lan, Prasadam, Indira, Crawford, Ross, Zhou, Yinghong and Xiao, Yin (2022). Inflammatory macrophages interrupt osteocyte maturation and mineralization via regulating the Notch signaling pathway. Molecular Medicine, 28 (1) 102, 1-21. doi: 10.1186/s10020-022-00530-4
2022
Journal Article
Dual photothermal nanocomposites for drug-resistant infectious wound management
Li, Changgui, Xian, Jiaru, Hong, Jixuan, Cao, Xiaxin, Zhang, Changze, Deng, Qiaoyuan, Qin, Ziyu, Chen, Maohua, Zheng, Xiaofei, Li, Mengting, Hou, Jingwei, Zhou, Yinghong and Yin, Xueqiong (2022). Dual photothermal nanocomposites for drug-resistant infectious wound management. Nanoscale, 14 (31), 11284-11297. doi: 10.1039/d2nr01998a
2022
Journal Article
Synovial macrophages in cartilage destruction and regeneration-lessons learnt from osteoarthritis and synovial chondromatosis
Li, Yingjie, Zhou, Yinghong, Wang, Yifan, Crawford, Ross and Xiao, Yin (2022). Synovial macrophages in cartilage destruction and regeneration-lessons learnt from osteoarthritis and synovial chondromatosis. Biomedical Materials, 17 (1) 012001, 012001. doi: 10.1088/1748-605X/ac3d74
2022
Journal Article
Phase control of ZIF-7 nanoparticles via mechanochemical synthesis
Bin Zulkifli, Muhammad Yazid, Yao, Yuqi, Chen, Ruiqi, Chai, Milton, Su, Kun, Li, Xuemei, Zhou, Yinghong, Lin, Rijia, Zhu, Zhonghua, Liang, Kang, Chen, Vicki and Hou, Jingwei (2022). Phase control of ZIF-7 nanoparticles via mechanochemical synthesis. Chemical Communications, 58 (88), 12297-12300. doi: 10.1039/d2cc04054a
2021
Journal Article
The identification of critical time windows of postnatal root elongation in response to Wnt/beta-catenin signaling
Wang, Jun, Jiang, Yong, Xie, Xudong, Zhang, Shiwen, Xu, Chunmei, Zhou, Yinghong and Feng, Jian Q. (2021). The identification of critical time windows of postnatal root elongation in response to Wnt/beta-catenin signaling. Oral Diseases, 28 (2), 442-451. doi: 10.1111/odi.13753
2021
Journal Article
Carbon nanomaterials modified biomimetic dental implants for diabetic patients
Vijay, Renjini, Mendhi, Jayanti, Prasad, Karthika, Xiao, Yin, MacLeod, Jennifer, Ostrikov, Kostya (Ken) and Zhou, Yinghong (2021). Carbon nanomaterials modified biomimetic dental implants for diabetic patients. Nanomaterials, 11 (11) 2977, 2977. doi: 10.3390/nano11112977
2021
Journal Article
Multifunctional Ca-Zn-Si-based micro-nano spheres with anti-infective, anti-inflammatory, and dentin regenerative properties for pulp capping application
Li, Zhengmao, Xie, Kunke, Yang, Shuang, Yu, Ting, Xiao, Yin and Zhou, Yinghong (2021). Multifunctional Ca-Zn-Si-based micro-nano spheres with anti-infective, anti-inflammatory, and dentin regenerative properties for pulp capping application. Journal of Materials Chemistry B, 9 (39), 8289-8299. doi: 10.1039/d1tb01517f
2021
Journal Article
Modulatory role of silver nanoparticles and mesenchymal stem cell-derived exosome-modified barrier membrane on macrophages and osteogenesis
Lu, Haiping, Zhang, Yi, Xiong, Shan, Zhou, Yinghong, Xiao, Lan, Ma, Yaping, Xiao, Yin and Wang, Xin (2021). Modulatory role of silver nanoparticles and mesenchymal stem cell-derived exosome-modified barrier membrane on macrophages and osteogenesis. Frontiers in Chemistry, 9 699802. doi: 10.3389/fchem.2021.699802
2021
Journal Article
Untargeted and targeted gingival metabolome in rodents reveal metabolic links between high-fat diet-induced obesity and periodontitis
Chen, Zi-yun, Xu, Tian-tian, Liang, Zhao-jia, Zhao, Li, Xiong, Xiao-qin, Xie, Kun-ke, Yu, Wan-xin, Zeng, Xiao-wen, Gao, Jie, Zhou, Ying-hong, Luo, Gang and Yu, Ting (2021). Untargeted and targeted gingival metabolome in rodents reveal metabolic links between high-fat diet-induced obesity and periodontitis. Journal of Clinical Periodontology, 48 (8), 1137-1148. doi: 10.1111/jcpe.13486
2021
Journal Article
Current application of beta-tricalcium phosphate in bone repair and its mechanism to regulate osteogenesis
Lu, Haiping, Zhou, Yinghong, Ma, Yaping, Xiao, Lan, Ji, Wenjun, Zhang, Yi and Wang, Xin (2021). Current application of beta-tricalcium phosphate in bone repair and its mechanism to regulate osteogenesis. Frontiers in Materials, 8 698915. doi: 10.3389/fmats.2021.698915
2021
Journal Article
Reduction of mechanical loading in tendons induces heterotopic ossification and activation of the beta-catenin signaling pathway
Wang, Tao, Chen, Peilin, Chen, Lianzhi, Zhou, Yinghong, Wang, Allan, Zheng, Qiujian, Mitchell, Christopher A., Leys, Toby, Tuan, Rocky S. and Zheng, Ming H. (2021). Reduction of mechanical loading in tendons induces heterotopic ossification and activation of the beta-catenin signaling pathway. Journal of Orthopaedic Translation, 29, 42-50. doi: 10.1016/j.jot.2021.03.004
2021
Journal Article
Effect of fibronectin, FGF-2, and BMP4 in the stemness maintenance of BMSCs and the metabolic and proteomic cues involved
Chen, Lingling, Carlton, Morgan, Chen, Xiaodan, Kaur, Navdeep, Ryan, Hollie, Parker, Tony J., Lin, Zhengmei, Xiao, Yin and Zhou, Yinghong (2021). Effect of fibronectin, FGF-2, and BMP4 in the stemness maintenance of BMSCs and the metabolic and proteomic cues involved. Stem Cell Research and Therapy, 12 (1) 165, 165. doi: 10.1186/s13287-021-02227-7
2021
Journal Article
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
Klionsky, Daniel J., Abdel-Aziz, Amal Kamal, Abdelfatah, Sara, Abdellatif, Mahmoud, Abdoli, Asghar, Abel, Steffen, Abeliovich, Hagai, Abildgaard, Marie H., Abudu, Yakubu Princely, Acevedo-Arozena, Abraham, Adamopoulos, Iannis E., Adeli, Khosrow, Adolph, Timon E., Adornetto, Annagrazia, Aflaki, Elma, Agam, Galila, Agarwal, Anupam, Aggarwal, Bharat B., Agnello, Maria, Agostinis, Patrizia, Agrewala, Javed N., Agrotis, Alexander, Aguilar, Patricia V., Ahmad, S. Tariq, Ahmed, Zubair M., Ahumada-Castro, Ulises, Aits, Sonja, Aizawa, Shu, Akkoc, Yunus ... Tong, Chun-Kit (2021). Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy, 17 (1), 1-382. doi: 10.1080/15548627.2020.1797280
2020
Journal Article
Synergistic regulation of osteoimmune microenvironment by IL-4 and RGD to accelerate osteogenesis
Li, Mengting, Wei, Fei, Yin, Xueqiong, Xiao, Lan, Yang, Lan, Su, Jiehua, Weng, Jie, Feng, Bo, Xiao, Yin and Zhou, Yinghong (2020). Synergistic regulation of osteoimmune microenvironment by IL-4 and RGD to accelerate osteogenesis. Materials Science and Engineering C: Materials for Biological Applications, 109 110508. doi: 10.1016/j.msec.2019.110508
2020
Book Chapter
The development of extracellular vesicle-integrated biomaterials for bone regeneration
Zhou, Yinghong and Xiao, Yin (2020). The development of extracellular vesicle-integrated biomaterials for bone regeneration. Biomimicked biomaterials: advances in tissue engineering and regenerative medicine. (pp. 97-108) edited by Heung Jae Chun, Rui L. Reis, Antonella Motta and Gilson Khang. Singapore: Springer . doi: 10.1007/978-981-15-3262-7_7
2020
Journal Article
Dihydrolipoic acid-gold nanoclusters regulate microglial polarization and have the potential to alter neurogenesis
Xiao, Lan, Wei, Fei, Zhou, Yinghong, Anderson, Gregory J., Frazer, David M., Lim, Yi Chieh, Liu, Tianqing and Xiao, Yin (2020). Dihydrolipoic acid-gold nanoclusters regulate microglial polarization and have the potential to alter neurogenesis. Nano Letters, 20 (1), 478-495. doi: 10.1021/acs.nanolett.9b04216
2020
Journal Article
Engineering of aerogel-based biomaterials for biomedical applications
Zheng, Longpo, Zhang, Shaodi, Ying, Zhengran, Liu, Junjian, Zhou, Yinghong and Chen, Feng (2020). Engineering of aerogel-based biomaterials for biomedical applications. International Journal of Nanomedicine, 15, 2363-2378. doi: 10.2147/ijn.s238005
2019
Journal Article
Aberrant activation of Wnt signaling pathway altered osteocyte mineralization
Zhou, Yinghong, Lin, Jinying, Shao, Jin, Zuo, Qiliang, Wang, Shengfang, Wolff, Annalena, Dung Trung Nguyen, , Rintoul, Llew, Du, Zhibin, Gu, Yuantong, Peng, Yong Y., Ramshaw, John A. M., Long, Xing and Xiao, Yin (2019). Aberrant activation of Wnt signaling pathway altered osteocyte mineralization. Bone, 127, 324-333. doi: 10.1016/j.bone.2019.06.027
Funding
Current funding
Past funding
Supervision
Availability
- Dr Yinghong Zhou is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Biomimetic nanoplatform enhances bone regeneration through immunomodulation
Principal Advisor
Other advisors: Professor Saso Ivanovski, Dr Pingping Han
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Doctor Philosophy
Novel nanomaterials of cerium-doped ZIF-62 for periodontal tissue regeneration
Principal Advisor
Other advisors: Professor Saso Ivanovski
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Doctor Philosophy
Development of an oral biofilm-oral epithelial cells co-culture model based on jammed-packed microgel
Principal Advisor
Other advisors: Associate Professor Jaya Seneviratne
Media
Enquiries
Contact Dr Yinghong Zhou directly for media enquiries about:
- biomaterials
- bone tissue engineering
- regenerative dentistry
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