
Overview
Background
Andrew Martin is inaugural Professor of Innovative Clinical Trials and leads the University of Queensland’s cLinical Trials cApability (ULTRA) program. Andrew was Professor in the biostatistics group at the NHMRC Clinical Trials Centre University of Sydney. He maintains that role in an honorary capacity since joining UQ. Prior to academia, Andrew held senior biostatistics roles within research-based pharmaceutical organisations (Pfizer and Roche).
Grants
Category 1: $14.3M Category 3: $131.8M
Grants: 2023 Clinical Trials and Cohort Studies Grant ID 2032441 ($1,362,000): P3BEP Trial - Accelerating First-Line Chemotherapy to Improve Cure Rates for Advanced Germ Cell Tumours; 2022 NHMRC Partnership Projects Grant 2015773 ($1,166,592): Strengthening healthcare systems with Patient Reported Outcome Measures (PROMs); 2020 CA ($600,000): Immuno-metabolic biomarkers for metastatic prostate cancer treatment response; 2018 MRFF Grant APP1170066 ($1,596,631): WHEAT Study on reducing NEC in preterm infants; 2018 CA Grant APP1158397 ($479,375): SCORE trial for shared colorectal cancer care; 2018 CA Grant APP1159837 ($600,000): P3BEP Trial for advanced germ cell tumours; 2018 NHMRC Project Grant APP1159787 ($1,587,163): BCG+MM Trial for bladder cancer; 2016 Victorian Cancer ($300,000): SCORE project on shared care of Colorectal cancer survivors; 2015 CA Priority-driven Collaborative Cancer Research Scheme ($443,307): LEAD - Lung cancer diagnostic and treatment pathways; 2015 NHMRC Project Grant 1108328 ($624,824): Oral Nicotinamide for skin cancer chemoprevention after Transplant; 2014 Co-funded Grant 1079794 ($597,095): Methoxyflurane to reduce discomfort of prostate biopsy; 2013 NHMRC Project Grant 1064121 ($880,425): CHEST Australia project for quicker primary care consultations in lung cancer; 2012 NHMRC Project Grant APP1047100 ($2,203,171): Bovine lactoferrin study on low birthweight infants; 2011 National Breast Cancer Foundation ($199,606): Physical well-being for metastatic breast cancer; 2011 NHMRC Project Grant 1028555 ($187,018): Evidence on reduced child obesity rates; 2011 NHMRC Project Grant 1026977 ($586,691): Oral nicotinamide for skin cancer prevention; 2011 Australasian College of Dermatologists grant ($25,000): Nicotinamide for non-melanoma skin cancer in renal transplant recipients; 2010 NHMRC Project Grant 1007628 ($369,208): NEU-HORIZONS study on riluzole for oxaliplatin neurotoxicity; 2010 NHMRC Project Grant 1003414 ($564,410): Phase II prostate cancer follow-up trial in primary care.
Statistical lead on the following projects receiving industry funding with USyd as administering institution: ENZARAD NCT02446444 ($12,178,000); ENZAMET NCT02446405 ($20,408,129); INTEGRATE ACTRN12612000239864 ($6,900,000); INTEGRATE IIa ACTRN12616000420448 ($22,264,248); INTEGRATE IIb NCT04879368 ($36,330,215); DASL-HiCaP NCT04136353 ($33,777,579).
Availability
- Professor Andrew Martin is:
- Available for supervision
Research impacts
Research Achievements and Collaborations: Has made original, innovative, and distinguished contributions to methodological research, as well as the design, conduct, analysis, interpretation, and dissemination of clinical research that has had an impact at an international level policy, practice, and subsequent research programs. Has been responsible for the provision of statistical leadership to collaborative trials groups to design, undertake, analyse, and report on clinical trials, as well as promoting investigator-initiated research activities. 2020-2024 Scopus/SciVal author publication metrics: FWCI of 5.21, 51% in top 10% most cited worldwide, 39% international collaboration 3,763 citations (10,934 overall). Received the 2020 ACTA (Australian Clinical Trials Alliance) Statistics in Trials Interest Group Excellence in Trial Statistics Award for ENZAMET Trial. Research funding in last 5 years: $3.1M category 1 and $76.7M category 3.
Contributions to the Field: Led methodological research with international impact. Examples in the last 5 years focus on the topic of changes to the design of ongoing trials. This work has been cited in the CONSERVE 2021 Statement (JAMA. 2021;326(3):257-265 FWCI 7.38; top 1% of general medical journals). Also co-published innovative method for appropriately adjusting estimates of effect obtained from trials that terminate early based on the results of an interim analysis (Statistical Methods in Medical Research – top 11% for statistics journals). Co-designed andled the statistical aspects of design, conduct, analysis, and interpretation of many trial. Two key examples in the last 5 years include ENZAMET and TheraP. (1) ENZAMET study selected for plenary presentation at ASCO (peak international clinical oncology conference attended by over 30,000 international delegates). Am second author for both main N Engl J Med paper (2019;381:121) (journal ranked top 1% general medicine), the quality of life J Clin Oncol paper (2022;40:837-46) (journal ranked top 2% cancer research), and the follow-up Lancet Oncol paper (2022;23:1389) (journal ranked top 1% cancer research). Results were used in support of successful registration of enzalutamide with US FDA in this indication and have been incorporated into US and European treatment guidelines. (2) TheraP evaluated efficacy of cutting-edge targeted radiopharmaceutical (Lu-PSMA) in advance prostate cancer that delivers radiation to cells expressing the prostate-specific membrane antigen. Selected for oral presentation at highly prestigious ASCO 2020 and ASCO GU 2021 conferences. Second senior author of The Lancet paper (2021;397:797) (journal ranked top 1% general medicine). Has led to 2 additional RCTs of Lu-PSMA that I co-designed. One (ENZA-p) was just published in Lancet Oncol (2024 Apr 12:S1470-2045(24)00135-9) (journal ranked top 1% cancer research).
Works
Search Professor Andrew Martin’s works on UQ eSpace
2012
Journal Article
Effectiveness and cost-effectiveness of sentinel lymph node biopsy compared with axillary node dissection in patients with early-stage breast cancer: A decision model analysis
Verry, H., Lord, S. J., Martin, A., Gill, G., Lee, C. K., Howard, K., Wetzig, N. and Simes, J. (2012). Effectiveness and cost-effectiveness of sentinel lymph node biopsy compared with axillary node dissection in patients with early-stage breast cancer: A decision model analysis. British Journal of Cancer, 106 (6), 1045-1052. doi: 10.1038/bjc.2012.62
2012
Journal Article
Identification of infants with major cognitive delay using parental report
Martin, Andrew J., Darlow, Brian A., Salt, Alison, Hague, Wendy, Sebastian, Lucille, Mann, Kristy and Tarnow-Mordi, William (2012). Identification of infants with major cognitive delay using parental report. Developmental Medicine and Child Neurology, 54 (3), 254-259. doi: 10.1111/j.1469-8749.2011.04161.x
2012
Journal Article
Oral nicotinamide reduces actinic keratoses in phase II double-blinded randomized controlled trials
Surjana, Devita, Halliday, Gary M., Martin, Andrew J., Moloney, Fergal J. and Damian, Diona L. (2012). Oral nicotinamide reduces actinic keratoses in phase II double-blinded randomized controlled trials. Journal of Investigative Dermatology, 132 (5), 1497-1500. doi: 10.1038/jid.2011.459
2011
Journal Article
Safety and efficacy of pregabalin in patients with central post-stroke pain
Kim, Jong S., Bashford, Guy, Murphy, T. Kevin, Martin, Andrew, Dror, Vardit and Cheung, Raymond (2011). Safety and efficacy of pregabalin in patients with central post-stroke pain. Pain, 152 (5), 1018-1023. doi: 10.1016/j.pain.2010.12.023
2011
Journal Article
Efficacy of Pregabalin for Peripheral Neuropathic Pain: Results of an 8-Week, Flexible-Dose, Double-Blind, Placebo-Controlled Study Conducted in China
Guan, Yuzhou, Ding, Xinsheng, Cheng, Yan, Fan, Dongsheng, Tan, Lan, Wang, Yongjun, Zhao, Zhongxin, Hong, Zhen, Zhou, Dong, Pan, Xiaoping, Chen, Shengdi, Martin, Andrew, Tang, Haiyun and Cui, Liying (2011). Efficacy of Pregabalin for Peripheral Neuropathic Pain: Results of an 8-Week, Flexible-Dose, Double-Blind, Placebo-Controlled Study Conducted in China. Clinical Therapeutics, 33 (2), 159-166. doi: 10.1016/j.clinthera.2011.02.007
2010
Journal Article
A Verification System for Interval-Based Specification Languages
Chen, Chunqing, Dong, Jin Song, Sun, Jun and Martin, Andrew (2010). A Verification System for Interval-Based Specification Languages. Acm Transactions On Software Engineering and Methodology, 19 (4) 13. doi: 10.1145/1734229.1734232
2005
Journal Article
Randomized trial of sertraline versus venlafaxine XR in major depression: Efficacy and discontinuation symptoms
Sir, Aytekin, D'Souza, Russell F., Uguz, Sukru, George, Tom, Vahip, Simavi, Hopwood, Malcolm, Martin, Andrew J., Lam, William and Burt, Tal (2005). Randomized trial of sertraline versus venlafaxine XR in major depression: Efficacy and discontinuation symptoms. Journal of Clinical Psychiatry, 66 (10), 1312-1320. doi: 10.4088/JCP.v66n1015
2004
Journal Article
A phase II trial of capecitabine in heavily pre-treated platinum-resistant ovarian cancer
Rischin, Danny, Phillips, Kelly-Anne, Friedlander, Michael, Harnett, Paul, Quinn, Michael, Richardson, Gary and Martin, Andrew (2004). A phase II trial of capecitabine in heavily pre-treated platinum-resistant ovarian cancer. Gynecologic Oncology, 93 (2), 417-421. doi: 10.1016/j.ygyno.2004.01.037
2003
Journal Article
The benefits and costs of tamoxifen for breast cancer prevention
Eckermann, Simon D., Martin, Andrew J., Stockler, Martin R. and Simes, R. John (2003). The benefits and costs of tamoxifen for breast cancer prevention. Australian and New Zealand Journal of Public Health, 27 (1), 34-40. doi: 10.1111/j.1467-842X.2003.tb00377.x
2002
Journal Article
Cholesterol-lowering therapy with pravastatin in patients with average cholesterol levels and established ischaemic heart disease: is it cost-effective?
Glasziou, P. P., Eckermann, S. D., Mulray, S. E., Simes, R. J., Martin, A. J., Kirby, A. C., Hall, J. P., Caleo, S., White, H. D. and Tonkin, A. M. (2002). Cholesterol-lowering therapy with pravastatin in patients with average cholesterol levels and established ischaemic heart disease: is it cost-effective?. Medical Journal of Australia, 177 (8), 428-434. doi: 10.5694/j.1326-5377.2002.tb04883.x
2000
Journal Article
A comparison of standard gamble, time trade-off and adjusted time trade-off scores
Martin, A., Glasziou, P. P., Simes, R. J. and Lumley, T. (2000). A comparison of standard gamble, time trade-off and adjusted time trade-off scores. International Journal of Technology Assessment in Health, 16 (1), 137-147. doi: 10.1017/S0266462300161124
2000
Journal Article
Successful treatment of invasive nasal cryptococcosis in a ferret
Malik, R., Martin, P., McGill, J., Martin, A. and Love, D. N. (2000). Successful treatment of invasive nasal cryptococcosis in a ferret. Australian Veterinary Journal, 78 (3), 158-159. doi: 10.1111/j.1751-0813.2000.tb10582.x
1999
Journal Article
Quality of life assessment, evidence-based medicine and cancer prevention
Martin, A. (1999). Quality of life assessment, evidence-based medicine and cancer prevention. Cancer Forum, 23 (3), 142-143.
1999
Journal Article
A cardiovascular extension of the Health Measurement Questionnaire
Martin, A. J., Glasziou, P. P. and Simes, R. J. (1999). A cardiovascular extension of the Health Measurement Questionnaire. Journal of Epidemiology and Community Health, 53 (9), 548-557. doi: 10.1136/jech.53.9.548
1998
Journal Article
Predicting patients' utilities from quality of life items: an improved scoring system for the UBQ-H
Martin, A. J., Glasziou, P. P., Simes, R. J. and Lumley, T. (1998). Predicting patients' utilities from quality of life items: an improved scoring system for the UBQ-H. Quality of Life Research, 7 (8), 703-711. doi: 10.1023/A:1008857131564
1998
Journal Article
Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels
Tonkin, A., Aylward, P., Colquhoun, D., Glasziou, P., Harris, P., MacMahon, S., Magnus, P., Newel, D., Nestel, P., Sharpe, N., Hunt, D., Shaw, J., Simes, R. J., Thompson, P., Thomson, A., West, M., White, H., Simes, S., Hague, W., Caleo, S., Hall, J., Martin, A., Mulray, S., Barter, P., Beilin, L., Collins, R., McNeil, J., Meier, P., Willimott, H. ... Keech, A. (1998). Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. New England Journal of Medicine, 339 (19), 1349-1357. doi: 10.1056/NEJM199811053391902
1998
Journal Article
Quality-of-life assessment in health care research and practice
Martin, Andrew J. and Stockler, Martin (1998). Quality-of-life assessment in health care research and practice. Evaluation and the Health Professions, 21 (2), 141-156. doi: 10.1177/016327879802100202
1995
Journal Article
Design features and baseline characteristics of the LIPID (long-term intervention with pravastatin in ischemic disease) study: A randomized trial in patients with previous acute myocardial infarction and/or unstable angina pectoris
Tonkin, A., Aylward, P., Colquhoun, D., Glasziou, P., Harris, P., Hunt, D., MacMahon, S., Nestel, P., Sharpe, N., Símes, J., Thompson, P., Thomson, A., West, M., White, H., Shaw, J., Ablett, M., MacAskill, M., Turner, R., Magnus, P., Wallace, P., Keech, A., Newell, D., Raupach, H., Hague, W., Hall, J., Mulray, S., Wiseman, V., Davies, P., Smithers, D. ... Thompson, R. (1995). Design features and baseline characteristics of the LIPID (long-term intervention with pravastatin in ischemic disease) study: A randomized trial in patients with previous acute myocardial infarction and/or unstable angina pectoris. The American Journal of Cardiology, 76 (7), 474-479. doi: 10.1016/S0002-9149(99)80133-7
1995
Journal Article
A controlled trial of a behavioral and educational intervention following coronary artery bypass surgery
Oldenburg, B., Martin, A., Greenwood, J., Bernstein, L. and Allan, R. (1995). A controlled trial of a behavioral and educational intervention following coronary artery bypass surgery. Journal of Cardiopulmonary Rehabilitation, 15 (1), 39-46. doi: 10.1097/00008483-199501000-00006
1994
Journal Article
Mark‐recapture estimates of injecting drug users in Sydney
Duque‐Portugal, Francisco, Martin, Andrew J., Taylor, Richard and Ross, Michael W. (1994). Mark‐recapture estimates of injecting drug users in Sydney. Australian Journal of Public Health, 18 (2), 201-204. doi: 10.1111/j.1753-6405.1994.tb00226.x
Funding
Current funding
Supervision
Availability
- Professor Andrew Martin is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Advanced methods for biomarker informed endometrial cancer
Associate Advisor
Other advisors: Dr Eva Baxter, Dr Zoe West, Professor Andreas Obermair
Media
Enquiries
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