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Dr John Kemp
Dr

John Kemp

Email: 

Overview

Background

John Kemp is a senior research fellow at the University of Queensland. He first developed a keen interest in genetics while studying a Bachelor of Science at the University of Pretoria (RSA). After being awarded a first for his honours degree, he secured a scholarship from the University of Newcastle upon Tyne (UK) to study a master’s degree in medical genetics, which he subsequently completed with distinction. John was awarded a Wellcome Trust PhD studentship in molecular genetics and life-course epidemiology at the University of Bristol (UK). He duly completed his PhD, focussing on the genetics of osteoporosis (OP). His expertise lies in the genetic mapping of complex traits related to OP, and his research has yielded a step change in understanding the genetic architecture of OP. Through his extensive network of experts in functional genomics and murine genetics, he has mapped may OP loci to target genes and identified nine genes that represent new opportunities for drug development. These findings have since been published in top-tier journals such as Nature Genetics, and his contributions have been further recognised by the way of several international young investigator awards. His other interests include applying new statistical genetics methodologies to OP research, including approaches for causal modelling through Mendelian Randomization. John’s expertise extends beyond statistical genetics, as he has >6 years of experience performing advanced molecular genetics laboratory techniques and has used these to advance his OP research.

Availability

Dr John Kemp is:
Available for supervision

Qualifications

  • Masters (Coursework) of Science, Newcastle University
  • Doctor of Philosophy, University of Bristol

Research interests

  • Identifying pharmacological targets for osteoporosis intervention.

    Osteoporosis is a debilitating disease characterized by weak bones and increased risk of fracture. This research applies innovative statistical and molecular genetic methods to the world’s largest study of osteoporosis in order to identify genes, proteins and metabolites that may in the future serve as pharmacological targets to restore lost bone and prevent fracture.

Works

Search Professor John Kemp’s works on UQ eSpace

144 works between 2009 and 2026

81 - 100 of 144 works

2015

Journal Article

Meta-analysis of genome-wide association studies for neuroticism, and the polygenic association with major depressive disorder

De Moor, Marleen H.M, Van Den Berg, Stephanie M, Verweij, Karin J.H, Krueger, Robert F, Luciano, Michelle, Arias Vasquez, Alejandro, Matteson, Lindsay K, Derringer, Jaime, Esko, Tonu, Amin, Najaf, Gordon, Scott D, Hansell, Narelle K, Hart, Amy B, Seppala, Ilkka, Huffman, Jennifer E, Konte, Bettina, Lahti, Jari, Lee, Minyoung, Miller, Mike, Nutile, Teresa, Tanaka, Toshiko, Teumer, Alexander, Viktorin, Alexander, Wedenoja, Juho, Abecasis, Goncalo R, Adkins, Daniel E, Agrawal, Arpana, Allik, Juri, Appel, Katja ... Boomsma, Dorret I (2015). Meta-analysis of genome-wide association studies for neuroticism, and the polygenic association with major depressive disorder. JAMA Psychiatry, 72 (7), 642-650. doi: 10.1001/jamapsychiatry.2015.0554

Meta-analysis of genome-wide association studies for neuroticism, and the polygenic association with major depressive disorder

2015

Journal Article

A genome-wide approach to children's aggressive behavior: the EAGLE consortium

Pappa, Irene, St Pourcain, Beate, Benke, Kelly, Cavadino, Alana, Hakulinen, Christian, Nivard, Michel G., Nolte, Ilja M., Tiesler, Carla M. T., Bakermans-Kranenburg, Marian J., Davies, Gareth E., Evans, David M., Geoffroy, Marie-Claude, Grallert, Harald, Groen-Blokhuis, Maria M., Hudziak, James J., Kemp, John P., Keltikangas-Järvinen, Liisa, McMahon, George, Mileva-Seitz, Viara R., Motazedi, Ehsan, Power, Christine, Raitakari, Olli T., Ring, Susan M., Rivadeneira, Fernando, Rodriguez, Alina, Scheet, Paul A., Seppälä, Ilkka, Snieder, Harold, Standl, Marie ... Tiemeier, Henning (2015). A genome-wide approach to children's aggressive behavior: the EAGLE consortium. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 171 (5), 1-11. doi: 10.1002/ajmg.b.32333

A genome-wide approach to children's aggressive behavior: the EAGLE consortium

2015

Journal Article

TCTEX1D2 mutations underlie Jeune asphyxiating thoracic dystrophy with impaired retrograde intraflagellar transport

Schmidts, Miriam, Hou, Yuqing, Cortes, Claudio R., Mans, Dorus A., Huber, Celine, Boldt, Karsten, Patel, Mitali, van Reeuwijk, Jeroen, Plaza, Jean-Marc, van Beersum, Sylvia E. C., Yap, Zhi Min, Letteboer, Stef J. F., Taylor, S. Paige, Herridge, Warren, Johnson, Colin A., Scambler, Peter J., Ueffing, Marius, Kayserili, Hulya, Krakow, Deborah, King, Stephen M., Beales, Philip L., Al-Gazali, Lihadh, Wicking, Carol, Cormier-Daire, Valerie, Roepman, Ronald, Mitchison, Hannah M., Witman, George B., Al-Turki, Saeed, Anderson, Carl ... Zheng, Hou-Feng (2015). TCTEX1D2 mutations underlie Jeune asphyxiating thoracic dystrophy with impaired retrograde intraflagellar transport. Nature Communications, 6 (7074) 7074, 1-13. doi: 10.1038/ncomms8074

TCTEX1D2 mutations underlie Jeune asphyxiating thoracic dystrophy with impaired retrograde intraflagellar transport

2015

Journal Article

Genetic variants in adult bone mineral density and fracture risk genes are associated with the rate of bone mineral density acquisition in adolescence

Warrington, Nicole M., Kemp, John P., Tilling, Kate, Tobias, Jonathan H. and Evans, David M. (2015). Genetic variants in adult bone mineral density and fracture risk genes are associated with the rate of bone mineral density acquisition in adolescence. Human Molecular Genetics, 24 (14) ddv143, 4158-4166. doi: 10.1093/hmg/ddv143

Genetic variants in adult bone mineral density and fracture risk genes are associated with the rate of bone mineral density acquisition in adolescence

2015

Journal Article

A genome-wide association study of body mass index across early life and childhood

Warrington, Nicole M., Howe, Laura D., Paternoster, Lavinia, Kaakinen, Marika, Herrala, Sauli, Huikari, Ville, Wu, Yan Yan, Kemp, John P., Timpson, Nicholas J., Pourcain, Beate St, Smith, George Davey, Tilling, Kate, Jarvelin, Marjo-Riitta, Pennell, Craig E., Evans, David M., Lawlor, Debbie A., Briollais, Laurent and Palmer, Lyle J. (2015). A genome-wide association study of body mass index across early life and childhood. International Journal of Epidemiology, 44 (2) dyv077, 700-712. doi: 10.1093/ije/dyv077

A genome-wide association study of body mass index across early life and childhood

2015

Journal Article

Genome-wide association study of blood lead shows multiple associations near ALAD

Warrington, Nicole M., Zhu, Gu, Dy, Veronica, Heath, Andrew C., Madden, Pamela A. F., Hemani, Gibran, Kemp, John P., Mcmahon, George, St Pourcain, Beate, Timpson, Nicholas J., Taylor, Caroline M., Golding, Jean, Lawlor, Debbie A., Steer, Colin, Montgomery, Grant W., Martin, Nicholas G., Smith, George Davey, Evans, David M. and Whitfield, John B. (2015). Genome-wide association study of blood lead shows multiple associations near ALAD. Human Molecular Genetics, 24 (13) ddv112, 3871-3879. doi: 10.1093/hmg/ddv112

Genome-wide association study of blood lead shows multiple associations near ALAD

2015

Journal Article

Whole-genome sequence-based analysis of thyroid function

Taylor, Peter N., Porcu, Eleonora, Chew, Shelby, Campbell, Purdey J., Traglia, Michela, Brown, Suzanne J., Mullin, Benjamin H., Shihab, Hashem A., Min, Josine, Walter, Klaudia, Memari, Yasin, Huang, Jie, Barnes, Michael R., Beilby, John P., Charoen, Pimphen, Danecek, Petr, Dudbridge, Frank, Forgetta, Vincenzo, Greenwood, Celia, Grundberg, Elin, Johnson, Andrew D., Hui, Jennie, Lim, Ee M., McCarthy, Shane, Muddyman, Dawn, Panicker, Vijay, Perry, John R. B., Bell, Jordana T., Yuan, Wei ... Yang, Jian (2015). Whole-genome sequence-based analysis of thyroid function. Nature Communications, 6 (1) 5681, 5681.1-5681.10. doi: 10.1038/ncomms6681

Whole-genome sequence-based analysis of thyroid function

2015

Journal Article

A novel common variant in DCST2 is associated with length in early life and height in adulthood

van der Valk, Ralf J. P., Kreiner-Moller, Eskil, Kooijman, Marjolein N., Guxens, Monica, Stergiakouli, Evangelia, Saaf, Annika, Bradfield, Jonathan P., Geller, Frank, Hayes, M. Geoffrey, Cousminer, Diana L., Koerner, Antje, Thiering, Elisabeth, Curtin, John A., Myhre, Ronny, Huikari, Ville, Joro, Raimo, Kerkhof, Marjan, Warrington, Nicole M., Pitkanen, Niina, Ntalla, Ioanna, Horikoshi, Momoko, Veijola, Riitta, Freathy, Rachel M., Teo, Yik-Ying, Barton, Sheila J., Evans, David M., Kemp, John P., St Pourcain, Beate, Ring, Susan M. ... for the Early Growth Genetics (EGG) Consortium (2015). A novel common variant in DCST2 is associated with length in early life and height in adulthood. Human Molecular Genetics, 24 (4) ddu510, 1155-1168. doi: 10.1093/hmg/ddu510

A novel common variant in DCST2 is associated with length in early life and height in adulthood

2015

Journal Article

Associations of vitamin D pathway genes with circulating 25-hydroxyvitamin-D, 1,25-dihydroxyvitamin-D, and prostate cancer: a nested case–control study

Gilbert, Rebecca, Bonilla, Carolina, Metcalfe, Chris, Lewis, Sarah, Evans, David M., Fraser, William D., Kemp, John P., Donovan, Jenny L., Hamdy, Freddie C., Neal, David E., Lane, J. Athene, Smith, George Davey, Lathrop, Mark and Martin, Richard M. (2015). Associations of vitamin D pathway genes with circulating 25-hydroxyvitamin-D, 1,25-dihydroxyvitamin-D, and prostate cancer: a nested case–control study. Cancer Causes and Control, 26 (2), 205-218. doi: 10.1007/s10552-014-0500-5

Associations of vitamin D pathway genes with circulating 25-hydroxyvitamin-D, 1,25-dihydroxyvitamin-D, and prostate cancer: a nested case–control study

2014

Journal Article

Heritability and genome-wide analyses of problematic peer relationships during childhood and adolescence

St Pourcain, Beate, Haworth, C. M. A., Davis, O. S. P., Wang, Kai, Timpson, Nicholas J., Evans, David M., Kemp, John P., Ronald, Angelica, Price, Tom, Meaburn, Emma, Ring, Susan M., Golding, Jean, Hakonarson, Hakon, Plomin, R. and Smith, George Davey (2014). Heritability and genome-wide analyses of problematic peer relationships during childhood and adolescence. Human Genetics, 134 (6), 539-551. doi: 10.1007/s00439-014-1514-5

Heritability and genome-wide analyses of problematic peer relationships during childhood and adolescence

2014

Journal Article

Genome-wide association study for refractive astigmatism reveals genetic co-determination with spherical equivalent refractive error: the CREAM consortium

Li, Qing, Wojciechowski, Robert, Simpson, Claire L., Hysi, Pirro G., Verhoeven, Virginie J. M., Ikram, Mohammad Kamran, Hohn, Rene, Vitart, Veronique, Hewitt, Alex W., Oexle, Konrad, Makela, Kari-Matti, MacGregor, Stuart, Pirastu, Mario, Fan, Qiao, Cheng, Ching-Yu, St Pourcain, Beate, McMahon, George, Kemp, John P., Northstone, Kate, Rahi, Jugnoo S., Cumberland, Phillippa M., Martin, Nicholas G., Sanfilippo, Paul G., Lu, Yi, Wang, Ya Xing, Hayward, Caroline, Polasek, Ozren, Campbell, Harry, Bencic, Goran ... Guggenheim, Jeremy A. (2014). Genome-wide association study for refractive astigmatism reveals genetic co-determination with spherical equivalent refractive error: the CREAM consortium. Human Genetics, 134 (2), 131-146. doi: 10.1007/s00439-014-1500-y

Genome-wide association study for refractive astigmatism reveals genetic co-determination with spherical equivalent refractive error: the CREAM consortium

2014

Journal Article

Genome-wide association study of height-adjusted BMI in childhood identifies functional variant in ADCY3

Stergiakouli, Evangelia, Gaillard, Romy, Tavare, Jeremy M., Balthasar, Nina, Loos, Ruth J., Taal, Hendrik R., Evans, David M., Rivadeneira, Fernando, St Pourcain, Beate, Uitterlinden, Andre G., Kemp, John P., Hofman, Albert, Ring, Susan M., Cole, Tim J., Jaddoe, Vincent W.V., Smith, George Davey and Timpson, Nicholas J. (2014). Genome-wide association study of height-adjusted BMI in childhood identifies functional variant in ADCY3. Obesity, 22 (10), 2252-2259. doi: 10.1002/oby.20840

Genome-wide association study of height-adjusted BMI in childhood identifies functional variant in ADCY3

2014

Journal Article

A rare variant in APOC3 is associated with plasma triglyceride and VLDL levels in Europeans

Timpson, Nicholas J., Walter, Klaudia, Min, Josine L., Tachmazidou, Ioanna, Malerba, Giovanni, Shin, So-Youn, Chen, Lu, Futema, Marta, Southam, Lorraine, Iotchkova, Valentina, Cocca, Massimiliano, Huang, Jie, Memari, Yasin, McCarthy, Shane, Danecek, Petr, Muddyman, Dawn, Mangino, Massimo, Menni, Cristina, Perry, John R. B., Ring, Susan M., Gaye, Amadou, Dedoussis, George, Farmaki, Aliki-Eleni, Burton, Paul, Talmud, Philippa J., Gambaro, Giovanni, Spector, Tim D., Smith, George Davey, Durbin, Richard ... Yang, Jian (2014). A rare variant in APOC3 is associated with plasma triglyceride and VLDL levels in Europeans. Nature Communications, 5 (1) 4871, 1-10. doi: 10.1038/ncomms5871

A rare variant in APOC3 is associated with plasma triglyceride and VLDL levels in Europeans

2014

Journal Article

Common variation near ROBO2 is associated with expressive vocabulary in infancy

St Pourcain, Beate, Cents, Rolieke A. M., Whitehouse, Andrew J. O., Haworth, Claire M. A., Davis, Oliver S. P., O'Reilly, Paul F., Roulstone, Susan, Wren, Yvonne, Ang, Qi W., Velders, Fleur P., Evans, David M., Kemp, John P., Warrington, Nicole M., Miller, Laura, Timpson, Nicholas J., Ring, Susan M., Verhulst, Frank C., Hofman, Albert, Rivadeneira, Fernando, Meaburn, Emma L., Price, Thomas S., Dale, Philip S., Pillas, Demetris, Yliherva, Anneli, Rodriguez, Alina, Golding, Jean, Jaddoe, Vincent W. V., Jarvelin, Marjo-Riitta, Plomin, Robert ... Smith, George Davey (2014). Common variation near ROBO2 is associated with expressive vocabulary in infancy. Nature Communications, 5 (1) A4831, 1-9. doi: 10.1038/ncomms5831

Common variation near ROBO2 is associated with expressive vocabulary in infancy

2014

Journal Article

Birth weight is positively related to bone size in adolescents but inversely related to cortical bone mineral density: findings from a large prospective cohort study

Steer, Colin D., Sayers, Adrian, Kemp, John, Fraser, William D. and Tobias, Jon H. (2014). Birth weight is positively related to bone size in adolescents but inversely related to cortical bone mineral density: findings from a large prospective cohort study. Bone, 65 (100), 77-82. doi: 10.1016/j.bone.2014.05.008

Birth weight is positively related to bone size in adolescents but inversely related to cortical bone mineral density: findings from a large prospective cohort study

2014

Journal Article

Cis and trans effects of human genomic variants on gene expression

Bryois, Julien, Buil, Alfonso, Evans, David M., Kemp, John P., Montgomery, Stephen B., Conrad, Donald F., Ho, Karen M., Ring, Susan, Hurles, Matthew, Deloukas, Panos, Smith, George Davey and Dermitzakis, Emmanouil T. (2014). Cis and trans effects of human genomic variants on gene expression. PLoS Genetics, 10 (7) e1004461, e1004461. doi: 10.1371/journal.pgen.1004461

Cis and trans effects of human genomic variants on gene expression

2014

Journal Article

Genetic variation in prostate-specific antigen-detected prostate cancer and the effect of control selection on genetic association studies

Knipe, Duleeka W., Evans, David M., Kemp, John P., Eeles, Rosalind, Easton, Douglas F., Kote-Jarai, Zsofia, Al Omama, Ali Amin, Benlloch, Sara, Donovan, Jenny L., Hamdy, Freddie C., Neal, David E., Davey Smith, George, Lathrop, Mark and Martin, Richard M. (2014). Genetic variation in prostate-specific antigen-detected prostate cancer and the effect of control selection on genetic association studies. Cancer Epidemiology, Biomarkers and Prevention, 23 (7), 1356-1365. doi: 10.1158/1055-9965.EPI-13-0889

Genetic variation in prostate-specific antigen-detected prostate cancer and the effect of control selection on genetic association studies

2014

Journal Article

Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment

Kemp, John P., Medina-Gomez, Carolina, Estrada, Karol, St Pourcain, Beate, Heppe, Denise H. M., Warrington, Nicole M., Oei, Ling, Ring, Susan M., Kruithof, Claudia J., Timpson, Nicholas J., Wolber, Lisa E., Reppe, Sjur, Gautvik, Kaare, Grundberg, Elin, Ge, Bing, van der Eerden, Bram, van de Peppel, Jeroen, Hibbs, Matthew A., Ackert-Bicknell, Cheryl L., Choi, Kwangbom, Koller, Daniel L., Econs, Michael J., Williams, Frances M. K., Foroud, Tatiana, Carola Zillikens, M., Ohlsson, Claes, Hofman, Albert, Uitterlinden, Andre G., Davey Smith, George ... Evans, David M. (2014). Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment. PLoS Genetics, 10 (6) e1004423, 1-18. doi: 10.1371/journal.pgen.1004423

Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment

2014

Journal Article

Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants

van der Valk, Ralf J. P., Duijts, Liesbeth, Timpson, Nicolas J., Salam, Muhammad T., Standl, Marie, Curtin, John A., Genuneit, Jon, Kerhof, Marjan, Kreiner-Møller, Eskil, Cáceres, Alejandro, Gref, Anna, Liang, Liming L., Taal, H. Rob, Bouzigon, Emmanuelle, Demenais, Florence, Nadif, Rachel, Ober, Carole, Thompson, Emma E., Estrada, Karol, Hofman, Albert, Uitterlinden, André G., van Duijn, Cornélia, Rivadeneira, Fernando, Li, Xia, Eckel, Sandrah P., Berhane, Kiros, Gauderman, W. James, Granell, Raquel, Evans, David M. ... de Jongste, Johan C. (2014). Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants. Journal of Allergy and Clinical Immunology, 134 (1), 46-55. doi: 10.1016/j.jaci.2013.08.053

Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants

2014

Journal Article

Does bone resorption stimulate periosteal expansion? A cross-sectional analysis of beta-C-telopeptides of type I collagen (CTX), genetic markers of the RANKL pathway, and periosteal circumference as measured by pQCT

Kemp, John P., Sayers, Adrian, Paternoster, Lavinia, Evans, David M., Deere, Kevin, St Pourcain, Beate, Timpson, Nicholas J., Ring, Susan M., Lorentzon, Mattias, Lehtimäki, Terho, Eriksson, Joel, Kähönen, Mika, Raitakari, Olli, Laaksonen, Marika, Sievänen, Harri, Viikari, Jorma, Lyytikäinen, Leo‐Pekka, Smith, George Davey, Fraser, William D., Vandenput, Liesbeth, Ohlsson, Claes and Tobias, Jon H. (2014). Does bone resorption stimulate periosteal expansion? A cross-sectional analysis of beta-C-telopeptides of type I collagen (CTX), genetic markers of the RANKL pathway, and periosteal circumference as measured by pQCT. Journal of Bone and Mineral Research, 29 (4), 1015-1024. doi: 10.1002/jbmr.2093

Does bone resorption stimulate periosteal expansion? A cross-sectional analysis of beta-C-telopeptides of type I collagen (CTX), genetic markers of the RANKL pathway, and periosteal circumference as measured by pQCT

Funding

Current funding

  • 2025 - 2029
    Using human genetics, single cell transcriptomics and animal models to accelerate drug development for patients with osteoporosis.
    NHMRC Investigator Grants
    Open grant
  • 2023 - 2027
    Identifying genetic and lifestyle determinants of abdominal aortic calcification that predispose to cardiovascular disease (MRFF Cardiovascular Health Mission Grant administered by Edith Cowan Uni)
    Edith Cowan University
    Open grant

Past funding

  • 2021 - 2025
    Identifying drug targets for osteoporosis by synthesising murine single cell transcriptomics with data from human genetic association studies [ASBMR Rising Star Award]
    ASBMR Rising Star Award
    Open grant
  • 2020 - 2024
    Identifying pharmacological targets for osteoporosis intervention using whole genome and exome sequencing of bone related phenotypes
    NHMRC Investigator Grants
    Open grant
  • 2019 - 2023
    Using large scale genome-wide association studies to identify pharmacological targets for osteoporosis intervention
    NHMRC Project Grant
    Open grant
  • 2017 - 2020
    Identifying molecular genetic pathways and modifiable risk factors that underpin osteoporosis pathogenesis through genome-wide association and Mendelian randomization
    UQ Development Fellowships
    Open grant

Supervision

Availability

Dr John Kemp is:
Available for supervision

Looking for a supervisor? Read our advice on how to choose a supervisor.

Available projects

  • Identifying cellular and genetic determinants of osteoporosis and related co-morbidities

    Osteoporosis is a debilitating disease characterized by brittle bones and increased risk of fracture. This project applies innovative statistical and molecular genetic methods to the world’s largest study of osteoporosis in order to identify genes, proteins and metabolites that may in the future serve as pharmacological targets to restore lost bone and prevent fracture.

Supervision history

Current supervision

  • Doctor Philosophy

    Using single cell transcriptomics, gene-mapping, and animal models to accelerate drug discovery for patients with osteoporosis

    Principal Advisor

    Other advisors: Dr Nicole Warrington

Completed supervision

Media

Enquiries

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communications@uq.edu.au