Overview
Background
John Kemp is a senior research fellow at the University of Queensland. He first developed a keen interest in genetics while studying a Bachelor of Science at the University of Pretoria (RSA). After being awarded a first for his honours degree, he secured a scholarship from the University of Newcastle upon Tyne (UK) to study a master’s degree in medical genetics, which he subsequently completed with distinction. John was awarded a Wellcome Trust PhD studentship in molecular genetics and life-course epidemiology at the University of Bristol (UK). He duly completed his PhD, focussing on the genetics of osteoporosis (OP). His expertise lies in the genetic mapping of complex traits related to OP, and his research has yielded a step change in understanding the genetic architecture of OP. Through his extensive network of experts in functional genomics and murine genetics, he has mapped may OP loci to target genes and identified nine genes that represent new opportunities for drug development. These findings have since been published in top-tier journals such as Nature Genetics, and his contributions have been further recognised by the way of several international young investigator awards. His other interests include applying new statistical genetics methodologies to OP research, including approaches for causal modelling through Mendelian Randomization. John’s expertise extends beyond statistical genetics, as he has >6 years of experience performing advanced molecular genetics laboratory techniques and has used these to advance his OP research.
Availability
- Dr John Kemp is:
- Available for supervision
Qualifications
- Masters (Coursework) of Science, Newcastle University
- Doctor of Philosophy, University of Bristol
Research interests
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Identifying pharmacological targets for osteoporosis intervention.
Osteoporosis is a debilitating disease characterized by weak bones and increased risk of fracture. This research applies innovative statistical and molecular genetic methods to the world’s largest study of osteoporosis in order to identify genes, proteins and metabolites that may in the future serve as pharmacological targets to restore lost bone and prevent fracture.
Works
Search Professor John Kemp’s works on UQ eSpace
2013
Journal Article
Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error
Cheng C.-Y., Schache M., Ikram M.K., Young T.L., Guggenheim J.A., Vitart V., MacGregor S., Verhoeven V.J.M., Barathi V.A., Liao J., Hysi P.G., Bailey-Wilson J.E., St. Pourcain B., Kemp J.P., McMahon G., Timpson N.J., Evans D.M., Montgomery G.W., Mishra A., Wang Y.X., Wang J.J., Rochtchina E., Polasek O., Wright A.F., Amin N., Van Leeuwen E.M., Wilson J.F., Pennell C.E., Van Duijn C.M. ... Consortium for Refractive Error and Myopia (2013). Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error. American Journal of Human Genetics, 93 (2), 264-277. doi: 10.1016/j.ajhg.2013.06.016
2013
Journal Article
Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization
Bønnelykke, Klaus, Matheson, Melanie C., Pers, Tune H., Granell, Raquel, Strachan, David P., Alves, Alexessander Couto, Linneberg, Allan, Curtin, John A., Warrington, Nicole M., Standl, Marie, Kerkhof, Marjan, Jonsdottir, Ingileif, Bukvic, Blazenka K., Kaakinen, Marika, Sleimann, Patrick, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Schramm, Katharina, Baltic, Svetlana, Kreiner-Møller, Eskil, Simpson, Angela, St Pourcain, Beate, Coin, Lachlan, Hui, Jennie, Walters, Eugene H., Tiesler, Carla M. T., Duffy, David L., Jones, Graham, Ring, Susan M. ... Brown, Matthew A. (2013). Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization. Nature Genetics, 45 (8), 902-906. doi: 10.1038/ng.2694
2013
Journal Article
Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity
Cousminer D.L., Berry D.J., Timpson N.J., Ang W., Thiering E., Byrne E.M., Rob Taal H., Huikari V., Bradfield J.P., Kerkhof M., Groen-Blokhuis M.M., Kreiner-Moller E., Marinelli M., Holst C., Leinonen J.T., Perry J.R.B., Surakka I., Pietilainen O., Kettunen J., Anttila V., Kaakinen M., Sovio U., Pouta A., Das S., Lagou V., Power C., Prokopenko I., Evans D.M., Kemp J.P. ... Middeldorp, Christel (2013). Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. Human Molecular Genetics, 22 (13), 2735-2747. doi: 10.1093/hmg/ddt104
2013
Journal Article
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders
den Hoed, Marcel, Eijgelsheim, Mark, Esko, Tonu, Brundel, Bianca J. J. M., Peal, David S., Evans, David M., Nolte, Ilja M., Segre, Ayellet V., Holm, Hilma, Handsaker, Robert E., Westra, Harm-Jan, Johnson, Toby, Isaacs, Aaron, Yang, Jian, Lundby, Alicia, Zhao, Jing Hua, Kim, Young Jin, Go, Min Jin, Almgren, Peter, Bochud, Murielle, Boucher, Gabrielle, Cornelis, Marilyn C., Gudbjartsson, Daniel, Hadley, David, van der Harst, Pim, Hayward, Caroline, den Heijer, Martin, Igl, Wilmar, Jackson, Anne U. ... Loos, Ruth J. F. (2013). Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nature Genetics, 45 (6), 621-634. doi: 10.1038/ng.2610
2013
Journal Article
Genome-wide association study identifies loci affecting blood copper, selenium and zinc.
Evans, David M., Zhu, Gu, Dy, Veronica, Heath, Andrew C., Madden, Pamela A. F., Kemp, John P., McMahon, George, St Pourcain, Beate, Timpson, Nicholas J., Golding, Jean, Lawlor, Debbie A., Steer, Colin, Montgomery, Grant W., Martin, Nicholas G, Smith, George Davey and Whitfield, John B. (2013). Genome-wide association study identifies loci affecting blood copper, selenium and zinc.. Human Molecular Genetics, 22 (19), 3998-4006. doi: 10.1093/hmg/ddt239
2013
Journal Article
Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia (vol 45, pg 314, 2013)
Verhoeven, Virginie J. M., Hysi, Pirro G., Wojciechowski, Robert, Fan, Qiao, Guggenheim, Jeremy A., Hoehn, Rene, MacGregor, Stuart, Hewitt, Alex W., Nag, Abhishek, Cheng, Ching-Yu, Yonova-Doing, Ekaterina, Zhou, Xin, Ikram, M. Kamran, Buitendijk, Gabrielle H. S., McMahon, George, Kemp, John P., St Pourcain, Beate, Simpson, Claire L., Makela, Kari-Matti, Lehtimaki, Terho, Kahonen, Mika, Paterson, Andrew D., Hosseini, S. Mohsen, Wong, Hoi Suen, Xu, Liang, Jonas, Jost B., Parssinen, Olavi, Wedenoja, Juho, Yip, Shea Ping ... Hammond, Christopher J. (2013). Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia (vol 45, pg 314, 2013). Nature Genetics, 45 (6), 712-712. doi: 10.1038/ng0613-712b
2013
Journal Article
Corrigendum: Common variants at 12q15 and 12q24 are associated with infant head circumference (vol 44, pg 532, 2012)
Taal, H. Rob, St Pourcain, Beate, Thiering, Elisabeth, Das, Shikta, Mook-Kanamori, Dennis O., Warrington, Nicole M., Kaakinen, Marika, Kreiner-Moller, Eskil, Bradfield, Jonathan P., Freathy, Rachel M., Geller, Frank, Guxens, Monica, Cousminer, Diana L., Kerkhof, Marjan, Timpson, Nicholas J., Ikram, M. Arfan, Beilin, Lawrence J., Bonnelykke, Klaus, Buxton, Jessica L., Charoen, Pimphen, Chawes, Bo Lund Krogsgaard, Eriksson, Johan, Evans, David M., Hofman, Albert, Kemp, John P., EKim, Cecilia, Klopp, Norman, Lahti, Jari, Lye, Stephen J. ... Jaddoe, Vincent W. V. (2013). Corrigendum: Common variants at 12q15 and 12q24 are associated with infant head circumference (vol 44, pg 532, 2012). Nature Genetics, 45 (6), 713-713. doi: 10.1038/ng0613-713a
2013
Journal Article
Using genetic proxies for lifecourse sun exposure to assess the causal relationship of sun exposure with circulating vitamin d and prostate cancer risk
Bonilla, C., Gilbert, R., Kemp, J. P., Timpson, N. J., Evans, D. M., Donovan, J. L., Hamdy, F. C., Neal, D. E., Fraser, W. D., Smith, G. D., Lewis, S. J., Lathrop, M. and Martin, R. M. (2013). Using genetic proxies for lifecourse sun exposure to assess the causal relationship of sun exposure with circulating vitamin d and prostate cancer risk. Cancer Epidemiology Biomarkers and Prevention, 22 (4), 597-606. doi: 10.1158/1055-9965.EPI-12-1248
2013
Journal Article
Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia
Verhoeven V.J.M., Hysi P.G., Wojciechowski R., Fan Q., Guggenheim J.A., Hohn R., Macgregor S., Hewitt A.W., Nag A., Cheng C.-Y., Yonova-Doing E., Zhou X., Ikram M.K., Buitendijk G.H.S., Mcmahon G., Kemp J.P., Pourcain B.S., Simpson C.L., Makela K.-M., Lehtimaki T., Kahonen M., Paterson A.D., Hosseini S.M., Wong H.S., Xu L., Jonas J.B., Parssinen O., Wedenoja J., Yip S.P. ... Hammond C.J. (2013). Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. Nature Genetics, 45 (3), 314-318. doi: 10.1038/ng.2554
2013
Journal Article
Examination of the relationship between variation at 17q21 and childhood wheeze phenotypes
Granell, R., Henderson A. J., Timpson, N., St. Pourcain, B., Kemp, J. P., Ring, S. M., Ho, K., Montgomery, S. B., Dermitzakis, E. T., Evans, D. M. and Sterne, J. A. C. (2013). Examination of the relationship between variation at 17q21 and childhood wheeze phenotypes. Journal of Allergy and Clinical Immunology, 131 (3), 685-694. doi: 10.1016/j.jaci.2012.09.021
2013
Journal Article
Meta-analysis of genome-wide studies identifies WNT16 and ESR1 SNPs associated with bone mineral density in premenopausal women
Koller D.L., Zheng H.-F., Karasik D., Yerges-Armstrong L., Liu C.-T., McGuigan F., Kemp J.P., Giroux S., Lai D., Edenberg H.J., Peacock M., Czerwinski S.A., Choh A.C., McMahon G., St Pourcain B., Timpson N.J., Lawlor D.A., Evans D.M., Towne B., Blangero J., Carless M.A., Kammerer C., Goltzman D., Kovacs C.S., Prior J.C., Spector T.D., Rousseau F., Tobias J.H., Akesson K. ... Foroud T. (2013). Meta-analysis of genome-wide studies identifies WNT16 and ESR1 SNPs associated with bone mineral density in premenopausal women. Journal of Bone and Mineral Research, 28 (3), 547-558. doi: 10.1002/jbmr.1796
2013
Journal Article
Coordinated genetic scaling of the human eye: Shared determination of axial eye length and corneal curvature
Guggenheim, J. A., Zhou, X., Evans, D. M., Timpson, N. J., McMahon, G., Kemp, J. P., Pourcain, B. S., Northstone, K., Ring, S. M., Fan, Q., Wong, T. -Y., Cheng, C. Y., Khor, C. C., Aung, T., Saw, S. M. and Williams, C. (2013). Coordinated genetic scaling of the human eye: Shared determination of axial eye length and corneal curvature. Investigative Ophthalmology and Visual Science, 54 (3), 1715-1721. doi: 10.1167/iovs.12-10560
2013
Journal Article
Genetic determinants of trabecular and cortical volumetric bone mineral densities and bone microstructure
Paternoster, Lavinia, Lorentzon, Mattias, Lehtimaki, Terho, Eriksson, Joel, Kahonen, Mika, Raitakari, Olli, Laaksonen, Marika, Sievanen, Harri, Viikari, Jorma V, Lyytikainen, Leo-Pekka, Mellstrom, Dan, Karlsson, Magnus, Ljunggren, Osten, Grundberg, Elin, Kemp, John P., Sayers, Adrian, Nethander, Maria, Evans, David M., Vandenput, Liesbeth, Tobias, Jon H. and Ohlsson, Claes (2013). Genetic determinants of trabecular and cortical volumetric bone mineral densities and bone microstructure. PLoS Genetics, 9 (2) e1003247, 1-15. doi: 10.1371/journal.pgen.1003247
2013
Journal Article
A genome-wide association study for corneal curvature identifies the platelet-derived growth factor receptor alpha gene as a quantitative trait locus for eye size in white Europeans
Guggenheim, Jeremy A., McMahon, George, Kemp, John P., Akhtar, Saeed, St Pourcain, Beate, Northstone, Kate, Ring, Susan M., Evans, David M., Smith, George Davey, Timpson, Nicholas J. and Williams, Cathy (2013). A genome-wide association study for corneal curvature identifies the platelet-derived growth factor receptor alpha gene as a quantitative trait locus for eye size in white Europeans. Molecular Vision, 19, 243-253.
2013
Journal Article
Body stature growth trajectories during childhood and the development of myopia
Northstone, Kate, Guggenheim, Jeremy A., Howe, Laura D., Tilling, Kate, Paternoster, Lavinia, Kemp, John P., McMahon, George and Williams, Cathy (2013). Body stature growth trajectories during childhood and the development of myopia. Ophthalmology, 120 (5), 1064-1073. doi: 10.1016/j.ophtha.2012.11.004
2013
Journal Article
Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances
Fatemifar, Ghazaleh, Hoggart, Clive J., Paternoster, Lavinia, Kemp, John P., Prokopenko, Inga, Horikoshi, Momoko, Wright, Victoria J., Tobias, Jon H., Richmond, Stephen, Zhurov, Alexei I., Toma, Arshed M., Pouta, Anneli, Taanila, Anja, Sipila, Kirsi, Lahdesmaki, Raija, Pillas, Demetris, Geller, Frank, Feenstra, Bjarke, Melbye, Mads, Nohr, Ellen A., Ring, Susan M., St Pourcain, Beate, Timpson, Nicholas J., Smith, George D., Jarvelin, Marjo-Riitta and Evans, David M. (2013). Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances. Human Molecular Genetics, 22 (18) ddt231, 3807-3817. doi: 10.1093/hmg/ddt231
2013
Journal Article
New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism
Horikoshi M., Yaghootkar H., Mook-Kanamori D.O., Sovio U., Taal H.R., Hennig B.J., Bradfield J.P., St Pourcain B., Evans D.M., Charoen P., Kaakinen M., Cousminer D.L., Lehtimaki T., Kreiner-Moller E., Warrington N.M., Bustamante M., Feenstra B., Berry D.J., Thiering E., Pfab T., Barton S.J., Shields B.M., Kerkhof M., Van Leeuwen E.M., Fulford A.J., Kutalik Z., Zhao J.H., Den Hoed M., Mahajan A. ... Freathy R.M. (2013). New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. Nature Genetics, 45 (1), 76-82. doi: 10.1038/ng.2477
2013
Journal Article
Common Variants in Left/Right Asymmetry Genes and Pathways Are Associated with Relative Hand Skill
Brandler, William M., Morris, Andrew P., Evans, David M., Scerri, Thomas S., Kemp, John P., Timpson, Nicholas J., St Pourcain, Beate, Smith, George Davey, Ring, Susan M., Stein, John, Monaco, Anthony P., Talcott, Joel B., Fisher, Simon E., Webber, Caleb and Paracchini, Silvia (2013). Common Variants in Left/Right Asymmetry Genes and Pathways Are Associated with Relative Hand Skill. PLoS Genetics, 9 (9) e1003751, e100375.1-e100375.11. doi: 10.1371/journal.pgen.1003751
2013
Journal Article
Common variation contributes to the genetic architecture of social communication traits
St Pourcain, Beate, Whitehouse, Andrew J. O., Ang, Wei Q., Warrington, Nicole M., Glessner, Joseph T., Wang, Kai, Timpson, Nicholas J., Evans, David M., Kemp, John P., Ring,Susan M., McArdle, Wendy L., Golding, Jean, Hakonarson, Hakon, Pennell, Craig E. and Smith, George Davey (2013). Common variation contributes to the genetic architecture of social communication traits. Molecular Autism, 4 (1) 34, 34.1-34.12. doi: 10.1186/2040-2392-4-34
2013
Journal Article
Distinct relationships of intramuscular and subcutaneous fat with cortical bone: Findings from a cross-sectional study of young adult males and females
Deere, K., Sayers, A., Viljakainen, H. T., Lawlor, D. A., Sattar, N., Kemp, J. P., Fraser, W. D. and Tobias, J. H. (2013). Distinct relationships of intramuscular and subcutaneous fat with cortical bone: Findings from a cross-sectional study of young adult males and females. Journal of Clinical Endocrinology and Metabolism, 98 (6), E1041-E1049. doi: 10.1210/jc.2013-1272
Funding
Current funding
Past funding
Supervision
Availability
- Dr John Kemp is:
- Available for supervision
Looking for a supervisor? Read our advice on how to choose a supervisor.
Available projects
-
Identifying cellular and genetic determinants of osteoporosis and related co-morbidities
Osteoporosis is a debilitating disease characterized by brittle bones and increased risk of fracture. This project applies innovative statistical and molecular genetic methods to the world’s largest study of osteoporosis in order to identify genes, proteins and metabolites that may in the future serve as pharmacological targets to restore lost bone and prevent fracture.
Supervision history
Current supervision
-
Doctor Philosophy
Using single cell transcriptomics, gene-mapping, and animal models to accelerate drug discovery for patients with osteoporosis
Principal Advisor
Other advisors: Dr Nicole Warrington
Completed supervision
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2025
Doctor Philosophy
Identifying genetic and cellular determinants of musculoskeletal disorders
Principal Advisor
Other advisors: Dr Nicole Warrington
-
2023
Doctor Philosophy
Investigating a possible causal relationship between bone mineral density, osteoarthritis, and chronic pain
Principal Advisor
Other advisors: Dr Daniel Hwang, Associate Professor Adam Ewing
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2021
Doctor Philosophy
Chromosome arm aneuploidies shape tumour evolution, metastasis, chemotherapy response and patient prognosis
Associate Advisor
Media
Enquiries
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