
Overview
Background
John Kemp is a senior research fellow at the University of Queensland. He first developed a keen interest in genetics while studying a Bachelor of Science at the University of Pretoria (RSA). After being awarded a first for his honours degree, he secured a scholarship from the University of Newcastle upon Tyne (UK) to study a master’s degree in medical genetics, which he subsequently completed with distinction. John was awarded a Wellcome Trust PhD studentship in molecular genetics and life-course epidemiology at the University of Bristol (UK). He duly completed his PhD, focussing on the genetics of osteoporosis (OP). His expertise lies in the genetic mapping of complex traits related to OP, and his research has yielded a step change in understanding the genetic architecture of OP. Through his extensive network of experts in functional genomics and murine genetics, he has mapped may OP loci to target genes and identified nine genes that represent new opportunities for drug development. These findings have since been published in top-tier journals such as Nature Genetics, and his contributions have been further recognised by the way of several international young investigator awards. His other interests include applying new statistical genetics methodologies to OP research, including approaches for causal modelling through Mendelian Randomization. John’s expertise extends beyond statistical genetics, as he has >6 years of experience performing advanced molecular genetics laboratory techniques and has used these to advance his OP research.
Availability
- Dr John Kemp is:
- Not available for supervision
Qualifications
- Masters (Coursework) of Science, Newcastle University
- Doctor of Philosophy, University of Bristol
Research interests
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Identifying pharmacological targets for osteoporosis intervention.
Osteoporosis is a debilitating disease characterized by weak bones and increased risk of fracture. This research applies innovative statistical and molecular genetic methods to the world’s largest study of osteoporosis in order to identify genes, proteins and metabolites that may in the future serve as pharmacological targets to restore lost bone and prevent fracture.
Works
Search Professor John Kemp’s works on UQ eSpace
2012
Journal Article
Genome-wide association study of three-dimensional facial morphology identifies a variant in PAX3 associated with nasion position
Paternoster, Lavinia, Zhurov, Alexei I., Toma, Arshed M., Kemp, John P., St. Pourcain, Beate, Timpson, Nicholas J., McMahon, George, McArdle, Wendy, Ring, Susan M., Smith, George Davey, Richmond, Stephen and Evans, David M. (2012). Genome-wide association study of three-dimensional facial morphology identifies a variant in PAX3 associated with nasion position. American Journal of Human Genetics, 90 (3), 478-485. doi: 10.1016/j.ajhg.2011.12.021
2012
Journal Article
Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis
Paternoster, Lavinia, Standl, Marie, Chen, Chi-Mei, Ramasamy, Adaikalavan, Bonnelykke, Klaus, Duijts, Liesbeth, Ferreira, Manuel A., Alves, Alexessander C., Thyssen, Jacob P., Albrecht, Eva, Baurecht, Hansjorg, Feenstra, Bjarke, Sleiman, Patrick M. A., Hysi, Piro, Warrington, Nicole M., Curjuric, Ivan, Myhre, Ronny, Curtin, John A., Groen-Blokhuis, Maria M., Kerkhof, Marjan, Saaf, Annika, Franke, Andre, Ellinghaus, David, Folster-Holst, Regina, Dermitzakis, Emmanouil, Montgomery, Stephen B., Prokisch, Holger, Heim, Katharina, Hartikainen, Anna-Lisa ... EArly Genetics Lifecourse Epidemiology (EAGLE) Consortium (2012). Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis. Nature Genetics, 44 (2), 187-192. doi: 10.1038/ng.1017
2012
Conference Publication
Meta-Analysis of Genome-Wide Scans for Total Body Bmd Reveals An Interaction with Weight Bearing At the Wnt16 Locus
Kemp, John P., Medina-Gomez, Carolina, Estrada, Karol, Eriksson, Joel, Liu, Jeff, Reppe, Sjur, Evans, David M., Heppe, Denise, VandenPut, Liesbeth, Herrera, Lizbeth, Ring, Susan M., Kruithof, Claudia, Timpson, Nicholas J., Zillikens, M. Carola, Olstad, Ole K., Zheng, Hou-Feng, Richards, Brent, St Pourcain, Beate, Hofman, Albert, Jaddoe, Vincent W., Smith, George Davey, Lorentzon, Mattias, Gautvik, Kaare M., Uitterlinden, Andre G., Brommage, Robert, Ohlsson, Claes, Tobias, Jonathan H. and Rivadeneira, Fernando (2012). Meta-Analysis of Genome-Wide Scans for Total Body Bmd Reveals An Interaction with Weight Bearing At the Wnt16 Locus. Osteoporosis and Bone Conference, Manchester England, Jul 01-04, 2012. LONDON: SPRINGER LONDON LTD.
2012
Conference Publication
Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity, pleiotropy and age-specific effects at the WNT16 locus
Medina-Gomez, C., Kemp, J. P., Estrada, K., Eriksson, J., Liu, J., Reppe, S., Evans, D. M., Heppe, D., van den Put, L., Herrera, L., Ring, S. M., Kruithof, C., Timpson, N. J., Zillikens, M. C., Olstad, O. K., St Pourcain, B., Hofman, A., Jaddoe, V. W., Smith, G. D., Lorentzon, M., Gautvik, K. M., Uitterlinden, A. G., Brommage, R., Ohlsson, C., Tobias, J. H. and Rivadeneira, F. (2012). Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity, pleiotropy and age-specific effects at the WNT16 locus. 39th Annual Congress of the European-Calcified-Tissue-Society (ECTS), Stockholm Sweden, May 19-23, 2012. NEW YORK: ELSEVIER SCIENCE INC. doi: 10.1016/j.bone.2012.02.085
2012
Conference Publication
A Genome-Wide Association Meta-Analysis and a Mouse Gene Deletion Model Identify Wnt16 as a Potential Regulator of Cortical Bone Thickness
Tobias, Jonathan, Ohlsson, Claes, Paternoster, Lavinia, Lehtimaki, Terho, Kahonen, Mika, Raitakari, Olli, Laaksonen, Marika, Viikari, Jorma, Mellstrom, Dan, Moverare-Skitric, Sofia, Karlsson, Magnus, Ljunggren, Osten, Kemp, John P., Nethander, Maria, Vandenput, Liesbeth, Brommage, Robert, Liu, Jeff, Evans, David M. and Lorentzon, Mattias (2012). A Genome-Wide Association Meta-Analysis and a Mouse Gene Deletion Model Identify Wnt16 as a Potential Regulator of Cortical Bone Thickness. Osteoporosis and Bone Conference, Manchester England, Jul 01-04, 2012. LONDON: SPRINGER LONDON LTD.
2012
Journal Article
Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity and age-specific effects at the WNT16 locus
Medina-Gomez, Carolina, Kemp, John P., Estrada, Karol, Eriksson, Joel, Liu, Jeff, Reppe, Sjur, Evans, David M., Heppe, Denise H. M., Vandenput, Liesbeth, Herrera, Lizbeth, Ring, Susan M., Kruithof, Claudia J., Timpson, Nicholas J., Zillikens, M.C., Olstad, Ole K., Zheng, Hou-Feng, Richards, J. Brent, St. Pourcain, Beate, Hofman, Albert, Jaddoe, Vincent W. V., Smith, George Davey, Lorentzon, Mattias, Gautvik, Kaare M., Uitterlinden, Andre G., Brommage, Robert, Ohlsson, Claes, Tobias, Jonathan H. and Rivadeneira, Fernando (2012). Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity and age-specific effects at the WNT16 locus. PLoS Genetics, 8 (7) e1002718, e1002718.1-e1002718.14. doi: 10.1371/journal.pgen.1002718
2011
Journal Article
Genome-wide population-based association study of extremely overweight young adults - the GOYA study
Paternoster, Lavinia, Evans, David M., Aagaard Nohr, Ellen, Holst, Claus, Gaborieau, Valerie, Brennan, Paul, Prior Gjesing, Anette, Grarup, Niels, Witte, Daniel R., Jorgensen, Torben, Linneberg, Allan, Lauritzen, Torsten, Sandbaek, Anelli, Hansen, Torben, Pedersen, Oluf, Elliott, Katherine S., Kemp, John P., St. Pourcain, Beate, McMahon, George, Zelenika, Diana, Hager, Jorg, Lathrop, Mark, Timpson, Nicholas J., Smith, George Davey and Sorensen, Thorkild I. A. (2011). Genome-wide population-based association study of extremely overweight young adults - the GOYA study. PLoS One, 6 (9) e24303, e24303.1-e24303.9. doi: 10.1371/journal.pone.0024303
2011
Journal Article
Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture risk
Duncan, Emma L., Danoy, Patrick, Kemp, John P., Leo, Paul J., McCloskey, Eugene, Nicholson, Geoffrey C., Eastell, Richard, Prince, Richard L., Eisman, John A., Jones, Graeme, Sambrook, Philip N., Reid, Ian R., Dennison, Elaine M., Wark, John, Richards, J. Brent, Uitterlinden, Andre G., Spector, Tim D., Esapa, Chris, Cox, Roger D., Brown, Steve D. M., Thakker, Rajesh V., Addison, Kathryn A., Bradbury, Linda A., Center, Jacqueline R., Cooper, Cyrus, Cremin, Catherine, Estrada, Karol, Felsenberg, Dieter, Glueer, Claus-C. ... Brown, Matthew A. (2011). Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture risk. PLoS Genetics, 7 (4) e1001372, e1001372.1-e1001372.10. doi: 10.1371/journal.pgen.1001372
2011
Journal Article
Nuclear factors involved in mitochondrial translation cause a subgroup of combined respiratory chain deficiency
Kemp, John P., Smith, Paul M., Pyle, Angela, Neeve, Vivienne C. M., Tuppen, Helen A. L., Schara, Ulrike, Talim, Beril, Topaloglu, Haluk, Holinski-Feder, Elke, Abicht, Angela, Czermin, Birgit, Lochmuller, Hanns, McFarland, Robert, Chinnery, Patrick F., Chrzanowska-Lightowlers, Zofia M. A., Lightowlers, Robert N., Taylor, Robert W. and Horvath, Rita (2011). Nuclear factors involved in mitochondrial translation cause a subgroup of combined respiratory chain deficiency. Brain, 134 (1), 183-195. doi: 10.1093/brain/awq320
2011
Journal Article
Adult height variants affect birth length and growth rate in children
Paternoster, Lavinia, Howe, Laura D., Tilling, Kate, Weedon, Michael N., Freathy, Rachel M., Frayling, Timothy M., Kemp, John P., Smith, George Davey, Timpson, Nicholas J., Ring, Susan M., Evans, David M. and Lawlor, Debbie A. (2011). Adult height variants affect birth length and growth rate in children. Human Molecular Genetics, 20 (20) ddr309, 4069-4075. doi: 10.1093/hmg/ddr309
2010
Journal Article
Genome-wide association meta-analysis of cortical bone mineral density unravels allelic heterogeneity at the RANKL locus and potential Pleiotropic effects on bone
Paternoster, Lavinia, Lorentzon, Mattias, Vandenput, Liesbeth, Karlsson, Magnus K., Ljunggren, Osten, Kindmark, Andreas, Mellstrom, Dan, Kemp, John P., Jarett, Caroline E., Holly, Jeff M. P., Sayers, Adrian, St. Pourcain, Beate, Timpson, Nicholas J., Deloukas, Panos, Smith, George Davey, Ring, Ssusan M., Evans, David M., Tobias, Jon H. and Ohlsson, Claes (2010). Genome-wide association meta-analysis of cortical bone mineral density unravels allelic heterogeneity at the RANKL locus and potential Pleiotropic effects on bone. PLoS Genetics, 6 (11) e1001217, e1001217.1-e1001217.12. doi: 10.1371/journal.pgen.1001217
2009
Journal Article
Molecular basis of infantile reversible cytochrome c oxidase deficiency myopathy
Horvath, Rita, Kemp, John P., Tuppen, Helen A. L., Hudson, Gavin, Oldfors, Andreas, Marie, Suely K. N., Moslemi, Ali-Reza, Servidei, Serenella, Holme, Elisabeth, Shanske, Sara, Kollberg, Guttab, Jayakar, Panul, Pyle, Angela, Marks, Harold M., Holinski-Feder, Elke, Scavina, Mena, Walter, Maggie C., Oku, Jorida, Gunther-Scholz, Andrea, Smith, Paul M., McFarland, Robert, Chrzanowska-Lightowlers, Zofia M. A., Lightowlers, Robert N., Hirano, Michio, Lochmuller, Hanns, Taylor, Robert W., Chinnery, Patrick F., Tulinius, Mar and Dimauro, Salvatore (2009). Molecular basis of infantile reversible cytochrome c oxidase deficiency myopathy. Brain, 132 (11), 3165-3174. doi: 10.1093/brain/awp221
Funding
Current funding
Past funding
Supervision
Availability
- Dr John Kemp is:
- Not available for supervision
Supervision history
Current supervision
-
Doctor Philosophy
Using single cell transcriptomics, gene-mapping, and animal models to accelerate drug discovery for patients with osteoporosis
Principal Advisor
Other advisors: Dr Nicole Warrington
-
Doctor Philosophy
Identifying genetic and cellular determinants of musculoskeletal disorders
Principal Advisor
Other advisors: Dr Nicole Warrington
-
Doctor Philosophy
Identifying genetic and cellular determinants of musculoskeletal disorders
Principal Advisor
Other advisors: Dr Nicole Warrington
Completed supervision
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2023
Doctor Philosophy
Investigating a possible causal relationship between bone mineral density, osteoarthritis, and chronic pain
Principal Advisor
Other advisors: Dr Daniel Hwang, Associate Professor Adam Ewing
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2021
Doctor Philosophy
Chromosome arm aneuploidies shape tumour evolution, metastasis, chemotherapy response and patient prognosis
Associate Advisor
Other advisors: Dr Harald Oey
Media
Enquiries
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